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詳細

合田　浩明Gouda Hiroaki

■所属部署名生物物理化学
■職名教授
Last Updated :2025/04/01

研究者情報

基本情報

プロフィール情報

  • 氏名

    合田　浩明, Gouda Hiroaki

所属

  • 生物物理化学, 教授

施設

  • 旗の台校舎

学位

  • 博士(薬学), 東京大学, 1993年03月

研究キーワード

  • 分子ドッキング計算、自由エネルギー計算、量子化学計算

所属学協会

  • 日本薬学会、日本薬学会医薬化学部会、日本薬学会構造活性相関部会、情報計算化学生物学会

受賞

  • 2003年 9月 CBI学会2003年大会　最優秀ポスター賞 2006年 7月 日本薬学会構造活性相関部会　SAR Promotion Award 2011年 6月 第８回森村豊明会奨励賞

学術貢献活動

  • 日本薬学会物理系薬学部会・世話人（2017年4月〜2019年3月） 日本薬学会構造活性相関部会・常任幹事

業績

論文

  • Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds, Daichi Hayakawa; Nanako Terauchi; Aika Iwasaki; Yurie Watanabe; Hiroaki Gouda, Chemical Physics Letters, :139754 - 139754, 2022年06月
  • Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds, Daichi Hayakawa; Nanako Terauchi; Aika Iwasaki; Yurie Watanabe; Hiroaki Gouda, Chemical Physics Letters, :139754 - 139754, 2022年06月
  • Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist, TAKASAKI Ichiro ;WATANABE Ai ;OKADATakuya;KANAYAMA Daisuke ;NAGASHIMA Ryota;SHUDO Miyu;SHIMODAIRA Ayako ;NUNOMURA Kazuto ;LIN Bangzhong ;WATANABE Yurie ;GOUDA Hiroaki;MIYATA Atsuro ;KURIHARA Takashi ;TOYOOKA Naoki, Eur J Med Chem, 231:114160, 2022年03月, 原著, 査読あり, DOI:10.1016/j.ejmech.2022.114160
  • Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors, UENOHARA Yuka ;TSUMOTO Saori ;HIRAYAMA Shigeto ;HIGASHI Eika ;WATANABE Yurie ;GOUDA Hiroaki;NAGASE Hiroshi ;FUJII Hideaki, Bioorg Med Chem, 53:116552, 2022年01月, 原著, 査読あり
  • Unpolarizable molecular model describing electron distribution for treating halogen bonds, HAYAKAWA Daichi;WATANABE-ODA Yurie ;GOUDA Hiroaki, Chemical Physics Letters, 779:138824, 2021年09月, 原著, 査読あり
  • Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7, NAKAMURA Akihiro;SUZUKI Yoshiyuki;SAKAMOTO Yasumitsu;ROPPONGI Saori;KUSHIBIKI Chisato;YONEZAWA Natsuri;TAKAHASHI Masato;SHIDA Yosuke;GOUDA Hiroaki;NONAKA Takamasa;TANAKA Nobutada;OGASAWARA Wataru, Sci Rep, 11(1):7929, 2021年04月, 原著, 査読あり
  • Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer, ENDO Satoshi;OGURI Hiroaki;SEGAWA Jin;KAWAI Mina;HU Dawei;XIA Shuang;OKADA Takuya;IRIE Katsumasa;FUJII Shinya;GOUDA Hiroaki;IGUCHI Kazuhiro;MATSUKAWA Takuo;FUJIMOTO Naohiro;NAKAYAMA Toshiyuki;TOYOOKA Naoki;MATSUNAGA Toshiyuki;IKARI Akira, J Med Chem, 63(18):10396 - 10411, 2020年09月, 原著, 査読あり
  • Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives, IWAMATSU Chiharu;HAYAKAWA Daichi;KONO Tomomi;HONJO Ayaka;ISHIZAKI Saki;HIRAYAMA Shigeto;GOUDA Hiroaki;FUJII Hideaki, Molecules, 25(17):3792, 2020年08月, 原著, 査読あり
  • A molecular interaction field describing nonconventional intermolecular interactions and its application to protein-ligand interaction prediction, HAYAKAWA Daichi;SAWADA Nahoko;WATANABE Yurie ;GOUDA Hiroaki, J Mol Graph Model, 96:107515, 2020年05月, 原著, 査読あり
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, TAKASAKI Ichiro;OGASHI Haruna;OKADA Takuya;SHIMODAIRA Ayaka;HAYAKAWA Daichi;WATANABE Ai;MIYATA Atsuro;KURIHARA Takashi;GOUDA Hiroaki;TOYOOKA Naoki, Eur J Med Chem, 186:111902, 2020年01月, 原著, 査読あり
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, 2019年11月
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, 2019年11月
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, 2019年11月
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase, SAKAMOTO Yasumitsu ;SUZUKI Yoshiyuki ;NAKAMURA Akihiro ;WATANABE Yurie ;SEKIYA Mizuki ;ROPPONGI Saori ;KUSHIBIKI Chisato ;IIZUKA Ippei ;TANI Osamu;SAKASHITA Hitoshi ;INAKA Koji ;TANAKA Hiroaki ;YAMADA Mitsugu;OHTA Kazunori ;HONMA Nobuyuki ;SHIDA Yosuke ;OGASAWARA Wataru ;NAKANISHI-MATSUI Mayumi ;NONAKA Takamasa ;GOUDA Hiroaki;TANAKA Nobutada, Sci Rep, 9(1):13587, 2019年09月, 原著, 査読あり
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), 2019年09月
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), 2019年09月
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), 2019年09月
  • Formal Syntheses of (−)-Lepadiformines A, C, and (−)-Fasicularin, TAKASHIMA Katsuki;HAYAKAWA Daichi;GOUDA Hiroaki;TOYOOKA Naoki, J Org Chem, 84(9):5222 - 5229, 2019年05月, 原著, 査読あり
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, 2019年04月
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, 2019年04月
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, 2019年04月
  • DFT study of the influence of acetyl groups of cellulose acetate on its intrinsic birefringence and wavelength dependence, HAYAKAWA Daichi;GOUDA Hiroaki;HIRONO Shuichi;UEDA Kazuyoshi, Carbohydr Polym, 207:122 - 130, 2019年03月, 原著, 査読あり
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), 2018年12月
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), 2018年12月
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), 2018年12月
  • Computational study on formation of 15-membered azalactone by double reductive amination using molecular mechanics and density functional theory calculations, GOUDA Hiroaki;NAKAYAMA Naofumi;MIURA Tomoaki;KANEMOTO Kenichi;AJITO Keiichi, J Antibiot (Tokyo), 71(5):549 - 556, 2018年05月, 原著, 査読あり
