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Ashino Takashi

■FacultyHealth Chemistry
■PositionAssociate Professor
Last Updated :2026/04/14

Researcher

基本情報

Profile and Settings

  • 氏名

    Ashino Takashi

Affiliation

  • Health Chemistry, Associate Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Pharmaceutical Science, Showa University, Jan. 2008

Achievements

Published Papers

  • Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes., Tatsuro Miyoshi;Brian C Keller;Takashi Ashino;Satoshi Numazawa, PloS one, 18(10), Oct. 2023, Peer-reviewed, DOI:10.1371/journal.pone.0291905
  • Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-6., Takashi Ashino; Yuki Nakamura; Hirokazu Ohtaki; Yoichiro Iwakura; Satoshi Numazawa, International immunopharmacology, 117:110039, Apr. 2023, Peer-reviewed, DOI:10.1016/j.intimp.2023.110039
  • Toxicity manifestations and sex differences due to MARTA olanzapine., Natsumi Hattori-Usami; Asuka Kaizaki-Mitsumoto; Takashi Ashino; Masayuki Yamamoto; Satoshi Numazawa, The Journal of toxicological sciences, 48(4):191 - 202, Apr. 2023, Peer-reviewed, DOI:10.2131/jts.48.191
  • Interleukin-6 regulates the expression of hepatic canalicular efflux drug transporters after cecal ligation and puncture-induced sepsis: A comparison with lipopolysaccharide treatment., Takashi Ashino; Yuki Nakamura; Hirokazu Ohtaki; Yoichiro Iwakura; Satoshi Numazawa, Toxicology letters, 374:40 - 47, Feb. 2023, Peer-reviewed, DOI:10.1016/j.toxlet.2022.12.003
  • Toxicity manifestations and sex differences due to MARTA olanzapine, Natsumi Hattori-Usami, Asuka Kaizaki-Mitsumoto, Takashi Ashino, Masayuki Yamamoto, Satoshi Numazawa, The Journal of Toxicological Sciences, 48(4):191 - 202, 2023, Peer-reviewed, DOI:10.2131/jts.48.191
  • 酸化ストレス関連疾患における薬物代謝酵素シトクロムP450発現制御, 芦野　隆, 昭和学士会雑誌, 81(5):387 - 394, Jan. 2022, Peer-reviewed
  • Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality., Yoshitaka Yamazaki; Mikako Terashima-Hasegawa; Atsufumi Manabe; Toshikazu Shiba; Yumi Kawazoe; Takashi Ashino; Masahiro Hosonuma; Satoshi Numazawa, Fundamental Toxicological Sciences, 8(3):89 - 96, Jul. 2021, Peer-reviewed, DOI:10.2131/fts.8.89
  • Reactive sulfur species inhibit the migration of PDGF-treated vascular smooth muscle cells by blocking the reactive oxygen species-regulated Akt signaling pathway., Shunichi Ishii; Takashi Ashino; Hiroki Fujimori; Satoshi Numazawa, Free Radical Research, 55(2):186 - 197, Feb. 2021, Peer-reviewed, DOI:10.1080/10715762.2021.1887485
  • Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice., Takashi Ashino; Masayuki Yamamoto; Satoshi Numazawa, Drug metabolism and disposition, 48(8):673 - 680, Aug. 2020, Peer-reviewed, DOI:10.1124/dmd.120.000010
  • Inorganic polyphosphate protects against lipopolysaccharide-induced lethality and tissue injury through regulation of macrophage recruitment., Mikako Terashima-Hasegawa; Takashi Ashino; Yumi Kawazoe; Toshikazu Shiba; Atsufumi Manabe; Satoshi Numazawa, Biochemical pharmacology, 159:96 - 105, Jan. 2019, Peer-reviewed, DOI:10.1016/j.bcp.2018.11.017
  • Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling., Takashi Ashino; Takashi Kohno; Varadarajan Sudhahar; Dipankar Ash; Masuko Ushio-Fukai; Tohru Fukai, American Journal of Physiology - Cell Physiology, 315(6):C850 - C862, Dec. 2018, Peer-reviewed, DOI:10.1152/ajpcell.00230.2018
