小谷　透Kotani Toru

One-year outcomes in sepsis: a prospective multicenter cohort study in Japan., Liu Keibun;Watanabe Shinichi;Nakamura Kensuke;Nakano Hidehiko;Motoki Maiko;Kamijo Hiroshi;Ayaka Matsuoka;Ishii Kenzo;Morita Yasunari;Hongo Takashi;Shimojo Nobutake;Tanaka Yukiko;Hanazawa Manabu;Hamagami Tomohiro;Oike Kenji;Kasugai Daisuke;Sakuda Yutaka;Irie Yuhei;Nitta Masakazu;Akieda Kazuki;Shimakura Daigo;Katsukawa Hajime;Kotani Toru;McWilliams David;Nydahl Peter;Schaller Stefan J;Ogura Takayuki; , Journal of intensive care, 13(1), 2025年05月, 原著, 査読あり

Clinical efficacy of invimestrocel for acute respiratory distress syndrome caused by pneumonia: Comparison with historical data using propensity score analysis., 4. Ichikado K, Kotani T, Kawamura K, Kondoh Y, Imanaka H, Johkoh T, Fujimoto K, Nunomiya S, Kawayama T, Sawada M, Jenkins E, Tasaka S, Ichiyasu H, Sakagami T, Hashimoto S., Regenerative Therapy, 29:35 - 42, 2025年03月, 原著, 査読あり, DOI:10.1016/j.reth.2025.02.018

Association between changes in disease severity and physical function after surviving a critical illness: A multicentre retrospective observational study., Liu Keibun;Hamagami Tomohiro;Sugiyasu Naoki;Fujizuka Kenji;Kawauchi Akira;Yamada Sou;Ogura Takayuki;Hirata Naoko;Tani Takafumi;Taito Shunsuke;Ota Kohei;McWilliams David;Katsukawa Hajime;Kotani Toru, Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 37(6):889 - 895, 2024年05月, 原著, 査読あり, DOI:10.1016/j.aucc.2024.03.011

Clinical efficacy and safety of multipotent adult progenitor cells (invimestrocel) for acute respiratory distress syndrome (ARDS) caused by pneumonia: a randomized, open-label, standard therapy-controlled, phase 2 multicenter study (ONE-BRIDGE), Kazuya Ichikado, Toru Kotani, Yasuhiro Kondoh, Hideaki Imanaka, Takeshi Johkoh, Kiminori Fujimoto, Shin Nunomiya, Tomotaka Kawayama, Masanori Sawada, Eric Jenkins, Sadatomo Tasaka, Satoru Hashimoto, Stem Cell Res Ther, 14(1):217, 2023年08月, 原著, 査読あり, DOI:10.1186/s13287-023-03451-z

Current Practice and Barriers to the Implementation of Mobilization in ICUs in Japan: A Multicenter Prospective Cohort Study., Sakuramoto Hideaki;Nakamura Kensuke;Ouchi Akira;Okamoto Saiko;Watanabe Shinichi;Liu Keibun;Morita Yasunari;Katsukawa Hajime;Kotani Toru, Journal of clinical medicine, 12(12), 2023年06月, 原著, 査読あり, DOI:10.3390/jcm12123955

Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis., Fukumoto Shiori;Ohbayashi Masayuki;Okada Akira;Kohyama Noriko;Tamatsukuri Tatsuro;Inoue Hideki;Kato Akihito;Kotani Toru;Sagara Hironori;Dohi Kenji;Kogo Mari, Therapeutic drug monitoring, 45(3):392 - 399, 2023年05月, 原著, 査読あり, DOI:10.1097/FTD.0000000000001040

Relationship between grip strength during hospitalisation and mental disorders after discharge in critically ill patients: a post-hoc analysis of a prospective observational study., Notsuyu Ayano;Naraba Hiromu;Liu Keibun;Ikechi Daisuke;Nakano Hidehiko;Mochizuki Masaki;Takahashi Yuji;Watanabe Shinichi;Morita Yasunari;Kotani Toru;Nakamura Kensuke, BMJ open, 13(5), 2023年05月, 原著, 査読あり, DOI:10.1136/bmjopen-2022-068983.

