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Itabe Hiroyuki

■FacultyBiological Chemistry
■PositionProfessor
Last Updated :2025/07/18

Researcher

基本情報

Profile and Settings

  • 氏名

    Itabe Hiroyuki

Identifiers

  • ORCID ID

    0000-0002-8044-9494

Affiliation

  • Biological Chemistry, Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Pharmaceutical Science, The University of Tokyo, Jun. 1988

Achievements

Published Papers

  • Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils., Hitomi Ohinata, Wiraphol Phimarn, Mirei Mizuno, Takashi Obama, Kiyoshi Fukuhara, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe, Journal of Clinical Biology and Medicine, Feb. 2024, Peer-reviewed
  • Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells, Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Masahiro Chatani, Yuki Azetsu, Kosuke Kawaguchi, Twsuneo Imanaka, Hiroyuki Itabe., Exp Cell Res, Dec. 2023, Peer-reviewed
  • The oxidized lipoproteins in vivo: its diversity and behavior in the human circulation., Hiroyuki Itabe, Takashi Obama, International Journal of Molecular Sciences, 24:5747, May 2023, Peer-reviewed, DOI:10.3390/ijms24065747
  • High-Density Lipoprotein Suppresses Neutrophil Extracellular Traps Enhanced by Oxidized Low-Density Lipoprotein or Oxidized Phospholipids, Hitomi Ohinata; Takashi Obama; Tomohiko Makiyama; Yuichi Watanabe; Hiroyuki Itabe, International Journal of Molecular Sciences, 23(22):13992 - 13992, Nov. 2022
  • Sar1 Affects the Localization of Perilipin 2 to Lipid Droplets, Tomohiko Makiyama; Takashi Obama; Yuichi Watanabe; Hiroyuki Itabe, International Journal of Molecular Sciences, 23(12):6366 - 6366, Jun. 2022
  • Investigation of Lipoproteins Oxidation Mechanisms by the Analysis of Lipid Hydroperoxide Isomers., Shunji Kato; Yusuke Osuka; Saoussane Khalifa; Takashi Obama; Hiroyuki Itabe; Kiyotaka Nakagawa, Antioxidants (Basel, Switzerland), 10(10), Oct. 2021
  • Investigation of Lipoproteins Oxidation Mechanisms by the Analysis of Lipid Hydroperoxide Isomers., Shunji Kato; Yusuke Osuka; Saoussane Khalifa; Takashi Obama; Hiroyuki Itabe; Kiyotaka Nakagawa, Antioxidants (Basel, Switzerland), 10(10), Oct. 2021
  • Structure and dynamics of oxidized lipoproteins in vivo: roles of high-density lipoprotein., ITABE Hiroyuki;SAWADA Naoko;MAKIYAMA Tomohiko;OBAMA Takashi, Biomedicines, 9(6):655, Jun. 2021, Peer-reviewed
  • Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review, PHIMARN Wiraphol;SUNTAG Bunleu;ITABE Hiroyuki, J Evid Based Integr Med, 26:2515690X211011038, Apr. 2021, Peer-reviewed
  • Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review., Phimarn Wiraphol;Sungthong Bunleu;Itabe Hiroyuki, Journal of evidence-based integrative medicine, 26, 2021
  • Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases., OBAMA Takashi;ITABE Hiroyuki, Int J Mol Sci, 21(21):8312, Nov. 2020, Peer-reviewed
  • Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins., SAWADA Naoko;OBAMA Takashi;MIZUNO Mirei;FUKUHARA Kiyoshi;IWAMOTO Sanju;AIUCHI Toshihiro;MAKIYAMA Tomohiko;ITABE Hiroyuki, Antioxidants (Basel), 9(11):1045, Oct. 2020, Peer-reviewed
  • Circulating Oxidized LDL, Increased in Patients With Acute Myocardial Infarction, Is Accompanied by Heavily Modified HDL, SAWADA Naoko;OBAMA Takashi;KOBA Shinji;TAKAKI Takashi;IWAMOTO Sanju;AIUCHI Toshihiro;KATO Rina;KIKUCHI Masaki;HAMAZAKI Yuji;ITABE Hiroyuki, J Lipid Res, 61(6):816 - 829, Jun. 2020, Peer-reviewed
  • Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins., ODANAKA Hibiki;OBAMA Takashi;SAWADA Naoko;SUGANO Marika;ITABE Hiroyuki;YAMAMOTO Matsuo, Biol Res, 53(1):3, Jan. 2020, Peer-reviewed
  • Standard Pharmacist Intervention Checklist to Improve the Appropriate Use of Medications for Inpatients with Polypharmacy, Shimamura Hiroshi;Katsuragi Satoko;Yoshikawa Masayuki;Nakura Miyuki;Sasaki Tadanori;Itabe Hiroyuki, BPB Reports, 3(6):196 - 201, 2020, Peer-reviewed, DOI:10.1248/bpbreports.3.6_196
  • 動脈硬化とNETs：酸化LDLとの相乗的作用, 小濵　孝士;板部　洋之, Thromb Med, 9(4):304 - 310, Dec. 2019, Peer-reviewed
  • Proteomics of human glomerulonephritis by laser microdissection and liquid chromatography-tandem mass spectrometry., KAWATA NAOTO;KANG Dedong;AIUCHI Toshihiro;OBAMA Takashi;YOSHITAKE Osamu;SHIBATA Takanori;TAKIMOTO Masafumi;ITABE Hiroyuki;HONDA Kazuho, Nephrology (Carlton), :13676 - 13684, Nov. 2019, Peer-reviewed
  • The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions, ITABE Hiroyuki;KATO Rina;SAWADA Naoko;OBAMA Takashi;YAMAMOTO Matsuo, Curr Med Chem, 26(9):1576 - 1593, Sep. 2019, Peer-reviewed
  • Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis., UEKITA Hironori;ISHIBASHI Toshiyuki;SHIOMI Masashi;KOYAMA Hidenori;OHTSUKA Shukuko;YAMAMOTO Hiroshi;YAMAGISHI Shoichi;INOUE Hiroyoshi;ITABE Hiroyuki;SUGIMOTO Koichi;KAMIOKA Masashi;OHKAWARA Hiroshi;WADA Ikuo;YASUCHIKA Takeishi, Fukushima J Med Sci, 65(3):109 - 121, Sep. 2019, Peer-reviewed
  • Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation, OBAMA Takashi;OHINATA Hitomi;TAKAKI Takashi;IWAMOTO Sanju;SAWADA Naoko;AIUCHI Toshihiro;KATO Rina;ITABE Hiroyuki, Front Immunol, 10:1899, Aug. 2019, Peer-reviewed
  • Evaluation of Protein-Protein Interactions using an On-Membrane Digestion Technique, OBAMA Takashi;MIYAZAKI Takuro;AIUCHI Toshihiro;MIYAZAKI Akira;ITABE Hiroyuki, J Vis Exp, (149):e, Jul. 2019, Peer-reviewed
  • The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions, Hiroyuki Itabe; Rina Kato; Naoko Sawada; Takashi Obama; Matsuo Yamamoto, Current Medicinal Chemistry, 26(9):1576 - 1593, May 2019
  • Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice., KATO Rina;HAYASHI Masataka;AIUCHI Toshihiro;SAWADA Naoko;OBAMA Takashi;ITABE Hiroyuki, Free Radic Biol Med, 130:348 - 360, Jan. 2019, Peer-reviewed