  • Chemical-induced coordinated and reciprocal changes in heme metabolism, cytochrome P450 synthesis and others in the liver of humans and rodents., Takemi Yoshida; Takashi Ashino; Yasuna Kobayashi, The Journal of Toxicological Sciences, 41(Special):SP89 - SP103, Mar. 2017, Peer-reviewed, DOI:10.2131/jts.41.SP89
  • Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury., Takashi Ashino; Masayuki Yamamoto; Satoshi Numazawa, Scientific Reports, 6:26291, May 2016, Peer-reviewed, DOI:10.1038/srep26291
  • Regulation of neointimal hyperplasia by Nrf2 antioxidant system, Ashino T; Numazawa S, Journal of The Showa University Society, 75(2):120 - 125, Nov. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.120
  • Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes., Takashi Ashino; Kanae Hakukawa; Yuka Itoh; Satoshi Numazawa, The Journal of Toxicological Sciences, 39(6):815 - 820, Jun. 2014, Peer-reviewed, DOI:10.2131/jts.39.815
  • Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5., Takashi Ashino; Haruyo Ohkubo-Morita; Masayuki Yamamoto; Takemi Yoshida; Satoshi Numazawa, Redox Biology, 2:284 - 288, Jan. 2014, Peer-reviewed, DOI:10.1016/j.redox.2013.12.025
  • IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury., Takashi Kohno; Norifumi Urao; Takashi Ashino; Varadarajan Sudhahar; Hyoe Inomata; Minako Yamaoka-Tojo; Ronald D McKinney; Tohru Fukai; Masuko Ushio-Fukai, American Journal of Physiology - Cell Physiology, 305(6):C591 - C600, Sep. 2013, Peer-reviewed, DOI:10.1152/ajpcell.00011.2013
  • Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia., Takashi Ashino; Masayuki Yamamoto; Takemi Yoshida; Satoshi Numazawa, Arteriosclerosis, Thrombosis, and Vascular Biology, 33(4):760 - 768, Apr. 2013, Peer-reviewed, DOI:10.1161/ATVBAHA.112.300614
  • Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury., Takashi Kohno; Norifumi Urao; Takashi Ashino; Varadarajan Sudhahar; Ronald D. McKinney; Takao Hamakubo; Hiroko Iwanari; Masuko Ushio-Fukai; Tohru Fukai, Arteriosclerosis, Thrombosis, and Vascular Biology, 33(4):805 - 813, Apr. 2013, Peer-reviewed, DOI:10.1161/ATVBAHA.112.300862
  • Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice., Misaki Kojima; Takashi Ashino; Takemi Yoshida; Yoichiro Iwakura; Masakuni Degawa, Biological and Pharmaceutical Bulletin, 35(2):246 - 250, Feb. 2012, Peer-reviewed, DOI:10.1248/bpb.35.246
  • Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the xxpression of Cyp7a1 transcriptional regulators in the mouse liver., Misaki Kojima; Takashi Ashino; Takemi Yoshida; Yoichiro Iwakura; Masakuni Degawa, Biological and Pharmaceutical Bulletin, 34(10):1644 - 1647, Oct. 2011, Peer-reviewed, DOI:10.1248/bpb.34.1644
  • Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1., Takashi Ashino; Jinko Sugiuchi; Junna Uehara; Yumiko Naito-Yamamoto; Sachiyo Kenmotsu; Yoichiro Iwakura; Seiji Shioda; Satoshi Numazawa; Takemi Yoshida, The Journal of Toxicological Sciences, 36(5):635 - 643, Oct. 2011, Peer-reviewed, DOI:10.2131/jts.36.635
  • Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits., Sachiko Tanaka; Hiroaki Kondo; Kingo Kanda; Takashi Ashino; Tomoya Nakamachi; Kenji Sekikawa; Yoichiro Iwakura; Seiji Shioda; Satoshi Numazawa; Takemi Yoshida, Journal of Neuroscience Research, 89(4):506 - 514, Apr. 2011, Peer-reviewed, DOI:10.1002/jnr.22582
  • Novel Role of Copper Transporter ATP7A in PDGF-induced Vascular Smooth Muscle Cell Migration, Ashino T, The Showa University Journal of Pharmaceutical Sciences, 1(2):141 - 153, Dec. 2010, Peer-reviewed
  • Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration., Takashi Ashino; Varadarajan Sudhahar; Norifumi Urao; Jin Oshikawa; Gin-Fu Chen; Huan Wang; Yuqing Huo; Lydia Finney; Stefan Vogt; Ronald D. McKinney; Edward B. Maryon; Jack H. Kaplan; Masuko Ushio-Fukai; Tohru Fukai, Circulation Research, 107(6):787 - 799, Sep. 2010, Peer-reviewed, DOI:10.1161/CIRCRESAHA.110.225334
  • IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice., Misaki Kojima; Takashi Ashino; Takemi Yoshida; Yoichiro Iwakura; Masashi Sekimoto; Masakuni Degawa, Biochemical and Biophysical Research Communications, 379(2):239 - 242, Feb. 2009, Peer-reviewed, DOI:10.1016/j.bbrc.2008.12.032
  • In vivo study on the roles of cytochrome P450 enzymes for metabolism of 3,4-methylenedioxymethamphetamine (Ecstasy) in rats., Nasrin Akhter; Sachiko Tanaka; Takashi Ashino; Noriaki Shima; Munehiro Katagi; Hitoshi Tsuchihashi; Anower Hussain Mian; Satoshi Numazawa; Takemi Yoshida, Forensic Toxicology, 26(2):52 - 57, Nov. 2008, Peer-reviewed
  • Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages., Takashi Ashino; Rieko Yamanaka; Masayuki Yamamoto; Hiroaki Shimokawa; Kenji Sekikawa; Yoichiro Iwakura; Seiji Shioda; Satoshi Numazawa; Takemi Yoshida, Molecular Immunology, 45(7):2106 - 2115, Apr. 2008, Peer-reviewed, DOI:10.1016/j.molimm.2007.10.011
  • Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver., Takashi Ashino; Yoshiko Arima; Seiji Shioda; Yoichiro Iwakura; Satoshi Numazawa; Takemi Yoshida, European Journal of Pharmacology, 558(1-3):199 - 207, Mar. 2007, Peer-reviewed, DOI:10.1016/j.ejphar.2006.11.072
  • Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association with an attenuated CYP2 beta induction by phenobarbital., Satoshi Numazawa; Sawako Shindo; Keiji Maruyama; Fumika Chibana; Yosuke Kawahara; Takashi Ashino; Sachiko Tanaka; Takemi Yoshida, FEBS Letters, 579(17):3560 - 3564, Jul. 2005, Peer-reviewed, DOI:10.1016/j.febslet.2005.05.028
  • Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver., Takashi Ashino; Takiko Oguro; Seiji Shioda; Reiko Horai; Masahide Asano; Kenji Sekikawa; Yoichiro Iwakura; Satoshi Numazawa; Takemi Yoshida, Drug Metabolism and Disposition, 32(7):707 - 714, Jul. 2004, Peer-reviewed, DOI:10.1124/dmd.32.7.707
  • Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate., Takashi Ashino; Shigenari Ozawa; Satoshi Numazawa; Takemi Yoshida, The Journal of Toxicological Sciences, 28(3):181 - 189, Aug. 2003, Peer-reviewed, DOI:10.2131/jts.28.181
  • Involvement of tumor necrosis factor alpha, rather than interleukin-1 alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver., Takiko Oguro; Yuko Takahashi; Takashi Ashino; Atsushi Takaki; Seiji Shioda; Reiko Horai; Masahide Asano; Kenji Sekikawa; Yoichiro Iwakura; Takemi Yoshida, FEBS Letters, 516(1-3):63 - 66, Apr. 2002, Peer-reviewed, DOI:10.1016/s0014-5793(02)02502-4

