前濱　朝彦Maehama Tomohiko

研究者情報

基本情報

プロフィール情報

• 氏名

  前濱　朝彦, Maehama Tomohiko

ID各種

• 研究者番号

  40322755

• ORCID ID

  0000-0002-9685-2317

所属

• 生化学, 教授

施設

• 旗の台校舎

学位

• 博士(理学), 東京工業大学, 1995年03月

研究キーワード

• がん抑制遺伝子
• がんシグナル
• ストレス応答

研究分野

• ライフサイエンス, 機能生物化学
• ライフサイエンス, 病態医化学

担当科目

• 医化学
• 脂質・ビタミン・生化学特論
• 生化学実習・臨床生化学演習

所属学協会

• 日本生化学会
• 日本癌学会
• 日本プロテインホスファターゼ研究会
• 日本分子生物学会

学術貢献活動

• 企画立案・運営等, 日本生化学会評議員
• 企画立案・運営等, 日本プロテインホスファターゼ研究会・世話人
• 査読, Cancer Science, Associate Editor

業績

論文

• Nucleolar stress: Molecular mechanisms and related human diseases., Maehama Tomohiko;Nishio Miki;Otani Junji;Mak Tak Wah;Suzuki Akira, Cancer science, 114(5), 2023年02月, 総説, 査読あり
• The TIGD5 gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor., Dai Yuntao;Kawaguchi Tetsuya;Nishio Miki;Otani Junji;Tashiro Hironori;Terai Yoshito;Sasaki Ryohei;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 27(11), 2022年08月, 原著, 査読あり
• N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ., Shiraishi Yusuke;Maehama Tomohiko;Nishio Miki;Otani Junji;Hikasa Hiroki;Mak Tak Wah;Sasaki Takehiko;Honma Teruki;Kondoh Yasumitsu;Osada Hiroyuki;Yoshida Minoru;Fujisawa Masato;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 27(10), 2022年08月, 原著, 査読あり
• Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers., Soyama Hirotoshi;Nishio Miki;Otani Junji;Sakuma Toshiko;Takao Shintaro;Hara Shigeo;Masuda Takaaki;Mimori Koshi;Toyokuni Shinya;Lydon John P;Nakao Kazuwa;Nishina Hiroshi;Fukumoto Takumi;Maehama Tomohiko;Suzuki Akira, Proceedings of the National Academy of Sciences of the United States of America, 119(29), 2022年07月, 原著, 査読あり
• Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation., Nakatani Keisuke;Maehama Tomohiko;Nishio Miki;Otani Junji;Yamaguchi Keiko;Fukumoto Miki;Hikasa Hiroki;Hagiwara Shinji;Nishina Hiroshi;Mak Tak Wah;Honma Teruki;Kondoh Yasumitsu;Osada Hiroyuki;Yoshida Minoru;Suzuki Akira, Cancer science, 112(10), 2021年08月, 原著, 査読あり
• TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands., Miyachi Yosuke;Nishio Miki;Otani Junji;Matsumoto Shinji;Kikuchi Akira;Mak Tak Wah;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 26(9), 2021年07月, 原著, 査読あり
• The role of Hippo-YAP signaling in squamous cell carcinomas., Maehama Tomohiko;Nishio Miki;Otani Junji;Mak Tak Wah;Suzuki Akira, Cancer science, 112(1), 2020年12月, 総説, 査読あり
• Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice., Nishio Miki;To Yoko;Maehama Tomohiko;Aono Yukari;Otani Junji;Hikasa Hiroki;Kitagawa Akihiro;Mimori Koshi;Sasaki Takehiko;Nishina Hiroshi;Toyokuni Shinya;Lydon John P;Nakao Kazuwa;Wah Mak Tak;Kiyono Tohru;Katabuchi Hidetaka;Tashiro Hironori;Suzuki Akira, Cancer science, 111(10), 2020年08月, 原著, 査読あり
• Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica., Watanabe Natsuki;Nakada-Tsukui Kumiko;Maehama Tomohiko;Nozaki Tomoyoshi, Microorganisms, 8(7), 2020年07月, 原著, 査読あり
• YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma., Omori Hirofumi;Nishio Miki;Masuda Muneyuki;Miyachi Yosuke;Ueda Fumihito;Nakano Takafumi;Sato Kuniaki;Mimori Koshi;Taguchi Kenichi;Hikasa Hiroki;Nishina Hiroshi;Tashiro Hironori;Kiyono Tohru;Mak Tak Wah;Nakao Kazuwa;Nakagawa Takashi;Maehama Tomohiko;Suzuki Akira, Science advances, 6(12), 2020年03月, 原著, 査読あり
• Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica., Nakada-Tsukui Kumiko;Watanabe Natsuki;Maehama Tomohiko;Nozaki Tomoyoshi, Frontiers in cellular and infection microbiology, 9, 2019年06月, 総説, 査読あり
• MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner., Kato Wakako;Nishio Miki;To Yoko;Togashi Hideru;Mak Tak Wah;Takada Hidetoshi;Ohga Shouichi;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 24(7), 2019年05月, 原著, 査読あり
• Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency., Nishio Miki;Miyachi Yousuke;Otani Junji;Tane Shoji;Omori Hirofumi;Ueda Fumihito;Togashi Hideru;Sasaki Takehiko;Mak Tak Wah;Nakao Kazuwa;Fujita Yasuyuki;Nishina Hiroshi;Maehama Tomohiko;Suzuki Akira, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 2019年01月, 原著, 査読あり
• Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9., Goto Hiroki;Nishio Miki;To Yoko;Oishi Tatsuya;Miyachi Yosuke;Maehama Tomohiko;Nishina Hiroshi;Akiyama Haruhiko;Mak Tak Wah;Makii Yuma;Saito Taku;Yasoda Akihiro;Tsumaki Noriyuki;Suzuki Akira, Development (Cambridge, England), 145(6), 2018年03月, 原著, 査読あり
• Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein., Maehama Tomohiko;Kawahara Kohichi;Nishio Miki;Suzuki Akira;Hanada Kentaro, The Journal of biological chemistry, 289(30), 2014年, 原著, 査読あり
• Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11., Sasaki Masato;Kawahara Kohichi;Nishio Miki;Mimori Koshi;Kogo Ryunosuke;Hamada Koichi;Itoh Bunsho;Wang Jia;Komatsu Yukako;Yang Yong Ryoul;Hikasa Hiroki;Horie Yasuo;Yamashita Takayuki;Kamijo Takehiko;Zhang Yanping;Zhu Yan;Prives Carol;Nakano Toru;Mak Tak Wah;Sasaki Takehiko;Maehama Tomohiko;Mori Masaki;Suzuki Akira, Nature medicine, 17(8), 2011年07月, 原著, 査読あり
• Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells., Malchinkhuu Enkhzol;Sato Koichi;Maehama Tomohiko;Ishiuchi Shogo;Yoshimoto Yuhei;Mogi Chihiro;Kimura Takao;Kurose Hitoshi;Tomura Hideaki;Okajima Fumikazu, Molecular biology of the cell, 20(24), 2009年, 原著, 査読あり
• RalA functions as an indispensable signal mediator for the nutrient-sensing system., Maehama Tomohiko;Tanaka Masahiko;Nishina Hiroshi;Murakami Makoto;Kanaho Yasunori;Hanada Kentaro, The Journal of biological chemistry, 283(50), 2008年10月, 原著, 査読あり
• Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation., Okahara Fumiaki;Itoh Kouichi;Nakagawara Akira;Murakami Makoto;Kanaho Yasunori;Maehama Tomohiko, Molecular biology of the cell, 17(11), 2006年09月, 原著, 査読あり
• Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein., Okahara Fumiaki;Itoh Kouichi;Ebihara Michihiro;Kobayashi Masao;Maruyama Hiroki;Kanaho Yasunori;Maehama Tomohiko, Analytical biochemistry, 336(1), 2005年, 原著, 査読あり
• Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein., Okahara Fumiaki;Ikawa Hideki;Kanaho Yasunori;Maehama Tomohiko, The Journal of biological chemistry, 279(44), 2004年09月, 原著, 査読あり

講演・口頭発表等

• 成熟脂肪細胞特異的なMOB1欠損による高脂肪食誘発肥満や糖脂質代謝の改善, 西尾美希、山口慶子、大谷淳二、前濱朝彦、鈴木聡, 第97回日本生化学会大会, 2024年11月07日, 横浜市
• 転写後調節によるHippo-YAP経路の制御, 大谷淳二、鴇田璃子、古澤秀和、西尾美希、前濱朝彦、鈴木聡, 第83回日本癌学会学術総会, 2024年09月19日, 福岡市