  • Comparison of Protein Profiles of Gingival Crevicular Fluids Collected from Incisors, Canines, and Molars, TAKEMARU Mai;SAWADA Naoko;AIUCHI Toshihiro;ITABE Hiroyuki;YAMAMOTO Matsuo, The Showa University Journal of Medical Sciences, 31(4):365 - 372, 2019, Peer-reviewed, DOI:10.15369/sujms.31.365
  • Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis, Uekita Hironori;Ishibashi Toshiyuki;Shiomi Masashi;Koyama Hidenori;Ohtsuka Shukuko;Yamamoto Hiroshi;Yamagishi Shoichi;Inoue Hiroyoshi;Itabe Hiroyuki;Sugimoto Koichi;Kamioka Masashi;Ohkawara Hiroshi;Wada Ikuo;Yasuchika Takeishi, FUKUSHIMA JOURNAL OF MEDICAL SCIENCE, 65(3):109 - 121, 2019, DOI:10.5387/fms.2019-12
  • Hypertension enhances advanced atherosclerosis and induces cardiac death in Watanabe heritable hyperlipidemic rabbits., NING Bo;CHEN Yajie;WAQAR Ahmed Bilal;YAN Haizhao;SHIOMI Masashi;ZHANG Jifeng;CHEN Y Eugene;WANG Yanli;ITABE Hiroyuki;LIANG Jingyan;FAN Jianglin, Am J Pathol, 188(12):2936 - 2947, Dec. 2018, Peer-reviewed
  • The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts., KUWATA Hiroshi;YUZURIHARA Chihiro;KINOSHITA Natsumi;TAKI Yuki;IKEGAMI Yuki;WASHIO Sana;HIRAKAWA Yushi;YODA Emiko;AIUCHI Toshihiro;ITABE Hiroyuki;NAKATANI Yoshihito;HARA Shuntaro, FEBS J, 285(11):2056 - 2070, Jun. 2018, Peer-reviewed
  • A Standard Intervention Practice to Promote Appropriate Lamotrigine Therapy by Pharmacists., SHIMAMURA Hiroshi;YAMADA Hiroko;OKADA Natsumi;UCHIKURA Takeshi;TANAKA Katsumi;SASAKI Tadanori;ITABE Hiroyuki, Biol Pharm Bull, 41(4):465 - 469, Apr. 2018, Peer-reviewed
  • Lp-PLA2 and metabolism of modified lipoproteins, 笹部　直子;板部　洋之, 臨床化学, 47(2):128 - 135, Apr. 2018, Peer-reviewed
  • Changes in apolipoprotein B and oxidized low-density lipoprotein levels in gingival crevicular fluids as a result of periodontal tissue conditions, M. Ishizuka; R. Kato; Y. Moriya; E. Noguchi; Y. Koide; S. Inoue; H. Itabe; M. Yamamoto, JOURNAL OF PERIODONTAL RESEARCH, 52(3):594 - 602, Jun. 2017
  • Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia., YAMADA Satoshi;KOIKE Tomonari;NAKAGAWA Takayuki;KUNIYOSHI Nobue;YING Yu;ITABE Hiroyuki;YAMASHITA Atsushi;ASADA Yujiro;SHIOMI Masashi, Exp Anim, 66(2):145 - 157, Apr. 2017, Peer-reviewed
  • Perilipins: a diversity of intracellular lipid droplet proteins., Itabe Hiroyuki;Yamaguchi Tomohiro;Nimura Satomi;Sasabe Naoko, Lipids in health and disease, 16(1):83, Apr. 2017, Peer-reviewed
  • Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth., Moriya Yumi;Obama Takashi;Aiuchi Toshihiro;Sugiyama Tomomi;Endo Yumiko;Koide Yoko;Noguchi Emiko;Ishizuka Motonori;Inoue Mitsuko;Itabe Hiroyuki;Yamamoto Matsuo, Journal of clinical periodontology, 44(4):353 - 362, Mar. 2017, Peer-reviewed
  • Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia., Yamada Satoshi;Koike Tomonari;Nakagawa Takayuki;Kuniyoshi Nobue;Ying Yu;Itabe Hiroyuki;Yamashita Atsushi;Asada Yuji;Shiomi Masashi, Experimental animals, 66(2), Dec. 2016
  • Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing, Takuro Miyazaki; Kazuo Tonami; Shoji Hata; Toshihiro Aiuchi; Koji Ohnishi; Xiao-Feng Lei; Joo-ri Kim-Kaneyama; Motohiro Takeya; Hiroyuki Itabe; Hiroyuki Sorimachi; Hirold Kurihara; Akira Miyazaki, JOURNAL OF CLINICAL INVESTIGATION, 126(9):3417 - 3432, Sep. 2016, Peer-reviewed
  • Nephronectin Expression Is Up-Regulated by BMP-2, Tamaki Kurosawa; Atsushi Yamada; Dai Suzuki; Naoko Morimura; Yoshiyuki Sasagane; Hiroyuki Itabe; Ryutaro Kamijo, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39(7):1211 - 1215, Jul. 2016, Peer-reviewed
  • Reduced Expression of Peroxireoxin 2 in Aortic Smooth Muscle Cells at the Onset of Atherogenesis in Apoe-Knockout Mice, H. Itabe; R. Kato; M. Hayashi; T. Obama; T. Aiuchi; T. Yamaguchi, CORONARY ARTERY DISEASE 2015, :53 - 56, 2016
  • Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes., NIMURA Satomi;YAMAGUCHI Tomohiro;UEDA Koki;KADOKURA Karin;AIUCHI Toshihiro;KATO Rina;OBAMA Takashi;ITABE Hiroyuki, Biochem Biophys Res Commun, 467(4):906 - 912, Nov. 2015, Peer-reviewed
  • Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation, YAMAGUCHI Tomohiro;FUJIKAWA Noriyuki;NIMURA Satomi;TOKUOKA Yutaro;TSUDA Sonoka;AIUCHI Toshihiro;KATO Rina;OBAMA Takashi;ITABE Hiroyuki, Biochim Biophys Acta, 1851(10):1285 - 1295, Oct. 2015, Peer-reviewed
  • 乳歯と永久歯の歯肉溝滲出液中に含まれるタンパク質の網羅的解析, 守屋 佑美; 小浜 孝士; 杉山 智美; 遠藤 由美子; 小出 容子; 野口 江美子; 石塚 元規; 井上 美津子; 板部 洋之; 山本 松男, 日本歯周病学会会誌, 57(秋季特別):116 - 116, Aug. 2015
  • 【バイオマーカー探索を指向した先端的薬学研究—その2—】巻頭言 , 板部　洋之, 昭和学士会雑誌, 75(3):255, Jun. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.255
  • Dietary Cholesterol Atherogenic Changes in Juvenile Rabbits., KEYAMURA Yuka;NAGANO Chifumi;KOHASHI Masayuki;NIIMI Manabu;NOZAKO Masanori;KOYAMA Takashi;ITABE Hiroyuki;YOSHIKAWA Tomohiro, Biol Pharm Bull, 38(5):785 - 788, May 2015, Peer-reviewed, DOI:10.1248/bpb.b14-00775
  • Expression of Nephronectin is inhibited by Oncostatin M via both JAK/STAT and MAPK pathways., KUROSAWA Tamaki;YAMADA Atsushi;TAKAMI Masamichi;SUZUKI Dai;SAITO Yoshiro;HIRANUMA Katsuhiro;ENOMOTO Takuya;MORIMURA Naoko;YAMAMOTO Matsuo;IIJIMA Takehiko;SHIROTA Tatsuo;ITABE Hiroyuki;KAMIJO Ryutaro, FEBS Open Bio, 5:303 - 307, Apr. 2015, Peer-reviewed
  • Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis., ARITA OKUBO Shigeko;KIM KANEYAMA Joo-ri;LEI Xiao-Feng;FU Wen-Guang;OHNISHI Koji;TAKEYA Motohiro;MIYAUCHI Aya;HONDA Hirokazu;ITABE Hiroyuki;MIYAZAKI Takuro;MIYAZAKI Akira, Cardiovasc Res, 105(3):361 - 371, Mar. 2015, Peer-reviewed, DOI:10.1093/cvr/cvv003
  • Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis, Shigeko Arita-Okubo; Joo-ri Kim-Kaneyama; Xiao-Feng Lei; Wen-Guang Fu; Koji Ohnishi; Motohiro Takeya; Aya Miyauchi; Hirokazu Honda; Hiroyuki Itabe; Takuro Miyazaki; Akira Miyazaki, CARDIOVASCULAR RESEARCH, 105(3):361 - 371, Mar. 2015, Peer-reviewed
  • Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms., LEI Xiao-Feng;KIM KANEYAMA Joo‐ri;ARITA‐OKUBO Shigeko;OFFERMANNS Stefan;ITABE Hiroyuki;MIYAZAKI Takuro;MIYAZAKI Akira, J Am Heart Assoc, 3(3):e000747, May 2014, Peer-reviewed
