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Hasebe Yuki

■FacultyAdvanced Cancer Translational Research Institute
■PositionAssistant Professor
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Last Updated :2025/06/05

Researcher

基本情報

Profile and Settings

  • 氏名

    Hasebe Yuki

Identifiers

  • 研究者番号

    90623843

  • ORCID ID

    https://orcid.org/0000-0001-9925-7508

  • J-Global ID

    200901010536802561

Affiliation

  • Advanced Cancer Translational Research Institute, Assistant Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Pharmaceutical Science, Showa University, Mar. 2006

Achievements

Published Papers

  • Gamma-delta T cells are optimal immune cell carrier vehicles for adenovirus vector-based gene therapy, Yuki Hasebe; Michio Naoe, The Showa University Journal of Medical Sciences, 35(3):103 - 111, Oct. 2023, Peer-reviewed
    Gamma-delta T cells are optimal immune cell carrier vehicles for adenovirus vector-based gene therapy, Yuki Hasebe; Michio Naoe, The Showa University Journal of Medical Sciences, 35(3):103 - 111, Oct...See More
  • Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer., Shigetoshi Nishihara; Toshimitsu Yamaoka; Fumihiro Ishikawa; Kensuke Higuchi; Yuki Hasebe; Ryo Manabe; Yasunari Kishino; Sojiro Kusumoto; Koichi Ando; Yusuke Kuroda; Tohru Ohmori; Hironori Sagara; Hitoshi Yoshida; Junji Tsurutani, Genes, 13(12):2183, Nov. 2022, Peer-reviewed, DOI:10.3390/genes13122183
    Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer., Shigetoshi Nishihara; Toshimitsu Yamaoka; Fumihiro Ishikawa; Kensuke Higuchi; Y...See More
  • Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation., Shigetoshi Nishihara; Toshimitsu Yamaoka; Fumihiro Ishikawa; Tohru Ohmori; Koichi Ando; Sojiro Kusumoto; Yasunari Kishino; Ryo Manabe; Yuki Hasebe; Hironori Sagara; Hitoshi Yoshida; Junji Tsurutani, Cells, 11(14):2201, Jul. 2022, Peer-reviewed, DOI:10.3390/cells11142201
    Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation., Shigetoshi Nishihara; Toshimitsu Yamaoka; Fumihiro Is...See More
  • A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer., Takehiko Nakasato; Chiho Kusaka; Mika Ota; Yuki Hasebe; Kumiko Ueda; Tsutomu Unoki; Kazuhiko Oshinomi; Jun Morita; Yoshiko Maeda; Takeshi Shichijo; Michio Naoe; Yoshio Ogawa, Diagnostics (Basel, Switzerland), 10(3):151, Mar. 2020, Peer-reviewed, DOI:10.3390/diagnostics10030151
    A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer., Takehiko Nakasato; Chiho Kusaka; Mika Ota; Yuki Hasebe; Kumiko U...See More
  • Development of a Highly Sensitive Technique for Capturing Renal Cell Cancer Circulating Tumor Cells., Naoe Michio;Kusaka Chiho;Ohta Mika;Hasebe Yuki;Unoki Tsutomu;Shimoyama Hideaki;Nakasato Takehiko;Oshinomi Kazuhiko;Morita Jun;Fuji Kohzo;Ogawa Yoshio;Tsukada Mana;Sunagawa Masataka;Ishii Hikaru, Diagnostics (Basel, Switzerland), 9(3):96, Aug. 2019, Peer-reviewed
    Development of a Highly Sensitive Technique for Capturing Renal Cell Cancer Circulating Tumor Cells., Naoe Michio;Kusaka Chiho;Ohta Mika;Hasebe Yuki;Unoki Tsutomu;Shimoyama Hideaki;Nakasato Takehiko;O...See More
  • Detection of Circulating Tumor Cells and the Importance of their Measurement in Urological Cancers, Michio Naoe; Mika Ohta; Yuki Hasebe; Yuki Matsui; Tsutomu Unoki; Hideaki Shimoyama; Yoshio Ogawa; Mana Tsukada; Masataka Sunagawa; Hikaru Ishii; Masayuki Ishige; Hironori Osawa; Masaharu Matuzaki, UROLOGICAL SCIENCE, 29(4):176 - 179, Jul. 2018, Peer-reviewed
    Detection of Circulating Tumor Cells and the Importance of their Measurement in Urological Cancers, Michio Naoe; Mika Ohta; Yuki Hasebe; Yuki Matsui; Tsutomu Unoki; Hideaki Shimoyama; Yoshio Ogawa; Ma...See More
