SMTP-44D prevents negative symptoms of diabetic neuropathy by inhibiting sciatic nerve apoptosis, Ayaka Aoki, Keita Shibata, Ryosuke Shinouchi, Keiji Hasumi, Koji Nobe, Journal of Pharmacological Sciences, 159(1):25 - 34, 2025年09月, 原著, 査読あり, DOI:10.1016/j.jphs.2025.06.006
SMTP-44D prevents negative symptoms of diabetic neuropathy by inhibiting sciatic nerve apoptosis, Ayaka Aoki, Keita Shibata, Ryosuke Shinouchi, Keiji Hasumi, Koji Nobe, Journal of Pharmacological Scie...詳細
SMTP-44D prevents negative symptoms of diabetic neuropathy by inhibiting sciatic nerve apoptosis, Ayaka Aoki, Keita Shibata, Ryosuke Shinouchi, Keiji Hasumi, Koji Nobe, Journal of Pharmacological Sciences, 159(1):25 - 34, 2025年09月, 原著, 査読あり, DOI:10.1016/j.jphs.2025.06.006
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic, Balazs R Varga, Rajendra Uprety, Barnali Paul, Alexis Knoll, Nokomis Ramos-Gonzalez, Kevin Appourchaux, Tori Taylor, Bengisu Turgutalp, Ryosuke Shinouchi, Shainnel O Eans, Ashai K Williams, Steven G Vasquez-Grinnell, Saheem Zaidi, Antonina L Nazarova, Andras Varadi, Valerie Le Rouzic, Taylor G Brown, Shani Martinez, Michael Ansonoff, Rebecca Notis Dardashti, Amanda Hunkele, Joan Subrath, Matthew Welch, Jin Xu, Grace C Rossi, John Pintar, Gavril W Pasternak, Vsevolod Katritch, Jay P McLaughlin, Ying Xian Pan, Susruta Majumdar, ACS Chemical Neuroscience, 2025年06月, 原著, 査読あり, DOI:10.1021/acschemneuro.5c00312
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic, Balazs R Varga, Rajendra Uprety, Barnali Paul, Alexis Knoll, Nokomis Ramos-Gonzalez, Kevin Appourchau...詳細
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic, Balazs R Varga, Rajendra Uprety, Barnali Paul, Alexis Knoll, Nokomis Ramos-Gonzalez, Kevin Appourchaux, Tori Taylor, Bengisu Turgutalp, Ryosuke Shinouchi, Shainnel O Eans, Ashai K Williams, Steven G Vasquez-Grinnell, Saheem Zaidi, Antonina L Nazarova, Andras Varadi, Valerie Le Rouzic, Taylor G Brown, Shani Martinez, Michael Ansonoff, Rebecca Notis Dardashti, Amanda Hunkele, Joan Subrath, Matthew Welch, Jin Xu, Grace C Rossi, John Pintar, Gavril W Pasternak, Vsevolod Katritch, Jay P McLaughlin, Ying Xian Pan, Susruta Majumdar, ACS Chemical Neuroscience, 2025年06月, 原著, 査読あり, DOI:10.1021/acschemneuro.5c00312
Antioxidant and anti-inflammatory effects of SMTP-44D in a streptozotocin-induced diabetic neuropathy mouse model., Shinouchi Ryosuke;Shibata Keita;Nagatsuka Taiju;Hasumi Keiji;Nobe Koji, Journal of diabetes and its complications, 39(7), 2025年04月, 原著, 査読あり, DOI:10.1016/j.jdiacomp.2025.109061
Antioxidant and anti-inflammatory effects of SMTP-44D in a streptozotocin-induced diabetic neuropathy mouse model., Shinouchi Ryosuke;Shibata Keita;Nagatsuka Taiju;Hasumi Keiji;Nobe Koji, Journal of d...詳細
Antioxidant and anti-inflammatory effects of SMTP-44D in a streptozotocin-induced diabetic neuropathy mouse model., Shinouchi Ryosuke;Shibata Keita;Nagatsuka Taiju;Hasumi Keiji;Nobe Koji, Journal of diabetes and its complications, 39(7), 2025年04月, 原著, 査読あり, DOI:10.1016/j.jdiacomp.2025.109061
Structure-guided design of partial agonists at an opioid receptor, Balazs R Varga, Sarah M Bernhard, Amal El Daibani, Saheem A Zaidi, Jordy H Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R Hammond, Shainnel O Eans, Violetta Weinreb, Elyssa B Margolis, Jonathan F Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar, Tao Che, nature communications, 2025年03月, 原著, 査読あり, DOI:10.1038/s41467-025-57734-5