  • Add-on effect of probucol in atherosclerotic, cholesterol-fed rabbits treated with atorvastatin., KEYAMURA Yuka;NAGANO Chifumi;KOHASHI Masayuki;NIIMI Manabu;NOZAKO Masanori;KOYAMA Takashi;YASUFUKU Reiko;IMAIZUMI Ayako;ITABE Hiroyuki;YOSHIKAWA Tomohiro, PloS One, 9(5):e96929, May 2014, Peer-reviewed, DOI:10.1371/journal.pone.0096929
  • Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein., SASABE Naoko;KEYAMURA Yuka;OBAMA Takashi;INOUE Nozomi;MASUKO Yukihiro;IGARASHI Yu;AIUCHI Toshihiro;KATO Rina;YAMAGUCHI Tomohiro;KUWATA Hiroshi;IWAMOTO Sanju;MIYAZAKI Akira;HARA Shuntaro;YOSHIKAWA Tomohiro;ITABE Hiroyuki, Lipids Health Dis, 13:48, Mar. 2014, Peer-reviewed, DOI:10.1186/1476-511X-13-48
  • The apolipoprotein B concentration in gingival crevicular fluid increases in patients with diabetes mellitus., NOGICHI Emiko;KATO Rina;OHNO Kayoko;MITSUI Atsushi;OBAMA Takashi;HIRANO Tsutomu;ITABE Hiroyuki;YAMAMOTO Matsuo, Clin Biochem, 47(1月2日):67 - 71, Jan. 2014
  • 薬学部2～4年生の海外留学と英語に関する意識調査, 小林　文;齋藤　勲;沼澤　聡;中村　明弘;高松　智;金光　卓也;半田　智子;橋本　みゆき;平泉　由香;板部　洋之;昭和大学薬学部海外学生実習・研修推進委員会, 昭和大学薬学雑誌, 4(2):179 - 188, Dec. 2013, Peer-reviewed
  • Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease, Chizuko Kitabayashi; Takahiko Naruko; Kenichi Sugioka; Kei Yunoki; Masashi Nakagawa; Mayumi Inaba; Masahiko Ohsawa; Yoshio Konishi; Masahito Imanishi; Takeshi Inoue; Hiroyuki Itabe; Minoru Yoshiyama; Kazuo Haze; Anton E. Becker; Makiko Ueda, Hemodialysis International, 17(4):557 - 567, Oct. 2013
  • Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 production in HL-60-derived neutrophils., NOSE Fuyuki;YAMAGUCHI Tomohiro;KATO Rina;AIUCHI Toshihiro;OBAMA Takashi;HARA Shuntaro;YAMAMOTO Matsuo;ITABE Hiroyuki, PloS One, 8(8):e71542, Aug. 2013, Peer-reviewed
  • Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity, Yuki Kawakami; Tomoko Hosokawa; Tomoko Morinaka; Shioka Irino; Shiori Hirano; Hirokazu Kobayashi; Akiko Yoshioka; Toshiko Suzuki-Yamamoto; Miyuki Yokoro; Masumi Kimoto; Hideaki Tsuji; Hiromi Yamashita; Shinobu Doi; Chikao Yutani; Rina Kato; Hiroyuki Itabe; Teruyuki Kanada; Takahiko Hada; Yoshitaka Takahashi, Food Chemistry, 131(4):1069 - 1075, Apr. 2012
  • Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells, NAGAHAMA Yu;OBAMA Takashi;USUI Michihiko;KANAZAWA Yukari;IWAMOTO Sanju;SUZUKI Kazushige;MIYAZAKI Akira;YAMAGUCHI Tomohiro;YAMAMOTO Matsuo;ITABE Hiroyuki, Biochem Biophys Res Commun, 413(4):566 - 571, Oct. 2011, DOI:10.1016/j.bbrc.2011.09.002
  • The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment, Satoshi Koyama; Katsuki Ohtani; Jun Fukuzawa; Naoyuki Yao; Mitsuko Fukuda; Seong-Jae Jang; Naoyuki Hasebe; Kenjiro Kikuchi; Hiroyuki Itabe; Itsuro Yoshida; Yasuhiko Suzuki; Nobutaka Wakamiya, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(9):836 - 842, Sep. 2011
  • Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway., OBAMA Takashi;NAGAOKA Sayaka;AKAGI Kazuki;KATO Rina;HORIUCHI Naomi;HORAI Yasushi;AIUCHI Toshihiro;ARATA Satoru;YAMAGUCHI Tomohiro;WATANABE Mitsuhiro;ITABE Hiroyuki, PloS One, 6(8):e22917, Aug. 2011, Peer-reviewed
  • Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22, K. Suzuki; Y. Sakiyama; M. Usui; T. Obama; R. Kato; H. Itabe; M. Yamamoto, JOURNAL OF PERIODONTAL RESEARCH, 45(4):488 - 495, Aug. 2010
  • Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients, Y. Sakiyama; R. Kato; S. Inoue; K. Suzuki; H. Itabe; M. Yamamoto, Journal of Periodontal Research, 45(2):216 - 222, Apr. 2010
  • IFN-γ down-regulates secretoglobin 3A1 gene expression., Yamada, A; Suzuki, D; Miyazono, A; Oshima, K; Kamiya, A; Zhao, B; Takami, M; Donnelly, R.P; Itabe, H; Yamamoto, M; Kimura, S; Kamijo, R, Biochem. Biophys. Res. Commun., 379(4):964 - 968, 2009
  • Circulating oxidized lipoproteins and cardiovascular risk, Hiroyuki Itabe, Current Cardiovascular Risk Reports, 3(1):18 - 22, 2009
  • Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis, M. Akagi; S. Kanata; S. Mori; H. Itabe; T. Sawamura; C. Hamanishi, Osteoarthritis and Cartilage, 15(3):281 - 290, Mar. 2007
  • Plasma oxidized LDL levels increases in the early stages of atherosclerosis in apoE-KO mice, Rina Kato; Chihiro Mori; Keiko Kitazato; Satoru Arata; Hiroyuki Itabe, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127:29 - 29, 2007
  • Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages, K. Kobayashi; K. Tada; H. Itabe; T. Ueno; P. H. Liu; A. Tsutsumi; M. Kuwana; T. Yasuda; Y. Shoenfeld; P. G. De Groot; Eiji Matsuura, Lupus, 16(12):929 - 938, 2007
  • A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol, Y Masuda; S Maeda; A Watanabe; Y Sano; T Aiuchi; S Nakajo; H Itabe; K Nakaya, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(2):454 - 460, Jul. 2006
  • Interleukin-10 expression is positively correlated with oxidized LDL deposition and inversely with T-lymphocyte infiltration in atherosclerotic intimas of human coronary arteries, S Sumiyoshi; Y Nakashima; YX Chen; H Itabe; K Sueishi, PATHOLOGY RESEARCH AND PRACTICE, 202(3):141 - 150, 2006
  • Oxidized phosphatidylcholine in alveolar macrophages in idiopathic interstitial pneumonias, N Yoshimi; Y Ikura; Y Sugama; S Kayo; M Ohsawa; S Yamamoto; Y Inoue; K Hirata; H Itabe; J Yoshikawa; M Ueda, LUNG, 183(2):109 - 121, Mar. 2005
  • Measurement of oxidized LDL present in human plasma and atherosclerotic lesions, Hiroyuki Itabe; Makiko Ueda; Masaaki Uno; Tatsuya Takano, International Congress Series, 1262(C):87 - 90, May 2004
  • Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway, YX Li; Y Higashi; H Itabe; YH Song; J Du; P Delafontaine, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 23(12):2178 - 2184, Dec. 2003
  • Minimally modified LDL is an oxidized LDL enriched with oxidized phosphatidylcholines, H Itabe; M Mori; Y Fujimoto; Y Higashi; T Takano, JOURNAL OF BIOCHEMISTRY, 134(3):459 - 465, Sep. 2003
  • Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum, Y Higashi; H Itabe; H Fukase; M Mori; Y Fujimoto; T Takano, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(24):21450 - 21458, Jun. 2003
  • The role of CD36 in peripheral nerve remyelination after crush injury, M Eto; H Yoshikawa; H Fujimura; Naba, I; H Sumi-Akamaru; S Takayasu; H Itabe; S Sakoda, EUROPEAN JOURNAL OF NEUROSCIENCE, 17(12):2659 - 2666, Jun. 2003
  • Raised plasma oxidised LDL in acute cerebral infarction, M Uno; KT Kitazato; K Nishi; H Itabe; S Nagahiro, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 74(3):312 - 316, Mar. 2003
  • Oxidized low-density lipoproteins: What is understood and what remains to be clarified, H Itabe, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 26(1):1 - 9, Jan. 2003
  • "Elevation of plasma oxidized LDL in acute cerebral infarction. J. Neurol. Neurosurg. Psychiatry.", "Journal of Neurology, Neurosurgery and Psychiatry", 74, 312-316, 2003
  • Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris - Important role of NAD(P)H oxidase, H Azumi; N Inoue; Y Ohashi; M Terashima; T Mori; H Fujita; K Awano; K Kobayashi; K Maeda; K Hata; T Shinke; S Kobayashi; K Hirata; S Kawashima; H Itabe; Y Hayashi; S Imajoh-Ohmi; H Itoh; M Yokoyama, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 22(11):1838 - 1844, Nov. 2002
  • Atherosclerosis and sensitive determination of oxidized LDL using monoclonal antibody, H Itabe, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 122(10):745 - 753, Oct. 2002
  • Oxidized LDL in carotid plaques and plasma associates with plaque instability, K Nishi; H Itabe; M Uno; KT Kitazato; H Horiguchi; K Shinno; S Nagahiro, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 22(10):1649 - 1654, Oct. 2002
  • Distribution of microsomal triglyceride transfer protein within sub-endoplasmic reticulum regions in human hepatoma cells, Y Higashi; H Itabe; H Fukase; M Mori; Y Fujimoto; R Sato; T Imanaka; T Takano, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1581(3):127 - 136, Apr. 2002
  • Pathophysiological role of oxidized low-density lipoprotein in plaque instability in coronary artery diseases, S Ehara; M Ueda; T Naruko; K Haze; T Matsuo; M Ogami; Y Ikura; H Itabe; R Komatsu; M Yoshiyama; K Takeuchi; J Yoshikawa, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 16(1):60 - 64, Jan. 2002
  • The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells, K Ohtani; Y Suzuki; S Eda; T Kawai; T Kase; H Keshi; Y Sakai; A Fukuoh; T Sakamoto; H Itabe; T Suzutani; M Gasawara; Yoshida, I; N Wakamiya, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(47):44222 - 44228, Nov. 2001
  • Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum, M Mori; H Itabe; Y Higashi; Y Fujimoto; M Shiomi; M Yoshizumi; Y Ouchi; T Takano, JOURNAL OF LIPID RESEARCH, 42(11):1771 - 1781, Nov. 2001
  • Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits, K Ishikawa; D Sugawara; J Goto; Y Watanabe; K Kawamura; M Shiomi; H Itabe; Y Maruyama, CIRCULATION, 104(15):1831 - 1836, Oct. 2001
  • Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes, S Ehara; M Ueda; T Naruko; K Haze; A Itoh; M Otsuka; R Komatsu; T Matsuo; H Itabe; T Takano; Y Tsukamoto; M Yoshiyama; K Takeuchi; J Yoshikawa; AE Becker, CIRCULATION, 103(15):1955 - 1960, Apr. 2001
  • Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice, K Ishikawa; D Sugawara; Wang, X; K Suzuki; H Itabe; Y Maruyama; AJ Lusis, CIRCULATION RESEARCH, 88(5):506 - 512, Mar. 2001
  • Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis, N Sakata; N Uesugi; S Takebayashi; R Nagai; T Jono; S Horiuchi; M Takeya; H Itabe; T Takano; T Myint; N Taniguchi, CARDIOVASCULAR RESEARCH, 49(2):466 - 475, Feb. 2001
  • Reduction of sphingomyelin level without accumulation of ceramide iu Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta-cyclodextrin, M Fukasawa; M Nishijima; H Itabe; T Takano; K Hanada, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(44):34028 - 34034, Nov. 2000
  • Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques, Y Okura; M Brink; H Itabe; KJ Scheidegger; A Kalangos; P Delafontaine, CIRCULATION, 102(22):2680 - 2686, Nov. 2000
  • Onion-bulb formation after a single compression injury in the macrophage scavenger receptor knockout mice, Naba, I; H Yoshikawa; S Sakoda; H Itabe; H Suzuki; T Kodama; T Yanagihara, EXPERIMENTAL NEUROLOGY, 166(1):83 - 89, Nov. 2000
  • Circulating oxidized low density lipoprotein levels - A biochemical risk marker for coronary heart disease, S Toshima; A Hasegawa; M Kurabayashi; H Itabe; T Takano; J Sugano; K Shimamura; J Kimura; Michishita, I; T Suzuki; R Nagai, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(10):2243 - 2247, Oct. 2000
  • Preparation of radioactive aldehyde-containing phosphatidylcholine, H Itabe; K Suzuki; R Hosoya; M Mori; Y Higashi; Y Fujimoto; T Takano, ANALYTICAL BIOCHEMISTRY, 285(1):151 - 155, Oct. 2000
  • Lysosomal accumulation of oxidized phosphatidylcholine-apolipoprotein B complex in macrophages: intracellular fate of oxidized low density lipoprotein, H Itabe; K Suzuki; Y Tsukamoto; R Komatsu; M Ueda; M Mori; Y Higashi; T Takano, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1487(2-3):233 - 245, Sep. 2000
  • Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid, Naba, I; H Yoshikawa; S Sakoda; H Itabe; H Suzuki; T Kodama; T Yanagihara, NEUROSCIENCE LETTERS, 290(1):5 - 8, Aug. 2000
  • Enhanced degradation of phospholipids by phospholipase A2 in liver of carbon tetrachloride-treated rat, A Ryu; H Itabe; M Mutoh; Kudo, I; H Arai; K Inoue, JOURNAL OF HEALTH SCIENCE, 46(4):275 - 281, Aug. 2000