  • In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor, TAKASAKI Ichiro;WATANABE Ai;YOKAI Masafumi;WATANABE Yurie ;HAYAKAWA Daichi;NAGASHIMA Ryota;FUKUCHI Mamoru;OKADA Takuya;TOYOOKA Naoki;MIYATA Atsuro;GOUDA Hiroaki;KURIHARA Takasi, J Pharmacol Exp Ther, 365(1):1 - 8, 2018年04月, 原著, 査読あり
  • Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase, TAKAHARA Satoyuki;NAKAGAWA Kiyomi;UCHIYAMA Tsugumi;YOSHIDA Tomoyuki;MATSUMOTO Kazunori;KAWASUMI Yasuo;MIZUGUCHI MIneyuki;OBITA Takayuki;WATANABE Yurie ;HAYAKAWA Daichi;GOUDA Hiroaki;MORI Hisashi;TOYOOKA Naoki, Bioorg Med Chem Lett, 28(3):441 - 445, 2018年02月, 原著, 査読あり
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, 2018年02月
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, 2018年02月
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, 2018年02月
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, 2018年02月
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, 2018年02月
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, 2018年02月
  • A docking model of dapsone bound to HLA-B*13:01 explains the risk of dapsone hypersensitivity syndrome, WATANABE Hideaki;WATANABE Yurie ;TASHIRO Yasuya;MUSHIRODA Taisei;OZEKI Takeshi;HASHIZUME Hideo;SUEKI Hirohiko;YAMAMOTO Toshinori;UTSUNOMIYA-TATE Naoko;GOUDA Hiroaki;KUSAKABE Yoshio, J Dermatol Sci, 88(3):320 - 329, 2017年12月, 原著, 査読あり
  • Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells, ENDO Satoshi;XIA Shuang;SUYAMA Miho;MORIKAWA Yosifumi;OGURI Hiroaki;HU Dawei;AO Yoshinori;TAKAHARA Satoyuki;HORINO Yoshikazu;HAYAKAWA Yoshihiro;WATANABE Yurie ;GOUDA Hiroaki;HARA Akira;KUWATA Kazuo;TOYOOKA Naoki;MATSUNAGA Toshiyuki;IKARI Akira, J Med Chem, 60(20):8441 - 8455, 2017年10月, 原著, 査読あり
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor., YAMAMOTO Naoshi;OHRUI Sayaka;OKADA Takahiro;YATA Masahiro;SAITOH Tsuyoshi;KUTSUMURA Noriki;NAGUMO Yasuyuki;IRUKAYAMA-TOMOBE Yoko;OGAWA Yasuhiro;WATANABE Yurie;HAYAKAWA Daichi;GOUDA Hiroaki;YANAGISAWA Masashi;NAGASE Hiroshi, Bioorg Med Chem Lett, 27(17):4176 - 4179, 2017年09月, 原著, 査読あり
  • A novel serine racemase inhibitor suppresses neuronal over-activation in vivo, MORI Hisashi;WADA Ryogo;TAKAHARA Satoyuki;HORINO Yoshikazu;IZUMI Hironori;ISHIMOTO Tetsuya;YOSHIDA Tomoyuki;MIZUGUCHI Mineyuki;OBITA Takayuki;GOUDA Hiroaki;HIRONO Shuichi;TOYOOKA Naoki, Bioorg Med Chem, 25(14):3736 - 3745, 2017年07月, 原著, 査読あり
  • Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations, WATANABE Yurie ;FUKUYOSHI Shuichi;KATO Koichi;HIRATSUKA Masahiro;YAMAOTSU Noriyuki;HIRONO Shuichi;GOUDA Hiroaki;ODA Akifumi, J Mol Graph Model, 74:326 - 336, 2017年06月, 原著, 査読あり
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, 2017年03月
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, 2017年03月
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, 2017年03月
  • Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies, NAGASE Hiroshi;YAMAMOTO Naoshi;YATA Masahiro;OHRUI Sayaka;OKADA Takahiro;SAITOH Tsuyoshi;KUTSUMURA Noriki;NAGUMO Yasuyuki;IRUKAYAMA-TOMOBE Yoko;ISHIKAWA Yukiko;OGAWA Yasuhiro;HIRAYAMA Shigeto;KURODA Daisuke;WATANABE Yurie ;GOUDA Hiroaki;YANAGISAWA Masashi, J Med Chem, 60(3):1018 - 1040, 2017年02月, 原著, 査読あり
  • Molecular Orbital Study of the Formation of Intramolecular Hydrogen Bonding of a Ligand Molecule in a Protein Aromatic Hydrophobic Pocket, KOSEKI Jun;GOUDA Hiroaki;HIRONO Shuichi, Chem Pharm Bull, 64(7):1031 - 1035, 2016年07月, 原著, 査読あり
  • オレキシン受容体作動薬 創薬への展望 小分子オレキシン作動薬のデザインと合成, 長瀬 博; 永原 崇志; 斉藤 毅; 沓村 憲樹; 入鹿山 容子; 小川 靖裕; 黒田 大祐; 合田 浩明; 藤井 秀明; 柳沢 正史, 日本睡眠学会定期学術集会プログラム・抄録集, 41回:105 - 105, 2016年07月
  • オレキシン受容体作動薬 創薬への展望 小分子オレキシン作動薬のデザインと合成, 長瀬 博; 永原 崇志; 斉藤 毅; 沓村 憲樹; 入鹿山 容子; 小川 靖裕; 黒田 大祐; 合田 浩明; 藤井 秀明; 柳沢 正史, 日本睡眠学会定期学術集会プログラム・抄録集, 41回:105 - 105, 2016年07月
  • In silico and pharmacological screening identify novel PAC1 receptor antagonists, Watanabe Ai; Okada Takuya; Fukuchi Mamoru; Gouda Hiroaki; Kurihara Takashi; Miyata Atsuro; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3):S236, 2016年03月
  • In silico and pharmacological screening identify novel PAC1 receptor antagonists, Watanabe Ai; Okada Takuya; Fukuchi Mamoru; Gouda Hiroaki; Kurihara Takashi; Miyata Atsuro; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3):S236, 2016年03月
  • Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase, KUSAKABE Yoshio;ISHIHARA Masaaki;UMEDA Tomonobu;KURODA Daisuke;NAKANISHI Masayuki;KITADE Yukio;GOUDA Hiroaki;NAKAMURA Kazuo T;TANAKA Nobutada, Sci Rep, 17(5):16641, 2015年11月, 原著, 査読あり
  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists, NAGAHARA Takashi;SAITOH Tsuyoshi;KUTSUMURA Noriki;IRUKAYAMA-TOMOBE Yoko;OGAWA Yasuhiro;KURODA Daisuke;GOUDA Hiroaki;KUMAGAI Hidetoshi;FUJII Hideaki;YANAGISAWA Masashi;NAGASE Hiroshi, J Med Chem, 58(20):7931 - 7937, 2015年10月, 原著, 査読あり
  • Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1, HU Dawei;MIYAGI Namiki;ARAI Yuki;OGURI Hiroaki;MIURA Takeshi;NISHINAKA Toru;TERADA Tomoyuki;GOUDA Hiroaki;EL-KABBANI Ossama;XIA Shuang;TOYOOKA Naoki;HARA Akira;MATSUNAGA Toshiyuki;IKARI Akira;ENDO Satoshi, Org Biomol Chem, 13(27):7487 - 7499, 2015年07月, 原著, 査読あり
  • Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity, SAKAMOTO Yasumitsu;SUZUKI YoshiyukI;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, Sci Rep, 5:11151, 2015年06月, 原著, 査読あり
  • コンピュータを利用したドラッグデザインの実際 , 合田　浩明, 昭和学士会雑誌, 75(3):302 - 311, 2015年06月, 査読あり, DOI:10.14930/jshowaunivsoc.75.302
  • Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase, Akihiro Sugawara; Nobuo Maita; Hiroaki Gouda; Tsuyoshi Yamamoto; Tomoyasu Hirose; Saori Kimura; Yoshifunai Saito; Hayato Nakano; Takako Kasai; Hirofumi Nakano; Kazuro Shiomi; Shuichi Hirono; Takeshi Watanabe; Hisaaki Taniguchi; Satoshi Omura; Toshiaki Sunazuka, JOURNAL OF MEDICINAL CHEMISTRY, 58(12):4984 - 4997, 2015年06月
  • Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase, Akihiro Sugawara; Nobuo Maita; Hiroaki Gouda; Tsuyoshi Yamamoto; Tomoyasu Hirose; Saori Kimura; Yoshifunai Saito; Hayato Nakano; Takako Kasai; Hirofumi Nakano; Kazuro Shiomi; Shuichi Hirono; Takeshi Watanabe; Hisaaki Taniguchi; Satoshi Omura; Toshiaki Sunazuka, JOURNAL OF MEDICINAL CHEMISTRY, 58(12):4984 - 4997, 2015年06月
  • Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors, KONOURA Kazuya;FUJII Hideaki;IMAIDE Satomi;GOUDA Hiroaki;HIRAYAMA Shigeto;HIRONO Shuichi;NAGASE Hiroshi, Bioorg Med Chem, 23(3):439 - 448, 2015年02月, 原著, 査読あり
  • Crystallization and preliminary X-ray crystallographic studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI YoshiyukI;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, Acta Crystallogr F Struct Biol Commun, 71(2):206 - 210, 2015年02月, 原著, 査読あり
  • Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, JOURNAL OF PHARMACEUTICAL SCIENCES, 104(1):223 - 232, 2015年01月
  • Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, JOURNAL OF PHARMACEUTICAL SCIENCES, 104(1):223 - 232, 2015年01月
  • An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions, Nakano H; Sugawara A; Hirose T; Gouda H; Hirono S; Omura S; Sunazuka T, Tetrahedron, 71:6569 - 6579, 2015年
  • An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions, Nakano H; Sugawara A; Hirose T; Gouda H; Hirono S; Omura S; Sunazuka T, Tetrahedron, 71:6569 - 6579, 2015年
  • Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton, WATANABE Yoshikazu;KITAZAWA Shota;FUJII Hideaki;NEMOTO Toru;HIRAYAMA Shigeto;IWAI Takashi;GOUDA Hiroaki;HIRONO Shuichi;NAGASE Hiroshi, Bioorg Med Chem Lett, 24(21):4980 - 4983, 2014年11月, 原著, 査読あり
  • Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton., Watanabe Y; Kitazawa S; Fujii H; Nemoto T; Hirayama S; Iwai T; Gouda H; Hirono S; Nagasea H, Bioorganic & medicinal chemistry letters, 24(21):4980 - 4983, 2014年11月
  • Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton., Watanabe Y; Kitazawa S; Fujii H; Nemoto T; Hirayama S; Iwai T; Gouda H; Hirono S; Nagasea H, Bioorganic & medicinal chemistry letters, 24(21):4980 - 4983, 2014年11月
  • In silico and pharmacological screenings identify novel serine racemase inhibitors, MORI Hisashi;WADA Ryogo;LI Jie;ISHIMOTO Tetsuya;MIZUGUCHI Mineyuki;OBITA Takayuki;GOUDA Hiroaki;HIRONO Shuichi;TOYOOKA Naoki, Bioorg Med Chem Lett, 24(16):3732 - 3735, 2014年08月, 原著, 査読あり
  • Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism, NAGASE Hiroshi;NAKAJIMA Ryo;YAMAMOTO Naoshi;HIRAYAMA Shigeto;IWAI Takashi;NEMOTO Toru;GOUDA Hiroaki;HIRONO Shuichi;FUJII Hideaki, Bioorg Med Chem Lett, 24(13):2851 - 2854, 2014年07月, 原著, 査読あり
  • Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism., Nagase H; Nakajima R; Yamamoto N; Hirayama S; Iwai T; Nemoto T; Gouda H; Hirono S; Fujii H, Bioorganic & medicinal chemistry letters, 24(13):2851 - 2854, 2014年07月
  • Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism., Nagase H; Nakajima R; Yamamoto N; Hirayama S; Iwai T; Nemoto T; Gouda H; Hirono S; Fujii H, Bioorganic & medicinal chemistry letters, 24(13):2851 - 2854, 2014年07月
  • In Silico Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.17, HANDA Koichi;NAKAGOME Izumi;YAMAOTSU Noriyuki;GOUDA Hiroaki;HIRONO Shuichi, Drug Metab Pharmacokinet, 29(1):52 - 60, 2014年02月, 原著, 査読あり
  • Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units., Villeneuve M; Kawai M; Horiuchi K; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE, Microbiology (Reading, England), 159(Pt 11):2405 - 2415, 2013年11月
  • Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units., Villeneuve M; Kawai M; Horiuchi K; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE, Microbiology (Reading, England), 159(Pt 11):2405 - 2415, 2013年11月
  • Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor, Tomoyasu Hirose; Nobuo Maita; Hiroaki Gouda; Jun Koseki; Tsuyoshi Yamamoto; Akihiro Sugawara; Hirofumi Nakano; Shuichi Hirono; Kazuro Shiomi; Takeshi Watanabe; Hisaaki Taniguchi; K. Barry Sharpless; Satoshi Omura; Toshiaki Sunazuka, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(40):15892 - 15897, 2013年10月
  • Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor, Tomoyasu Hirose; Nobuo Maita; Hiroaki Gouda; Jun Koseki; Tsuyoshi Yamamoto; Akihiro Sugawara; Hirofumi Nakano; Shuichi Hirono; Kazuro Shiomi; Takeshi Watanabe; Hisaaki Taniguchi; K. Barry Sharpless; Satoshi Omura; Toshiaki Sunazuka, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(40):15892 - 15897, 2013年10月
