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Nishimura Yuki

■FacultyMedical Pharmacology
■PositionSenior Lecturer
Last Updated :2025/07/30

Researcher

基本情報

Profile and Settings

  • 氏名

    Nishimura Yuki

Affiliation

  • Medical Pharmacology, Senior Lecturer

Location

  • Hatanodai Campus

Degree

  • Doctor of Medical Science, Showa University, Jul. 2001

Research Keywords

  • drug-drug interaction
  • cytochrome P450
  • Food-drug interaction

Achievements

Published Papers

  • Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study., Shinya Koichiro;Nishimura Yuki;Ryu Kakei;Sambe Takehiko;Fujishiro Masaya;Nakauchi Akihiro;Kashiwabuchi Yumika;Iwase Mariko;Chokki Hirokazu;Kurata Norimitsu;Matsuyama Takaaki;Kiuchi Yuji, International journal of dermatology, 62(5):694 - 699, May 2023, Peer-reviewed, DOI:10.1111/ijd.16303
  • Lack of inhibitory effect of wood creosote on cytochrome P450‐mediated drug metabolism, Hirokazu Chokki; Yuki Nishimura; Mariko Iwase; Norimitsu Kurata; Koichiro Shinya; Mayumi Tsuji; Masafumi Ito; Mutsumi Asai; Hirofumi Morino; Takanori Miura; Takashi Shibata; Yuji Kiuchi, Traditional & Kampo Medicine, 9(1):3 - 9, Apr. 2022, Peer-reviewed
  • Inhibition of CYP3A-mediated Midazolam Metabolism by Kaempferia Parviflora., Kashiwabuchi Yumika;Nishimura Yuki;Kurata Norimitsu;Iwase Mariko;Kiuchi Yuji;Nobe Koji, Food safety, 10(1):32 - 41, Mar. 2022, Peer-reviewed
  • Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38., Mariko Iwase; Ken-Ichi Fujita; Yuki Nishimura; Natsumi Seba; Yusuke Masuo; Hiroo Ishida; Yukio Kato; Yuji Kiuchi, Cancer chemotherapy and pharmacology, 83(5):993 - 998, May 2019, Peer-reviewed, DOI:10.1007/s00280-019-03784-8
  • Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism, GOMI Yurika;NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;SHINYA Koichiro;KIUCHI Yuji, The Showa University Journal of Medical Sciences, 31(1):29 - 39, Mar. 2019, Peer-reviewed, DOI:10.15369/sujms.31.29
  • Effect of benifuuki tea on cytochrome P450-mediated metabolic activity in rats, Takahito Hirai; Yuki Nishimura; Norimitsu Kurata; Hokuto Namba; Mariko Iwase; Yurika Gomi; Hiromichi Tsuchiya; Tomoyuki Yamakawa; Yuji Kiuchi, In Vivo, 32(1):33 - 40, Jan. 2018, Peer-reviewed
  • Inhibitory Effects of Gastrointestinal Drugs on CYP Activities in Human Liver Microsomes, Iwase Mariko;Nishimura Yuki;Kurata Norimitsu;Namba Hokuto;Hirai Takahito;Kiuchi Yuji, Biological and Pharmaceutical Bulletin, 40(10):1654 - 1660, Oct. 2017, Peer-reviewed, DOI:10.1248/bpb.b17-00118
  • Evaluation of CYP2D6 Protein Expression and Activity in the Small Intestine to Determine Its Metabolic Capability in the Japanese Population, Kawakami Momoko;Takenoshita-Nakaya Sachiko;Takeba Yuko;Nishimura Yuki;Oda Masayuki;Watanabe Minoru;Ohta Yuki;Kobayashi Shinjiro;Ohtsubo Takehito;Kobayashi Shinichi;Uchida Naoki;Matsumoto Naoki, Biological and Pharmaceutical Bulletin, 40(9):1344 - 1351, Sep. 2017, Peer-reviewed, DOI:10.1248/bpb.b16-00370
  • Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats, Namba Hokuto;Nishimura Yuki;Kurata Norimitsu;Iwase Mariko;Hirai Takahito;Kiuchi Yuji, Biological and Pharmaceutical Bulletin, 40(9):1361 - 1365, Sep. 2017, Peer-reviewed, DOI:10.1248/bpb.b16-01016
  • OBJECTIVE AND SUBJECTIVE EVALUATIONS TO DETERMINE THE MIDAZOLAM OPTIMAL DOSE IN THE DENTAL TREATMENT, KONDO Keisuke; IKEDA Miyuki; SAMBE Takehiko; UCHIDA Naoki; IWASE Mariko; NISHIMURA Yuki; MANABE Atsuhumi; RYU Kakei; KOBAYASHI Shinichi; INADA Yoko, Journal of The Showa University Society, 75(6):665 - 674, Dec. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.665
  • Inhibition of CYP3A4-mediated midazolam metabolism by repeat oral administration of Anchusan in humans, Hirokazu Toshima; Takehiko Sanbe; Junichiro Kizaki; Katsuji Oguchi; Naoki Uchida; Yuki Nishimura; Mariko Iwase; Yoshie Harimoto; Momoko Kawakami; Makiko Hirosawa; Shinichi Kobayashi, Journal of the Showa Medical Association, 73(2):120 - 128, Apr. 2013, Peer-reviewed, DOI:10.14930/jshowaunivsoc.73.120
  • Effect of the short-term anchusan treatment on CYP3A4-mediated midazolam metabolism in healthy subjects, Takehiko Sambe; Yuki Nishimura; Naoki Uchida; Hirokazu Toshima; Mariko Iwase; Yoshie Harimoto; Momoko Kawakami; Kakei Ryu; Yoshito Kobayashi; Yasuyuki Kondo; Katsuji Oguchi; Shinichi Kobayashi, Journal of the Showa Medical Association, 73(2):67 - 75, Apr. 2013, Peer-reviewed, DOI:10.14930/jshowaunivsoc.73.67
  • In vivo inhibition of CYP3A-mediated midazolam metabolism by anchusan in rats., Yusuke Saito; Yuki Nishimura; Norimitsu Kurata; Mariko Iwase; Kayo Aoki; Hajime Yasuhara, Journal of pharmacological sciences, 115(3):399 - 407, 2011
  • Effects of continuous ingestion of herbal teas on intestinal CYP3A in the rat, Kazuhiro Matsuda; Yuki Nishimura; Norimitsu Kurata; Mariko Iwase; Hajime Yasuhara, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103(2):214 - 221, Feb. 2007
  • Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities., Yuki Nishimura; Norimitsu Kurata; Eriko Sakurai; Hajime Yasuhara, Journal of pharmacological sciences, 96(3):293 - 300, Nov. 2004

