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Gouda Hiroaki

■FacultyBiophysical Chemistry
■PositionProfessor
Last Updated :2025/04/01

Researcher

基本情報

Profile and Settings

  • 氏名

    Gouda Hiroaki

Affiliation

  • Biophysical Chemistry, Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Pharmaceutical Science, The University of Tokyo, Mar. 1993

Achievements

Published Papers

  • Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds, Daichi Hayakawa; Nanako Terauchi; Aika Iwasaki; Yurie Watanabe; Hiroaki Gouda, Chemical Physics Letters, :139754 - 139754, Jun. 2022
  • Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds, Daichi Hayakawa; Nanako Terauchi; Aika Iwasaki; Yurie Watanabe; Hiroaki Gouda, Chemical Physics Letters, :139754 - 139754, Jun. 2022
  • Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist, TAKASAKI Ichiro ;WATANABE Ai ;OKADATakuya;KANAYAMA Daisuke ;NAGASHIMA Ryota;SHUDO Miyu;SHIMODAIRA Ayako ;NUNOMURA Kazuto ;LIN Bangzhong ;WATANABE Yurie ;GOUDA Hiroaki;MIYATA Atsuro ;KURIHARA Takashi ;TOYOOKA Naoki, Eur J Med Chem, 231:114160, Mar. 2022, Peer-reviewed, DOI:10.1016/j.ejmech.2022.114160
  • Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors, UENOHARA Yuka ;TSUMOTO Saori ;HIRAYAMA Shigeto ;HIGASHI Eika ;WATANABE Yurie ;GOUDA Hiroaki;NAGASE Hiroshi ;FUJII Hideaki, Bioorg Med Chem, 53:116552, Jan. 2022, Peer-reviewed
  • Unpolarizable molecular model describing electron distribution for treating halogen bonds, HAYAKAWA Daichi;WATANABE-ODA Yurie ;GOUDA Hiroaki, Chemical Physics Letters, 779:138824, Sep. 2021, Peer-reviewed
  • Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7, NAKAMURA Akihiro;SUZUKI Yoshiyuki;SAKAMOTO Yasumitsu;ROPPONGI Saori;KUSHIBIKI Chisato;YONEZAWA Natsuri;TAKAHASHI Masato;SHIDA Yosuke;GOUDA Hiroaki;NONAKA Takamasa;TANAKA Nobutada;OGASAWARA Wataru, Sci Rep, 11(1):7929, Apr. 2021, Peer-reviewed
  • Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer, ENDO Satoshi;OGURI Hiroaki;SEGAWA Jin;KAWAI Mina;HU Dawei;XIA Shuang;OKADA Takuya;IRIE Katsumasa;FUJII Shinya;GOUDA Hiroaki;IGUCHI Kazuhiro;MATSUKAWA Takuo;FUJIMOTO Naohiro;NAKAYAMA Toshiyuki;TOYOOKA Naoki;MATSUNAGA Toshiyuki;IKARI Akira, J Med Chem, 63(18):10396 - 10411, Sep. 2020, Peer-reviewed
  • Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives, IWAMATSU Chiharu;HAYAKAWA Daichi;KONO Tomomi;HONJO Ayaka;ISHIZAKI Saki;HIRAYAMA Shigeto;GOUDA Hiroaki;FUJII Hideaki, Molecules, 25(17):3792, Aug. 2020, Peer-reviewed
  • A molecular interaction field describing nonconventional intermolecular interactions and its application to protein-ligand interaction prediction, HAYAKAWA Daichi;SAWADA Nahoko;WATANABE Yurie ;GOUDA Hiroaki, J Mol Graph Model, 96:107515, May 2020, Peer-reviewed
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, TAKASAKI Ichiro;OGASHI Haruna;OKADA Takuya;SHIMODAIRA Ayaka;HAYAKAWA Daichi;WATANABE Ai;MIYATA Atsuro;KURIHARA Takashi;GOUDA Hiroaki;TOYOOKA Naoki, Eur J Med Chem, 186:111902, Jan. 2020, Peer-reviewed
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, Nov. 2019
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, Nov. 2019
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, Ichiro Takasaki; Haruna Ogashi; Takuya Okada; Ayaka Shimodaira; Daichi Hayakawa; Ai Watanabe; Atsuro Miyata; Takashi Kurihara; Hiroaki Gouda; Naoki Toyooka, European Journal of Medicinal Chemistry, :111902, Nov. 2019
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase, SAKAMOTO Yasumitsu ;SUZUKI Yoshiyuki ;NAKAMURA Akihiro ;WATANABE Yurie ;SEKIYA Mizuki ;ROPPONGI Saori ;KUSHIBIKI Chisato ;IIZUKA Ippei ;TANI Osamu;SAKASHITA Hitoshi ;INAKA Koji ;TANAKA Hiroaki ;YAMADA Mitsugu;OHTA Kazunori ;HONMA Nobuyuki ;SHIDA Yosuke ;OGASAWARA Wataru ;NAKANISHI-MATSUI Mayumi ;NONAKA Takamasa ;GOUDA Hiroaki;TANAKA Nobutada, Sci Rep, 9(1):13587, Sep. 2019, Peer-reviewed
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), Sep. 2019
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), Sep. 2019
  • Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase., Sakamoto Y; Suzuki Y; Nakamura A; Watanabe Y; Sekiya M; Roppongi S; Kushibiki C; Iizuka I; Tani O; Sakashita H; Inaka K; Tanaka H; Yamada M; Ohta K; Honma N; Shida Y; Ogasawara W; Nakanishi-Matsui M; Nonaka T; Gouda H; Tanaka N, Scientific Reports, 9(1), Sep. 2019
  • Formal Syntheses of (−)-Lepadiformines A, C, and (−)-Fasicularin, TAKASHIMA Katsuki;HAYAKAWA Daichi;GOUDA Hiroaki;TOYOOKA Naoki, J Org Chem, 84(9):5222 - 5229, May 2019, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, Apr. 2019
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, Apr. 2019
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry, 27(8):1747 - 1758, Apr. 2019
  • DFT study of the influence of acetyl groups of cellulose acetate on its intrinsic birefringence and wavelength dependence, HAYAKAWA Daichi;GOUDA Hiroaki;HIRONO Shuichi;UEDA Kazuyoshi, Carbohydr Polym, 207:122 - 130, Mar. 2019, Peer-reviewed
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), Dec. 2018
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), Dec. 2018
  • Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, Y. Watanabe; K. Kato; S. Fukuyoshi; M. Hiratsuka; N. Yamaotsu; S. Hirono; H. Gouda; A. Oda, Journal of Physics: Conference Series, 1136(1), Dec. 2018
  • Computational study on formation of 15-membered azalactone by double reductive amination using molecular mechanics and density functional theory calculations, GOUDA Hiroaki;NAKAYAMA Naofumi;MIURA Tomoaki;KANEMOTO Kenichi;AJITO Keiichi, J Antibiot (Tokyo), 71(5):549 - 556, May 2018, Peer-reviewed
  • In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor, TAKASAKI Ichiro;WATANABE Ai;YOKAI Masafumi;WATANABE Yurie ;HAYAKAWA Daichi;NAGASHIMA Ryota;FUKUCHI Mamoru;OKADA Takuya;TOYOOKA Naoki;MIYATA Atsuro;GOUDA Hiroaki;KURIHARA Takasi, J Pharmacol Exp Ther, 365(1):1 - 8, Apr. 2018, Peer-reviewed
  • Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase, TAKAHARA Satoyuki;NAKAGAWA Kiyomi;UCHIYAMA Tsugumi;YOSHIDA Tomoyuki;MATSUMOTO Kazunori;KAWASUMI Yasuo;MIZUGUCHI MIneyuki;OBITA Takayuki;WATANABE Yurie ;HAYAKAWA Daichi;GOUDA Hiroaki;MORI Hisashi;TOYOOKA Naoki, Bioorg Med Chem Lett, 28(3):441 - 445, Feb. 2018, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, Feb. 2018
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, Feb. 2018
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, Feb. 2018
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, Feb. 2018
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, Feb. 2018
  • Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells., Endo S; Xia S; Suyama M; Morikawa Y; Oguri H; Hu D, Ao Y; Takahara S; Horino Y; Hayakawa Y; Watanabe Y; Gouda H; Hara A; Kuwata K; Toyooka N; Matsunaga T; Ikari A, Journal of medicinal chemistry, 61(3):1380 - 1380, Feb. 2018
  • A docking model of dapsone bound to HLA-B*13:01 explains the risk of dapsone hypersensitivity syndrome, WATANABE Hideaki;WATANABE Yurie ;TASHIRO Yasuya;MUSHIRODA Taisei;OZEKI Takeshi;HASHIZUME Hideo;SUEKI Hirohiko;YAMAMOTO Toshinori;UTSUNOMIYA-TATE Naoko;GOUDA Hiroaki;KUSAKABE Yoshio, J Dermatol Sci, 88(3):320 - 329, Dec. 2017, Peer-reviewed
  • Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis and Cisplatin Resistance of Lung Cancer Cells, ENDO Satoshi;XIA Shuang;SUYAMA Miho;MORIKAWA Yosifumi;OGURI Hiroaki;HU Dawei;AO Yoshinori;TAKAHARA Satoyuki;HORINO Yoshikazu;HAYAKAWA Yoshihiro;WATANABE Yurie ;GOUDA Hiroaki;HARA Akira;KUWATA Kazuo;TOYOOKA Naoki;MATSUNAGA Toshiyuki;IKARI Akira, J Med Chem, 60(20):8441 - 8455, Oct. 2017, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor., YAMAMOTO Naoshi;OHRUI Sayaka;OKADA Takahiro;YATA Masahiro;SAITOH Tsuyoshi;KUTSUMURA Noriki;NAGUMO Yasuyuki;IRUKAYAMA-TOMOBE Yoko;OGAWA Yasuhiro;WATANABE Yurie;HAYAKAWA Daichi;GOUDA Hiroaki;YANAGISAWA Masashi;NAGASE Hiroshi, Bioorg Med Chem Lett, 27(17):4176 - 4179, Sep. 2017, Peer-reviewed
  • A novel serine racemase inhibitor suppresses neuronal over-activation in vivo, MORI Hisashi;WADA Ryogo;TAKAHARA Satoyuki;HORINO Yoshikazu;IZUMI Hironori;ISHIMOTO Tetsuya;YOSHIDA Tomoyuki;MIZUGUCHI Mineyuki;OBITA Takayuki;GOUDA Hiroaki;HIRONO Shuichi;TOYOOKA Naoki, Bioorg Med Chem, 25(14):3736 - 3745, Jul. 2017, Peer-reviewed
  • Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations, WATANABE Yurie ;FUKUYOSHI Shuichi;KATO Koichi;HIRATSUKA Masahiro;YAMAOTSU Noriyuki;HIRONO Shuichi;GOUDA Hiroaki;ODA Akifumi, J Mol Graph Model, 74:326 - 336, Jun. 2017, Peer-reviewed
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, Mar. 2017
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, Mar. 2017
  • Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics, Iso Serina; Takahara Satoyuki; Gouda Hiroaki; Miyata Atsuro; Kurihara Takashi; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3):S185, Mar. 2017
  • Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies, NAGASE Hiroshi;YAMAMOTO Naoshi;YATA Masahiro;OHRUI Sayaka;OKADA Takahiro;SAITOH Tsuyoshi;KUTSUMURA Noriki;NAGUMO Yasuyuki;IRUKAYAMA-TOMOBE Yoko;ISHIKAWA Yukiko;OGAWA Yasuhiro;HIRAYAMA Shigeto;KURODA Daisuke;WATANABE Yurie ;GOUDA Hiroaki;YANAGISAWA Masashi, J Med Chem, 60(3):1018 - 1040, Feb. 2017, Peer-reviewed
  • Molecular Orbital Study of the Formation of Intramolecular Hydrogen Bonding of a Ligand Molecule in a Protein Aromatic Hydrophobic Pocket, KOSEKI Jun;GOUDA Hiroaki;HIRONO Shuichi, Chem Pharm Bull, 64(7):1031 - 1035, Jul. 2016, Peer-reviewed
  • オレキシン受容体作動薬 創薬への展望 小分子オレキシン作動薬のデザインと合成, 長瀬 博; 永原 崇志; 斉藤 毅; 沓村 憲樹; 入鹿山 容子; 小川 靖裕; 黒田 大祐; 合田 浩明; 藤井 秀明; 柳沢 正史, 日本睡眠学会定期学術集会プログラム・抄録集, 41回:105 - 105, Jul. 2016
  • オレキシン受容体作動薬 創薬への展望 小分子オレキシン作動薬のデザインと合成, 長瀬 博; 永原 崇志; 斉藤 毅; 沓村 憲樹; 入鹿山 容子; 小川 靖裕; 黒田 大祐; 合田 浩明; 藤井 秀明; 柳沢 正史, 日本睡眠学会定期学術集会プログラム・抄録集, 41回:105 - 105, Jul. 2016
  • In silico and pharmacological screening identify novel PAC1 receptor antagonists, Watanabe Ai; Okada Takuya; Fukuchi Mamoru; Gouda Hiroaki; Kurihara Takashi; Miyata Atsuro; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3):S236, Mar. 2016
  • In silico and pharmacological screening identify novel PAC1 receptor antagonists, Watanabe Ai; Okada Takuya; Fukuchi Mamoru; Gouda Hiroaki; Kurihara Takashi; Miyata Atsuro; Toyooka Naoki; Takasaki Ichiro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3):S236, Mar. 2016
  • Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase, KUSAKABE Yoshio;ISHIHARA Masaaki;UMEDA Tomonobu;KURODA Daisuke;NAKANISHI Masayuki;KITADE Yukio;GOUDA Hiroaki;NAKAMURA Kazuo T;TANAKA Nobutada, Sci Rep, 17(5):16641, Nov. 2015, Peer-reviewed
  • Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists, NAGAHARA Takashi;SAITOH Tsuyoshi;KUTSUMURA Noriki;IRUKAYAMA-TOMOBE Yoko;OGAWA Yasuhiro;KURODA Daisuke;GOUDA Hiroaki;KUMAGAI Hidetoshi;FUJII Hideaki;YANAGISAWA Masashi;NAGASE Hiroshi, J Med Chem, 58(20):7931 - 7937, Oct. 2015, Peer-reviewed
  • Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1, HU Dawei;MIYAGI Namiki;ARAI Yuki;OGURI Hiroaki;MIURA Takeshi;NISHINAKA Toru;TERADA Tomoyuki;GOUDA Hiroaki;EL-KABBANI Ossama;XIA Shuang;TOYOOKA Naoki;HARA Akira;MATSUNAGA Toshiyuki;IKARI Akira;ENDO Satoshi, Org Biomol Chem, 13(27):7487 - 7499, Jul. 2015, Peer-reviewed
  • Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity, SAKAMOTO Yasumitsu;SUZUKI YoshiyukI;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, Sci Rep, 5:11151, Jun. 2015, Peer-reviewed
  • コンピュータを利用したドラッグデザインの実際 , 合田　浩明, 昭和学士会雑誌, 75(3):302 - 311, Jun. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.302
  • Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase, Akihiro Sugawara; Nobuo Maita; Hiroaki Gouda; Tsuyoshi Yamamoto; Tomoyasu Hirose; Saori Kimura; Yoshifunai Saito; Hayato Nakano; Takako Kasai; Hirofumi Nakano; Kazuro Shiomi; Shuichi Hirono; Takeshi Watanabe; Hisaaki Taniguchi; Satoshi Omura; Toshiaki Sunazuka, JOURNAL OF MEDICINAL CHEMISTRY, 58(12):4984 - 4997, Jun. 2015
  • Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase, Akihiro Sugawara; Nobuo Maita; Hiroaki Gouda; Tsuyoshi Yamamoto; Tomoyasu Hirose; Saori Kimura; Yoshifunai Saito; Hayato Nakano; Takako Kasai; Hirofumi Nakano; Kazuro Shiomi; Shuichi Hirono; Takeshi Watanabe; Hisaaki Taniguchi; Satoshi Omura; Toshiaki Sunazuka, JOURNAL OF MEDICINAL CHEMISTRY, 58(12):4984 - 4997, Jun. 2015
  • Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors, KONOURA Kazuya;FUJII Hideaki;IMAIDE Satomi;GOUDA Hiroaki;HIRAYAMA Shigeto;HIRONO Shuichi;NAGASE Hiroshi, Bioorg Med Chem, 23(3):439 - 448, Feb. 2015, Peer-reviewed
  • Crystallization and preliminary X-ray crystallographic studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI YoshiyukI;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, Acta Crystallogr F Struct Biol Commun, 71(2):206 - 210, Feb. 2015, Peer-reviewed
  • Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, JOURNAL OF PHARMACEUTICAL SCIENCES, 104(1):223 - 232, Jan. 2015
  • Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, JOURNAL OF PHARMACEUTICAL SCIENCES, 104(1):223 - 232, Jan. 2015
  • An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions, Nakano H; Sugawara A; Hirose T; Gouda H; Hirono S; Omura S; Sunazuka T, Tetrahedron, 71:6569 - 6579, 2015
  • An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions, Nakano H; Sugawara A; Hirose T; Gouda H; Hirono S; Omura S; Sunazuka T, Tetrahedron, 71:6569 - 6579, 2015
  • Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton, WATANABE Yoshikazu;KITAZAWA Shota;FUJII Hideaki;NEMOTO Toru;HIRAYAMA Shigeto;IWAI Takashi;GOUDA Hiroaki;HIRONO Shuichi;NAGASE Hiroshi, Bioorg Med Chem Lett, 24(21):4980 - 4983, Nov. 2014, Peer-reviewed
  • Design, synthesis, and structure-activity relationship of novel opioid kappa receptor selective agonists: alpha-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton, Yoshikazu Watanabe; Shota Kitazawa; Hideaki Fujii; Toru Nemoto; Shigeto Hirayama; Takashi Iwai; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagasea, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(21):4980 - 4983, Nov. 2014
  • Design, synthesis, and structure-activity relationship of novel opioid kappa receptor selective agonists: alpha-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton, Yoshikazu Watanabe; Shota Kitazawa; Hideaki Fujii; Toru Nemoto; Shigeto Hirayama; Takashi Iwai; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagasea, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(21):4980 - 4983, Nov. 2014
  • In silico and pharmacological screenings identify novel serine racemase inhibitors, MORI Hisashi;WADA Ryogo;LI Jie;ISHIMOTO Tetsuya;MIZUGUCHI Mineyuki;OBITA Takayuki;GOUDA Hiroaki;HIRONO Shuichi;TOYOOKA Naoki, Bioorg Med Chem Lett, 24(16):3732 - 3735, Aug. 2014, Peer-reviewed
  • Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism, NAGASE Hiroshi;NAKAJIMA Ryo;YAMAMOTO Naoshi;HIRAYAMA Shigeto;IWAI Takashi;NEMOTO Toru;GOUDA Hiroaki;HIRONO Shuichi;FUJII Hideaki, Bioorg Med Chem Lett, 24(13):2851 - 2854, Jul. 2014, Peer-reviewed
  • Design and synthesis of quinolinopropellane derivatives with selective delta opioid receptor agonism, Hiroshi Nagase; Ryo Nakajima; Naoshi Yamamoto; Shigeto Hirayama; Takashi Iwai; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(13):2851 - 2854, Jul. 2014
  • Design and synthesis of quinolinopropellane derivatives with selective delta opioid receptor agonism, Hiroshi Nagase; Ryo Nakajima; Naoshi Yamamoto; Shigeto Hirayama; Takashi Iwai; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(13):2851 - 2854, Jul. 2014
