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姫野　誠一郎Himeno Seiichro

■所属部署名衛生薬学
■職名客員教授
Last Updated :2026/07/24

研究者情報

基本情報

プロフィール情報

  • 氏名

    姫野　誠一郎, Himeno Seiichro

所属

  • 衛生薬学, 客員教授

施設

  • 旗の台校舎

学位

  • 保健学博士, 東京大学, 1989年11月

研究キーワード

  • 重金属、微量元素、毒性、輸送

所属学協会

  • 日本薬学会、日本毒性学会、日本免疫毒性学会、日本微量元素学会、日本衛生学会、ヒ素研究会

受賞

  • 日本免疫毒性学会, 日本免疫毒性学会　学会賞, ヒ素曝露による健康被害における免疫機能の攪乱, 姫野誠一郎, 2022年09月, 日本国

学術貢献活動

  • 企画立案・運営等, 日本免疫毒性学会監事、日本微量元素学会理事・副理事長

業績

論文

  • Time-dependent post-exposure self-recovery rescues arsenic-induced behavioral and biochemical alterations in mice., Hossain S, Sarder SJ, Suchona TI, Shahriar S, Das S, Mia S, Ahmed B, Ahsan F, Meem TY, Nikkon F, Himeno S, Hossain K, Saud ZA., Food Chem Toxicol., 214:116174, 2026年08月, 原著, 査読あり, DOI:10.1016/j.fct.2026.116174
  • Functional characterization of a novel ZIP8 variant causing impaired manganese homeostasis and congenital disorders of glycosylation., Fujishiro H, Morisada N, Mitani N, Nakayama R, Goto N, Nishito Y, Kambe T, Okamoto N, Wada Y, Ishida Y, Suzuki H, Nozu K, Kosaki K, Himeno S, Sumi D., Biometals, 2026年07月, 原著, 査読あり, DOI:10.1007/s10534-026-00862-2
  • In Vitro Evaluation of Cadmium-Induced Phosphate Reabsorption Impairment., Fujishiro, H., Nakayama, R., Takahashi, M., Tamoto, A., Taguchi, H., Takeuchi, K., Himeno, S., Sumi, D., J. Appl. Toxicol., 2026年03月, 原著, 査読あり, DOI:10.1002/jat.70134
  • Association between arsenic exposure and CCL5: its implications in asthma and skin lesions, Goni, O., Uddin, N., Rimi, R. K., Rossi, K. N., Abedin, F., Beauty, S. A., Sarder, S. J., Sadi, J., Islam, M., Mondal, V., Kabir, K. M. A., Siddique, A. E., Hossain, S., Hoque, M. A., Agusa, T., Sumi, D., Saud, Z. A., Himeno, S., Hossain, K., Exposure and Health, 18(7), 2025年12月, 原著, 査読あり, DOI:10.1007/s12403-025-00746-9
  • Ghrelin-disrupting activity of arsenic and its relation to cardiometabolic diseases., Rossi KN, Abedin F, Mohanto NC, Ahmed B, Mia S, Uddin N, Rimi RK, Goni O, Sarder SJ, Hossain S, Islam M, Jubayar AM, Islam MS, Hossain S, Hoque MA, Sumi D, Saud ZA, Himeno S, Hossain K., Toxicol Appl Pharmacol, 507:117676, 2025年12月, 原著, 査読あり, DOI:10.1016/j.taap.2025.117676
  • Relationship of fractalkine with arsenic exposure and the risk of cardiovascular diseases., Uddin, N., Rimi, R.K., Goni, O., Mohanto, N.C., Rossi, K.N., Abedin, F., Beauty, S.A., Ahmed, B., Mia, S., Sarder, S.J., Hossain, S., Islam, M., Noman, A.S.M., Hoque, M.A., Sumi, D., Mann, K.K., Saud, Z.A., Himeno, S., Hossain, K., Environ. Toxicol. Pharmacol., 2025年09月, 原著, 査読あり, DOI:10.1016/j.etap.2025.104824.