Presentations

  • 日本人健康成人男性におけるブラックジンジャー反復投与時のCYP3A4を介するミダゾラム代謝に及ぼす影響, 三邉　武彦;諸星　北人;西村　有希;龍　家圭;肥田　典子;山崎　太義;岩瀬　万里子;倉田　知光;五味　由梨佳;木内　祐二;小林　真一;内田　直樹, 第40回日本臨床薬理学会学術総会, 04 Dec. 2019, 東京
  • Inhibitory effects of black ginger extract on CYP3A-mediated midazolam metabolism., NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;GOMI Yurika;KASHIWABUCHI Yumika;KIUCHI Yuji, 2018 International Meeteing on 22nd MDO and 33rd JSSX, 02 Oct. 2018, Kanazawa
  • Inhibitory effect of Polypodium leucotomos extract on CYP3A-mediated midazolam metabolism, GOMI Yurika;NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;KIUCHI Yuji, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 03 Jul. 2018, Kyoto
  • Effect of Benifuuki tea on cytochrome P450s in rats., 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第89回日本薬理学会年会, 10 Mar. 2016, 神奈川
  • Effect of Benifuuki tea on cytochrome P450s in rats., 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第89回日本薬理学会年会, 10 Mar. 2016, 神奈川
  • べにふうき茶反復投与のラットチトクロームP450に対する影響, 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第36回日本臨床薬理学会学術総会, 11 Dec. 2015, 東京
  • The estimation of drug interaction by pazopanib through the inhibition of UDP-glucuronosyltransferase (UGT) 1A1, IWASE Mariko;FUJITA Ken-ichi;NISHIMURA Yuki;OGUCHI Katsuji, 日本薬物動態学会第30回年会, 13 Nov. 2015, 東京
  • Assessment of potential factors related to low CYP2C19 activity in liver cancer patients, NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;YASUHARA Rika;YASUHARA Hajime;KOBAYASHI Yasuna;YAMAMOTO Toshinori;AOKI Takeshi;MURAKAMI Masahiko;SAITO Koji;KOBAYASHI Shinichi;OGUCHI Katsuji, 19th North American ISSX Meeting and 29th JSSX Meeting, 20 Oct. 2014, San Francisco
  • The inhibitory effects of gastrointestinal and respiratory drugs on human hepatic microsomal cytochrome P450 activities., IWASE Mariko, 19th North America ISSX and 29th JSSX meeting, 19 Oct. 2014, San Francisco
  • Drug-drug interaction with OTC drugs ～The inhibitory effect of NSAIDs and cough suppressants on CYP activities., IWASE Mariko;NISHIMURA Yuki;KURATA Norimitsu;UCHIDA Naoki;KOBAYASHI Shinichi, 6th European Congress of Pharmacology, 17 Jul. 2012, Granada

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