  • Simple and practical sandwich-type enzyme immunoassay for human oxidatively modified low density lipoprotein using antioxidized phosphatidylcholine monoclonal antibody and antihuman apolipoprotein-B antibody, H Kohno; N Sueshige; K Oguri; H Izumidate; T Masunari; M Kawamura; H Itabe; T Takano; A Hasegawa; R Nagai, CLINICAL BIOCHEMISTRY, 33(4):243 - 253, Jun. 2000
  • In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques, Y Imanaga; N Sakata; S Takebayashi; A Matsunaga; J Sasaki; K Arakawa; R Nagai; S Horiuchi; H Itabe; T Takano, ATHEROSCLEROSIS, 150(2):343 - 355, Jun. 2000
  • Hemodialysis impairs endothelial function via oxidative stress - Effects of vitamin E-coated dialyzer, H Miyazaki; H Matsuoka; H Itabe; M Usui; S Ueda; S Okuda; T Imaizumi, CIRCULATION, 101(9):1002 - 1006, Mar. 2000
  • “Oxidized low density lipoprotein: The occurrence and metabolism in circulation and in foam cells.”, Hiroyuki Itabe, Tatsuya Takano, “Journal of Atherosclerosis and Thrombosis”, 7:123 - 131, 2000, Peer-reviewed
  • Presence of phospholipid-neutral lipid complex structures in atherosclerotic lesions as detected by a novel monoclonal antibody, M Mori; H Itabe; K Takatoku; K Shima; J Inoue; M Nishiura; H Takahashi; H Ohtake; R Sato; Y Higashi; T Imanaka; S Ikegami; T Takano, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(35):24828 - 24837, Aug. 1999
  • Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase, H Itabe; R Hosoya; K Karasawa; S Jimi; K Saku; S Takebayashi; T Imanaka; T Takano, JOURNAL OF BIOCHEMISTRY, 126(1):153 - 161, Jul. 1999
  • Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins, S Horkko; DA Bird; E Miller; H Itabe; N Leitinger; G Subbanagounder; JA Berliner; P Friedman; EA Dennis; LK Curtiss; W Palinski; JL Witztum, JOURNAL OF CLINICAL INVESTIGATION, 103(1):117 - 128, Jan. 1999
  • Immunohistochemical localization of different epitopes of advanced glycation end products in human atherosclerotic lesions, N Sakata; Y Imanaga; J Meng; Y Tachikawa; S Takebayashi; R Nagai; S Horiuchi; H Itabe; T Takano, ATHEROSCLEROSIS, 141(1):61 - 75, Nov. 1998
  • Oxidized phospholipids as a new landmark in atherosclerosis, H Itabe, PROGRESS IN LIPID RESEARCH, 37(2-3):181 - 207, Jul. 1998
  • Presence of oxidized LDL in transplant arteriosclerotic lesions obtained from renal transplant recipients with hypercholesterolemia, S Tanabe; M Ueda; YS Han; T Nakatani; T Kishimoto; H Itabe; T Takano, TRANSPLANTATION PROCEEDINGS, 30(1):116 - 118, Feb. 1998
  • Appearance of cross linked proteins in human atheroma and rat pre-fibrotic liver detected by a new monoclonal antibody, H Itabe; S Jimi; S Kamimura; K Suzuki; N Uesugi; T Imanaka; H Shijo; T Takano, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1406(1):28 - 39, Feb. 1998
  • Detection of oxidized phosphatidylcholines in human atherosclerotic lesions and in plasma LDL fractions, H Itabe; T Sanaka; Michishita, I; T Takano, PATHOPHYSIOLOGY OF LIPID PEROXIDES AND RELATED FREE RADICALS, :13 - 24, 1998
  • Deposition of oxidized low-density lipoprotein and collagenosis occur coincidentally in human coronary stenosis: an immunohistochemical study of atherectomy, S Jimi; K Saku; H Kusaba; H Itabe; N Koga; S Takebayashi, CORONARY ARTERY DISEASE, 9(9):551 - 557, 1998
  • Oxidized phosphatidylcholines that modify proteins - Analysis by monoclonal antibody against oxidized low density lipoprotein, H Itabe; H Yamamoto; M Suzuki; Y Kawai; Y Nakagawa; A Suzuki; T Imanaka; T Takano, JOURNAL OF BIOLOGICAL CHEMISTRY, 271(52):33208 - 33217, Dec. 1996
  • Lipid islands in human gastric mucosa: Morphological and immunohistochemical findings, E Kaiserling; H Heinle; H Itabe; T Takano; W Remmele, GASTROENTEROLOGY, 110(2):369 - 374, Feb. 1996
  • Sensitive detection of oxidatively modified low density lipoprotein using a monoclonal antibody, H Itabe; H Yamamoto; T Imanaka; K Shimamura; H Uchiyama; J Kimura; T Sanaka; Y Hata; T Takano, JOURNAL OF LIPID RESEARCH, 37(1):45 - 53, Jan. 1996
  • “Characterization of vitronectins in atherosclerotic lesions.”, Mori M, Iwasaki K, Sato R, Komine Y, Itabe H, Imanaka T, and Takano T., “Journal of Atherosclerosis and Thrombosis”, 3:25 - 31, 1996, Peer-reviewed
  • A MONOCLONAL-ANTIBODY AGAINST OXIDIZED LIPOPROTEIN RECOGNIZES FOAM CELLS IN ATHEROSCLEROTIC LESIONS - COMPLEX-FORMATION OF OXIDIZED PHOSPHATIDYLCHOLINES AND POLYPEPTIDES, H ITABE; E TAKESHIMA; H IWASAKI; J KIMURA; Y YOSHIDA; T IMANAKA; T TAKANO, JOURNAL OF BIOLOGICAL CHEMISTRY, 269(21):15274 - 15279, May 1994
  • PEROXIDIZED LIPOPROTEINS IN ATHEROSCLEROTIC LESIONS DETECTED BY A MONOCLONAL-ANTIBODY, T TAKANO; HO MOWRI; H ITABE, ACTIVE OXYGENS, LIPID PEROXIDES, AND ANTIOXIDANTS, :139 - 147, 1993
  • SUBSTRATE-SPECIFICITY OF A COA-DEPENDENT STEAROYL TRANSACYLASE FROM BOVINE TESTIS MEMBRANES, H ITABE; WC KING; CN REYNOLDS; JA GLOMSET, JOURNAL OF BIOLOGICAL CHEMISTRY, 267(22):15319 - 15325, Aug. 1992
  • SWISS 3T3 CELLS PREFERENTIALLY INCORPORATE SN-2-ARACHIDONOYL MONOACYLGLYCEROL INTO SN-1-STEAROYL-2-ARACHIDONOYL PHOSPHATIDYLINOSITOL, CMF SIMPSON; H ITABE; CN REYNOLDS; WC KING; JA GLOMSET, JOURNAL OF BIOLOGICAL CHEMISTRY, 266(24):15902 - 15909, Aug. 1991
  • PREFERENTIAL HYDROLYSIS OF OXIDIZED PHOSPHOLIPIDS BY PERITONEAL-FLUID OF RATS TREATED WITH CASEIN, H ITABE; KUDO, I; K INOUE, BIOCHIMICA ET BIOPHYSICA ACTA, 963(2):192 - 200, Nov. 1988
  • IDENTIFICATION OF 2-AZELAOYLPHOSPHATIDYLCHOLINE AS ONE OF THE CYTO-TOXIC PRODUCTS GENERATED DURING OXYHEMOGLOBIN-INDUCED PEROXIDATION OF PHOSPHATIDYLCHOLINE, H ITABE; Y KUSHI; S HANDA; K INOUE, BIOCHIMICA ET BIOPHYSICA ACTA, 962(1):8 - 15, Sep. 1988
  • GENERATION OF TOXIC PHOSPHOLIPID(S) DURING OXYHEMOGLOBIN-INDUCED PEROXIDATION OF PHOSPHATIDYLCHOLINES, H ITABE; T KOBAYASHI; K INOUE, BIOCHIMICA ET BIOPHYSICA ACTA, 961(1):13 - 21, Jul. 1988
  • PEROXIDATION OF LIPOSOMES IN THE PRESENCE OF HUMAN-ERYTHROCYTES AND INDUCTION OF MEMBRANE DAMAGE OF ERYTHROCYTES BY PEROXIDIZED LIPOSOMES, T KOBAYASHI; H ITABE; K INOUE; S NOJIMA, BIOCHIMICA ET BIOPHYSICA ACTA, 814(1):170 - 178, 1985