Structure-guided design of partial agonists at an opioid receptor, Balazs R Varga, Sarah M Bernhard, Amal El Daibani, Saheem A Zaidi, Jordy H Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L Nazarova...詳細
Structure-guided design of partial agonists at an opioid receptor, Balazs R Varga, Sarah M Bernhard, Amal El Daibani, Saheem A Zaidi, Jordy H Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R Hammond, Shainnel O Eans, Violetta Weinreb, Elyssa B Margolis, Jonathan F Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar, Tao Che, nature communications, 2025年03月, 原著, 査読あり, DOI:10.1038/s41467-025-57734-5
Analysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy ., Sasaki Akiko;Shinouchi Ryosuke;Nobe Koji;Kiuchi Yuji, Neuro endocrinology letters, 45(7-8), 2024年12月, 原著, 査読あり
Analysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy ., Sasaki Akiko;Shinouchi Ryosuke;Nobe Koji;Kiuchi Yu...詳細
Analysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy ., Sasaki Akiko;Shinouchi Ryosuke;Nobe Koji;Kiuchi Yuji, Neuro endocrinology letters, 45(7-8), 2024年12月, 原著, 査読あり
The effect of hand therapy on alleviating chemotherapy-induced peripheral neuropathy in a model mouse, Ryosuke Shinouchi; Akiko Sasaki; Takashi Takaki; Mayumi Tsuji; Yuji Kiuchi; Koji Nobe, Neuroscience Letters, 800:137138 - 137138, 2023年03月, 原著, 査読あり, DOI:10.1016/j.neulet.2023.137138
The effect of hand therapy on alleviating chemotherapy-induced peripheral neuropathy in a model mouse, Ryosuke Shinouchi; Akiko Sasaki; Takashi Takaki; Mayumi Tsuji; Yuji Kiuchi; Koji Nobe, Neuroscien...詳細
The effect of hand therapy on alleviating chemotherapy-induced peripheral neuropathy in a model mouse, Ryosuke Shinouchi; Akiko Sasaki; Takashi Takaki; Mayumi Tsuji; Yuji Kiuchi; Koji Nobe, Neuroscience Letters, 800:137138 - 137138, 2023年03月, 原著, 査読あり, DOI:10.1016/j.neulet.2023.137138
SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment., Shinouchi Ryosuke;Shibata Keita;Jono Shiori;Hasumi Keiji;Nobe Koji, International journal of molecular sciences, 23(9):5187 - 5187, 2022年05月, 原著, 査読あり, DOI:10.3390/ijms23095187
SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment., Shinouchi Ryosuke;Sh...詳細
SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment., Shinouchi Ryosuke;Shibata Keita;Jono Shiori;Hasumi Keiji;Nobe Koji, International journal of molecular sciences, 23(9):5187 - 5187, 2022年05月, 原著, 査読あり, DOI:10.3390/ijms23095187
Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice., Michiru Nagao; Masataka Tajima; Erika Sugiyama; Ryosuke Shinouchi; Keita Shibata; Masayuki Yoshikawa; Takushi Yamamoto; Vilasinee Hirunpanich Sato; Koji Nobe; Hitoshi Sato, Pharmacology research & perspectives, 10(2):e00919, 2022年04月, 原著, 査読あり, DOI:10.1002/prp2.919
Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice., Michiru Nagao; Masataka...詳細
Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice., Michiru Nagao; Masataka Tajima; Erika Sugiyama; Ryosuke Shinouchi; Keita Shibata; Masayuki Yoshikawa; Takushi Yamamoto; Vilasinee Hirunpanich Sato; Koji Nobe; Hitoshi Sato, Pharmacology research & perspectives, 10(2):e00919, 2022年04月, 原著, 査読あり, DOI:10.1002/prp2.919
SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities, SHINOUCHI Ryosuke;SHIBATA Keita;HASHIMOTO Terumasa;JONO Shiori;HASUMI Keiji;NOBE Koji, pharmacology research & perspectives, 8(6):e00648, 2020年12月, 原著, 査読あり, DOI:10.1002/prp2.648
SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities, SHINOUCHI Ryosuke;SHIBATA Keita;HASHIMOTO Terumasa;JONO Shiori;HASUMI Keiji;NOBE Koji, ...詳細
SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities, SHINOUCHI Ryosuke;SHIBATA Keita;HASHIMOTO Terumasa;JONO Shiori;HASUMI Keiji;NOBE Koji, pharmacology research & perspectives, 8(6):e00648, 2020年12月, 原著, 査読あり, DOI:10.1002/prp2.648
講演・口頭発表等
Evaluating analogs of [D-Trp]CJ-15,208 for orally-active kappa opioid receptor antagonism as potential therapeutics to prevent stress-induced cocaine reinstatement, Ryosuke Shinouchi, Jenna Richman, Andrew Watson, Caroline Eggers, Shainnel O. Eans, Bowen Tsai, Jeremy S. Coleman, Dmitry Yakovlev, Brian I. Knap, Jean M. Bidlack, Jane V. Aldrich, and Jay, P. McLaughlin, 2025 UF CARE 12th Annual Symposium, 2025年04月07日
Evaluating analogs of [D-Trp]CJ-15,208 for orally-active kappa opioid receptor antagonism as potential therapeutics to prevent stress-induced cocaine reinstatement, Ryosuke Shinouchi, Jenna Richman, A...詳細
Evaluating analogs of [D-Trp]CJ-15,208 for orally-active kappa opioid receptor antagonism as potential therapeutics to prevent stress-induced cocaine reinstatement, Ryosuke Shinouchi, Jenna Richman, Andrew Watson, Caroline Eggers, Shainnel O. Eans, Bowen Tsai, Jeremy S. Coleman, Dmitry Yakovlev, Brian I. Knap, Jean M. Bidlack, Jane V. Aldrich, and Jay, P. McLaughlin, 2025 UF CARE 12th Annual Symposium, 2025年04月07日
Efficacy modulation by semi-synthetic diversification of mitragynine pseudoindoxyl, Barnali Paul, Peng Huang, Nokomis Ramos-Gonzalez, Emily Wells, Balazs R. Varga, Kevin Appourchaux, Qianru Jiang, Shainnel O'Eans, Ryosuke Shinouchi, Sabrina Masood, Caleb A Seekins, Parthasaradhireddy Tanguturi, Tao Che, John M Streicher, Evan O'Brien, Jay, P. McLaughlin, Brian K Kobilka, Susruta Majumdar, International Narcotics Research Conference 2024, 2024年07月10日
Efficacy modulation by semi-synthetic diversification of mitragynine pseudoindoxyl, Barnali Paul, Peng Huang, Nokomis Ramos-Gonzalez, Emily Wells, Balazs R. Varga, Kevin Appourchaux, Qianru Jiang, Sha...詳細
Efficacy modulation by semi-synthetic diversification of mitragynine pseudoindoxyl, Barnali Paul, Peng Huang, Nokomis Ramos-Gonzalez, Emily Wells, Balazs R. Varga, Kevin Appourchaux, Qianru Jiang, Shainnel O'Eans, Ryosuke Shinouchi, Sabrina Masood, Caleb A Seekins, Parthasaradhireddy Tanguturi, Tao Che, John M Streicher, Evan O'Brien, Jay, P. McLaughlin, Brian K Kobilka, Susruta Majumdar, International Narcotics Research Conference 2024, 2024年07月10日
Evaluation of the antioxidant and anti-inflammatory effects of SMTP-44D against streptozotocin-induced diabetic neuropathy in mice, Ryosuke Shinouchi, Keita Shibata, Shiori Jono, Terumasa Hashimoto, Keiji Hasumi, Koji Nobe, Experimental Biology 2020, 2020年04月06日, San Diego
Evaluation of the antioxidant and anti-inflammatory effects of SMTP-44D against streptozotocin-induced diabetic neuropathy in mice, Ryosuke Shinouchi, Keita Shibata, Shiori Jono, Terumasa Hashimoto, K...詳細
Evaluation of the antioxidant and anti-inflammatory effects of SMTP-44D against streptozotocin-induced diabetic neuropathy in mice, Ryosuke Shinouchi, Keita Shibata, Shiori Jono, Terumasa Hashimoto, Keiji Hasumi, Koji Nobe, Experimental Biology 2020, 2020年04月06日, San Diego