Maehama Tomohiko

Researcher

基本情報

Profile and Settings

• 氏名

  Maehama Tomohiko

Identifiers

• 研究者番号

  40322755

• ORCID ID

  0000-0002-9685-2317

• J-Global ID

  200901036721878492

Affiliation

• Biochemistry, Professor

Location

• Hatanodai Campus

Degree

• DSc/PhD, Tokyo Institute of Technology, Mar. 1995

Research Areas

• Life Science, Functional biochemistry
• Life Science, Pathological biochemistry

Academic Contributions

• Peer review, Cancer Science, Associate Editor

Achievements

Published Papers

• MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes., Nishio Miki;Yamaguchi Keiko;Otani Junji;Yuguchi Katsuya;Kohno Daisuke;Sasaki Tsutomu;Kitamura Tadahiro;Shinohara Masakazu;Soga Tomoyoshi;Kawamura Koichi;Sasaki Atsuo T;Oshima Masashi;Hikasa Hiroki;Woo Minna;Sasaki Takehiko;Nishina Hiroshi;Nakao Kazuwa;Maehama Tomohiko;Suzuki Akira, Proceedings of the National Academy of Sciences of the United States of America, 122(17):e2424741122, Apr. 2025, Peer-reviewed
• Hippo経路によるがん制御, 前濱 朝彦, 昭和医科大学雑誌, 85(2):167 - 100, 2025, Peer-reviewed, DOI:https://doi.org/10.14930/jsmu.85.2_96
• Nucleolar stress: Molecular mechanisms and related human diseases., Maehama Tomohiko;Nishio Miki;Otani Junji;Mak Tak Wah;Suzuki Akira, Cancer science, 114(5), Feb. 2023, Peer-reviewed
• The TIGD5 gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor., Dai Yuntao;Kawaguchi Tetsuya;Nishio Miki;Otani Junji;Tashiro Hironori;Terai Yoshito;Sasaki Ryohei;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 27(11), Aug. 2022, Peer-reviewed
• N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ., Shiraishi Yusuke;Maehama Tomohiko;Nishio Miki;Otani Junji;Hikasa Hiroki;Mak Tak Wah;Sasaki Takehiko;Honma Teruki;Kondoh Yasumitsu;Osada Hiroyuki;Yoshida Minoru;Fujisawa Masato;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 27(10):602 - 612, Aug. 2022, Peer-reviewed
• Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers., Soyama Hirotoshi;Nishio Miki;Otani Junji;Sakuma Toshiko;Takao Shintaro;Hara Shigeo;Masuda Takaaki;Mimori Koshi;Toyokuni Shinya;Lydon John P;Nakao Kazuwa;Nishina Hiroshi;Fukumoto Takumi;Maehama Tomohiko;Suzuki Akira, Proceedings of the National Academy of Sciences of the United States of America, 119(29), Jul. 2022, Peer-reviewed
• Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation., Nakatani Keisuke;Maehama Tomohiko;Nishio Miki;Otani Junji;Yamaguchi Keiko;Fukumoto Miki;Hikasa Hiroki;Hagiwara Shinji;Nishina Hiroshi;Mak Tak Wah;Honma Teruki;Kondoh Yasumitsu;Osada Hiroyuki;Yoshida Minoru;Suzuki Akira, Cancer science, 112(10), Aug. 2021, Peer-reviewed
• TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands., Miyachi Yosuke;Nishio Miki;Otani Junji;Matsumoto Shinji;Kikuchi Akira;Mak Tak Wah;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 26(9):714 - 726, Jul. 2021, Peer-reviewed
• The role of Hippo-YAP signaling in squamous cell carcinomas., Maehama Tomohiko;Nishio Miki;Otani Junji;Mak Tak Wah;Suzuki Akira, Cancer science, 112(1):51 - 60, Dec. 2020, Peer-reviewed
• Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice., Nishio Miki;To Yoko;Maehama Tomohiko;Aono Yukari;Otani Junji;Hikasa Hiroki;Kitagawa Akihiro;Mimori Koshi;Sasaki Takehiko;Nishina Hiroshi;Toyokuni Shinya;Lydon John P;Nakao Kazuwa;Wah Mak Tak;Kiyono Tohru;Katabuchi Hidetaka;Tashiro Hironori;Suzuki Akira, Cancer science, 111(10):3576 - 3587, Aug. 2020, Peer-reviewed
• Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica., Watanabe Natsuki;Nakada-Tsukui Kumiko;Maehama Tomohiko;Nozaki Tomoyoshi, Microorganisms, 8(7), Jul. 2020, Peer-reviewed
• YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma., Omori Hirofumi;Nishio Miki;Masuda Muneyuki;Miyachi Yosuke;Ueda Fumihito;Nakano Takafumi;Sato Kuniaki;Mimori Koshi;Taguchi Kenichi;Hikasa Hiroki;Nishina Hiroshi;Tashiro Hironori;Kiyono Tohru;Mak Tak Wah;Nakao Kazuwa;Nakagawa Takashi;Maehama Tomohiko;Suzuki Akira, Science advances, 6(12):eaay3324, Mar. 2020, Peer-reviewed
• Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica., Nakada-Tsukui Kumiko;Watanabe Natsuki;Maehama Tomohiko;Nozaki Tomoyoshi, Frontiers in cellular and infection microbiology, 9, Jun. 2019, Peer-reviewed
• MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner., Kato Wakako;Nishio Miki;To Yoko;Togashi Hideru;Mak Tak Wah;Takada Hidetoshi;Ohga Shouichi;Maehama Tomohiko;Suzuki Akira, Genes to cells : devoted to molecular & cellular mechanisms, 24(7), May 2019, Peer-reviewed
• Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency., Nishio Miki;Miyachi Yousuke;Otani Junji;Tane Shoji;Omori Hirofumi;Ueda Fumihito;Togashi Hideru;Sasaki Takehiko;Mak Tak Wah;Nakao Kazuwa;Fujita Yasuyuki;Nishina Hiroshi;Maehama Tomohiko;Suzuki Akira, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), Jan. 2019, Peer-reviewed
• Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9., Goto Hiroki;Nishio Miki;To Yoko;Oishi Tatsuya;Miyachi Yosuke;Maehama Tomohiko;Nishina Hiroshi;Akiyama Haruhiko;Mak Tak Wah;Makii Yuma;Saito Taku;Yasoda Akihiro;Tsumaki Noriyuki;Suzuki Akira, Development (Cambridge, England), 145(6), Mar. 2018, Peer-reviewed
• Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein., Maehama Tomohiko;Kawahara Kohichi;Nishio Miki;Suzuki Akira;Hanada Kentaro, The Journal of biological chemistry, 289(30), 2014, Peer-reviewed
• Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11., Sasaki Masato;Kawahara Kohichi;Nishio Miki;Mimori Koshi;Kogo Ryunosuke;Hamada Koichi;Itoh Bunsho;Wang Jia;Komatsu Yukako;Yang Yong Ryoul;Hikasa Hiroki;Horie Yasuo;Yamashita Takayuki;Kamijo Takehiko;Zhang Yanping;Zhu Yan;Prives Carol;Nakano Toru;Mak Tak Wah;Sasaki Takehiko;Maehama Tomohiko;Mori Masaki;Suzuki Akira, Nature medicine, 17(8), Jul. 2011, Peer-reviewed
• Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells., Malchinkhuu Enkhzol;Sato Koichi;Maehama Tomohiko;Ishiuchi Shogo;Yoshimoto Yuhei;Mogi Chihiro;Kimura Takao;Kurose Hitoshi;Tomura Hideaki;Okajima Fumikazu, Molecular biology of the cell, 20(24), 2009, Peer-reviewed
• RalA functions as an indispensable signal mediator for the nutrient-sensing system., Maehama Tomohiko;Tanaka Masahiko;Nishina Hiroshi;Murakami Makoto;Kanaho Yasunori;Hanada Kentaro, The Journal of biological chemistry, 283(50), Oct. 2008, Peer-reviewed
• Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation., Okahara Fumiaki;Itoh Kouichi;Nakagawara Akira;Murakami Makoto;Kanaho Yasunori;Maehama Tomohiko, Molecular biology of the cell, 17(11), Sep. 2006, Peer-reviewed
• Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein., Okahara Fumiaki;Itoh Kouichi;Ebihara Michihiro;Kobayashi Masao;Maruyama Hiroki;Kanaho Yasunori;Maehama Tomohiko, Analytical biochemistry, 336(1), 2005, Peer-reviewed
• Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein., Okahara Fumiaki;Ikawa Hideki;Kanaho Yasunori;Maehama Tomohiko, The Journal of biological chemistry, 279(44), Sep. 2004, Peer-reviewed