  • Three-dimensional quantitative structure-Activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, Drug Metabolism and Pharmacokinetics, 28(4):345 - 355, 2013年08月
  • Three-dimensional quantitative structure-Activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, Drug Metabolism and Pharmacokinetics, 28(4):345 - 355, 2013年08月
  • Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening, Masaki Wakasugi; Hiroaki Gouda; Tomoyasu Hirose; Akihiro Sugawara; Tsuyoshi Yamamoto; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, Bioorganic and Medicinal Chemistry, 21(11):3214 - 3220, 2013年06月
  • Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening, Masaki Wakasugi; Hiroaki Gouda; Tomoyasu Hirose; Akihiro Sugawara; Tsuyoshi Yamamoto; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, Bioorganic and Medicinal Chemistry, 21(11):3214 - 3220, 2013年06月
  • Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5 '-phosphatase 2 (SHIP2), Yoshinori Ichihara; Ryohei Fujimura; Hiroshi Tsuneki; Tsutomu Wada; Kentaro Okamoto; Hiroaki Gouda; Shuichi Hirono; Kenji Sugimoto; Yuji Matsuya; Toshiyasu Sasaoka; Naoki Toyooka, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62:649 - 660, 2013年04月
  • Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5 '-phosphatase 2 (SHIP2), Yoshinori Ichihara; Ryohei Fujimura; Hiroshi Tsuneki; Tsutomu Wada; Kentaro Okamoto; Hiroaki Gouda; Shuichi Hirono; Kenji Sugimoto; Yuji Matsuya; Toshiyasu Sasaoka; Naoki Toyooka, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62:649 - 660, 2013年04月
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons, Hideaki Fujii; Ryo Nakajima; Junko Akiyama; Naoshi Yamamoto; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7697 - 7701, 2012年12月
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons, Hideaki Fujii; Ryo Nakajima; Junko Akiyama; Naoshi Yamamoto; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7697 - 7701, 2012年12月
  • Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies., Fujii H; Imaide S; Hirayama S; Nemoto T; Gouda H; Hirono S; Nagase H, Bioorganic & medicinal chemistry letters, 22(24):7711 - 7714, 2012年12月
  • Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies., Fujii H; Imaide S; Hirayama S; Nemoto T; Gouda H; Hirono S; Nagase H, Bioorganic & medicinal chemistry letters, 22(24):7711 - 7714, 2012年12月
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain, Hiroshi Nagase; Junko Akiyama; Ryo Nakajima; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(8):2775 - 2779, 2012年04月
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain, Hiroshi Nagase; Junko Akiyama; Ryo Nakajima; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(8):2775 - 2779, 2012年04月
  • Three-Dimensional Solution Structure of Bottromycin A(2): A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci, Hiroaki Gouda; Yutaka Kobayashi; Takeshi Yamada; Tetsuya Ideguchi; Akihiro Sugawara; Tomoyasu Hirose; Satoshi Omura; Toshiaki Sunazuka; Shuichi Hirono, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2):169 - 171, 2012年02月
  • Three-Dimensional Solution Structure of Bottromycin A(2): A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci, Hiroaki Gouda; Yutaka Kobayashi; Takeshi Yamada; Tetsuya Ideguchi; Akihiro Sugawara; Tomoyasu Hirose; Satoshi Omura; Toshiaki Sunazuka; Shuichi Hirono, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2):169 - 171, 2012年02月
  • Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents, Akihiro Sugawara; Akito Sueki; Tomoyasu Hirose; Kenichiro Nagai; Hiroaki Gouda; Shuichi Hirono; Hideaki Shima; Kiyoko S. Akagawa; Satoshi Omura; Toshiaki Sunazuka, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(11):3373 - 3376, 2011年06月
  • Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents, Akihiro Sugawara; Akito Sueki; Tomoyasu Hirose; Kenichiro Nagai; Hiroaki Gouda; Shuichi Hirono; Hideaki Shima; Kiyoko S. Akagawa; Satoshi Omura; Toshiaki Sunazuka, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(11):3373 - 3376, 2011年06月
  • NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Toshiaki Sunazuka; Tomoyasu Hirose; Kanami Iguchi; Noriyuki Yamaotsu; Akihiro Sugawara; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 18(16):5835 - 5844, 2010年08月
  • NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Toshiaki Sunazuka; Tomoyasu Hirose; Kanami Iguchi; Noriyuki Yamaotsu; Akihiro Sugawara; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 18(16):5835 - 5844, 2010年08月
  • Investigation of Beckett-Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology, Hiroshi Nagase; Satomi Imaide; Miyuki Tomatsu; Shigeto Hirayama; Toru Nemoto; Noriko Sato; Mayumi Nakajima; Kaoru Nakao; Hidenori Mochizuki; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12):3801 - 3804, 2010年06月
