大西　伸幸Onishi Nobuyuki

研究者情報

基本情報

プロフィール情報

• 氏名

  大西　伸幸, Onishi Nobuyuki

所属

• 臨床薬理研究所臨床腫瘍診断学, 講師

施設

• 烏山病院

学位

• 博士(医学), 神戸大学, 2008年03月

業績

論文

• Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks., Onji Hiroshi;Tate Sota;Sakaue Tomohisa;Fujiwara Kohei;Nakano Shiho;Kawaida Miho;Onishi Nobuyuki;Matsumoto Takashi;Yamagami Wataru;Sugiyama Takashi;Higashiyama Shigeki;Pommier Yves;Kobayashi Yusuke;Murai Junko, Oncogene, 2024年07月, 原著, 査読あり
• KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway., Fujii Takashi;Nakano Yoshiko;Hagita Daichi;Onishi Nobuyuki;Endo Arumu;Nakagawa Masaya;Yoshiura Toru;Otsuka Yohei;Takeuchi Satoru;Suzuki Mario;Shimizu Yuzaburo;Toyooka Terushige;Matsushita Yuko;Hibiya Yuko;Tomura Satoshi;Kondo Akihide;Wada Kojiro;Ichimura Koichi;Tomiyama Arata, Cancers, 16(1), 2023年12月, 原著, 査読あり
• Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis., Megumi Uetaki; Nobuyuki Onishi; Yoshinao Oki; Takatsune Shimizu; Eiji Sugihara; Oltea Sampetrean; Takashi Watanabe; Hisano Yanagi; Kiyoshi Suda; Hiroya Fujii; Koichiro Kano; Hideyuki Saya; Hiroyuki Nobusue, Molecular biology of the cell, 33(9):mbcE21120609, 2022年06月, 原著, 査読あり
• A protein kinase D inhibitor suppresses AKT on T cells and antagonizes cancer immunotherapy by anti-PD-1., Miyamoto Kazuhide;Hayabuchi Hodaka;Tokifuji Yukiko;Ando Makoto;Onishi Nobuyuki;Okamura Tadashi;Yoshimura Akihiko;Chikuma Shunsuke, International immunology, 34(12):609 - 619, 2022年, 原著, 査読あり
• Isolation and characterization of neural stem/progenitor cells in the subventricular zone of the naked mole-rat brain, Yuki Yamamura; Yoshimi Kawamura; Yuki Oiwa; Kaori Oka; Nobuyuki Onishi; Hideyuki Saya; Kyoko Miura, Inflammation and Regeneration, 41(1):31 - 31, 2021年12月, 原著, 査読あり
• Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development., Fumiya Moribe; Momoko Nishikori; Tsuyoshi Takashima; Daiki Taniyama; Nobuyuki Onishi; Hiroshi Arima; Hiroyuki Sasanuma; Remi Akagawa; Fathi Elloumi; Shunichi Takeda; Yves Pommier; Eiichi Morii; Akifumi Takaori-Kondo; Junko Murai, PloS one, 16(1):e0237554, 2021年, 原著, 査読あり
• 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche, Naoyoshi Koike; Ryuichi Kota; Yoshiko Naito; Noriyo Hayakawa; Tomomi Matsuura; Takako Hishiki; Nobuyuki Onishi; Junichi Fukada; Makoto Suematsu; Naoyuki Shigematsu; Hideyuki Saya; Oltea Sampetrean, Communications Biology, 3(1):450 - 450, 2020年12月, 原著, 査読あり
• The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics., Kunitomi H; Oki Y; Onishi N; Kano K; Banno K; Aoki D; Saya H; Nobuse H, Genes Cells, 25(3):165 - 174, 2020年01月, 原著, 査読あり
• IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma., Satoshi Kofuji; Akiyoshi Hirayama; Alexander Otto Eberhardt; Risa Kawaguchi; Yuki Sugiura; Oltea Sampetrean; Yoshiki Ikeda; Mikako Warren; Naoya Sakamoto; Shuji Kitahara; Hirofumi Yoshino; Daisuke Yamashita; Kazutaka Sumita; Kara Wolfe; Lisa Lange; Satsuki Ikeda; Hiroko Shimada; Noriaki Minami; Akshiv Malhotra; Shin Morioka; Yuki Ban; Maya Asano; Victoria L Flanary; Annmarie Ramkissoon; Lionel M L Chow; Juri Kiyokawa; Tomoyuki Mashimo; Greg Lucey; Sergey Mareninov; Tatsuya Ozawa; Nobuyuki Onishi; Koichi Okumura; Jumpei Terakawa; Takiko Daikoku; Trisha Wise-Draper; Nazanin Majd; Kaori Kofuji; Mika Sasaki; Masaru Mori; Yonehiro Kanemura; Eric P Smith; Dimitrios Anastasiou; Hiroaki Wakimoto; Eric C Holland; William H Yong; Craig Horbinski; Ichiro Nakano; Ralph J DeBerardinis; Robert M Bachoo; Paul S Mischel; Wataru Yasui; Makoto Suematsu; Hideyuki Saya; Tomoyoshi Soga; Ingrid Grummt; Holger Bierhoff; Atsuo T Sasaki, Nature cell biology, 21(8):1003 - 1014, 2019年08月, 原著, 査読あり
• ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells., Takahashi N; Nobusue H; Shimizu T; Sugihara E; Yamaguchi-Iwai S; Onishi N; Kunitomi H; Kuroda T; Saya H, Cancer research, 79(12):3088 - 3099, 2019年04月, 原著, 査読あり
• Development of a functional thyroid model based on an organoid culture system, Yoshiyuki Saito; Nobuyuki Onishi; Hiroshi Takami; Ryo Seishima; Hiroyoshi Inoue; Yuki Hirata; Kaori Kameyama; Kenji Tsuchihashi; Eiji Sugihara; Shinya Uchino; Koichi Ito; Hirofumi Kawakubo; Hiroya Takeuchi; Yuko Kitagawa; Hideyuki Saya; Osamu Nagano, Biochemical and Biophysical Research Communications, 497(2):783 - 789, 2018年03月, 原著, 査読あり
• xCT promotes malignant phenotypes in EGFR-expressing glioma, Tsuchihashi Kenji; Okazaki Shogo; Yoshikawa Momoko; Seishima Ryo; Sampetrean Oltea; Onishi Nobuyuki; Wakimoto Hiroaki; Furnari Frank; Baba Eishi; Akashi Koichi; Saya Hideyuki; Nagano Osamu, CANCER RESEARCH, 77, 2017年07月, 原著, 査読あり
• Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells, Takatsugu Ishimoto; Keisuke Miyake; Tannistha Nandi; Masakazu Yashiro; Nobuyuki Onishi; Kie Kyon Huang; Suling Joyce Lin; Ramnarayanan Kalpana; Su Ting Tay; Yuka Suzuki; Byoung Chul Cho; Daisuke Kuroda; Kota Arima; Daisuke Izumi; Masaaki Iwatsuki; Yoshifumi Baba; Eiji Oki; Masayuki Watanabe; Hideyuki Saya; Kosei Hirakawa; Hideo Baba; Patrick Tan, GASTROENTEROLOGY, 153(1):191 - +, 2017年07月, 原著, 査読あり
• Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity, Walied A. Kamel; Eiji Sugihara; Hiroyuki Nobusue; Sayaka Yamaguchi-Iwai; Nobuyuki Onishi; Kenta Maki; Yumi Fukuchi; Koichi Matsuo; Akihiro Muto; Hideyuki Saya; Takatsune Shimizu, MOLECULAR CANCER THERAPEUTICS, 16(1):182 - 192, 2017年01月, 原著, 査読あり
• ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN, T. Ueda; Y. Nakata; N. Yamasaki; H. Oda; K. Sentani; A. Kanai; N. Onishi; K. Ikeda; Y. Sera; Z-i Honda; K. Tanaka; M. Sata; S. Ogawa; W. Yasui; H. Saya; J. Takita; H. Honda, ONCOGENE, 35(34):4447 - 4458, 2016年08月, 原著, 査読あり
• Tumour resistance in induced pluripotent stem cells derived from naked mole-rats, Shingo Miyawaki; Yoshimi Kawamura; Yuki Oiwa; Atsushi Shimizu; Tsuyoshi Hachiya; Hidemasa Bono; Ikuko Koya; Yohei Okada; Tokuhiro Kimura; Yoshihiro Tsuchiya; Sadafumi Suzuki; Nobuyuki Onishi; Naoko Kuzumaki; Yumi Matsuzaki; Minoru Narita; Eiji Ikeda; Kazuo Okanoya; Ken-ichiro Seino; Hideyuki Saya; Hideyuki Okano; Kyoko Miura, NATURE COMMUNICATIONS, 7:11471, 2016年05月, 原著, 査読あり
• The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-), Kenji Tsuchihashi; Shogo Okazaki; Mitsuyo Ohmura; Miyuki Ishikawa; Oltea Sampetrean; Nobuyuki Onishi; Hiroaki Wakimoto; Momoko Yoshikawa; Ryo Seishima; Yoshimi Iwasaki; Takayuki Morikawa; Shinya Abe; Ayumi Takao; Misato Shimizu; Takashi Masuko; Motoo Nagane; Frank B. Furnari; Tetsu Akiyama; Makoto Suematsu; Eishi Baba; Koichi Akashi; Hideyuki Saya; Osamu Nagano, CANCER RESEARCH, 76(10):2954 - 2963, 2016年05月, 原著, 査読あり
• Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor (vol 10, e0128288, 2015), Yayoi Yoshimura; Akihiko Shiino; Kazue Muraki; Tadateru Fukami; Shigeki Yamada; Takeshi Satow; Miyuki Fukuda; Masaaki Saiki; Masato Hojo; Susumu Miyamoto; Nobuyuki Onishi; Hideyuki Saya; Toshiro Inubushi; Kazuhiko Nozaki; Kenji Tanigaki, PLOS ONE, 11(2):e0149826, 2016年02月, 原著, 査読あり
• Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells, Sayaka I. Yamaguchi; Arisa Ueki; Eiji Sugihara; Nobuyuki Onishi; Tomonori Yaguchi; Yutaka Kawakami; Keisuke Horiuchi; Hideo Morioka; Morio Matsumoto; Masaya Nakamura; Akihiro Muto; Yoshiaki Toyama; Hideyuki Saya; Takatsune Shimizu, Cancer Science, 106(7):875 - 882, 2015年07月, 原著, 査読あり
• IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress, Takatsune Shimizu; Eiji Sugihara; Sayaka Yamaguchi-Iwai; Sakura Tamaki; Yuko Koyama; Walied Kamel; Arisa Ueki; Tomoki Ishikawa; Tatsuyuki Chiyoda; Satoru Osuka; Nobuyuki Onishi; Hiroko Ikeda; Junzo Kamei; Koichi Matsuo; Yumi Fukuchi; Toshihiro Nagai; Junya Toguchida; Yoshiaki Toyama; Akihiro Muto; Hideyuki Saya, CANCER RESEARCH, 74(22):6531 - 6541, 2014年11月, 原著, 査読あり
• Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation, Hiroyuki Nobusue; Nobuyuki Onishi; Takatsune Shimizu; Eiji Sugihara; Yoshinao Oki; Yuko Sumikawa; Tatsuyuki Chiyoda; Koichi Akashi; Hideyuki Saya; Koichiro Kano, NATURE COMMUNICATIONS, 5:3368, 2014年02月, 原著, 査読あり