Presentations

  • 化学療法誘発性末梢神経障害 (CIPN) モデルマウスを用いたハンドセラピー施術による神経障害改善効果の解明, 篠内　良介;佐々木　晶子;柴田　佳太;古林　創史;芦野　隆;坂井　信裕;細沼　雅弘;髙木　孝士;辻　まゆみ;野部　浩司;木内　祐二, 第53回日本臨床分子形態学会総会・学術集会, 22 Oct. 2021, Web公開
  • 血小板由来増殖因子による血管平滑筋細胞遊走におけるサルフェンイオウの役割, 芦野　隆;石井　俊一;沼澤　聡, 第48回日本毒性学会学術年会, 07 Jul. 2021, 神戸及びWeb参加
  • Gender differences in responsiveness to oxidative stress induced by Olanzapine., 服部　夏実;光本(貝崎)　明日香;芦野　隆;山本　雅之;沼澤　聡, 日本薬学会第141年会, 28 Mar. 2021, オンライン開催
  • 血小板由来増殖因子による血管平滑筋遊走における活性イオウ分子の遊走抑制のメカニズム, 石井　俊一;藤森　央基;渡部　真由;芦野　隆;沼澤　聡, フォーラム2020　衛生薬学・環境トキシコロジー, 04 Sep. 2020, 誌上発表
  • 盲腸結紮穿刺誘発敗血症による肝シトクロムP450発現変動における炎症性サイトカインの役割, 芦野　隆;中村　祐輝;大滝　博和;岩倉　洋一郎;沼澤　聡, 第47回日本毒性学会学術年会, 29 Jun. 2020, Web開催
  • 血小板由来増殖因子による血管平滑筋細胞遊走における活性イオウの役割と抑制のメカニズム, 石井　俊一;渡部　真由;芦野　隆;沼澤　聡, 日本薬学会第140年会, 27 Mar. 2020, Web公開
  • 盲腸結紮穿刺誘発敗血症による肝薬物排泄トランスポーター発現変動における炎症性サイトカインの役割, 芦野　隆;石坂　優太;栁町　有人;中村　祐輝;大滝　博和;岩倉　洋一郎;沼澤　聡, 日本薬学会第140年会, 26 Mar. 2020, Web公開
  • 炎症性サイトカイン遺伝子欠損マウスを用いた盲腸結紮穿刺誘発性敗血症にお けるシトクロムP450変動の検討, 中村　祐輝;芦野　隆;大滝　博和;渡邊　潤;岩倉　洋一郎;沼澤　聡, フォーラム2019：衛生薬学・環境トキシコロジー, 31 Aug. 2019, 京都
  • 参加型生涯研修プログラムの有用性評価 ―昭和大学薬剤師生涯研修認定制度（H30年度）の検証―, 田中　佐知子;芦野　隆;高松　智;唐沢　浩二;小林　文;亀井　大輔;熊木　良太;阿部　誠治;佐口　健一;加藤　肇;倉田　なおみ;加藤　裕久;中村　明弘, 第4回日本薬学教育学会大会, 24 Aug. 2019, 豊中
  • Nrf2/Keap1 oxidative stress–responsive system inhibits neointimal hyperplasia response to vascular injury by regulating vascular smooth muscle cell migration and apoptosis, ASHINO Takashi;YAMAMOTO Masayuki;NUMAZAWA Satoshi, IUTOX 15th International Congress of Toxicology, 17 Jul. 2019, Honolulu
  • 酸化ストレス防御因子Nrf2によるマクロファージおよび血管平滑筋細胞の接着、遊走制御を介した動脈硬化抑制機能, 芦野　隆;山本　雅之;沼澤　聡, 第46回日本毒性学会学術年会, 28 Jun. 2019, 徳島
  • 腹膜炎モデルにおける長鎖分割ポリリン酸の致死率改善効果, 山崎　喜貴;芦野　隆;川添　祐美;柴　肇一;沼澤　聡, 日本薬学会第139年会, 21 Mar. 2019, 千葉
  • 長鎖ポリリン酸のマクロファージ活性化抑制作用とエンドトキシンショックモデルの致死率改善効果, 寺島　実華子;芦野　隆;川添　祐美;柴　肇一;沼澤　聡;真鍋　厚史, 第149回日本歯科保存学会2018年度秋季学術大会, 02 Nov. 2018, 京都
  • 無機ポリリン酸によるマクロファージ遊走抑制を介したリポポリサッカライド誘発致死性ショック保護作用, 芦野　隆;寺島　実華子;川添　祐美;柴　肇一;真鍋　厚史;沼澤　聡, フォーラム2018衛生薬学・環境トキシコロジー, 10 Sep. 2018, 佐世保
  • 参加型生涯研修プログラムの有用性評価－昭和大学薬剤師生涯研修認定制度（平成29年度）の検証－, 芦野　隆;田中　佐知子;亀井　大輔;唐沢　浩二;高松　智;小林　文;阿部　誠治;熊木　良太;佐口　健一;加藤　肇;倉田　なおみ;加藤　裕久;中村　明弘, 第3回日本薬学教育学会大会, 01 Sep. 2018, 東京
  • 銅トランスポーターATP7Aによるスキャホールドタンパク質IQGAP1結合を介した血管平滑筋細胞遊走制御と新生内膜肥厚への役割, 芦野　隆;河野　隆志;SUDHAHAR V.;ASH D.;深井　真寿子;深井　透, 第45回日本毒性学会学術年会, 19 Jul. 2018, 大阪