  • In Silico Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.17, HANDA Koichi;NAKAGOME Izumi;YAMAOTSU Noriyuki;GOUDA Hiroaki;HIRONO Shuichi, Drug Metab Pharmacokinet, 29(1):52 - 60, Feb. 2014, Peer-reviewed
  • Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by alpha-methyl trans-cyclopropane groups rather than cis-cyclopropane units, Masumi Villeneuve; Mizuo Kawai; Kieko Horiuchi; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin, MICROBIOLOGY-SGM, 159(Pt 11):2405 - 2415, Nov. 2013
  • Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by alpha-methyl trans-cyclopropane groups rather than cis-cyclopropane units, Masumi Villeneuve; Mizuo Kawai; Kieko Horiuchi; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin, MICROBIOLOGY-SGM, 159(Pt 11):2405 - 2415, Nov. 2013
  • Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor, Tomoyasu Hirose; Nobuo Maita; Hiroaki Gouda; Jun Koseki; Tsuyoshi Yamamoto; Akihiro Sugawara; Hirofumi Nakano; Shuichi Hirono; Kazuro Shiomi; Takeshi Watanabe; Hisaaki Taniguchi; K. Barry Sharpless; Satoshi Omura; Toshiaki Sunazuka, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(40):15892 - 15897, Oct. 2013
  • Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor, Tomoyasu Hirose; Nobuo Maita; Hiroaki Gouda; Jun Koseki; Tsuyoshi Yamamoto; Akihiro Sugawara; Hirofumi Nakano; Shuichi Hirono; Kazuro Shiomi; Takeshi Watanabe; Hisaaki Taniguchi; K. Barry Sharpless; Satoshi Omura; Toshiaki Sunazuka, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(40):15892 - 15897, Oct. 2013
  • Three-dimensional quantitative structure-Activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, Drug Metabolism and Pharmacokinetics, 28(4):345 - 355, Aug. 2013
  • Three-dimensional quantitative structure-Activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes, Koichi Handa; Izumi Nakagome; Noriyuki Yamaotsu; Hiroaki Gouda; Shuichi Hirono, Drug Metabolism and Pharmacokinetics, 28(4):345 - 355, Aug. 2013
  • Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening, Masaki Wakasugi; Hiroaki Gouda; Tomoyasu Hirose; Akihiro Sugawara; Tsuyoshi Yamamoto; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, Bioorganic and Medicinal Chemistry, 21(11):3214 - 3220, Jun. 2013
  • Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening, Masaki Wakasugi; Hiroaki Gouda; Tomoyasu Hirose; Akihiro Sugawara; Tsuyoshi Yamamoto; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, Bioorganic and Medicinal Chemistry, 21(11):3214 - 3220, Jun. 2013
  • Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5 '-phosphatase 2 (SHIP2), Yoshinori Ichihara; Ryohei Fujimura; Hiroshi Tsuneki; Tsutomu Wada; Kentaro Okamoto; Hiroaki Gouda; Shuichi Hirono; Kenji Sugimoto; Yuji Matsuya; Toshiyasu Sasaoka; Naoki Toyooka, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62:649 - 660, Apr. 2013
  • Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5 '-phosphatase 2 (SHIP2), Yoshinori Ichihara; Ryohei Fujimura; Hiroshi Tsuneki; Tsutomu Wada; Kentaro Okamoto; Hiroaki Gouda; Shuichi Hirono; Kenji Sugimoto; Yuji Matsuya; Toshiyasu Sasaoka; Naoki Toyooka, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62:649 - 660, Apr. 2013
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons, Hideaki Fujii; Ryo Nakajima; Junko Akiyama; Naoshi Yamamoto; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7697 - 7701, Dec. 2012
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons, Hideaki Fujii; Ryo Nakajima; Junko Akiyama; Naoshi Yamamoto; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7697 - 7701, Dec. 2012
  • Essential structure of opioid kappa receptor agonist nalfurafine for binding to the kappa receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies, Hideaki Fujii; Satomi Imaide; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7711 - 7714, Dec. 2012
  • Essential structure of opioid kappa receptor agonist nalfurafine for binding to the kappa receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies, Hideaki Fujii; Satomi Imaide; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24):7711 - 7714, Dec. 2012
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain, Hiroshi Nagase; Junko Akiyama; Ryo Nakajima; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(8):2775 - 2779, Apr. 2012
  • Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain, Hiroshi Nagase; Junko Akiyama; Ryo Nakajima; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(8):2775 - 2779, Apr. 2012
  • Three-Dimensional Solution Structure of Bottromycin A(2): A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci, Hiroaki Gouda; Yutaka Kobayashi; Takeshi Yamada; Tetsuya Ideguchi; Akihiro Sugawara; Tomoyasu Hirose; Satoshi Omura; Toshiaki Sunazuka; Shuichi Hirono, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2):169 - 171, Feb. 2012
  • Three-Dimensional Solution Structure of Bottromycin A(2): A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci, Hiroaki Gouda; Yutaka Kobayashi; Takeshi Yamada; Tetsuya Ideguchi; Akihiro Sugawara; Tomoyasu Hirose; Satoshi Omura; Toshiaki Sunazuka; Shuichi Hirono, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2):169 - 171, Feb. 2012
  • Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents, Akihiro Sugawara; Akito Sueki; Tomoyasu Hirose; Kenichiro Nagai; Hiroaki Gouda; Shuichi Hirono; Hideaki Shima; Kiyoko S. Akagawa; Satoshi Omura; Toshiaki Sunazuka, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(11):3373 - 3376, Jun. 2011
  • Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents, Akihiro Sugawara; Akito Sueki; Tomoyasu Hirose; Kenichiro Nagai; Hiroaki Gouda; Shuichi Hirono; Hideaki Shima; Kiyoko S. Akagawa; Satoshi Omura; Toshiaki Sunazuka, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(11):3373 - 3376, Jun. 2011
  • NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Toshiaki Sunazuka; Tomoyasu Hirose; Kanami Iguchi; Noriyuki Yamaotsu; Akihiro Sugawara; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 18(16):5835 - 5844, Aug. 2010
  • NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Toshiaki Sunazuka; Tomoyasu Hirose; Kanami Iguchi; Noriyuki Yamaotsu; Akihiro Sugawara; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 18(16):5835 - 5844, Aug. 2010
  • Investigation of Beckett-Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology, Hiroshi Nagase; Satomi Imaide; Miyuki Tomatsu; Shigeto Hirayama; Toru Nemoto; Noriko Sato; Mayumi Nakajima; Kaoru Nakao; Hidenori Mochizuki; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12):3801 - 3804, Jun. 2010
  • Investigation of Beckett-Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology, Hiroshi Nagase; Satomi Imaide; Miyuki Tomatsu; Shigeto Hirayama; Toru Nemoto; Noriko Sato; Mayumi Nakajima; Kaoru Nakao; Hidenori Mochizuki; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12):3801 - 3804, Jun. 2010
  • Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, CHEMISTRY AND PHYSICS OF LIPIDS, 163(6):569 - 579, Jun. 2010
  • Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, CHEMISTRY AND PHYSICS OF LIPIDS, 163(6):569 - 579, Jun. 2010
  • [Practical in silico structure-based drug design]., Hirono S; Gouda H, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(12 Suppl):1590 - 1597, Sep. 2009
  • [Practical in silico structure-based drug design]., Hirono S; Gouda H, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(12 Suppl):1590 - 1597, Sep. 2009
  • Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Shinichi Terashima; Kanami Iguchi; Akihiro Sugawara; Yoshifumi Saito; Tsuyoshi Yamamoto; Tomoyasu Hirose; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 17(17):6270 - 6278, Sep. 2009
  • Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin, Hiroaki Gouda; Shinichi Terashima; Kanami Iguchi; Akihiro Sugawara; Yoshifumi Saito; Tsuyoshi Yamamoto; Tomoyasu Hirose; Kazuro Shiomi; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 17(17):6270 - 6278, Sep. 2009
  • Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin, Tomoyasu Hirose; Toshiaki Sunazuka; Akihiro Sugawara; Yoshihiko Noguchi; Toshiaki Tanaka; Kanami Iguchi; Tsuyoshi Yamamoto; Hiroaki Gouda; Kazuro Shiomi; Satoshi Omura, JOURNAL OF ANTIBIOTICS, 62(9):495 - 500, Sep. 2009
  • Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin, Tomoyasu Hirose; Toshiaki Sunazuka; Akihiro Sugawara; Yoshihiko Noguchi; Toshiaki Tanaka; Kanami Iguchi; Tsuyoshi Yamamoto; Hiroaki Gouda; Kazuro Shiomi; Satoshi Omura, JOURNAL OF ANTIBIOTICS, 62(9):495 - 500, Sep. 2009
  • Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens, Hiroaki Gouda; Toshiaki Sunazuka; Kanami Iguchi; Akihiro Sugawara; Tomoyasu Hirose; Yoshihiko Noguchi; Yoshifumi Saito; Yuichi Yanai; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2630 - 2633, May 2009
  • Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens, Hiroaki Gouda; Toshiaki Sunazuka; Kanami Iguchi; Akihiro Sugawara; Tomoyasu Hirose; Yoshihiko Noguchi; Yoshifumi Saito; Yuichi Yanai; Tsuyoshi Yamamoto; Takeshi Watanabe; Kazuro Shiomi; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2630 - 2633, May 2009
  • Design and synthesis of novel delta opioid receptor agonists and their pharmacologies, Hiroshi Nagase; Yumiko Osa; Toru Nemoto; Hideaki Fujii; Masayuki Imai; Takashi Nakamura; Toshiyuki Kanemasa; Akira Kato; Hiroaki Gouda; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2792 - 2795, May 2009
  • Design and synthesis of novel delta opioid receptor agonists and their pharmacologies, Hiroshi Nagase; Yumiko Osa; Toru Nemoto; Hideaki Fujii; Masayuki Imai; Takashi Nakamura; Toshiyuki Kanemasa; Akira Kato; Hiroaki Gouda; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2792 - 2795, May 2009
  • Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity, Masato Iwatsuki; Yukio Koizumi; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tomoda; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2888 - 2890, May 2009
  • Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity, Masato Iwatsuki; Yukio Koizumi; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tomoda; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(10):2888 - 2890, May 2009
  • Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case, Kazuya Yasuo; Noriyuki Yamaotsu; Hiroaki Gouda; Hideki Tsujishita; Shuichi Hirono, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 49(4):853 - 864, Apr. 2009
  • Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case, Kazuya Yasuo; Noriyuki Yamaotsu; Hiroaki Gouda; Hideki Tsujishita; Shuichi Hirono, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 49(4):853 - 864, Apr. 2009
  • Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide, Toshiaki Sunazuka; Akihiro Sugawara; Kanami Iguchi; Tomoyasu Hirose; Kenichiro Nagai; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Hideaki Ui; Hiroaki Gouda; Kazuro Shiomi; Takeshi Watanabe; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY, 17(7):2751 - 2758, Apr. 2009
  • Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide, Toshiaki Sunazuka; Akihiro Sugawara; Kanami Iguchi; Tomoyasu Hirose; Kenichiro Nagai; Yoshihiko Noguchi; Yoshifumi Saito; Tsuyoshi Yamamoto; Hideaki Ui; Hiroaki Gouda; Kazuro Shiomi; Takeshi Watanabe; Satoshi Omura, BIOORGANIC & MEDICINAL CHEMISTRY, 17(7):2751 - 2758, Apr. 2009
  • Structure Determination and Total Synthesis of Bottromycin A(2): A Potent Antibiotic against MRSA and VRE, Hiroyuki Shimamura; Hiroaki Gouda; Kenichiro Nagai; Tomoyasu Hirose; Maki Ichioka; Yujiro Furuya; Yutaka Kobayashi; Shuichi Hirono; Toshiaki Sunazuka; Satoshi Omura, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(5):914 - 917, 2009
  • Structure Determination and Total Synthesis of Bottromycin A(2): A Potent Antibiotic against MRSA and VRE, Hiroyuki Shimamura; Hiroaki Gouda; Kenichiro Nagai; Tomoyasu Hirose; Maki Ichioka; Yujiro Furuya; Yutaka Kobayashi; Shuichi Hirono; Toshiaki Sunazuka; Satoshi Omura, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(5):914 - 917, 2009
  • 10 A Potent Chitinase Inhibitor, Argifin; An Effective Solid Phase Total Synthesis, and Creation of Novel Chitinase Inhibitor via Molecule Design and in situ Click Chemistry(Oral Presentation), Sunazuka Toshiaki; Hirose Tomoyasu; Sugawara Akihiro; Iguchi Kanami; Endo Ayako; Saito Yoshifumi; Yamamoto Tsuyoshi; Ui Hideaki; Gouda Hiroaki; Hirono Shuichi; Shiomi Kazuro; Watanabe Takeshi; Sharpless K. Barry; Omura Satoshi, Symposium on the Chemistry of Natural Products, symposium papers, (50):83 - 88, Sep. 2008
  • 10 A Potent Chitinase Inhibitor, Argifin; An Effective Solid Phase Total Synthesis, and Creation of Novel Chitinase Inhibitor via Molecule Design and in situ Click Chemistry(Oral Presentation), Sunazuka Toshiaki; Hirose Tomoyasu; Sugawara Akihiro; Iguchi Kanami; Endo Ayako; Saito Yoshifumi; Yamamoto Tsuyoshi; Ui Hideaki; Gouda Hiroaki; Hirono Shuichi; Shiomi Kazuro; Watanabe Takeshi; Sharpless K. Barry; Omura Satoshi, Symposium on the Chemistry of Natural Products, symposium papers, (50):83 - 88, Sep. 2008
  • In silico multi-filter screening approaches for developing novel beta-secretase inhibitors, Taku Fujimoto; Yasuo Matsushita; Hiroaki Gouda; Noriyuki Yamaotsu; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9):2771 - 2775, May 2008
  • In silico multi-filter screening approaches for developing novel beta-secretase inhibitors, Taku Fujimoto; Yasuo Matsushita; Hiroaki Gouda; Noriyuki Yamaotsu; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9):2771 - 2775, May 2008
  • Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens, Hiroaki Gouda; Yuichi Yanai; Akihiro Sugawara; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 16(7):3565 - 3579, Apr. 2008
  • Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens, Hiroaki Gouda; Yuichi Yanai; Akihiro Sugawara; Toshiaki Sunazuka; Satoshi Omura; Shuichi Hirono, BIOORGANIC & MEDICINAL CHEMISTRY, 16(7):3565 - 3579, Apr. 2008
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG., Villeneuve M; Kawai M; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE; Nakahara H, Biochimica et biophysica acta, 1768(7):1717 - 1726, Jul. 2007
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG., Villeneuve M; Kawai M; Watanabe M; Aoyagi Y; Hitotsuyanagi Y; Takeya K; Gouda H; Hirono S; Minnikin DE; Nakahara H, Biochimica et biophysica acta, 1768(7):1717 - 1726, Jul. 2007
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1768(7):1717 - 1726, Jul. 2007
  • Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG, Masumi Villeneuve; Mizuo Kawai; Motoko Watanabe; Yutaka Aoyagi; Yukio Hitotsuyanagi; Koichi Takeya; Hiroaki Gouda; Shuichi Hirono; David E. Minnikin; Hiroo Nakahara, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1768(7):1717 - 1726, Jul. 2007
  • Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure, M Iwatsuki; H Tomoda; R Uchida; H Gouda; S Hirono; S Omura, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(23):7486 - 7491, Jun. 2006
  • Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure, M Iwatsuki; H Tomoda; R Uchida; H Gouda; S Hirono; S Omura, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(23):7486 - 7491, Jun. 2006
  • Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation, H Gouda; T Sunazuka; K Yoshida; A Sugawara; Y Sakoh; S Omura; S Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(9):2496 - 2499, May 2006
  • Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation, H Gouda; T Sunazuka; K Yoshida; A Sugawara; Y Sakoh; S Omura; S Hirono, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(9):2496 - 2499, May 2006
  • Antitumor activity of ZSTK474, a new phosphatidylitiositol 3-kinase inhibitor, Shin-ichi Yaguchi; Yasuhisa Fukui; Khiro Koshimizu; Hisashi Yoshimi; Toshiyuki Matsuno; Hiroaki Gouda; Shuichi Hirono; Kanaini Yamazaki; Takao Yamori, JOURNAL OF THE NATIONAL CANCER INSTITUTE, 98(8):545 - 556, Apr. 2006
  • Antitumor activity of ZSTK474, a new phosphatidylitiositol 3-kinase inhibitor, Shin-ichi Yaguchi; Yasuhisa Fukui; Khiro Koshimizu; Hisashi Yoshimi; Toshiyuki Matsuno; Hiroaki Gouda; Shuichi Hirono; Kanaini Yamazaki; Takao Yamori, JOURNAL OF THE NATIONAL CANCER INSTITUTE, 98(8):545 - 556, Apr. 2006
  • Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method, H Gouda; T Sunazuka; H Ui; M Handa; Y Sakoh; Y Iwai; S Hirono; S Omura, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51):18286 - 18291, Dec. 2005
  • Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method, H Gouda; T Sunazuka; H Ui; M Handa; Y Sakoh; Y Iwai; S Hirono; S Omura, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51):18286 - 18291, Dec. 2005
  • Molecular dynamics simulation study of the negative correlation in antibody AZ28-catalyzed oxy-Cope rearrangement, T Asada; H Gouda; PA Kollman, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(42):12535 - 12542, Oct. 2002
  • Molecular dynamics simulation study of the negative correlation in antibody AZ28-catalyzed oxy-Cope rearrangement, T Asada; H Gouda; PA Kollman, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(42):12535 - 12542, Oct. 2002
  • Three dimensional structure analysis of alpha-conotoxin EI(nicotinic acetylcholine receptor antagonist)by molecular dynamics simulation, Matsuo M.; Gouda H.; Yamaotsu N.; Hirono S., Seibutsu Butsuri, 41:S102, 2001
  • Three dimensional structure analysis of alpha-conotoxin EI(nicotinic acetylcholine receptor antagonist)by molecular dynamics simulation, Matsuo M.; Gouda H.; Yamaotsu N.; Hirono S., Seibutsu Butsuri, 41:S102, 2001
  • 84(P77) STRUCTURE OF CHLOROPEPTIN, A PEPTIDE ANTIBIOTIC INHIBITING gp120-CD4 BINDING, Matsuzaki Keiichi; Gouda Hiroaki; Okamoto Megumi; Hirono Shuichi; Tanaka Haruo; Omura Satoshi; McCauley John A.; Sprengeler Paul A.; Furst George T.; Smith Amos B. III, Symposium on the Chemistry of Natural Products, symposium papers, (38):499 - 504, Sep. 1996
  • 84(P77) STRUCTURE OF CHLOROPEPTIN, A PEPTIDE ANTIBIOTIC INHIBITING gp120-CD4 BINDING, Matsuzaki Keiichi; Gouda Hiroaki; Okamoto Megumi; Hirono Shuichi; Tanaka Haruo; Omura Satoshi; McCauley John A.; Sprengeler Paul A.; Furst George T.; Smith Amos B. III, Symposium on the Chemistry of Natural Products, symposium papers, (38):499 - 504, Sep. 1996

Presentations

  • 物理化学的特性を表す特性球に基づいたHLA-抗原ペプチド相互作用のデータベース構築と解析, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会141年会, 28 Mar. 2021, オンライン開催
  • 高精度タンパク質-リガンド相互作用解析を目指したprobe-based QM modeling法の考案と検証, 早川　大地;渡邉　友里江;合田　浩明, 第47回構造活性相関シンポジウム, 13 Dec. 2019, 熊本
  • タンパク質-リガンド相互作用解析のためのprobe-based QM modeling 法, 早川　大地;合田　浩明, 第63回日本薬学会関東支部大会, 14 Sep. 2019, 東京
  • Non-conventional相互作用を記述可能な分子相互作用場計算法の構築とタンパク質-リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第139年会, 22 Mar. 2019, 千葉
  • 量子化学計算とプローブ分子に基づいた分子相互作用場の算出とタンパク質−リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 第46回構造活性相関シンポジウム, 04 Dec. 2018, 大阪
  • セルロースアセテートのアセチル基が 固有複屈折へ及ぼす影響の計算化学による検討, 早川　大地;合田　浩明;上田　一義, セルロース学会第25回年次大会, 05 Jul. 2018, 宇治
  • 分子動力学計算を用いたアルドケト還元酵素AKR1C3のC154Y及びL159V変異体の溶液構造解析, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 日本薬学会第138年会, 27 Mar. 2018, 金沢
  • ハロゲン結合や弱い水素結合を記述可能な分子相互作用場計算法の構築, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第138年会, 27 Mar. 2018, 金沢
  • Structural analysis of aldo-keto reductase 1C3 and its C154Y mutant using molecular dynamics simulation, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第45回構造活性相関シンポジウム, 29 Nov. 2017, 土浦
  • Molecular dynamics study for C154Y mutant of aldo-keto reductase 1C3, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第40回ケモインフォマティクス討論会, 26 Oct. 2017, 宇部
  • S46 family bacterial dipeptidyl aminopeptidases as novel antibiotics targets., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;ITO Yasuhiro;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, International Union of Microbiological Societies 2017, 17 Jul. 2017, Singapore
  • Effect of the Arg456His mutation on the threedimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations, WATANABE Yurie ;KATO Koichi;FUKUYOSHI Shuichi;HIRATSUKA Masahiro;YAMAOTSU Noriyuki;HIRONO Shuichi;GOUDA Hiroaki;ODA Akifumi, XXIX IUPAP Conference on Computational Physics(CCP2017), 10 Jul. 2017, Paris
  • Molecular dynamics study of interaction between PACAP (6'-38') and N-terminal extracellular domain of the human splice variant hPAC1-R-short aiming at development of neuropathic pain medicine, WATANABE Yurie ;ODA Akifumi;GOUDA Hiroaki, XXIX IUPAP Conference on Computational Physics(CCP2017), 10 Jul. 2017, Paris