An evaluation of the impact of the implementation of the Tele-ICU: A retrospective observational study., 渡邉太郎、大杉浩一、住永有梨、染井将行、喜久山和貴、森麻衣子、丸尾寛子、河野奈緒、小谷透, J Intensive Care, 11(1):9, 2023年01月, 原著, 査読あり, DOI:10.1186/s40560-023-00657-4

Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicenter prospective observational cohort study in Japan., Liu K, Kotani T, Nakamura K, Takai C, Morita Y, Ishii K, Fujizuka K, Yasumura D, Taniguchi D, Hamagami T, Shimojo N, Nitta M, Takashi H, Akieda K, Maeda A, Kaneko T, Sakuda Y, Andoh K, Nagatomi A, Tanaka Y, Irie Y, Kamijo H, Hanazawa M, Kasugai D, Matsuoka A, Oike K, Lefor AK, Takahashi K, Katsukawa H, Ogura T., BMJ open, :2587, 2022年12月, 査読あり, DOI:https://doi.org/10.3390/jcm110 92587

Association between Early Mobilization in the ICU and Psychiatric Symptoms after Surviving a Critical Illness: A Multi-Center Prospective Cohort Study., Watanabe Shinichi;Liu Keibun;Nakamura Kensuke;Kozu Ryo;Horibe Tatsuya;Ishii Kenzo;Yasumura Daisetsu;Takahashi You;Nanba Tomoya;Morita Yasunari;Kanaya Takahiro;Suzuki Shuichi;Lefor Alan Kawarai;Katsukawa Hajime;Kotani Toru, Journal of clinical medicine, 11(9):2587, 2022年05月, 原著, 査読あり, DOI:10.3390/jcm11092587

Clinical Implications of Determining Individualized Positive End-Expiratory Pressure Using Electrical Impedance Tomography in Post-Cardiac Surgery Patients: A Prospective, Non-Randomized Interventional Study., Bito Kiyoko;Shono Atsuko;Kimura Shinya;Maruta Kazuto;Omoto Tadashi;Aoki Atsushi;Oe Katsunori;Kotani Toru, Journal of clinical medicine, 11(11):3022, 2022年05月, 原著, 査読あり, DOI:10.3390/jcm11113022

A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling., Hassan D, Shono A, van Kalken CK, van del Spek PJ, Krenning EP, Kotani T., Purinergic Signal., 18:13 - 59, 2021年11月, 総説, 査読あり, DOI:10.1007/s11302-021-09814-6

Evaluation of a simultaneous adsorption device for cytokines and neutrophil-platelet complexes in vitro and in a lung-protective ventilated rabbit acute lung injury model., Sekiya Y, Shimada K, Takahashi H, Kuga C, Komachi S, Miwa K, Kotani T., Intensive Care Med Exp., 9(1):49, 2021年09月, 原著, 査読あり, DOI:10.1186/s40635-021-00414-7

Extracorporeal Membrane Oxygenation for Secondary Organizing Pneumonia after Severe SARS-CoV-2 Infection: A Case Report., Kimura Tomoyuki;Onitsuka Chisato;Kawahara Tomoko;Fukuda Yosuke;Homma Tetsuya;Watanabe Taro;Ohsugi Koichi;Ichikawa Yuki;Shono Atsuko;Kotani Toru;Sagara Hironori, Medicina (Kaunas, Lithuania), 57(10):1013, 2021年09月, 原著, 査読あり, DOI:10.3390/medicina57101013

Risk Factors of Patient-Related Safety Events during Active Mobilization for Intubated Patients in Intensive Care Units-A Multi-Center Retrospective Observational Study., Katsukawa Hajime;Ota Kohei;Liu Keibun;Morita Yasunari;Watanabe Shinichi;Sato Kazuhiro;Ishii Kenzo;Yasumura Daisetsu;Takahashi Yo;Tani Takafumi;Oosaki Hitoshi;Nanba Tomoya;Kozu Ryo;Kotani Toru, Journal of clinical medicine, 10(12):2607, 2021年06月, 原著, 査読あり, DOI:10.3390/jcm10122607