  • Cadmium uptake into rat osteoblast UMR-106 cells is mediated via multiple pathways, Fujishiro H, Ikeue Y, Himeno S, Sumi D., Biological Trace Element Research, 2025年09月, 原著, 査読あり, DOI:10.1007/s12011-025-04842-4
  • Regular Exercise with Panax Ginseng Supplementation Attenuates Arsenic-Induced Muscular Weakness and Neurobehavioral Changes in Mice, Beauty SA, Sarder SJ, Hossain J, Uddin N, Goni O, Rimi RK, Hossain S, Nikkon F, Himeno S, Hossain K, Saud ZA., Neurotoxicity Research, 43:34, 2025年09月, 原著, 査読あり, DOI:10.1007/s12640-025-00756-0
  • Phosphorus and potassium distributions in the kidneys of mice administered with renal tubular invasion heavy metals by micro-PIXE, Shino Homma-Takeda , Hitomi Fujishiro, Izumi Tanaka, Haruko Yakumaru, Hiroki Taguchi, Kyoko Ayama, Masakazu Oikawa, Seiichiro Himeno, The European Physical Journal Plus, 140:879, 2025年09月, 原著, 査読あり, DOI:10.1140/epjp/s13360-025-06819-7
  • 新規セレンタンパク質によるセレンの新たな生理作用, 姫野誠一郎, ファルマシア, 61(8):713 - 718, 2025年08月, 総説, 査読あり
  • Dynamic intra-renal changes in cadmium distribution detected by LA-ICP-MS in mice administered cadmium-metallothionein., Fujishiro H, Matsumoto K, Umemoto H, Tsuneyama K, Matsukawa T, Kubota A, Himeno S, Sumi D., Metallomics, 17(6):mfaf017, 2025年06月, 原著, 査読あり, DOI:10.1093/mtomcs/mfaf017
  • Novel evidence of arsenic-related excess adiposity and its implication in the risk of cardiometabolic diseases., Jubayar AM, Khan S, Sadi J, Uddin N, Goni O, Khatun M, Siddique AE, Kabir E, Rimi RK, Beauty SA, Rossi KN, Abedin F, Sarder SJ, Islam MS, Sarker MK, Hossain S, Sumi D, Saud ZA, Barchowsky A, Wahed AS, Himeno S, Hossain K., Environmental Research, 271:121059, 2025年02月, 原著, 査読あり, DOI:10.1016/j.envres.2025.121059
  • Combined Effects of Arsenic and Bisphenol-A on Locomotor Activity and Oxidative Stress Mediated Neurotoxicity in Mice., Beauty SA, Hossain J, Sarder SJ, Uddin N, Goni O, Abedin F, Rossi KN, Rimi RK, Himeno S, Hossain K, Saud ZA., Biological Trace Element Research, 2025年01月, 原著, 査読あり, DOI:10.1007/s12011-025-04522-3
  • Estimation of daily cadmium intake in the United States through food analysis in 1980., Katsue Suzuki-Inoue, Seiichiro Himeno, Shosuke Suzuki, Fundamental Toxicological Sciences, 11(5):251 - 257, 2024年10月, 原著, 査読あり, DOI:10.2131/fts.11.251
  • Ferroptosis is involved in cisplatin sensitivity of the S3 segment of immortalized proximal tubule cells., Taguchi, H., Sumi, D., Himeno, S., Fujishiro, H., Toxicology, 506:153840, 2024年08月, 原著, 査読あり, DOI:10.1016/j.tox.2024.153840