  • Investigation of Beckett-Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology, Hiroshi Nagase; Satomi Imaide; Miyuki Tomatsu; Shigeto Hirayama; Toru Nemoto; Noriko Sato; Mayumi Nakajima; Kaoru Nakao; Hidenori Mochizuki; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12):3801 - 3804, 2010年06月
  • Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, CHEMISTRY AND PHYSICS OF LIPIDS, 163(6):569 - 579, 2010年06月
  • Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, CHEMISTRY AND PHYSICS OF LIPIDS, 163(6):569 - 579, 2010年06月
  • [Practical in silico structure-based drug design]., Hirono S; Gouda H, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(12 Suppl):1590 - 1597, 2009年09月
  • [Practical in silico structure-based drug design]., Hirono S; Gouda H, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(12 Suppl):1590 - 1597, 2009年09月
  • Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Shinichi Terashima; Kanami Iguchi; Akihiro Sugawara; Yoshifumi Saito; Tsuyoshi Yamamoto; Tomoyasu Hirose; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 17(17):6270 - 6278, 2009年09月
  • Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Shinichi Terashima; Kanami Iguchi; Akihiro Sugawara; Yoshifumi Saito; Tsuyoshi Yamamoto; Tomoyasu Hirose; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 17(17):6270 - 6278, 2009年09月
  • Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin, Tomoyasu Hirose; Toshiaki Sunazuka; Akihiro Sugawara; Yoshihiko Noguchi; Toshiaki Tanaka; Kanami Iguchi; Tsuyoshi Yamamoto; Hiroaki Gouda; Kazuro Shiomi; Satoshi Omura, JOURNAL OF ANTIBIOTICS, 62(9):495 - 500, 2009年09月
  • Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin, Tomoyasu Hirose; Toshiaki Sunazuka; Akihiro Sugawara; Yoshihiko Noguchi; Toshiaki Tanaka; Kanami Iguchi; Tsuyoshi Yamamoto; Hiroaki Gouda; Kazuro Shiomi; Satoshi Omura, JOURNAL OF ANTIBIOTICS, 62(9):495 - 500, 2009年09月
  • Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens, Hiroaki Gouda; Toshiaki Sunazuka; Kanami Iguchi; Akihiro Sugawara; Tomoyasu Hirose; Yoshihiko Noguchi; Yoshifumi Saito; Yuichi Yanai; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2630 - 2633, 2009年05月
  • Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens, Hiroaki Gouda; Toshiaki Sunazuka; Kanami Iguchi; Akihiro Sugawara; Tomoyasu Hirose; Yoshihiko Noguchi; Yoshifumi Saito; Yuichi Yanai; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2630 - 2633, 2009年05月
  • Design and synthesis of novel delta opioid receptor agonists and their pharmacologies, Hiroshi Nagase; Yumiko Osa; Toru Nemoto; Hideaki Fujii; Masayuki Imai; Takashi Nakamura; Toshiyuki Kanemasa; Akira Kato; Hiroaki Gouda; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2792 - 2795, 2009年05月
  • Design and synthesis of novel delta opioid receptor agonists and their pharmacologies, Hiroshi Nagase; Yumiko Osa; Toru Nemoto; Hideaki Fujii; Masayuki Imai; Takashi Nakamura; Toshiyuki Kanemasa; Akira Kato; Hiroaki Gouda; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2792 - 2795, 2009年05月
  • Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity, Masato Iwatsuki; Yukio Koizumi; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tomoda; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2888 - 2890, 2009年05月
  • Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity, Masato Iwatsuki; Yukio Koizumi; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tomoda; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2888 - 2890, 2009年05月
  • Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case, Kazuya Yasuo; Noriyuki Yamaotsu; Hiroaki Gouda; Hideki Tsujishita; Shuichi Hirono, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 49(4):853 - 864, 2009年04月
  • Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case, Kazuya Yasuo; Noriyuki Yamaotsu; Hiroaki Gouda; Hideki Tsujishita; Shuichi Hirono, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 49(4):853 - 864, 2009年04月
  • Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide, Toshiaki Sunazuka; Akihiro Sugawara; Kanami Iguchi; Tomoyasu Hirose; Kenichiro Nagai; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Hideaki Ui; Hiroaki Gouda; Kazuro Shiomi; Takeshi Watanabe; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY, 17(7):2751 - 2758, 2009年04月
  • Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide, Toshiaki Sunazuka; Akihiro Sugawara; Kanami Iguchi; Tomoyasu Hirose; Kenichiro Nagai; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Hideaki Ui; Hiroaki Gouda; Kazuro Shiomi; Takeshi Watanabe; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY, 17(7):2751 - 2758, 2009年04月
  • Structure Determination and Total Synthesis of Bottromycin A(2): A Potent Antibiotic against MRSA and VRE, Hiroyuki Shimamura; Hiroaki Gouda; Kenichiro Nagai; Tomoyasu Hirose; Maki Ichioka; Yujiro Furuya; Yutaka Kobayashi; Shuichi Hirono; Toshiaki Sunazuka; Satoshi Omura, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(5):914 - 917, 2009年
  • Structure Determination and Total Synthesis of Bottromycin A(2): A Potent Antibiotic against MRSA and VRE, Hiroyuki Shimamura; Hiroaki Gouda; Kenichiro Nagai; Tomoyasu Hirose; Maki Ichioka; Yujiro Furuya; Yutaka Kobayashi; Shuichi Hirono; Toshiaki Sunazuka; Satoshi Omura, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(5):914 - 917, 2009年