  • エンドトキシンショックによる多臓器障害における長鎖分割ポリリン酸の保護効果, 芦野　隆;寺島　実華子;川添　祐美;柴　肇一;真鍋　厚史;沼澤　聡, 日本薬学会第138年会, 26 Mar. 2018, 金沢
  • 参加型生涯研修プログラムの有用性評価 ―昭和大学薬剤師生涯研修認定制度（H28 年度）の検証―, 田中　佐知子;芦野　隆;亀井　大輔;唐沢　浩二;佐口　健一;高松　智;加藤　肇;加藤　裕久;中村　明弘, 第2回日本薬学教育学会大会, 03 Sep. 2017, 名古屋
  • Nrf2欠損による薬物代謝能低下とシトクロムP450誘導能の低下, 芦野　隆;山本　雅之;沼澤　聡, フォーラム2017　衛生薬学・環境トキシコロジー, 01 Sep. 2017, 仙台
  • Nrf2欠損によるペントバルビタール代謝遅延とシトクロムP450遺伝子発現抑制, 芦野　隆;山本　雅之;沼澤　聡, 第44回日本毒性学会学術年会, 12 Jul. 2017, 横浜
  • エンドトキシンショックにおける長鎖分割ポリリン酸の致死率低下効果, 寺島　実華子;芦野　隆;田中　大貴;瀧上　彩香;川添　祐美;柴　肇一;真鍋　厚史;沼澤　聡, 第44回日本毒性学会学術年会, 11 Jul. 2017, 横浜
  • Nrf2欠損マウスにおけるペントバルビタールの薬効延長とCYP2B遺伝子発現低下, 芦野　隆;山本　雅之;沼澤　聡, 日本薬学会第137年会, 27 Mar. 2017, 仙台
  • Nrf2/Keap1酸化ストレス応答システムによるマクロファージおよび血管平滑筋細胞遊走制御を介した血管内膜肥厚抑制機構, 綿山　真由;甘利　美佳;吉川　佳那;芦野　隆;山本　雅之;沼澤　聡, フォーラム2016　衛生薬学・環境トキシコロジー, 10 Sep. 2016, 東京
  • Monocyte chemotactic protein-1による単球/マクロファージ浸潤、遊走におけるレドックス感受性転写因子Nrf2の役割, 芦野　隆;山本　雅之;沼澤　聡, 第43回日本毒性学会学術年会, 30 Jun. 2016, 名古屋
  • Nrf2 システムによる血管細胞アポトーシス調節を介した血管内膜肥厚抑制機能, 芦野　隆;山本　雅之;沼澤　聡, 日本薬学会第136年会, 29 Mar. 2016, 横浜
  • 血管傷害後内膜肥厚形成段階の血管平滑筋細胞アポトーシスにおけるKeap1/Nrf2システムの役割, 芦野　隆;山本　雅之;沼澤　聡, 第42回日本毒性学会学術年会, 01 Jul. 2015, 金沢
  • 危険ドラッグ含有合成カンナビノイドによる薬物代謝酵素シトクロムP450阻害作用, 芦野　隆;伯川　加菜絵;桜井　彩華;伊藤　有香;沼澤　聡, 日本薬学会第135年会, 28 Mar. 2015, 神戸
  • Novel role of Kelch-like ECH-associated protein 1/NF-E2-related factor 2 system in vascular smooth muscle cell apoptosis following vascular injury, ASHINO Takashi;YAMAMOTO Masayuki;NUMAZAWA Satoshi, American Heart Association 2014 Scientific Sessions, 18 Nov. 2014, Chicago
  • 合成カンナビノイドによる薬物代謝酵素シトクロムP450 1A阻害作用, 芦野　隆;伊藤　有香;伯川　加菜絵;沼澤　聡, 第41回日本毒性学会学術年会, 03 Jul. 2014, 神戸
  • MCP-1によるマクロファージ遊走におけるNrf2の役割, 渡邊　円香;芦野　隆;山本　雅之;沼澤　聡, 日本薬学会第134年会, 27 Mar. 2014, 熊本
  • 転写因子Nrf2のROS-ERK経路を介した血管傷害後のリモデリング調節機構, 芦野　隆;山本　雅之;吉田　武美;沼澤　聡, 第40回日本毒性学会学術年会, 19 Jun. 2013, 千葉
  • CYP2B10およびCYP2A5遺伝子発現における酸化ストレス応答転写因子Nrf2の関与, 芦野　隆;大久保　陽世;山本　雅之;吉田　武美;沼澤　聡, 第17回P450、UGT、SULT研究会, 01 Jun. 2013, 宮崎
  • The current status of "uncontrolled drug" and effect of novel recreational drug such as α-PVP and ethylphenidate, KAIZAKI Asuka;TANAKA Sachiko;ASHINO Takashi;NUMAZAWA Satoshi, 第86回日本薬理学会年会, 21 Mar. 2013, 福岡
  • 最近の違法(脱法)ハーブの流通実態, 日下部　直子;渡辺　俊;貝崎　明日香;芦野　隆;沼澤　聡, 第56回日本薬学会関東支部大会, 13 Oct. 2012, 東京

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