• Acquired expression of NFATc1 downregulates e-cadherin and promotes cancer cell invasion, Tsukasa Oikawa; Atsuko Nakamura; Nobuyuki Onishi; Taketo Yamada; Koichi Matsuo; Hideyuki Saya, Cancer Research, 73(16):5100 - 5109, 2013年08月, 原著, 査読あり
• Twist2 functions as a tumor suppressor in murine osteosarcoma cells, Tomoki Ishikawa; Takatsune Shimizu; Arisa Ueki; Sayaka I. Yamaguchi; Nobuyuki Onishi; Eiji Sugihara; Shinji Kuninaka; Takeshi Miyamoto; Hideo Morioka; Robert Nakayama; Eisuke Kobayashi; Yoshiaki Toyama; Yo Mabuchi; Yumi Matsuzaki; Rui Yamaguchi; Satoru Miyano; Hideyuki Saya, CANCER SCIENCE, 104(7):880 - 888, 2013年07月, 原著, 査読あり
• Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis, Mayumi Kitagawa; Suet Yin Sarah Fung; Nobuyuki Onishi; Hideyuki Saya; Sang Hyun Lee, PLOS ONE, 8(6):e64826, 2013年06月, 原著, 査読あり
• IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells, Satoru Osuka; Oltea Sampetrean; Takatsune Shimizu; Isako Saga; Nobuyuki Onishi; Eiji Sugihara; Jun Okubo; Satoshi Fujita; Shingo Takano; Akira Matsumura; Hideyuki Saya, STEM CELLS, 31(4):627 - 640, 2013年04月, 原著, 査読あり
• xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma., Momoko Yoshikawa; Kenji Tsuchihashi; Takatsugu Ishimoto; Toshifumi Yae; Takeshi Motohara; Eiji Sugihara; Nobuyuki Onishi; Takashi Masuko; Kunio Yoshizawa; Shuichi Kawashiri; Makio Mukai; Seiji Asoda; Hiromasa Kawana; Taneaki Nakagawa; Hideyuki Saya; Osamu Nagano, Cancer research, 73(6):1855 - 66, 2013年03月, 原著, 査読あり
• Up-Regulation of Imp3 Confers In Vivo Tumorigenicity on Murine Osteosarcoma Cells, Arisa Ueki; Takatsune Shimizu; Kenta Masuda; Sayaka I. Yamaguchi; Tomoki Ishikawa; Eiji Sugihara; Nobuyuki Onishi; Shinji Kuninaka; Keita Miyoshi; Akihiro Muto; Yoshiaki Toyama; Kouji Banno; Daisuke Aoki; Hideyuki Saya, PLOS ONE, 7(11):e50621, 2012年11月, 原著, 査読あり
• Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor, E. Sugihara; T. Shimizu; K. Kojima; N. Onishi; K. Kai; J. Ishizawa; K. Nagata; N. Hashimoto; H. Honda; M. Kanno; M. Miwa; S. Okada; M. Andreeff; H. Saya, ONCOGENE, 31(23):2849 - 2861, 2012年06月, 原著, 査読あり
• Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells, Mayumi Tamada; Osamu Nagano; Seiji Tateyama; Mitsuyo Ohmura; Toshifumi Yae; Takatsugu Ishimoto; Eiji Sugihara; Nobuyuki Onishi; Takehiro Yamamoto; Hiroshi Yanagawa; Makoto Suematsu; Hideyuki Saya, CANCER RESEARCH, 72(6):1438 - 1448, 2012年03月, 原著, 査読あり
• Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma, Takatsune Shimizu; Tomoki Ishikawa; Sayaka Iwai; Arisa Ueki; Eiji Sugihara; Nobuyuki Onishi; Shinji Kuninaka; Takeshi Miyamoto; Yoshiaki Toyama; Hiroshi Ijiri; Hajime Mori; Yumi Matsuzaki; Tomonori Yaguchi; Hiroshi Nishio; Yutaka Kawakami; Yasuo Ikeda; Hideyuki Saya, MOLECULAR CANCER RESEARCH, 10(3):454 - 468, 2012年03月, 原著, 査読あり
• Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells, Takeshi Motohara; Sachiko Masuko; Takatsugu Ishimoto; Toshifumi Yae; Nobuyuki Onishi; Teruyuki Muraguchi; Atsushi Hirao; Yumi Matsuzaki; Hironori Tashiro; Hidetaka Katabuchi; Hideyuki Saya; Osamu Nagano, CARCINOGENESIS, 32(11):1597 - 1606, 2011年11月, 原著, 査読あり
• Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12, Yusuke Kobayashi; Takatsune Shimizu; Hideaki Naoe; Arisa Ueki; Joe Ishizawa; Tatsuyuki Chiyoda; Nobuyuki Onishi; Eiji Sugihara; Osamu Nagano; Kouji Banno; Shinji Kuninaka; Daisuke Aoki; Hideyuki Saya, American Journal of Pathology, 179(3):1471 - 1482, 2011年09月, 原著, 査読あり
• Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells, Oltea Sampetrean; Isako Saga; Masaya Nakanishi; Eiji Sugihara; Raita Fukaya; Nobuyuki Onishi; Satoru Osuka; Masaki Akahata; Kazuharu Kai; Hachiro Sugimoto; Atsushi Hirao; Hideyuki Saya, NEOPLASIA, 13(9):784 - U28, 2011年09月, 原著, 査読あり
• Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase, Akinori Yoda; Kyoko Toyoshima; Yasuhide Watanabe; Nobuyuki Onishi; Yuki Hazaka; Yusuke Tsukuda; Junichi Tsukada; Takeshi Kondo; Yoshiya Tanaka; Yasuhiro Minami, JOURNAL OF BIOLOGICAL CHEMISTRY, 283(27):18969 - 18979, 2008年07月, 原著, 査読あり
• Chk2 kinase is required for methylglyoxal-induced G(2)/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling, Shuichi Kani; Emiko Nakayama; Akinori Yoda; Nobuyuki Onishi; Nagako Sougawa; Yuki Hazaka; Tsuyoshi Umeda; Kohsuke Takeda; Hidenori Ichijo; Yasuhiro Hamada; Yasuhiro Minami, GENES TO CELLS, 12(8):919 - 928, 2007年08月, 原著, 査読あり
• Wip1 phosphatase modulates ATM-dependent signaling pathways, Sathyavageeswaran Shreeram; Oleg N. Demidov; Weng Kee Hee; Hiroshi Yamaguchi; Nobuyuki Onishi; Calvina Kek; Oleg N. Timofeev; Crissy Dudgeon; Albert J. Fornace; Carl W. Anderson; Yasuhiro Minami; Ettore Appella; Dmitry V. Bulavin, MOLECULAR CELL, 23(5):757 - 764, 2006年09月, 原著, 査読あり
• Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1, Akinori Yoda; Xiao Zhou Xu; Nobuyuki Onishi; Kyoko Toyoshima; Hiroko Fujimoto; Naoko Kato; Isao Oishi; Takeshi Kondo; Yasuhiro Minami, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(34):24847 - 24862, 2006年08月, 原著, 査読あり
• Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase, H. Fujimoto; N. Onishi; N. Kato; M. Takekawa; X. Z. Xu; A. Kosugi; T. Kondo; M. Imamura; I. Oishi; A. Yoda; Y. Minami, CELL DEATH AND DIFFERENTIATION, 13(7):1170 - 1180, 2006年07月, 原著, 査読あり
• The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway, Oishi, I; H Suzuki; N Onishi; R Takada; S Kani; B Ohkawara; Koshida, I; K Suzuki; G Yamada; GC Schwabe; S Mundlos; H Shibuya; S Takada; Y Minami, GENES TO CELLS, 8(7):645 - 654, 2003年07月, 原著, 査読あり