Presentations

  • Infectious diseases and oxidized lipoproteins, 板部　洋之;小濵　孝士, 第94回日本生化学大会, 05 Nov. 2021, Web開催
  • 細胞内脂肪滴形成機構における小胞出芽制御因子Sar1の影響, 牧山　智彦;小濵　孝士;板部　洋之, 第63回脂質生化学会, 10 Jun. 2021, オンライン開催
  • 好中球細胞外トラップ形成におけるlysoPCの関与, 小濵　孝士;澤田　直子;牧山　智彦;板部　洋之, 第63回日本脂質生化学会, 10 Jun. 2021, オンライン開催
  • エライジン酸が結合したリン脂質による細胞膜へのAkt集積抑制, 石橋　賢一;松田　英里香;矢野　彩緒里;川村　拓己;濱　弘太郎;横山　和明;板部　洋之;厚味　厳一, 第63回日本脂質生化学会, 10 Jun. 2021, オンライン開催
  • 細胞内脂肪滴形成機構における小胞出芽制御因子Sar1の影響, 牧山　智彦;小濵　孝士;板部　洋之, 第63回脂質生化学会, 10 Jun. 2021, オンライン開催
  • 好中球細胞外トラップ：感染制御から血管疾患の増悪へ, 小濵　孝士;板部　洋之, 第21回Pharmaco-Hematologyシンポジウム, 22 May 2021, 東京（On-line会議）
  • 血中酸化リポタンパク質の実態：LDLとHDLの関わりについて(シンポジウム2「新しい酸化脂質解析法を用いたオキシリピッドバイオロジー研究」), 板部　洋之, 第73回日本酸化ストレス学会, 07 Oct. 2020, Web開催
  • Formation of oxidatively modified lipoprotein particles associated with HDL in the ccirculation, 澤田　直子;板部　洋之;小濵　孝士;木庭　新治;巖本　三壽;髙木　孝士;フィマーン　ウィラポール;牧山　智彦;相内　敏弘, 第93回日本生化学会大会, 15 Sep. 2020, Web開催
  • 血管疾患における好中球細胞外トラップの役割と酸化LDLの関与 (ミニシンポジウム), 小濵　孝士;板部　洋之, 第62回日本脂質生化学会, 15 May 2020, 誌上開催
  • 血中酸化リポタンパク質生成におけるHDLの関わり, 澤田　直子;小濵　孝士;巖本　三壽;木庭　新治;髙木　孝士;相内　敏弘;板部　洋之, 第62回日本脂質生化学会, 15 May 2020, 東京（誌上開催）
  • LMC-LC-MS/MS法を用いたラット膜性腎症症モデルの病態に関与する蛋白の検討, 康　徳東;髙木　孝士;小濵　孝士;板部　洋之;本田　一穂, 第125回日本解剖学会・全国学術集会, 26 Mar. 2020, 誌上開催
  • Involvement of high-density lipoprotein in oxidatively modified forms of low-density lipoproteins in human circulation., ITABE Hiroyuki;SAWADA Naoko;OBAMA Takashi, 17th Annual Meeting and Conference of Society for Free Radical-India-2020 (SFRR-India 2020), 12 Feb. 2020, Mumbai (India)
  • ハイドロキシアパタイト上での培養が不死化接合上皮細胞および口腔上皮細胞の遺伝子発現に及ぼす影響, 田中　慧介;相澤　怜;田中　準一;澤田　直子;関　辰明;田中　麻友;相内　敏弘;板部　洋之;美島　健二;山本　松男, 第62回秋季日本歯周病学会学術大会, 25 Oct. 2019, 北九州
  • 好中球細胞外トラップ形成によるリポタンパク質変性の促進, 小濵　孝士;髙木　孝士;澤田　直子;相内　敏弘;板部　洋之, 第92回日本生化学会大会, 19 Sep. 2019, 横浜
  • Lipidomic analysis using stable isotope-labelled PCs to show that HDL has ability to prevent oxidized PC accumulation in LDL, 澤田　直子;小濵　孝士;福原　潔;水野　美麗;巖本　三壽;相内　敏弘;板部　洋之, 第92回日本生化学会大会, 19 Sep. 2019, 横浜
  • 歯の表面物質「ペリクル」のタンパク質組成とその由来, 小田中　響;板部　洋之;小濵　孝士;澤田　直子;菅野　真莉加;山本　松男, 第92回日本生化学会大会, 18 Sep. 2019, 横浜
  • 酸化LDLによる好中球細胞外トラップ形成促進と血管内皮細胞の応答, 小濵　孝士;大日方　瞳;髙木　孝士;澤田　直子;相内　敏弘;板部　洋之, 第61回日本脂質生化学会, 04 Jul. 2019, 札幌
  • Oxidized HDL-LDL complex that increases in plasma from patients with acute myocardial infarction, 澤田　直子;小濵　孝士;巖本　三壽;木庭　新治;髙木　孝士;相内　敏弘;板部　洋之, 第61回日本脂質生化学会, 04 Jul. 2019, 札幌
  • レーザーマイクロダイセクションと質量分析による腎生検組織の蛋白解析法の腎疾患診断や病態評価への応用, 川田　尚人;康　德東;柴田　孝則;村上　雅彦;瀧本　雅文;板部　洋之;本田　一穂, 第62回日本腎臓学会学術集会, 22 Jun. 2019, 名古屋
  • Peroxiredoxin 2 levels change temporally and spatially in aortic media before atherosclerotic lesion formation in apoE-knockout mice, ITABE Hiroyuki;KATO Rina;AIUCHI Toshihiro;SAWADA Naoko;OBAMA Takashi, The 9th Biennial Meeting of Society for free radical Research-Asia, 05 Apr. 2019, Kyoto
  • Oxidatively modified low-density lipoproteins enhance endothelial inflammatory responses through accelerated neutrophil extracellular trap formation, OBAMA Takashi;SAWADA Naoko;AIUCHI Toshihiro;KATO Rina;ITABE Hiroyuki, The 9th Biennial Meeting of Society for free radical Research-Asia, 05 Apr. 2019, Kyoto
  • 健常者および急性心筋梗塞患者血中に存在する酸化LDLの性状解析, 澤田　直子;小濵　孝士;巖本　三壽;木庭　新治;相内　敏弘;加藤　里奈;板部　洋之, 日本薬学会第139年会, 21 Mar. 2019, 千葉
  • レドックス酵素Peroxiredoxin2の大動脈中膜における発現低下と動脈硬化病巣形成, 加藤　里奈;澤田　直子;小濵　孝士;板部　洋之, 平成30年度文部科学省私立大学研究ブランディング事業 研究成果報告会・シンポジウム, 23 Feb. 2019, 東京
  • 動脈硬化初発病変形成時の酸化ストレス上昇, 加藤　里奈;築地　可奈;西内　愛香;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;澤田　直子;小濵　孝士;板部　洋之, 第33回日本酸化ストレス学会関東支部会, 15 Dec. 2018, 東京
  • 動脈硬化初期過程の平滑筋細胞の酸化ストレス亢進は抗酸化タンパク質Peroxiredoxin 2とThioredoxinの低下が関与する, 加藤　里奈;嶋﨑　萌夏;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;澤田　直子;小濵　孝士;板部　洋之, 第91回日本生化学会大会, 26 Sep. 2018, 京都
  • 好中球細胞外トラップ形成への酸化LDLの関与と血管内皮細胞の炎症応答, 小濵　孝士;綾部　かれん;大日方　瞳;大矢　夏菜;栗原　徹;須賀　日咲子;高林　衿花;澤田　直子;相内　敏弘;加藤　里奈;板部　洋之, 第91回日本生化学会大会, 24 Sep. 2018, 京都
  • 動脈硬化初期病変進展過程の酸化ストレスと抗酸化タンパク質発現の関係, 西内　愛香;加藤　里奈;築地　可奈;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;澤田　直子;小濵　孝士;板部　洋之, 第62回日本薬学会関東支部大会, 15 Sep. 2018, 東京