  • CTC(末梢血循環癌細胞)同定法と泌尿器科癌領域におけるCTC検査の重要性, 直江 道夫;太田 実香;長谷部 友紀;松井 祐輝;鵜木 勉;下山 英明;中里 武彦;小川 良雄;塚田 愛;砂川 正隆;石毛 真行;大澤 宏典;松崎 正晴, 泌尿器外科, 31(臨増):591 - 595, Jun. 2018, Peer-reviewed
  • DETECTION OF CIRCULATING TUMOR CELLS IN UROLOGICAL CANCER, 直江 道夫;下山 英明;中里 武彦;長谷部 友紀;辻山 和子;小川 良雄;石毛 真行;大澤 宏典;松崎 正晴;服部 徹;河合 岳志, 西日本泌尿器科, 79(10):441 - 448, Oct. 2017, Peer-reviewed
  • 【Liquid Biopsyの現状と将来展望】 泌尿器科癌領域におけるCTC(末梢循環癌細胞)検査, 直江　道夫;下山　英明;中里　武彦;長谷部　友紀;辻山　和子;小川　良雄;石毛　真行;松崎　正晴;大澤　宏典, 細胞, 48(5):212 - 217, May 2016, Peer-reviewed
  • Gamma-delta T cells may function as carrier vehicles in adenovirus vector-based gene therapy, Naoe, Michio; Ogawa, Yoshio; Hasebe, Yuki; Fuji, Kozo; Iwamoto, Sanju; Mizuguchi, Hiroyuki; Aoi, Takashi; Terao, Shuji, Journal of Cancer Science and Therapy, 5(11), 2013, Peer-reviewed
    Gamma-delta T cells may function as carrier vehicles in adenovirus vector-based gene therapy, Naoe, Michio; Ogawa, Yoshio; Hasebe, Yuki; Fuji, Kozo; Iwamoto, Sanju; Mizuguchi, Hiroyuki; Aoi, Takashi; ...See More
  • Enhancement of IL-2-induced cytotoxicity by interferon-alpha in renal cell carcinoma., Michio Naoe; Yoshio Ogawa; Yuki Hasebe; Jun Morita; Takeshi Shichijo; Atsushi Igarashi; Kozo Fuji; Sanju Iwamoto; Toru Suzuki; Shuji Terao, Oncology research, 19(10-11):479 - 86, 2011, Peer-reviewed
    Enhancement of IL-2-induced cytotoxicity by interferon-alpha in renal cell carcinoma., Michio Naoe; Yoshio Ogawa; Yuki Hasebe; Jun Morita; Takeshi Shichijo; Atsushi Igarashi; Kozo Fuji; Sanju Iwamoto;...See More
  • Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells, Kiyoshi Egawa; Yuki Hasebe; Motoko Shibanuma; Kiyoshi Nose, NEW TRENDS IN THE MOLECULAR AND BIOLOGICAL BASIS FOR CLINICAL ONCOLOGY, :153 - 156, 2009, Peer-reviewed
    Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells, Kiyoshi Egawa; Yuki Hasebe; Motoko Shibanuma; Kiyoshi Nose, NEW TRENDS IN TH...See More
  • Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells., Yuki Hasebe; Kiyoshi Egawa; Motoko Shibanuma; Kiyoshi Nose, Cancer science, 98(1):58 - 67, Jan. 2007, Peer-reviewed
    Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells., Yuki Hasebe; Kiyoshi Egawa; Motoko Shibanuma; Kiyoshi Nose, Cancer scienc...See More
  • Anthracyclines, small-molecule inhibitors of hypoxia-inducible factor-1 alpha activation., Yohko Yamazaki; Yuki Hasebe; Kiyoshi Egawa; Kiyoshi Nose; Setsuko Kunimoto; Daishiro Ikeda, Biological & pharmaceutical bulletin, 29(10):1999 - 2003, Oct. 2006, Peer-reviewed
    Anthracyclines, small-molecule inhibitors of hypoxia-inducible factor-1 alpha activation., Yohko Yamazaki; Yuki Hasebe; Kiyoshi Egawa; Kiyoshi Nose; Setsuko Kunimoto; Daishiro Ikeda, Biological & phar...See More
  • Inhibition of angiogenesis and HIF-1alpha activity by antimycin A1., Masayuki Maeda; Yuki Hasebe; Kiyoshi Egawa; Motoko Shibanuma; Kiyoshi Nose, Biological & pharmaceutical bulletin, 29(7):1344 - 8, Jul. 2006, Peer-reviewed
    Inhibition of angiogenesis and HIF-1alpha activity by antimycin A1., Masayuki Maeda; Yuki Hasebe; Kiyoshi Egawa; Motoko Shibanuma; Kiyoshi Nose, Biological & pharmaceutical bulletin, 29(7):1344 - 8, ...See More
  • Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids., Yuki Hasebe; Kiyoshi Egawa; Yoko Yamazaki; Setsuko Kunimoto; Yasuaki Hirai; Yoshiteru Ida; Kiyoshi Nose, Biological & pharmaceutical bulletin, 26(10):1379 - 83, Oct. 2003, Peer-reviewed
    Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids., Yuki Hasebe; Kiyoshi Egawa; Yoko Yamazaki; Setsuko ...See More