  • 10 キチナーゼ阻害剤Argifinの固相全合成と分子設計、in situクリックケミストリーを駆使した新規キチナーゼ阻害剤の創製(口頭発表の部), 砂塚 敏明; 廣瀬 友靖; 菅原 章公; 井口 加奈美; 遠藤 綾子; 斉藤 佳史; 山本 剛; 宇井 英明; 合田 浩明; 広野 修一; 塩見 和朗; 渡邉 剛志; Sharpless K. Barry; 大村 智, 天然有機化合物討論会講演要旨集, (50):83 - 88, 2008年09月
  • 10 キチナーゼ阻害剤Argifinの固相全合成と分子設計、in situクリックケミストリーを駆使した新規キチナーゼ阻害剤の創製(口頭発表の部), 砂塚 敏明; 廣瀬 友靖; 菅原 章公; 井口 加奈美; 遠藤 綾子; 斉藤 佳史; 山本 剛; 宇井 英明; 合田 浩明; 広野 修一; 塩見 和朗; 渡邉 剛志; Sharpless K. Barry; 大村 智, 天然有機化合物討論会講演要旨集, (50):83 - 88, 2008年09月
  • In silico multi-filter screening approaches for developing novel beta-secretase inhibitors, Taku Fujimoto; Yasuo Matsushita; Hiroaki Gouda; Noriyuki Yamaotsu; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9):2771 - 2775, 2008年05月
  • In silico multi-filter screening approaches for developing novel beta-secretase inhibitors, Taku Fujimoto; Yasuo Matsushita; Hiroaki Gouda; Noriyuki Yamaotsu; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9):2771 - 2775, 2008年05月
  • Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens, Hiroaki Gouda; Yuichi Yanai; Akihiro Sugawara; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 16(7):3565 - 3579, 2008年04月
  • Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens, Hiroaki Gouda; Yuichi Yanai; Akihiro Sugawara; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 16(7):3565 - 3579, 2008年04月
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG., Villeneuve M; Kawai M; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE; Nakahara H, Biochimica et biophysica acta, 1768(7):1717 - 1726, 2007年07月
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG., Villeneuve M; Kawai M; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE; Nakahara H, Biochimica et biophysica acta, 1768(7):1717 - 1726, 2007年07月
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1768(7):1717 - 1726, 2007年07月
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1768(7):1717 - 1726, 2007年07月
  • Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure, M Iwatsuki; H Tomoda; R Uchida; H Gouda; S Hirono; S Omura, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(23):7486 - 7491, 2006年06月
  • Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure, M Iwatsuki; H Tomoda; R Uchida; H Gouda; S Hirono; S Omura, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(23):7486 - 7491, 2006年06月
  • Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation, H Gouda; T Sunazuka; K Yoshida; A Sugawara; Y Sakoh; S Omura; S Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(9):2496 - 2499, 2006年05月
  • Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation, H Gouda; T Sunazuka; K Yoshida; A Sugawara; Y Sakoh; S Omura; S Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(9):2496 - 2499, 2006年05月
  • Antitumor activity of ZSTK474, a new phosphatidylitiositol 3-kinase inhibitor, Shin-ichi Yaguchi; Yasuhisa Fukui; Khiro Koshimizu; Hisashi Yoshimi; Toshiyuki Matsuno; Hiroaki Gouda; Shuichi Hirono; Kanaini Yamazaki; Takao Yamori, JOURNAL OF THE NATIONAL CANCER INSTITUTE, 98(8):545 - 556, 2006年04月
  • Antitumor activity of ZSTK474, a new phosphatidylitiositol 3-kinase inhibitor, Shin-ichi Yaguchi; Yasuhisa Fukui; Khiro Koshimizu; Hisashi Yoshimi; Toshiyuki Matsuno; Hiroaki Gouda; Shuichi Hirono; Kanaini Yamazaki; Takao Yamori, JOURNAL OF THE NATIONAL CANCER INSTITUTE, 98(8):545 - 556, 2006年04月
  • Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method, H Gouda; T Sunazuka; H Ui; M Handa; Y Sakoh; Y Iwai; S Hirono; S Omura, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51):18286 - 18291, 2005年12月
  • Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method, H Gouda; T Sunazuka; H Ui; M Handa; Y Sakoh; Y Iwai; S Hirono; S Omura, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51):18286 - 18291, 2005年12月
  • Molecular dynamics simulation study of the negative correlation in antibody AZ28-catalyzed oxy-Cope rearrangement, T Asada; H Gouda; PA Kollman, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(42):12535 - 12542, 2002年10月
  • Molecular dynamics simulation study of the negative correlation in antibody AZ28-catalyzed oxy-Cope rearrangement, T Asada; H Gouda; PA Kollman, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(42):12535 - 12542, 2002年10月
  • 2P026ニコチン性アセチルコリン受容体阻害ペプチドα-conotoxin EIの分子動力学シミュレーションによる3次元構造構築, 松尾 基樹; 合田 浩明; 山乙 教之; 広野 修一, 生物物理, 41:S102, 2001年
  • 2P026ニコチン性アセチルコリン受容体阻害ペプチドα-conotoxin EIの分子動力学シミュレーションによる3次元構造構築, 松尾 基樹; 合田 浩明; 山乙 教之; 広野 修一, 生物物理, 41:S102, 2001年
  • 84(P77) gp120-CD4結合を阻害するペプチド抗生物質chloropeptinの構造(ポスター発表の部), 松崎 桂一; 合田 浩明; 岡本 恵; 広野 修一; 田中 晴雄; 大村 智; McCauley John A.; Sprengeler Paul A.; Furst George T.; Smith Amos B. III, 天然有機化合物討論会講演要旨集, (38):499 - 504, 1996年09月
  • 84(P77) gp120-CD4結合を阻害するペプチド抗生物質chloropeptinの構造(ポスター発表の部), 松崎 桂一; 合田 浩明; 岡本 恵; 広野 修一; 田中 晴雄; 大村 智; McCauley John A.; Sprengeler Paul A.; Furst George T.; Smith Amos B. III, 天然有機化合物討論会講演要旨集, (38):499 - 504, 1996年09月

