Kaneyama Shuri

Researcher

基本情報

Profile and Settings

• 氏名

  Kaneyama Shuri

Affiliation

• Institute for Extracellular Matrix Research, Extraordinary Professor

Location

• Hatanodai Campus

Degree

• Doctor of Pharmaceutical Science, Showa University, Mar. 2001

Achievements

Published Papers

• Innate Immune System Regulated by Stimulator of Interferon Genes, a Cytosolic DNA Sensor, Regulates Endothelial Function., Pham PT, Bavuu O, Kim-Kaneyama JR, Lei XF, Yamamoto T, Otsuka K, Suto K, Kusunose K, Yagi S, Yamada H, Soeki T, Shimabukuro M, Barber GN, Sata M, Fukuda D., J Am Heart Assoc., Nov. 2023, Peer-reviewed
• STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases., Pham PT, Fukuda D, Nishimoto S, Kim-Kaneyama JR, Lei XF, Takahashi Y, Sato T, Tanaka K, Suto K, Kawabata Y, Yamaguchi K, Yagi S, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Shimada K, Kanematsu Y, Takagi Y, Shimabukuro M, Setou M, Barber GN, Sata M., Eur Heart J., Nov. 2021, Peer-reviewed
• The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling, Tomokatsu Omoto; Joo-Ri Kim-Kaneyama; Xiao-Feng Lei; Akira Orimo; Koji Ohnishi; Kosuke Yoshihara; Aya Miyauchi; Shuo Li; Lin Gao; Takahiro Umemoto; Junichi Tanaka; Kenta Nakahara; Motohiro Takeya; Fumio Ishida; Shin-Ei Kudo; Shogo Haraguchi; Takuro Miyazaki; Akira Miyazaki, Oncogene, 37(9):1205 - 1219, Mar. 2018
• The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity, Yeha Kim; Soyeon Lim; Taejeong Ha; You-Hyang Song; Young-In Sohn; Dae-Jin Park; Sun-Sook Paik; Joo-ri Kim-Kaneyama; Mi-Ryoung Song; Amanda Leung; Edward M. Levine; In-Beom Kim; Yong Sook Goo; Seung-Hee Lee; Kyung Hwa Kang; Jin Woo Kim, ELIFE, 6, Jan. 2017, Peer-reviewed
• The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe, Michio Shimabukuro; Chinami Okawa; Hirotsugu Yamada; Shuhei Yanagi; Etsuko Uematsu; Noriko Sugasawa; Hirotsugu Kurobe; Yoichiro Hirata; Joo-ri Kim-Kaneyama; Xiao-Feng Lei; Shoichiro Takao; Yasutake Tanaka; Daiju Fukuda; Shusuke Yagi; Takeshi Soeki; Tetsuya Kitagawa; Hiroaki Masuzaki; Masao Sato; Masataka Sata, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 35:66 - 73, Sep. 2016, Peer-reviewed
• Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes, Christos Petropoulos; Christiane Oddou; Anouk Emadali; Edwige Hiriart-Bryant; Cyril Boyault; Eva Faurobert; Scott Vande Pol; Joo-ri Kim-Kaneyama; Alexandra Kraut; Yohann Coute; Marc Block; Corinne Albiges-Rizo; Olivier Destaing, JOURNAL OF CELL BIOLOGY, 213(5):585 - 599, Jun. 2016, Peer-reviewed
• Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability, S. H. Chang; T. Yasui; S. Taketomi; T. Matsumoto; J. R. Kim-Kaneyama; T. Omiya; Y. Hosaka; H. Inui; Y. Omata; R. Yamagami; D. Mori; F. Yano; U. Chung; S. Tanaka; T. Saito, OSTEOARTHRITIS AND CARTILAGE, 24(4):688 - 697, Apr. 2016, Peer-reviewed
• Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance, Sachiko Nishimoto; Daiju Fukuda; Yasutomi Higashikuni; Kimie Tanaka; Yoichiro Hirata; Chie Murata; Joo-ri Kim-Kaneyama; Fukiko Sato; Masahiro Bando; Shusuke Yagi; Takeshi Soeki; Tetsuya Hayashi; Issei Imoto; Hiroshi Sakaue; Michio Shimabukuro; Masataka Sata, SCIENCE ADVANCES, 2(3):e1501332, Mar. 2016, Peer-reviewed
• Hydrogen Peroxide-Inducible Clone-5 Regulates Mesangial Cell Proliferation in Proliferative Glomerulonephritis in Mice, Ariunbold Jamba; Shuji Kondo; Maki Urushihara; Takashi Nagai; Joo-ri Kim-Kaneyama; Akira Miyazaki; Shoji Kagami, PLOS ONE, 10(4):e0122773, Apr. 2015, Peer-reviewed
• Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice., KIM KANEYAMA Joo-ri;MIYAUCHI Aya;LEI Xiao-Feng;ARITA Shigeko;MINO Tomoko;TAKEDA Naoki;KOU Keitatsu ;ETO Koji ;YOSHIDA Takemi;MIYAZAKI Takuro;SHIODA Seiji;MIYAZAKI Akira, J Thromb Haemost, 10(9):1867 - 1874, Sep. 2012, Peer-reviewed, DOI:10.1111/j.1538-7836.2012.04856.x
• Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target, Joo-Ri Kim-Kaneyama, Seikagaku, 84(4):261 - 265, 2012
• Hydrogen Peroxide-Inducible Clone 5 (Hic-5) as a Potential Therapeutic Target for Vascular and Other Disorders, Joo-ri Kim-Kaneyama; Xiao-Feng Lei; Shigeko Arita; Aya Miyauchi; Takuro Miyazaki; Akira Miyazaki, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 19(7):601 - 607, 2012, Peer-reviewed
• Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling, Joo-ri Kim-Kaneyama; Naoki Takeda; Asami Sasai; Akira Miyazaki; Masataka Sata; Takahiro Hirabayashi; Motoko Shibanuma; Gen Yamada; Kiyoshi Nose, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 50(1):77 - 86, Jan. 2011, Peer-reviewed
• Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo, Joo-ri Kim-Kaneyama; Nanae Wachi; Masataka Sata; Soichiro Enomoto; Kiyoko Fukabori; Keitatsu Koh; Motoko Shibanuma; Kiyoshi Nose, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(4):682 - 687, Nov. 2008, Peer-reviewed
• Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo, J Kim-Kaneyama; W Suzuki; K Ichikawa; T Ohki; Y Kohno; M Sata; K Nose; M Shibanuma, JOURNAL OF CELL SCIENCE, 118(5):937 - 949, Mar. 2005, Peer-reviewed
• Transcriptional activation of the c-fos gene by a LIM protein, Hic-5, J Kim-Kaneyama; M Shibanuma; K Nose, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 299(3):360 - 365, Dec. 2002, Peer-reviewed