Roles of Early Mobilization Program in Preventing Muscle Weakness and Decreasing Psychiatric Disorders in Patients with Coronavirus Disease 2019 Pneumonia: A Retrospective Observational Cohort Study., Kotani Toru;Sugiyama Mizuki;Matsuzaki Fumika;Kubodera Kota;Saito Jin;Kaneki Mika;Shono Atsuko;Maruo Hiroko;Mori Maiko;Ohta Shin;Kasai Fumihito, Journal of clinical medicine, 10(13):2941, 2021年06月, 原著, 査読あり, DOI:10.3390/jcm10132941

Roles of Electrical Impedance Tomography in Determining a Lung Protective Strategy for Acute Respiratory Distress Syndrome in the Era of Coronavirus Disease 2019, Kotani T; Shono A, JMA Journal, 4(2):81 - 85, 2021年04月, 総説, 査読あり, DOI:10.31662/jmaj.2021-0014

Personalisation of Therapies in COVID-19 Associated Acute Respiratory Distress Syndrome, Using Electrical Impedance Tomography., Shono Atsuko;Kotani Toru;Frerichs Inéz, Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 7(1):62 - 66, 2021年01月, 原著, 査読あり, DOI:10.2478/jccm-2020-0045

Utility of SpO2/FiO2 ratio for acute hypoxemic respiratory failure with bilateral opacities in the ICU., Fukuda Yosuke;Tanaka Akihiko;Homma Tetsuya;Kaneko Keisuke;Uno Tomoki;Fujiwara Akiko;Uchida Yoshitaka;Suzuki Shintaro;Kotani Toru;Sagara Hironori, PloS one, 16(1):e0245927, 2021年01月, 原著

Effect of inhaled Nitric Oxide on acute cor pulmonale in COVID-19 pneumonia associated acute respiratory distress syndrome: A case report., Ichikawa Y, Maruo H, Motoyama H, Shono A, Somei M, Ohsugi K, Watanabe T, Kimura T, Mori M, Kikuyama K, Kotani T., Ann Clin Med Case Rep., 6(19):1 - 4, 2021年, 原著, 査読あり

Determinants of gait independence after mechanical ventilation in the intensive care unit: a Japanese multicenter retrospective exploratory cohort study., Watanabe Shinichi;Kotani Toru;Taito Shunsuke;Ota Kohei;Ishii Kenzo;Ono Mika;Katsukawa Hajime;Kozu Ryo;Morita Yasunari;Arakawa Ritsuro;Suzuki Shuichi, Journal of intensive care, 7, 2019年11月, 原著, 査読あり, DOI:10.1186/s40560-019-0404-2

Clinical implication of monitoring regional ventilation using electrical impedance tomography., Shono Atsuko;Kotani Toru, Journal of intensive care, 7(1):81 - 85, 2019年01月, 総説, 査読あり, DOI:10.1186/s40560-019-0358-4

Post-cardiotomy venovenous extracorporeal membrane oxygenation without heparinization., Takagaki Masami;Yamaguchi Hiroki;Ikeda Naoko;Takeda Kaori;Kasai Fumihito;Yahagi Kiyotaka;Kanzaki Shunji;Mitsuyama Shinichi;Kadowaki Tasuku;Kotani Toru, General thoracic and cardiovascular surgery, 67(11):1 - 5, 2018年08月, 原著, 査読あり

急性心筋梗塞によるElectrical Stormおよび急性呼吸窮迫症候群患者に対して、Veno-Arterial体外式膜型人工肺(ECMO)からVeno-Venous ECMOへ移行し救命し得た1例, 宗次 裕美;近藤 誠太;田中 秀彰;小倉 邦弘;小崎 遼太;酒井 孝志郎;荒井 研;松井 泰樹;辻田 裕昭;渡辺 則和;河村 光晴;濱嵜 裕司;森 麻衣子;宮下 亮一;小谷 透, 心臓, 50(Suppl.1):15 - 20, 2018年08月, 原著, 査読あり