講演・口頭発表等

  • 物理化学的特性を表す特性球に基づいたHLA-抗原ペプチド相互作用のデータベース構築と解析, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会141年会, 2021年03月28日, オンライン開催
  • 高精度タンパク質-リガンド相互作用解析を目指したprobe-based QM modeling法の考案と検証, 早川　大地;渡邉　友里江;合田　浩明, 第47回構造活性相関シンポジウム, 2019年12月13日, 熊本
  • タンパク質-リガンド相互作用解析のためのprobe-based QM modeling 法, 早川　大地;合田　浩明, 第63回日本薬学会関東支部大会, 2019年09月14日, 東京
  • Non-conventional相互作用を記述可能な分子相互作用場計算法の構築とタンパク質-リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第139年会, 2019年03月22日, 千葉
  • 量子化学計算とプローブ分子に基づいた分子相互作用場の算出とタンパク質−リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 第46回構造活性相関シンポジウム, 2018年12月04日, 大阪
  • セルロースアセテートのアセチル基が 固有複屈折へ及ぼす影響の計算化学による検討, 早川　大地;合田　浩明;上田　一義, セルロース学会第25回年次大会, 2018年07月05日, 宇治
  • 分子動力学計算を用いたアルドケト還元酵素AKR1C3のC154Y及びL159V変異体の溶液構造解析, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 日本薬学会第138年会, 2018年03月27日, 金沢
  • ハロゲン結合や弱い水素結合を記述可能な分子相互作用場計算法の構築, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第138年会, 2018年03月27日, 金沢
  • 分子動力学シミュレーションを用いた野生型AKR1C3及びC154Y変異体の溶液構造解析, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第45回構造活性相関シンポジウム, 2017年11月29日, 土浦
  • 分子動力学計算を用いたアルドケト還元酵素AKR1C3のC154Y変異体の溶液構造解析, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第40回ケモインフォマティクス討論会, 2017年10月26日, 宇部
  • S46 family bacterial dipeptidyl aminopeptidases as novel antibiotics targets., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;ITO Yasuhiro;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, International Union of Microbiological Societies 2017, 2017年07月17日, Singapore
  • Effect of the Arg456His mutation on the threedimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, WATANABE Yurie ;KATO Koichi;FUKUYOSHI Shuichi;HIRATSUKA Masahiro;YAMAOTSU Noriyuki;HIRONO Shuichi;GOUDA Hiroaki;ODA Akifumi, XXIX IUPAP Conference on Computational Physics(CCP2017), 2017年07月10日, Paris
  • Molecular dynamics study of interaction between PACAP (6'-38') and N-terminal extracellular domain of the human splice variant hPAC1-R-short aiming at development of neuropathic pain medicine, WATANABE Yurie ;ODA Akifumi;GOUDA Hiroaki, XXIX IUPAP Conference on Computational Physics(CCP2017), 2017年07月10日, Paris
  • 分子ドッキングと分子動力学計算による薬剤性過敏症症候群の原因薬剤とHLA の相互作用解析, 渡邉　友里江;日下部　吉男;楯　直子;合田　浩明, 日本薬学会第137年会, 2017年03月25日, 仙台
  • Structural Analysis of Dipeptidyl Peptidase 11 (DPP11) from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;SASAKI Kaoru;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, AsCA 2016, 2016年12月05日, Hanoi
  • オレキシン２受容体作動薬YNT-185の創製, 斉藤　毅;永原　崇志;沓村　憲樹;中嶋　龍;細川　直人;入鹿山　容子;小川　靖裕;富永　拡;黒田　大祐;合田　浩明;藤井　秀明;柳沢　正史;長瀬　博, 第34回メディシナルケミストリーシンポジウム, 2016年11月30日, つくば
  • Energy-based analysis and prediction of peptide-HLA interactions, KURODA Daisuke;GOUDA Hiroaki, 第44回構造活性相関シンポジウム・第31回農薬デザイン研究会, 2016年11月16日, 京都
  • Computational analysis of interaction between HLA-B*13:01 with Dapson responsible for drug-inducing hypersensitivity syndrome, GOUDA Hiroaki;WATANABE Yurie;KURODA Daisuke;KUSAKABE Yoshio;UTSUNOMIYA-TATE Naoko, CBI学会2016年大会, 2016年10月25日, 東京
  • 分子動力学計算を用いた薬剤過敏症候群を引き起こすレクチゾールとHLAの相互作用解析, 渡邉　友里江;日下部　吉男;楯　直子;黒田　大祐;合田　浩明, 日本コンピュータ化学会2016秋季年会, 2016年10月22日, 松江
