Takago Hideki

Researcher

基本情報

Profile and Settings

• 氏名

  Takago Hideki

Affiliation

• Office of Medical Education, Senior Lecturer

Location

• Hatanodai Campus

Achievements

Published Papers

• Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse, Hideki Takago* (*責任著者), Tomoko Oshima-Takago, Tobias Moser, Frontiers in Molecular Neuroscience, 11:492, Jan. 2019, Peer-reviewed, DOI:10.3389/fnmol.2018.00492
• Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals, Hideki Takago* (*責任著者), Tomoko Oshima-Takago, 362, 1:13, May 2018, Peer-reviewed
• NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups, Tomoko Oshima-Takago, Hideki Takago* (*責任著者), Open Biology, 7(7):pii 170032, Jul. 2017, Peer-reviewed
• Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells, Ryoichi Yoshimoto, Shinichi Iwasaki, Hideki Takago, Toshiaki Nakajima, Yoshinori Sahara, Ken Kitamura, Neuroscience, 284:632 - 642, Jan. 2015, Peer-reviewed
• Uniquantal release through a dynamic fusion poreis a candidate mechanism of hair cell exocytosis, Nikolai M. Chapochnikov#, Hideki Takago# (#共同筆頭著者), Chao-Hua Huang, Tina Pangršič, Darina Khimich, Jakob Neef, Elisabeth Auge, Fabian Göttfert, Stefan W. Hell, Carolin Wichmann, Fred Wolf, Tobias Moser, Neuron, 83(6):1389 - 1403, Sep. 2014, Peer-reviewed
• Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse, Zhizi Jing,　Mark A. Rutherford, Hideki Takago, Thomas Frank, Anna Fejtova, Darina Khimich, Tobias Moser, Nicola Strenzke, Journal of Neuroscience, 3(10):4456 - 4467, Mar. 2013, Peer-reviewed
• Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells, Tina Pangršič, Livia Lasarow, Kirsten Reuter, Hideki Takago, Martin Schwander, Dietmar Riede, Thomas Frank, Lisa M. Tarantino, Janice S. Bailey, Nicola Strenzke, Nils Brose, Ulrich Müller, Ellen Reisinger, Tobias Moser, Nature Neuroscience, 13(7):869 - 876, Jul. 2010, Peer-reviewed
• G protein-dependent presynaptic inhibition mediated by AMPA receptors at the calyx of Held, Hideki Takago#, Yukihiro Nakamura# (#共同筆頭著者), Tomoyuki Takahashi, Proceedings of National Academy of Sciences of the United States of America, 102(20):7368 - 7373, May 2005, Peer-reviewed
• A vasoactive agent enhances the effect of ATP on cochlear blood flow, Hideki Takago, Kazunori Yokoyama, Ken Kitamura, Acta Otolaryngologica, 121(2):130 - 134, Jan. 2001, Peer-reviewed
• 上顎洞異所性歯牙 の１症例, 鷹合 秀輝，原口 秀俊，野口 佳裕， 角田 篤信，前原 浩史，小松崎 篤, 耳鼻咽喉科展望, 41(1):67 - 70, 1998, Peer-reviewed

Presentations

• Synaptic ribbon-glutamate release site distance governs the exocytotic kinetics at the ribbon synapses in the retinal bipolar cell terminal, Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago, Ribbon Synapses Symposium 2025, Nov. 2025
• An attempt to build a predictive model for physician scientist career using IR data, 鷹合 秀輝, 小野 向日葵, 井上 明音, 香川 直輝, 大城 剛志, 三上 貴浩, 後藤 理英子, 有馬 牧子, 鈴木 慎太郎, 緒方 浩顕, 泉 美貴, 第57回日本医学教育学会大会, 25 Jul. 2025, 秋田市
• Visualizing the spatiotemporal dynamics of glutamate release from ribbon-associated and ribbon-free active zones in the goldfish retinal bipolar cell terminal, Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago, IBRO Neuroscience Reports 2023;15(Suppl):S705 [Conference abstract], Aug. 2023

Books etc

• 生き物と音の事典, 2.哺乳類 1. 霊長類ほか 14. 骨導、22. 聴力検査（P．80－P．81）、24. 難聴（P．84－P．85）, 生物音響学会, Joint work, 朝倉書店, 2019
• 内耳病態の解明と 展開, Ⅲ 実験モデルマウスの解析　3. 聴覚系のAMPA受容体, 喜多村 健，鷹合 秀輝，他15名, Joint work, 145-147, 善光堂, 2006

Research Projects

• 薬剤性難聴におけるcochlear synaptopathyの細胞生理学的検討, 鷹合　秀輝，中村　行宏，大島　知子, Principal investigator, 日本学術振興会, 科学研究費補助金, 基盤研究（C）, From 2023, Competitive research funding
• 感覚器リボンシナプスにおけるカルシウム-グルタミン酸連関の時空間動態機構の解明, 大島　知子，鷹合　秀輝，中村　行宏, Coinvestigator, 日本学術振興会, 科学研究費補助金, 基盤研究（C）, From 2022, To 2025, Competitive research funding
• STORM顕微鏡を用いた有毛細胞シナプスに おけるOtoferlinの構造機能解析, 鷹合　秀輝，大島　知子, Principal investigator, 日本学術振興会, 科学研究費補助金, 基盤研究（C）, 国立障害者リハビリテーションセンター研究所, From 2019, To 2025, Competitive research funding
• グルタミン酸イメージングによる加齢性難聴の病態解明研究, 鷹合　秀輝，大島　知子, Principal investigator, 日本学術振興会, 科学研究費補助金, 基盤研究（C）, 国立障害者リハビリテーションセンター研究所, From 2016, To 2020, Competitive research funding
• 光遺伝学を活用した新しい蝸牛神経刺激法：光学人工内耳の開発に向けて, 鷹合　秀輝，大島　知子, Principal investigator, 日本学術振興会, 科学研究費補助金, 挑戦的萌芽研究, 国立障害者リハビリテーションセンター研究所, From 2013, To 2016, Competitive research funding
• 聴覚系のグルタミン酸興奮毒性についてのパッチクランプ法による検討, 鷹合　秀輝, Principal investigator, 日本学術振興会, 科学研究費補助金, 若手研究(B), From 2007, To 2009, Competitive research funding