  • 昭和大学薬学部における国際交流の現状と成果―国際交流センターの役割を中心にー, 平泉　由香;橋本　みゆき;Ｍ　マイヤース;板部　洋之;中村　明弘;宮﨑　隆, 第3回日本薬学教育学会大会, 02 Sep. 2018, 東京
  • Alteration of peroxiredoxin 2 expression in athero-prone regions, 加藤　里奈;板部　洋之;相内　敏弘;澤田　直子;小濵　孝士, 日本過酸化脂質・抗酸化物質学会第26年会, 18 Aug. 2018, 仙台
  • 粥状動脈硬化症惹起性in vivo酸化LDLの分子構造の解明, 澤田　直子;小濵　孝士;巖本　三壽;木庭　新治;相内　敏弘;加藤　里奈;板部　洋之, 第60回日本脂質生化学会, 31 May 2018, 東京
  • 血管内皮細胞の炎症誘導における好中球細胞外トラップと酸化LDLの関与, 小濵　孝士;池田　葵;今井　瑞菜;上田　晃輝;門倉　夏林;髙橋　江里奈;澤田　直子;相内　敏弘;加藤　里奈;板部　洋之, 日本薬学会第138年会, 26 Mar. 2018, 金沢
  • Enhancement of oxidative stress by down-regulations of antioxidant proteins, peroxiredoxin 2 and thioredoxin, in the early stage of atherogenesis, 加藤　里奈;嶋崎　萌夏;小澤　雪乃;知念　良憲;渡辺　窓香;上當　明徳;高田　紫苑;相内　敏弘;笹部　直子;小濵　孝士;板部　洋之, 日本薬学会第138年会, 26 Mar. 2018, 金沢
  • Isolation and characterization of oxidized low-density lipoproteins in atherosclerosis patients, 澤田　直子;小濵　孝士;巖本　三壽;木庭　新治;相内　敏弘;加藤　里奈;板部　洋之, 日本薬学会第138年会, 26 Mar. 2018, 金沢
  • 動脈硬化発症の引き金となるレドックス関連酵素の発現変動, 加藤　里奈;笹部　直子;小濵　孝士;板部　洋之, 平成29年度文部科学省私立大学研究ブランディング事業研究成果報告会・シンポジウム, 24 Mar. 2018, 東京
  • Regulation of atherosclerosis by calpain proteolytic systems, 宮﨑　拓郎;礪波　一夫;秦　勝志;相内　敏弘;大西　紘二;雷　小峰;金山　朱里;竹屋　元裕;板部　洋之;反町　洋之;栗原　裕基;宮崎　章, 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）, 08 Dec. 2017, 神戸
  • Enhancement of oxidative stress by decreased expression of peroxiredoxin 2 and induction of phenotypic change in smooth muscle cells during progression of atherogenesis in early stage, 加藤　里奈;嶋﨑　萌夏;鈴木　花菜;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;笹部　直子;小濵　孝士;板部　洋之, 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）, 06 Dec. 2017, 神戸
  • Lipidomic analysis using stable isotope-labelled phospholipids showed metabolism of oxidized phospholipid in LDL by HDL, 笹部　直子;小濵　孝士;増田　しおり;髙田　夏鈴;櫻井　彩伽;長谷川　拓也;福原　潔;水野　美麗;相内　敏弘;加藤　里奈;板部　洋之, 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）, 06 Dec. 2017, 神戸
  • 動脈硬化初期病変進展過程における平滑筋細胞の酸化ストレス上昇と形質変化の関係性, 加藤　里奈;嶋﨑　萌夏;鈴木　花菜;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;笹部　直子;小濵　孝士;板部　洋之, 第49回日本動脈硬化学会総会・学術集会, 06 Jul. 2017, 広島
  • Oxidized LDL in gingival crevicular fluid and inflammation associated with periodontal diseases, 石塚　元規;板部　洋之;加藤　里奈;守屋　佑美;山本　松男;笹部　直子;小濵　孝士, 第59回日本脂質生化学会, 16 Jun. 2017, 京都
  • Peroxiredoxin 2 regulates oxidative stress in smooth muscle cells during atherogenesis in early stage., 加藤　里奈;嶋﨑　萌夏;鈴木　花菜;小澤　雪乃;知念　良憲;渡辺　窓香;相内　敏弘;笹部　直子;小濵　孝士;板部　洋之, 日本薬学会第137年会, 26 Mar. 2017, 仙台
  • Lipidomic analysis using stable isotope-labelled phospholipids to show that high-density lipoproteins have ability to protect low-density lipoproteins oxidation, 笹部　直子;小濵　孝士;増田　しおり;髙田　夏鈴;相内　敏弘;加藤　里奈;板部　洋之, 日本薬学会第137年会, 25 Mar. 2017, 仙台
  • Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions, MIYAZAKI Takuro;TONAMI Kazuo;HATA Shoji;AIUCHI Toshihiro;OHNISHI Koji;LEI Xiao-Feng;KANEYAMA Shuri;TAKEYA Motohiro;ITABE Hiroyuki;SORIMACHI Hiroyuki;KURIHARA Hiroki;MIYAZAKI Akira, 第24回日本血管生物医学会学術集会・第14回日韓血管生物合同シンポジウム, 09 Dec. 2016, 長崎
  • Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages, MIYAZAKI Takuro;TONAMI Kazuo;HATA Shoji;AIUCHI Toshihiro;OHNISHI Koji;LEI Xiao-Feng;KANEYAMA Shuri;TAKEYA Motohiro;ITABE Hiroyuki;SORIMACHI Hiroyuki;KURIHARA Hiroki;MIYAZAKI Takuro, 19th International Vascular Biology Meeting, 01 Nov. 2016, Boston
  • Analysis of oxidized phospholipids and modified proteins in oxidized LDL separated from human plasma, 笹部　直子;小濵　孝士;井上　望;橋本　哲弥;久保　祐貴;巖本　三壽;相内　敏弘;加藤　里奈;板部　洋之, フォーラム2016衛生薬学・環境トキシコロジー, 11 Sep. 2016, 東京
  • 動脈硬化初期病変の発症過程における平滑筋細胞の酸化ストレス上昇と脱分化型への形質変化, 加藤　里奈;嶋﨑　萌夏;鈴木　花菜;土肥　安紀子;皆川　瞳;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 第17回Pharmaco-Hematologyシンポジウム, 03 Sep. 2016, 東京
  • ラモトリギン適正使用に向けた処方監査手順の評価, 山田　寛子;岡田　菜津美;嶋村　弘史;内倉　健;佐々木　忠徳;板部　洋之, 日本病院薬剤師会関東ブロック第46回学術大会, 28 Aug. 2016, 千葉
  • 大動脈平滑筋細胞の脱分化を伴うPeroxiredoxin 2低下と動脈硬化初期病変の進展, 加藤　里奈;嶋﨑　萌夏;鈴木　花菜;土肥　安紀子;皆川　瞳;鈴木　裕之;松井　浩志;林　暢孝;相内　敏弘;笹部　直子;小濵　孝士;板部　洋之, 第48回日本動脈硬化学会総会・学術集会, 15 Jul. 2016, 東京
  • 乳歯と永久歯の歯肉溝滲出液における好中球機能の検討, 守屋　佑美;小濵　孝士;杉山　智美;遠藤　由美子;小出　容子;竹丸　真以;井上　美津子　;板部　洋之;山本　松男, 第330回昭和大学学士会例会, 25 Jun. 2016, 東京