  • Concomitant exposure to lower doses of arsenic, lead, and manganese induces greater synergistic neurotoxicity than individual metals in mice., Kabir, E., Shila, T.T., Islam, J., Beauty, S.A., Islam, F., Hossain, S., Nikkon, F., Himeno, S., Hossain, K., Saud, Z.A., Biological Trace Element Research, 2024年06月, 原著, 査読あり, DOI:10.1007/s12011-024-04260-y
  • Arsenic Exposure-Related Hypertension in Bangladesh and Reduced Circulating Nitric Oxide Bioavailability, Khatun, M., Haque, N., Siddique, A.E., Wahed, A.S., Islam, M.S., Khan, S., Jubayar, A.M., Sadi, J., Kabir, E., Shila, T.T., Islam, Z., Sarker, M.K., Banna, H.U., Hossain, S., Sumi, D., Saud, Z.A., Barchowsky, A., Himeno, S., Hossain, K., Environ. Health Perspect., 132(4):47003, 2024年04月, 原著, 査読あり, DOI:10.1289/EHP13018
  • 【環境化学物質が人体へ与える影響】ヒ素による健康影響　高血圧,動脈硬化,糖尿病との関連, 姫野 誠一郎, 医学のあゆみ, 285(2):123, 2023年04月, 総説
  • Association between serum periostin levels and the severity of arsenic-induced skin lesions., Moriom Khatun; Abu Eabrahim Siddique; Abdus S Wahed; Nazmul Haque; Selim Reza Tony; Jahidul Islam; Shahnur Alam; Md Khalequzzaman Sarker; Isabela Kabir; Shakhawoat Hossain; Daigo Sumi; Zahangir Alam Saud; Aaron Barchowsky; Seiichiro Himeno; Khaled Hossain, PloS one, 18(1):e0279893, 2023年, 原著, 査読あり, DOI:10.1371/journal.pone.0279893
  • Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity., Hitomi Fujishiro; Sara Miyamoto; Daigo Sumi; Taiho Kambe; Seiichiro Himeno, Biochemical and biophysical research communications, 616:26 - 32, 2022年08月, 原著, 査読あり, DOI:10.1016/j.bbrc.2022.05.068
  • Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma., Selim Reza Tony; Nazmul Haque; Abu Eabrahim Siddique; Moriom Khatun; Mizanur Rahman; Zohurul Islam; Md Shofikul Islam; Jahidul Islam; Shakhawoat Hossain; Md Ashraful Hoque; Zahangir Alam Saud; Daigo Sumi; Abdus S Wahed; Aaron Barchowsky; Seiichiro Himeno; Khaled Hossain, Chemosphere, 298:134277 - 134277, 2022年03月, 原著, 査読あり, DOI:10.1016/j.chemosphere.2022.134277
  • Parental Lead Exposure Promotes Neurobehavioral Disorders and Hepatic Dysfunction in Mouse Offspring., Hasan Ul Banna; Adiba Anjum; Sheta Biswas; Victor Mondal; Abu Eabrahim Siddique; Apurba Kumar Roy; Farjana Nikkon; Azizul Haque; Seiichiro Himeno; Kazi Abdus Salam; Khaled Hossain; Zahangir Alam Saud, Biological trace element research, 200:1171 - 1180, 2022年03月, 原著, 査読あり, DOI:10.1007/s12011-021-02709-y
  • Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation., Hitomi Fujishiro; Miharu Sumino; Daigo Sumi; Hitomi Umemoto; Koichi Tsuneyama; Takehisa Matsukawa; Kazuhito Yokoyama; Seiichiro Himeno, The Journal of toxicological sciences, 47(12):507 - 517, 2022年, 原著, 査読あり, DOI:10.2131/jts.47.507
