Morito Daisuke

Researcher

基本情報

Profile and Settings

• 氏名

  Morito Daisuke

Affiliation

• Biochemistry, Senior Lecturer

Location

• Hatanodai Campus

Degree

• Doctor of Science, Kyoto University, Mar. 2008

Achievements

Published Papers

• もやもや病遺伝子のクローニングから機能解明へ, 森戸　大介, 昭和学士会雑誌, 84(1):56 - 63, Mar. 2024, Peer-reviewed, DOI:https://doi.org/10.14930/jshowaunivsoc.84.56
• もやもや病遺伝子の代謝制御機能, 森戸　大介, 生化学, 91(6):815 - 819, Dec. 2019
• The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets., SUGIHARA M;MORITO Daisuke;AINUKI S;HIRANO Y;OGINO K;KITAMURA A;HIRATA H;NAGATA K, J Cell Biol, 218(3):949 - 960, Mar. 2019, Peer-reviewed, DOI:10.1083/jcb.201712120
• ミステリン　もやもや病の責任遺伝子産物, 森戸　大介, 医学のあゆみ, 267(13):1105 - 1110, Dec. 2018
• Nuclear export of ubiquitinated proteins via the UBIN-POST system, Shoshiro Hirayama; Munechika Sugihara; Daisuke Morito; Shun-ichiro Iemura; Tohru Natsume; Shigeo Murata; Kazuhiro Nagata, Proceedings of the National Academy of Sciences of the United States of America, 115(18):E4199 - E4208, May 2018
• Nuclear export of ubiquitinated proteins via the UBIN-POST system, Shoshiro Hirayama; Munechika Sugihara; Daisuke Morito; Shun-ichiro Iemura; Tohru Natsume; Shigeo Murata; Kazuhiro Nagata, Proceedings of the National Academy of Sciences of the United States of America, 115(18):E4199 - E4208, May 2018
• Nuclear export of ubiquitinated proteins via the UBIN-POST system, Shoshiro Hirayama; Munechika Sugihara; Daisuke Morito; Shun-ichiro Iemura; Tohru Natsume; Shigeo Murata; Kazuhiro Nagata, Proceedings of the National Academy of Sciences of the United States of America, 115(18):E4199 - E4208, May 2018
• Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor, Yuri Kotani; Daisuke Morito; Kenshiro Sakata; Shiori Ainuki; Munechika Sugihara; Tomohisa Hatta; Shun-ichiro Iemura; Seiji Takashima; Tohru Natsume; Kazuhiro Nagata, SCIENTIFIC REPORTS, 7, Mar. 2017
• Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor, Yuri Kotani; Daisuke Morito; Kenshiro Sakata; Shiori Ainuki; Munechika Sugihara; Tomohisa Hatta; Shun-ichiro Iemura; Seiji Takashima; Tohru Natsume; Kazuhiro Nagata, SCIENTIFIC REPORTS, 7, Mar. 2017
• Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor, Yuri Kotani; Daisuke Morito; Kenshiro Sakata; Shiori Ainuki; Munechika Sugihara; Tomohisa Hatta; Shun-ichiro Iemura; Seiji Takashima; Tohru Natsume; Kazuhiro Nagata, SCIENTIFIC REPORTS, 7, Mar. 2017
• Neuromuscular regulation in zebrafish by a large AAA plus ATPase/ubiquitin ligase, mysterin/RNF213, Yuri Kotani; Daisuke Morito; Satoru Yamazaki; Kazutoyo Ogino; Koichi Kawakami; Seiji Takashima; Hiromi Hirata; Kazuhiro Nagata, SCIENTIFIC REPORTS, 5, Nov. 2015
• Neuromuscular regulation in zebrafish by a large AAA plus ATPase/ubiquitin ligase, mysterin/RNF213, Yuri Kotani; Daisuke Morito; Satoru Yamazaki; Kazutoyo Ogino; Koichi Kawakami; Seiji Takashima; Hiromi Hirata; Kazuhiro Nagata, SCIENTIFIC REPORTS, 5, Nov. 2015
• Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments, Janine Kirstein; Daisuke Morito; Taichi Kakihana; Munechika Sugihara; Anita Minnen; Mark S. Hipp; Carmen Nussbaum-Krammer; Prasad Kasturi; F. Ulrich Hartl; Kazuhiro Nagata; Richard I. Morimoto, EMBO JOURNAL, 34(18):2334 - 2349, Sep. 2015
• Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments, Janine Kirstein; Daisuke Morito; Taichi Kakihana; Munechika Sugihara; Anita Minnen; Mark S. Hipp; Carmen Nussbaum-Krammer; Prasad Kasturi; F. Ulrich Hartl; Kazuhiro Nagata; Richard I. Morimoto, EMBO JOURNAL, 34(18):2334 - 2349, Sep. 2015
• Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?, Daisuke Morito; Kazuhiro Nagata, MOLECULAR CELL, 59(3):335 - 344, Aug. 2015
• Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?, Daisuke Morito; Kazuhiro Nagata, MOLECULAR CELL, 59(3):335 - 344, Aug. 2015
• Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA plus ATPase, which dynamically changes its oligomeric state, Daisuke Morito; Kouki Nishikawa; Jun Hoseki; Akira Kitamura; Yuri Kotani; Kazumi Kiso; Masataka Kinjo; Yoshinori Fujiyoshi; Kazuhiro Nagata, SCIENTIFIC REPORTS, 4, Mar. 2014
• Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA plus ATPase, which dynamically changes its oligomeric state, Daisuke Morito; Kouki Nishikawa; Jun Hoseki; Akira Kitamura; Yuri Kotani; Kazumi Kiso; Masataka Kinjo; Yoshinori Fujiyoshi; Kazuhiro Nagata, SCIENTIFIC REPORTS, 4, Mar. 2014
• The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality, Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 439(4):419 - 426, Oct. 2013
• The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality, Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 439(4):419 - 426, Oct. 2013
• Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G > A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients, Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 438(1):13 - 19, Aug. 2013
• Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G > A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients, Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 438(1):13 - 19, Aug. 2013
• ER stress proteins in autoimmune an inflammatory diseases, Daisuke Morito; Kazuhiro Nagata, FRONTIERS IN IMMUNOLOGY, 3(MAR), 2012
• ER stress proteins in autoimmune an inflammatory diseases, Daisuke Morito; Kazuhiro Nagata, FRONTIERS IN IMMUNOLOGY, 3(MAR), 2012
• Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development, Wanyang Liu; Daisuke Morito; Seiji Takashima; Yohei Mineharu; Hatasu Kobayashi; Toshiaki Hitomi; Hirokuni Hashikata; Norio Matsuura; Satoru Yamazaki; Atsushi Toyoda; Ken-ichiro Kikuta; Yasushi Takagi; Kouji H. Harada; Asao Fujiyama; Roman Herzig; Boris Krischek; Liping Zou; Jeong Eun Kim; Masafumi Kitakaze; Susumu Miyamoto; Kazuhiro Nagata; Nobuo Hashimoto; Akio Koizumi, PLOS ONE, 6(7), Jul. 2011
• Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development, Wanyang Liu; Daisuke Morito; Seiji Takashima; Yohei Mineharu; Hatasu Kobayashi; Toshiaki Hitomi; Hirokuni Hashikata; Norio Matsuura; Satoru Yamazaki; Atsushi Toyoda; Ken-ichiro Kikuta; Yasushi Takagi; Kouji H. Harada; Asao Fujiyama; Roman Herzig; Boris Krischek; Liping Zou; Jeong Eun Kim; Masafumi Kitakaze; Susumu Miyamoto; Kazuhiro Nagata; Nobuo Hashimoto; Akio Koizumi, PLOS ONE, 6(7), Jul. 2011
• Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508, Daisuke Morito; Kazuyoshi Hirao; Yukako Oda; Nobuko Hosokawa; Fuminori Tokunaga; Douglas M. Cyr; Keiji Tanaka; Kazuhiro Iwai; Kazuhiro Nagata, MOLECULAR BIOLOGY OF THE CELL, 19(4):1328 - 1336, Apr. 2008
• Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508, Daisuke Morito; Kazuyoshi Hirao; Yukako Oda; Nobuko Hosokawa; Fuminori Tokunaga; Douglas M. Cyr; Keiji Tanaka; Kazuhiro Iwai; Kazuhiro Nagata, MOLECULAR BIOLOGY OF THE CELL, 19(4):1328 - 1336, Apr. 2008
• MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination, Shoshiro Hirayama; Yuji Yamazaki; Akira Kitamura; Yukako Oda; Daisuke Morito; Katsuya Okawa; Hiroshi Kimura; Douglas M. Cyr; Hiroshi Kubota; Kazuhiro Nagata, MOLECULAR BIOLOGY OF THE CELL, 19(3):899 - 911, Mar. 2008
• MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination, Shoshiro Hirayama; Yuji Yamazaki; Akira Kitamura; Yukako Oda; Daisuke Morito; Katsuya Okawa; Hiroshi Kimura; Douglas M. Cyr; Hiroshi Kubota; Kazuhiro Nagata, MOLECULAR BIOLOGY OF THE CELL, 19(3):899 - 911, Mar. 2008
• EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming, K Hirao; Y Natsuka; T Tamura; Wada, I; D Morito; S Natsuka; P Romero; B Sleno; LO Tremblay; A Herscovics; K Nagata; N Hosokawa, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(14):9650 - 9658, Apr. 2006
• EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming, K Hirao; Y Natsuka; T Tamura; Wada, I; D Morito; S Natsuka; P Romero; B Sleno; LO Tremblay; A Herscovics; K Nagata; N Hosokawa, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(14):9650 - 9658, Apr. 2006
• Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF, N Yasui; T Mori; D Morito; O Matsushita; H Kourai; K Nagata; T Koide, BIOCHEMISTRY, 42(11):3160 - 3167, Mar. 2003
• Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF, N Yasui; T Mori; D Morito; O Matsushita; H Kourai; K Nagata; T Koide, BIOCHEMISTRY, 42(11):3160 - 3167, Mar. 2003