  • Comprehensive analysis of protein in gingival crevicular fluids from deciduous and permanent teeth (second report), 守屋　佑美;小濵　孝士;小出　容子;野口　江美子;石塚　元規;竹丸　真以;板部　洋之;山本　松男, 第59回春季日本歯周病学会学術大会, 20 May 2016, 鹿児島
  • Peroxiredoxin 2-reduced smooth muscle cells induce progression of atherogenesis in early stage., 加藤　里奈;林　暢孝;嶋﨑　萌夏;鈴木　花菜;鈴木　裕之;松井　浩志;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 日本薬学会第136年会, 29 Mar. 2016, 横浜
  • Reduced expression of peroxiredoxin 2 in smooth muscle cells at the onset of atherogenesis in apoE-knockout mice., ITABE Hiroyuki;KATO Rina;OBAMA Takashi;AIUCHI Toshihiro;Yamaguchi Yomohiro, 11th International Congress on Coronary Artery Disease (ICCAD 2015), 01 Dec. 2015, Florence
  • Comprehensive analysis of protein in gingival crevicular fluids from deciduous and permanent teeth, 守屋　佑美;小濵　孝士;杉山　智美;遠藤　由美子;小出　容子;野口　江美子;石塚　元規;井上　美津子;板部　洋之;山本　松男, 第58回秋季日本歯周病学会学術大会, 12 Sep. 2015, 浜松
  • 歯肉溝滲出液中のapoB、酸化LDLは歯周病の炎症状態を反映する, 石塚　元規;加藤　里奈;守屋　佑美;小出　容子;山本　松男;板部　洋之, 第68回酸化ストレス学会学術集会　, 11 Jun. 2015, 鹿児島
  • Comparison between gingival crevicular fluids from deciduous and permanent teeth using iTRAQ quantitative proteomics, MORIYA Yumi;OBAMA Takashi;SASABE Naoko;AIUCHI Toshihiro;ENDO Yuko;SUGIYAMA Tomomi;KOIDE Yoko;INOUE Mitsuko;ITABE Hiroyuki;YAMAMOTO Matsuo, EuroPerio8, 06 Jun. 2015, London
  • Oncostatin Mによるネフロネクチン発現制御機構の解明, 黒澤　珠希;山田　篤;高見　正道;鈴木　大;守村　直子;板部　洋之;上條　竜太郎, 日本薬学会第135年会, 28 Mar. 2015, 神戸
  • Dedifferentiated smooth muscle cells induce progression of atherogenesis in early stage., 加藤　里奈;林　暢孝;鈴木　裕之;三井　敦;松井　浩志;宮越　由佳;天日　雅行;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 日本薬学会第135年会, 28 Mar. 2015, 神戸
  • Induction of MCP-1 expression in the smooth muscle cells decreased in both of peroxiredoxin 2 and α-smooth muscle actin during the initial stage of atherogenesis., 加藤　里奈;林　暢孝;鈴木　裕之;三井　敦;松井　浩志;宮越　由佳;天日　雅行;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 第87回日本生化学会大会, 18 Oct. 2014, 京都
  • 動脈硬化の初発反応の探索：中膜平滑筋のperoxiredoxin2の発現低下とMCP-1発現亢進, 加藤　里奈;林　暢孝;鈴木　裕之;三井　敦;松井　浩志;宮越　由佳;天日　雅行;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 第46回日本動脈硬化学会総会・学術集会, 10 Jul. 2014, 東京
  • Identification of Hic-5 as a novel scaff old for the MKK4/JNK2 pathway in the development of abdominal aortic aneurysms, LEI Xiao-Feng;KIM KANEYAMA Joo-ri;ARITA Shigeko;OFFERMANNS Stefan;ITABE Hiroyuki;MIYAZAKI Takuro;MIYAZAKI Akira, The 18th International Vascular Biology Meeting, 16 Apr. 2014, Kyoto
  • 平滑筋細胞のperoxiredoxin2の発現は動脈硬化の初期過程に低下する, 加藤　里奈;林　暢孝;鈴木　裕之;松井　浩志;宮越　由佳;天日　雅行;相内　敏弘;笹部　直子;小濵　孝士;山口　智広;板部　洋之, 第86回日本生化学会大会, 13 Sep. 2013, 横浜
  • ヒト血漿酸化LDLの分離と酸化リン脂質のLC-MS/MS解析, 井上　望;増子　幸志;小濵　孝士;相内　敏弘;加藤　里奈;山口　智広;板部　洋之, 第14回Pharmaco-Hematologyシンポジウム, 01 Jun. 2013, 東京
  • 酸化LDL刺激が引き起こすヒト歯肉上皮細胞での炎症性物質の産生, 金澤　縁;長濱 優;小濵　孝士;鈴木　一成;臼井　通彦;相内　敏弘;加藤　里奈;山口　智広;山本　松男;板部　洋之, 日本薬学会第132年会, 29 Mar. 2013, 札幌
  • ステロイド産生細胞における脂肪滴局在タンパク質の解析, 藤縄　冴子;倉岡　愛;尾花　佳織;木曽　果奈子;山口　智広;澤田　直子;小濵　孝士;加藤　里奈;板部　洋之, 第56回日本薬学会関東支部大会, 13 Oct. 2012, 東京
  • 酸化LDL中の酸化修飾リポタンパク質のLC-MS/MS解析, 守谷　瑠梨子;伊藤　綾花;小濵　孝士;相内　敏弘;山口　智広;板部　洋之, 第56回日本薬学会関東支部大会, 13 Oct. 2012, 東京
  • 生体内酸化LDLに現れる特異的脂質成分の解析, 井上　望;増子　幸志;小濵　孝士;相内　敏弘;加藤　里奈;山口　智広;板部　洋之, 第56回日本薬学会関東支部大会, 13 Oct. 2012, 東京
  • 動脈硬化発症の初期課程における平滑筋細胞のパーオキシレドキシン2の発現低下, 長田　かおり;加藤　里奈;林　暢孝;鈴木　裕之;松井　浩志;米山　早紀子;相内　敏弘;小濵　孝士;山口　智広;板部　洋之, 第56回日本薬学会関東支部大会, 13 Oct. 2012, 東京
  • Separation and characterization of oxidized LDL from human plasma, ITABE Hiroyuki;OBAMA Takashi;KOBA Shinji;AIUCHI Toshiro;KATO Rina;YAMAGUCHI Tomohiro, International Conference on Biochemistry of Lipids, 05 Sep. 2012, Banff
  • ヒト血漿から分離した酸化LDLに存在する酸化脂質の網羅的解析, 小濵　孝士;髙橋　あい理;楠ノ瀬　雄也;木庭　新治;濱崎　裕司;小林　洋二;相内　敏弘;加藤　里奈;山口　智広;板部　洋之, 第54回日本脂質生化学会, 07 Jun. 2012, 福岡
  • apoEノックアウトマウスの動脈硬化初期段階の酸化ストレス亢進因子の探索, 鈴木　裕之;加藤　里奈;林　暢孝;宮越　由佳;天日　雅行;鶴巻　実香;松井　浩志;相内　敏弘;小濵　孝士;山口　智広;板部　洋之, 日本薬学会第132年会, 29 Mar. 2012, 札幌

Research Projects

  • 抗刷子縁抗体による近位尿細管上皮傷害とミトコンドリア異常の関連性, 康 徳東 , 本田 一穂 , 板部 洋之 , 高木 孝士 , 澤 智華. 川西 邦夫, 日本学術振興会 科学研究費助成事業 基盤研究(C), From 20230401, To 20260331

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