  • Structure and Functions of Dipeptidyl Peptidase 11 (DPP11) from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 2nd International Symposium (SSPC-2) Space Science of High Quality Protein Crystallization Technology, 2016年10月21日, Tokyo
  • Crystal structure of dipeptidyl amino peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 42nd Naito Conference on “In the Vanguard of Structural Biology”, 2016年10月05日, Sapporo
  • Crystal structure of dipeptidyl amino peptidase 11 (DPP11) from periodontal pathogen., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 2016 ISS R&D Conference, 2016年07月12日, San Diego
  • Crystal Structure analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 16th International Conference on the Crystallization of Biological Macromolecules, 2016年07月05日, Prague
  • 歯周病菌由来酸性アミノ酸特異的DPP（ジペプチジルペプチダーゼ）の構造生物学的研究, 六本木　沙織;鈴木　義之;飯塚　一平;館岡　千佳;藤本　真友;伊中　浩治;田仲　広明;山田　貢;太田　和敬;合田　浩明;野中　孝昌;小笠原　渉;田中　信忠;阪本　泰光, 日本薬学会第136年会, 2016年03月29日, 横浜
  • アミノ酸配列情報のみを用いたペプチド-HLA複合体の構造予測手法の開発と評価, 黒田　大祐;合田　浩明, 日本薬学会第136年会, 2016年03月28日, 横浜
  • 低分子オレキシン受容体アゴニストの創製, 斉藤　毅;永原　崇志;沓村　憲樹;入鹿山　容子;小川　靖裕;黒田　大祐;合田　浩明;藤井　秀明;柳沢　正史;長瀬　博, 第33回メディシナルケミストリーシンポジウム, 2015年11月26日, 千葉
  • Structural and mutational studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 9th General Meeting of The International Proteolysis Society, 2015年10月07日, Penang
  • インスリンシグナル増強作用を示す新規化合物CPDAのSHIP2阻害能評価, 梅田　知伸;山田　彩華;田中　信忠;小澤　新一郎;広野　修一;笹岡　利安;豊岡　尚樹;合田　浩明, 日本薬学会第135年会, 2015年03月28日, 神戸
  • 寄生虫選択性を指向したatpenin A5誘導体の設計、合成及び活性評価, 矢野　圭祐;大多和　正樹;有馬　志保;合田　浩明;広野　修一;大村　智;長光　亨, 日本薬学会第135年会, 2015年03月27日, 神戸
  • 新規糖尿病治療薬としての選択的SHIP2阻害剤のin silico創薬研究, 小澤　新一郎;合田　浩明;広野　修一, 日本薬学会第135年会, 2015年03月27日, 神戸
  • 種選択性向上を志向した atpenin A5 誘導体の設計、合成及び活性評価, 矢野　圭祐;宮尾　篤欣;大多和　正樹;有馬　志保;合田　浩明;広野　修一;大村　智;長光　亨, 第32回メディシナルケミストリーシンポジウム, 2014年11月27日, 神戸
  • カルボニル還元酵素 (CBR1) 阻害活性を有する8-Hydroxy-2-imino-2H-chromene-3-carboxamide 誘導体の創製, 小栗　弘成;遠藤　智史;宮城　菜未希;胡　大イ;荒井　裕貴;松永　俊之;五十里　彰;桑田　一夫;原　明;合田　浩明;豊岡　尚樹, 第32回メディシナルケミストリーシンポジウム, 2014年11月27日, 神戸
  • 新規インスリン抵抗性改善に基づく2型糖尿病治療薬の創製, 高原　理行;市原　克則;和田　努;恒枝　宏史;笹岡　利安;広野　修一;梅田　知伸;田中　信忠;合田　浩明;豊岡　尚樹, 第32回メディシナルケミストリーシンポジウム, 2014年11月26日, 神戸
  • 新規糖尿病治療薬としてのSHIP2選択的阻害剤のin silico創薬研究, 小澤　新一郎;合田　浩明;広野　修一, 第42回構造活性相関シンポジウム, 2014年11月13日, 熊本
  • 8-Hydroxy-2-imino-2H-chromene-3-carboxamide骨格を有するカルボニル還元酵素 (CBR1)阻害剤の構造活性相関, 宮城　菜未希;胡　大イ;遠藤　智史;荒井　裕貴;松永　俊之;五十里　彰;桑田　一夫;原　明;合田　浩明;豊岡　尚樹, 第42回構造活性相関シンポジウム, 2014年11月13日, 熊本
  • 新規インスリン抵抗性改善に基づく２型糖尿病治療薬の創製, 高原　理行;市原　克則;和田　努;恒枝　宏史;笹岡　利安;広野　修一;梅田　知伸;田中　信忠;合田　浩明;豊岡　尚樹, 日本薬学会第134年会, 2014年03月29日, 熊本
  • 新規ピロリ菌除菌剤の開発を志向したシアル酸合成酵素の構造解析, 日下部　吉男;梅田　知伸;北川　康行;田中　信忠;合田　浩明, 日本薬学会第134年会, 2014年03月29日, 熊本
  • 新規糖尿病治療薬としてのSHIP2阻害剤のin silico創薬研究, 小澤　新一郎;中作　菜穂;合田　浩明;広野　修一, 日本薬学会第134年会, 2014年03月29日, 熊本
  • 熱帯熱マラリア原虫由来酵素の発現系の改良と結晶化, 葉梨　繁樹;梅田　知伸;田中　信忠;日下部　吉男;中西　雅之;北出　幸夫;合田　浩明, 日本薬学会第134年会, 2014年03月28日, 熊本
  • δ選択的プロペラン型キノリン誘導体の設計・合成およびその薬理作用, 中嶋　龍;山本　直司;平山　重人;岩井　孝志;根本　徹;藤井　秀明;合田　浩明;広野　修一;長瀬　博, 第31回メディシナルケミストリーシンポジウム, 2013年11月21日, 広島

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