Excessive Extracellular ATP Desensitizes P2Y2 and P2X4 ATP Receptors Provoking Surfactant Impairment Ending in Ventilation-Induced Lung Injury, Djo Hasan; Joshua Satalin; Philip van der Zee; Michaela Kollisch-Singule; Paul Blankman; Atsuko Shono; Peter Somhorst; Corstiaan den Uil; Han Meeder; Toru Kotani; Gary Nieman, International Journal of Molecular Sciences, 19(4):1185, 2018年04月, 総説, 査読あり, DOI:10.3390/ijms19041185

Regional overdistension during prone positioning in a patient with acute respiratory failure who was ventilated with a low tidal volume: a case report., Kotani Toru;Hanaoka Masanori;Hirahara Shinya;Yamanaka Hisashi;Teschner Eckhard;Shono Atsuko, Journal of intensive care, 6, 2018年03月, 査読あり, DOI:10.1186/s40560-018-0290-z

Pharmacokinetics of recombinant human soluble thrombomodulin in disseminated intravascular coagulation patients with acute renal dysfunction, Hayakawa Mineji; Kushimoto Shigeki; Watanabe Eizo; Goto Koji; Suzuki Yasushi; Kotani Toru; Kiguchi Takeyuki; Yatabe Tomoaki; Tagawa Jun; Komatsu Fumiyo; Gando Satoshi, Thrombosis and haemostasis, 117(05):851 - 859, 2017年05月

Risk Factors for the Mortality of Pneumocystis jirovecii Pneumonia in Non-HIV Patients Who Required Mechanical Ventilation: A Retrospective Case Series Study, Toru Kotani; Shinshu Katayama; Yuya Miyazaki; Satoshi Fukuda; Yoko Sato; Koichi Ohsugi, BioMed Research International, 2017, 2017年05月, 原著, 査読あり, DOI:10.1155/2017/7452604

Roles of neurally adjusted ventilatory assist in improving gas exchange in a severe acute respiratory distress syndrome patient after weaning from extracorporeal membrane oxygenation: a case report, Yuya Goto; Shinshu Katayama; Atsuko Shono; Yosuke Mori; Yuya Miyazaki; Yoko Sato; Makoto Ozaki; Toru Kotani, Journal of Intensive Care, 4(1):26, 2016年12月

Effects of extrathoracic mechanical ventilation on pulmonary hypertension secondary to lung disease, Sato Yoko; Saeki Noriyuki; Asakura Takuma; Aoshiba Kazutetsu; Kotani Toru, Journal of anesthesia, 30(4):663 - 670, 2016年08月

Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome, Toru Kotani; Hitoshi Tanabe; Hiroaki Yusa; Satoshi Saito; Kenji Yamazaki; Makoto Ozaki, Journal of Anesthesia, 30(1):161 - 165, 2016年02月, 査読あり, DOI:10.1007/s00540-015-2084-y

Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) severe respiratory failure in Japan, TAKEDA Shinhiro; KOTANI Toru; NAKAGAWA Satoshi; ICHIBA Shingo; AOKAGE Toshiyuki; OCHIAI Ryoichi; TAENAKA Nobuyuki; KAWAMAE Kaneyuki; NISHIMURA Masaji; UJIKE Yoshihito; TAJIMI Kimitaka; Committee of Crisis Control the Japanese Society of Respiratory Care Medicine and Committee of Pandemic H1N1 Surveillance the Japanese Society of Intensive Care Medicine, Journal of anesthesia, 26(5):650 - 657, 2012年10月, 原著, 査読あり, DOI:10.1007/s00540-012-1402-x

Plasma leukocyte cell-derived chemotaxin 2 is associated with the severity of systemic inflammation in patients with sepsis, Ando Kazuyoshi; Kato Hidehito; Kotani Toru, Microbiology and immunology, 56(10):708 - 718, 2012年10月

Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome., Hidefumi Koh; Sadatomo Tasaka; Naoki Hasegawa; Koichiro Asano; Toru Kotani; Hiroshi Morisaki; Junzo Takeda; Seitaro Fujishima; Tomoyuki Matsuda; Satoru Hashimoto; Akitoshi Ishizaka, Respirology (Carlton, Vic.), 13(2):281 - 4, 2008年03月

Activation of a Neutrophil-Derived Inflammatory Response in the Airways During Cardiopulmonary Bypass, Toru Kotani; Yoshifumi Kotake; Hiroshi Morisaki; Junzo Takeda; Hideyuki Shimizu; Toshihiko Ueda; Akitoshi Ishizaka, Anesthesia & Analgesia, 103(6):1394 - 1399, 2006年12月, 原著, 査読あり, DOI:10.1213/01.ane.0000243391.05091.bb

Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury, Eileen N. Ogawa; Akitoshi Ishizaka; Sadatomo Tasaka; Hidefumi Koh; Hiroshi Ueno; Fumimasa Amaya; Masahito Ebina; Shingo Yamada; Yosuke Funakoshi; Junko Soejima; Kiyoshi Moriyama; Toru Kotani; Satoru Hashimoto; Hiroshi Morisaki; Edward Abraham; Junzo Takeda, American Journal of Respiratory and Critical Care Medicine, 174(4):400 - 407, 2006年08月, 原著, 査読あり, DOI:10.1164/rccm.200605-699OC

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome, Akitoshi Ishizaka; Tomoyuki Matsuda; Kurt H. Albertine; Hidefumi Koh; Sadatomo Tasaka; Naoki Hasegawa; Nobuoki Kohno; Toru Kotani; Hiroshi Morisaki; Junzo Takeda; Morio Nakamura; Xiaohui Fang; Thomas R. Martin; Michael A. Matthay; Satoru Hashimoto, American Journal of Physiology-Lung Cellular and Molecular Physiology, 286(6):L1088 - L1094, 2004年06月, 原著, 査読あり, DOI:10.1152/ajplung.00420.2002

Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits, Kiyoshi Moriyama; Akitoshi Ishizaka; Morio Nakamura; Hiroshi Kubo; Toru Kotani; Shinichi Yamamoto; Eileen N. Ogawa; Osamu Kajikawa; Charles W. Frevert; Yoshifumi Kotake; Hiroshi Morisaki; Hidefumi Koh; Sadatomo Tasaka; Thomas R. Martin; Junzo Takeda, American Journal of Physiology-Lung Cellular and Molecular Physiology, 286(6):L1114 - L1121, 2004年06月, 原著, 査読あり, DOI:10.1152/ajplung.00296.2003

Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung, Mariko Kotani; Toru Kotani; Akitoshi Ishizaka; Seitaro Fujishima; Hidefumi Koh; Sadatomo Tasaka; Makoto Sawafuji; Eiji Ikeda; Kiyoshi Moriyama; Yoshifumi Kotake; Hiroshi Morisaki; Naoki Aikawa; Akira Ohashi; Kouji Matsushima; Yuh-Chin T. Huang; Junzo Takeda, Critical Care Medicine, 32(2):514 - 519, 2004年02月, 原著, 査読あり, DOI:10.1097/01.CCM.0000110677.16968.E4

New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome, Akitoshi Ishizaka; Masazumi Watanabe; Tetsuji Yamashita; Yasuyo Ogawa; Hidefumi Koh; Naoki Hasegawa; Hidetoshi Nakamura; Koichiro Asano; Kazuhiro Yamaguchi; Mariko Kotani; Toru Kotani; Hiroshi Morisaki; Junzo Takeda; Koichi Kobayashi; Satoshi Ogawa, Critical Care Medicine, 29(4):896 - 898, 2001年04月

医療の質を担保した循環器診療における働き方改革　医師の働き方改革におけるrapid response systemの役割(The Role of Rapid Response System in Physician Work Style Reform), 小林　洋一;徳田　幸子;増島　絵里子;古田　康之;二瓶　友美;小谷　透;三浦　まき;土肥　謙二;根本　友重;路川　環, 第84回日本循環器学会学術集会, 2020年07月27日, オンライン開催