  • Non-malignant diseases associated with environmental arsenic exposure in Taiwan, Chile, and Bangladesh, HIMENO Seiichiro;HOSSAIN K, Metallomics Res, 1(1):rev-31 - rev-46, 2021年12月, 総説, 査読あり, DOI:10.11299/metallomicsresearch.MR202109
  • Gender differences in the risk of metabolic syndrome among chronic arsenic‑exposed individuals in Bangladesh, SARKER MK;TONY SR;SIDDIQUE AE;HAQUE N;ISLAM MS;HOSSAIN F;ISLAM Z;HOSSAIN S;HOQUE MA;SAUD ZA;SUMI D;HIMENO Seiichiro;HOSSAIN K, Expo Health, 14:595 - 608, 2021年10月, 原著, 査読あり, DOI:10.1007/s12403-021-00437-1
  • Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction., SARKER MK;TONY SR;SIDDIQUE AE;KARIM MR;HAQUE N;ISLAM Z;ISLAM MS;KHATUN M;ISLAM J;HOSSAIN S;ALAM SAUD Z;MIYATAKA H;SUMI D;BARCHOWSKY A;HIMENO Seiichiro;HOSSAIN K, Int J Environ Res Public Health, 18(18):9730, 2021年09月, 原著, 査読あり, DOI:10.3390/ijerph18189730
  • Comparisons of segment-specific toxicity of platinum-based agents and cadmium using S1, S2, and S3 cells derived from mouse kidney proximal tubules., FUJISHIRO H;TAGUCHI H;HAMAO S;SUMI D;HIMENO Seiichiro, Toxicol in Vitro, 75:105179, 2021年09月, 原著, 査読あり, DOI:10.1016/j.tiv.2021.105179
  • T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma., RAHMAN A;ISLAM MS;TONY SR;SIDDIQUE AE;MONDAL V;HOSEN Z;ISLAM Z;HOSSAIN MI;RAHMAN M;ANJUM A;PAUL SK;HOSSEN F;SARKER MK;HOSSAIN S;SALAM KA;HAQUE A;HOQUE MA;SAUD ZA;XIN L;SUMI D;HIMENO Seiichiro;HOSSAIN K, Toxicol Appl Pharmacol, 420:115532, 2021年06月, 原著, 査読あり, DOI:10.1016/j.taap.2021.115532
  • マンガン，カドミウムの必須性・毒性を左右する亜鉛輸送体の役割, 姫野　誠一郎;藤代　瞳, 薬学雑誌, 141(5):695 - 703, 2021年05月, 総説, 査読あり, DOI:10.1248/yakushi.20-00243-5
  • Single-Cell Imaging for Studies of Renal Uranium Transport and Intracellular Behavior, HOMMA-TAKEDA S;FUJISHIRO H;TANAKA I;YAKUMARU H;AYAMA K;UEHARA A;OIKAWA M;HIMENO Seiichiro;ISHIHARA H, Minerals, 11(2):191, 2021年02月, 原著, 査読あり, DOI:10.3390/min11020191
  • Arsenite suppresses IL-2-dependent tumoricidal activities of natural killer cells., SUMI D;TSUYAMA H;OGAWA T;OGAWA M;HIMENO Seiichiro, Toxicol Appl Pharmacol, 412:115353, 2021年02月, 原著, 査読あり, DOI:10.1016/j.taap.2020.115353
  • 低レベル曝露の時代の人体影響評価　－日本にもHuman Biomonitoringが必要では？, 姫野　誠一郎, 学術の動向, 25(11):64 - 68, 2020年11月, 査読あり

書籍等出版物

  • 第7版　衛生薬学　健康と環境, 原俊太郎・姫野誠一郎・吉成浩一, 共編者(共編著者), 丸善出版, 2025年02月, 査読あり
  • 衛生学・公衆衛生学　第2版, 第1章　衛生学・公衆衛生学の意義、第13章　保健統計, 姫野誠一郎, 共著, 1-9, 259-278, 医歯薬出版株式会社, 2025年01月, 査読なし
  • 化学物質の複合影響と健康リスク評価, 化学物質のHuman Biomonitoring, 姫野誠一郎, 共著, 119-128, 医歯薬出版株式会社, 2024年02月, 査読あり
  • Handbook on the Toxicology of Metals vol.II : Specific Metals 5th ed., Bismuth, HIMENO Seiichiro;FUJISHIRO H;SUMI D, 共著, Elsevier, 2021年12月, 査読あり

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