Presentations

• メカニカルストレス応答性アダプター分子 Hic-5 抑制による 変形性膝関節症進行抑制, 宮内　彩、田辺　桃子、金山　朱里, 第41回日本骨代謝学会学術集会, 28 Jul. 2023
• Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing, MIYAZAKI Takuro;HARAGUCHI Shogo;KANEYAMA Shuri;MIYAZAKI Akira, 20th International Vascular Biology Meeting, 05 Jun. 2018, Helsinki
• Regulation of atherosclerosis by calpain proteolytic systems, 宮﨑　拓郎;礪波　一夫;秦　勝志;相内　敏弘;大西　紘二;雷　小峰;金山　朱里;竹屋　元裕;板部　洋之;反町　洋之;栗原　裕基;宮崎　章, 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）, 08 Dec. 2017, 神戸
• 動脈硬化病変マクロファージの飲作用を介したLDLコレステロール取込み機構, 宮﨑　拓郎;雷　小峰;金山　朱里;宮崎　章, 第59回日本脂質生化学会, 16 Jun. 2017, 京都
• Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions, MIYAZAKI Takuro;TONAMI Kazuo;HATA Shoji;AIUCHI Toshihiro;OHNISHI Koji;LEI Xiao-Feng;KANEYAMA Shuri;TAKEYA Motohiro;ITABE Hiroyuki;SORIMACHI Hiroyuki;KURIHARA Hiroki;MIYAZAKI Akira, 第24回日本血管生物医学会学術集会・第14回日韓血管生物合同シンポジウム, 09 Dec. 2016, 長崎
• Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages, MIYAZAKI Takuro;TONAMI Kazuo;HATA Shoji;AIUCHI Toshihiro;OHNISHI Koji;LEI Xiao-Feng;KANEYAMA Shuri;TAKEYA Motohiro;ITABE Hiroyuki;SORIMACHI Hiroyuki;KURIHARA Hiroki;MIYAZAKI Takuro, 19th International Vascular Biology Meeting, 01 Nov. 2016, Boston
• Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis, ARITA-OKUBO Shigeko;KIM-KANEYAMA Joo-ri;LEI Xiao-Feng;MIYAZAKI Takuro;NAKADATE Toshio;MIYAZAKI Akira, 第48回日本動脈硬化学会総会・学術集会・第24回若手研究者奨励賞選考発表会, 14 Jul. 2016, 東京
• カルパイン-６はmRNAの成熟不全を介してマクロファージLDL取込みを促進する, 宮﨑　拓郎;雷　小峰;金山　朱里;宮崎　章, 第58回日本脂質生化学会, 09 Jun. 2016, 秋田
• 肝線維化における TGFβ 関連遺伝子 Hic5 の機能解析, 雷　小峰;金山　朱里;宮崎　章, 第52回日本肝臓学会総会, 19 May 2016, 千葉
• カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御, 宮﨑　拓郎;武富　芳隆;雷　小峰;金山　朱里;村上　誠;宮崎　章, BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会), 02 Dec. 2015, 神戸
• Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice, LEI Xiao-Feng;FU Wenguang;KIM KANEYAMA Joo-ri;MIYAZAKI Akira, 18th INTERNATIONAL SYMPOSIUM ON CELLS OF THE HEPATIC SINUSOID, 11 Nov. 2015, Asilomar
• カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御, 宮﨑　拓郎;雷　小峰;金山　朱里;宮崎　章, 第47回日本動脈硬化学会総会・学術集会, 10 Jul. 2015, 仙台
• Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signalling 3 degradation in vascular endothelial cells, MIYAZAKI Takuro;TAKETOMI Yoshitaka ;SAITO Yuta;HOSONO Tomohiko;LEI Xiao-Feng;KANEYAMA Shuri;ARATA Satoru;TAKAHASHI Haruo;MURAKAMI Makoto;MIYAZAKI Akira, 17th International Symposium on Atherosclerosis (ISA 2015), 23 May 2015, Amsterdam
• Identification of Hic-5 as a novel fibrogenic gene for liver fibrosis through downregulation of Smad7, 雷　小峰;付　文広;金山　朱里;大久保　茂子;宮﨑　拓郎;宮崎　章, 第47回日本結合組織学会学術大会, 15 May 2015, 東京
• Identification of Hic-5 as a novel scaff old for the MKK4/JNK2 pathway in the development of abdominal aortic aneurysms, LEI Xiao-Feng;KIM KANEYAMA Joo-ri;ARITA Shigeko;OFFERMANNS Stefan;ITABE Hiroyuki;MIYAZAKI Takuro;MIYAZAKI Akira, The 18th International Vascular Biology Meeting, 16 Apr. 2014, Kyoto
• VEGF-induced down-regulation of calpastatin in vascular endothelial cells confers destabilized and pro-inflammatory properties to pathological neovessels, MIYAZAKI Takuro;TAKETOMI Yoshitaka;HOSONO Tomohiko;LEI Xiao-Feng;KIM KANEYAMA Joo-ri;ARATA Satoru;MURAKAMI Makoto;MIYAZAKI Akira, The 18th International Vascular Biology Meeting, 15 Apr. 2014, Kyoto
• Calpain-6による動脈硬化病変およびマクロファージpinocytosisの制御, 宮﨑　拓郎;礪波　一夫;秦　勝志;雷　小峰;金山　朱里;反町　洋之;栗原　裕基;宮崎　章, 第21回血管生物医学会学術集会, 28 Sep. 2013, 豊中
• Calpain-6による動脈硬化病変およびマクロファージpinocytosisの制御, 宮﨑　拓郎;礪波　一夫;秦　勝志;雷　小峰;金山　朱里;反町　洋之;栗原　裕基;宮崎　章, 第86回日本生化学会大会, 13 Sep. 2013, 横浜
• Hic-5 deficiency blocks the development of angiotensin II-induced abdominal aortic aneurysms in mice, LEI Xiao-Feng;KIM KANEYAMA Joo-ri ;ARITA Shigeko;MIYAZAKI Takuro;MIYAZAKI Akira, 第44回日本動脈硬化学会総会・学術集会, 19 Jul. 2012, 福岡
• Hic-5 deficiency blocks the development of angiotensin II-induced abdominal aortic aneurysms in mice, LEI Xiao-Feng;KIM KANEYAMA Joo-ri;ARITA Shigeko;MIYAZAKI Takuro;MIYAZAKI Akira, the 17th International Vascular Biology Meeting, 02 Jun. 2012, Wiesbaden