  • 分子ドッキングと分子動力学計算による薬剤性過敏症症候群の原因薬剤とHLA の相互作用解析, 渡邉　友里江;日下部　吉男;楯　直子;合田　浩明, 日本薬学会第137年会, 25 Mar. 2017, 仙台
  • Structural Analysis of Dipeptidyl Peptidase 11 (DPP11) from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;SASAKI Kaoru;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, AsCA 2016, 05 Dec. 2016, Hanoi
  • Discovery of Non-peptidic Orexin Receptor Agonist YNT-185, 斉藤　毅;永原　崇志;沓村　憲樹;中嶋　龍;細川　直人;入鹿山　容子;小川　靖裕;富永　拡;黒田　大祐;合田　浩明;藤井　秀明;柳沢　正史;長瀬　博, 第34回メディシナルケミストリーシンポジウム, 30 Nov. 2016, つくば
  • Energy-based analysis and prediction of peptide-HLA interactions, KURODA Daisuke;GOUDA Hiroaki, 第44回構造活性相関シンポジウム・第31回農薬デザイン研究会, 16 Nov. 2016, 京都
  • Computational analysis of interaction between HLA-B*13:01 with Dapson responsible for drug-inducing hypersensitivity syndrome, GOUDA Hiroaki;WATANABE Yurie;KURODA Daisuke;KUSAKABE Yoshio;UTSUNOMIYA-TATE Naoko, CBI学会2016年大会, 25 Oct. 2016, 東京
  • 分子動力学計算を用いた薬剤過敏症候群を引き起こすレクチゾールとHLAの相互作用解析, 渡邉　友里江;日下部　吉男;楯　直子;黒田　大祐;合田　浩明, 日本コンピュータ化学会2016秋季年会, 22 Oct. 2016, 松江
  • Structure and Functions of Dipeptidyl Peptidase 11 (DPP11) from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 2nd International Symposium (SSPC-2) Space Science of High Quality Protein Crystallization Technology, 21 Oct. 2016, Tokyo
  • Crystal structure of dipeptidyl amino peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 42nd Naito Conference on “In the Vanguard of Structural Biology”, 05 Oct. 2016, Sapporo
  • Crystal structure of dipeptidyl amino peptidase 11 (DPP11) from periodontal pathogen., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 2016 ISS R&D Conference, 12 Jul. 2016, San Diego
  • Crystal Structure analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 16th International Conference on the Crystallization of Biological Macromolecules, 05 Jul. 2016, Prague
  • Structural biology of acidic amino acids specific DPP (dipeptidyl peptidase) from periodontal pathogen, 六本木　沙織;鈴木　義之;飯塚　一平;館岡　千佳;藤本　真友;伊中　浩治;田仲　広明;山田　貢;太田　和敬;合田　浩明;野中　孝昌;小笠原　渉;田中　信忠;阪本　泰光, 日本薬学会第136年会, 29 Mar. 2016, 横浜
  • How well can we model peptide-HLA interactions using sequence information alone?, 黒田　大祐;合田　浩明, 日本薬学会第136年会, 28 Mar. 2016, 横浜
  • Design and Synthesis of Non-Peptidic Orexin Receptor Agonists, 斉藤　毅;永原　崇志;沓村　憲樹;入鹿山　容子;小川　靖裕;黒田　大祐;合田　浩明;藤井　秀明;柳沢　正史;長瀬　博, 第33回メディシナルケミストリーシンポジウム, 26 Nov. 2015, 千葉
  • Structural and mutational studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis., SAKAMOTO Yasumitsu;SUZUKI Yoshiyuki;IIZUKA Ippei;TATEOKA Chika;ROPPONGI Saori;FUJIMOTO Mayu;INAKA Koji;TANAKA Hiroaki;YAMADA Mitsugu;OHTA Kazunori;GOUDA Hiroaki;NONAKA Takamasa;OGASAWARA Wataru;TANAKA Nobutada, 9th General Meeting of The International Proteolysis Society, 07 Oct. 2015, Penang
  • SHIP2 inhibition ability evaluation of new compound CPDA indicating the insulin signal reinforcement action, 梅田　知伸;山田　彩華;田中　信忠;小澤　新一郎;広野　修一;笹岡　利安;豊岡　尚樹;合田　浩明, 日本薬学会第135年会, 28 Mar. 2015, 神戸
  • Design, synthesis, and biological evaluation of a novel atpenin A5 derivative as a complex II inhibitor, 矢野　圭祐;大多和　正樹;有馬　志保;合田　浩明;広野　修一;大村　智;長光　亨, 日本薬学会第135年会, 27 Mar. 2015, 神戸
  • In silico drug design of selective inhibitor of SHIP2 as a novel therapeutic agent for diabetes, 小澤　新一郎;合田　浩明;広野　修一, 日本薬学会第135年会, 27 Mar. 2015, 神戸
  • Design, synthesis, and biological evaluation of a novel atpenin A5 derivative as a complex II inhibitor, 矢野　圭祐;宮尾　篤欣;大多和　正樹;有馬　志保;合田　浩明;広野　修一;大村　智;長光　亨, 第32回メディシナルケミストリーシンポジウム, 27 Nov. 2014, 神戸
  • Discovery of 8-Hydroxy-2-imino-2H-chromene-3-carboxamide analogues as a new scaffold for carbonyl reductase (CBR1) inhibitors, 小栗　弘成;遠藤　智史;宮城　菜未希;胡　大イ;荒井　裕貴;松永　俊之;五十里　彰;桑田　一夫;原　明;合田　浩明;豊岡　尚樹, 第32回メディシナルケミストリーシンポジウム, 27 Nov. 2014, 神戸
  • Studies on novel antidiabetic drug based on improvement of insulin resistance, 高原　理行;市原　克則;和田　努;恒枝　宏史;笹岡　利安;広野　修一;梅田　知伸;田中　信忠;合田　浩明;豊岡　尚樹, 第32回メディシナルケミストリーシンポジウム, 26 Nov. 2014, 神戸
  • In silico drug design of selective inhibitor of SHIP2 as a novel therapeutic agent for diabetes, 小澤　新一郎;合田　浩明;広野　修一, 第42回構造活性相関シンポジウム, 13 Nov. 2014, 熊本
  • Synthesis and structure-activity relationship of 8-hydroxy-2-imino-2H-chromene-3-carboxamide derivatives as CBR1 inhibitors, 宮城　菜未希;胡　大イ;遠藤　智史;荒井　裕貴;松永　俊之;五十里　彰;桑田　一夫;原　明;合田　浩明;豊岡　尚樹, 第42回構造活性相関シンポジウム, 13 Nov. 2014, 熊本
  • Discovery of novel antidiabetic drug based on improvement of insulin resistance, 高原　理行;市原　克則;和田　努;恒枝　宏史;笹岡　利安;広野　修一;梅田　知伸;田中　信忠;合田　浩明;豊岡　尚樹, 日本薬学会第134年会, 29 Mar. 2014, 熊本
  • Structure analysis of the N-acetylneuraminate synthase for novel drug discovery against Helicobacter pylori, 日下部　吉男;梅田　知伸;北川　康行;田中　信忠;合田　浩明, 日本薬学会第134年会, 29 Mar. 2014, 熊本
  • In silico drug design of SHIP2 inhibitors as a novel therapeutic agent for diabetes, 小澤　新一郎;中作　菜穂;合田　浩明;広野　修一, 日本薬学会第134年会, 29 Mar. 2014, 熊本
  • Expression system improvement of the enzyme from Plasmodium falciparum and crystallization, 葉梨　繁樹;梅田　知伸;田中　信忠;日下部　吉男;中西　雅之;北出　幸夫;合田　浩明, 日本薬学会第134年会, 28 Mar. 2014, 熊本
  • Design and synthesis of opioid delta selective propellane type quinoline derivatives, 中嶋　龍;山本　直司;平山　重人;岩井　孝志;根本　徹;藤井　秀明;合田　浩明;広野　修一;長瀬　博, 第31回メディシナルケミストリーシンポジウム, 21 Nov. 2013, 広島

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