Presentations

  • L-アスパラギナーゼによる薬物相互作用の機序解明に向けたラットにおける投与方法の検討, 長谷部 友紀, 西村 有希, 岩瀬 万里子, 倉田 知光, 今村 知世, 第71回昭和大学学士会総会, 30 Nov. 2024
  • 肺腺癌細胞PC-9におけるオシメルチニブの獲得耐性機序の検討, 西原 成俊, 山岡 利光, 長谷部 友紀, 眞鍋 亮, 楠本 壮二郎, 安藤 浩一, 相良 博典, 鶴谷 純司, 吉田 仁, 第69回昭和大学学士会総会, 03 Dec. 2022
  • 肺腺癌細胞PC-9におけるオシメルチニブの獲得耐性機序の検討, 山岡 利光, 長谷部 友紀, 眞鍋 亮, 岸野 康成, 楠本 壮二郎, 安藤 浩一, 大森 亨, 相良 博典, 鶴谷 純司, 第63回日本肺癌学会学術集会, 01 Dec. 2022
  • Resistance mechanisms against osimertinib in lung adenocarcinoma cells with EGFR-activating mutation, 西原 成俊, 山岡 利光, 長谷部 友紀, 石川 文博, 楠本 壮二郎, 大森 亨, 相良 博典, 吉田 仁, 鶴谷 純司, 第81回日本癌学会学術集会, 30 Sep. 2022
  • New circulating tumor cells evaluation method in prostate cancer from the points of detection rate improvement, quantitative evaluation and AR-V7-positive cells, NAKASATO Takehiko;NAOE Michio;HASEBE Yuki;TUJIYAMA Kazuko;MATSUI Yuki;OSHINOMI Kazuhiko;MORITA Jun;SHICHIJO Takeshi;MAEDA Yoshiko;FUJI Kohzo;OGAWA Yoshio;石毛　真行;大澤　宏典, 第105回日本泌尿器科学会総会, 23 Apr. 2017, 鹿児島
    New circulating tumor cells evaluation method in prostate cancer from the points of detection rate improvement, quantitative evaluation and AR-V7-positive cells, NAKASATO Takehiko;NAOE Michio;HASEBE Y...See More
  • 新規腎癌マーカー検査としての末梢循環癌細胞（CTC）検査に関する基礎的検討, 長谷部　友紀;直江　道夫;松井　祐輝;下山　英明;中里　武彦;石毛　真行;大澤　宏典;河合　武志;小川　良雄, 第105回日本泌尿器科学会総会, 22 Apr. 2017, 鹿児島
  • バイオマーカーとしての定量性とAR-V7陽性細胞を考慮した前立腺癌CTCの評価方法の検討, 中里　武彦;直江　道夫;長谷部　友紀;辻山　和子;黒川　一平;松井　祐輝;押野見　和彦;森田　順;七条　武志;前田　佳子;冨士　幸藏;小川　良雄;大澤　宏典;石毛　真行;松崎　正晴, 第26回泌尿器科分子・細胞研究会, 11 Mar. 2017, 大分
  • 泌尿器科領域におけるリキッドバイオプシーの重要性 (末梢血循環がん細胞の同定法), 直江　道夫;長谷部　友紀;小川　良雄, リキッドバイオプシー研究会, 21 Jan. 2017, 東京
  • アデノウイルスベクターデリバリーシステムの基礎的検討(Third report), 直江　道夫;長谷部　友紀;寺尾　秀治;水口　裕之;青井　貴之;冨士　幸藏;小川　良雄, 第103回日本泌尿器科学会総会, 18 Apr. 2015, 金沢
  • 末梢血中循環腎癌細胞の特異的同定法に関する基礎的検討, 直江　道夫;長谷部　友紀;中里　武彦;森田　順;冨士　幸藏;小川　良雄, 第24回泌尿器科分子・細胞研究会, 28 Feb. 2015, 東京
  • γδT細胞を用いた前立腺癌に対するアデノウイルスベクターデリバリーシステムの開発, 長谷部　友紀;小川　良雄;直江　道夫;冨士　幸藏;青井　貴之;水口　裕之;寺尾　秀治, 第79回日本泌尿器科学会東部総会, 13 Oct. 2014, 横浜
  • Development of the adenovirus vector delivery system using γδT cells to prostate cancer cell, HASEBE Yuki;OGAWA Yoshio;NAOE Michio;FUJI Kohzo;AOI T;MIZUGUCHI H;TERAO S, 第73回日本癌学会学術総会, 25 Sep. 2014, 横浜
    Development of the adenovirus vector delivery system using γδT cells to prostate cancer cell, HASEBE Yuki;OGAWA Yoshio;NAOE Michio;FUJI Kohzo;AOI T;MIZUGUCHI H;TERAO S, 第73回日本癌学会学術総会, 25 Sep. 2014, 横...See More

Research Projects

  • 非小細胞性肺癌における末梢血循環癌細胞（CTC）新規同定法の開発, 長谷部友紀, 日本学術振興会 科学研究費助成事業 基盤研究(C), From 20230401

Industrial Property Rights

  • Patent right, 癌に対する遺伝子治療剤およびその製造方法, 直江道夫, 長谷部友紀, 小川良雄, 寺尾秀治, 水口裕之, 青井貴之, 鈴木透, 特許6032697

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