Sasa Kiyohito

Researcher

基本情報

Profile and Settings

• 氏名

  Sasa Kiyohito

Affiliation

• Oral Physiology, Assistant Professor

Location

• Hatanodai Campus

Degree

• Doctor of Dental Science, Showa University, Mar. 2018

Achievements

Published Papers

• Lactate-induced histone lactylation by p300 promotes osteoblast differentiation., Minami Erika;Sasa Kiyohito;Yamada Atsushi;Kawai Ryota;Yoshida Hiroshi;Nakano Haruhisa;Maki Koutaro;Kamijo Ryutaro, PloS one, 18(12), Dec. 2023, Peer-reviewed
• Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates., Sasama Yuji;Yoshimura Kentaro;Hoshino Marie;Sasa Kiyohito;Akaike Takaaki;Morita Masanobu;Baba Kazuyoshi;Shirota Tatsuo;Miyamoto Yoichi, Journal of oral biosciences, Nov. 2023, Peer-reviewed
• BMP-2-mediated signaling suppresses salivary gland development., Ono Shinnosuke;Yamada Atsushi;Tanaka Junichi;Yukimori Akane;Sasa Kiyohito;Mishima Kenji;Funatsu Takahiro;Kamijo Ryutaro, Biochemical and biophysical research communications, 681:1 - 6, Sep. 2023, Peer-reviewed
• Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2., Nagasaki Kei;Yamada Atsushi;Sasa Kiyohito;Kamijo Ryutaro, FEBS open bio, 13(7):1357 - 1364, Jun. 2023, Peer-reviewed
• Cathepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro., Kawai Ryota;Sugisaki Risa;Miyamoto Yoichi;Yano Fumiko;Sasa Kiyohito;Minami Erika;Maki Koutaro;Kamijo Ryutaro, In vitro cellular & developmental biology. Animal, 59(1):10 - 18, Jan. 2023, Peer-reviewed
• Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx., Nishida Rie;Suzuki Dai;Akimoto Yoshihiro;Matsubara Sachie;Hayakawa Junri;Ushiyama Akira;Sasa Kiyohito;Miyamoto Yoichi;Iijima Takehiko;Kamijo Ryutaro, Journal of oral biosciences, 65(1):111 - 118, Jan. 2023, Peer-reviewed
• Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß., Tanaka Motohiro;Miyamoto Yoichi;Sasa Kiyohito;Yoshimura Kentaro;Yamada Atsushi;Shirota Tatsuo;Kamijo Ryutaro, In vitro cellular & developmental biology. Animal, 58(7):521 - 528, Aug. 2022, Peer-reviewed
• Extracellular acidification augments sclerostin and osteoprotegerin production by Ocy454 mouse osteocytes., Ikezaki-Amada Kaori;Miyamoto Yoichi;Sasa Kiyohito;Yamada Atsushi;Kinoshita Mitsuhiro;Yoshimura Kentaro;Kawai Ryota;Yano Fumiko;Shirota Tatsuo;Kamijo Ryutaro, Biochemical and biophysical research communications, 597, Jan. 2022, Peer-reviewed
• Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors., Kinoshita Mitsuhiro;Yamada Atsushi;Sasa Kiyohito;Ikezaki Kaori;Shirota Tatsuo;Kamijo Ryutaro, Scientific reports, 11(1), Oct. 2021, Peer-reviewed
• 炎症性骨破壊の新展開　プロテアーゼによる破骨細胞形成の促進, 杉崎 リサ;笹 清人;宮本 洋一;宇山 理紗;近津 大地;上條 竜太郎, 口腔組織培養学会誌, 30(1):35, Oct. 2021, Peer-reviewed
• Establishment of Down's syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT., Takeyoshi Asakawa; Atsushi Yamada; Masumi Kugino; Tomokazu Hasegawa; Kentaro Yoshimura; Kiyohito Sasa; Mitsuhiro Kinoshita; Masakazu Nitta; Karin Nagata; Tomomi Sugiyama; Ryutaro Kamijo; Takahiro Funatsu, Human cell, 35(1):379 - 383, Sep. 2021, Peer-reviewed
• Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in presence of γδ T cells., Reiko Takimoto; Tetsuo Suzawa; Atsushi Yamada; Kiyohito Sasa; Yoichi Miyamoto; Kentaro Yoshimura; Yuji Sasama; Motohiro Tanaka; Mitsuhiro Kinoshita; Kaori Ikezaki; Makoto Ichikawa; Matsuo Yamamoto; Tatsuo Shirota; Ryutaro Kamijo, Immunology, 162(3):306 - 313, Nov. 2020, Peer-reviewed
• Osteoblastic differentiation of bone marrow mesenchymal stem cells in uremic rats., KATO Tadashi;MIZOBUCHI Masahide;SASA Kiyohito;YAMADA Atsushi;OGATA Hiroaki;HONDA Hirokazu;SAKASHITA Akiko;KAMIJO Ryutaro, Biochem Biophys Res Commun, 532(1):11 - 18, Oct. 2020, Peer-reviewed, DOI:10.1016/j.bbrc.2020.05.096
• モノカルボン酸トランスポーターによる骨・軟骨代謝の調節, 笹 清人;吉村 健太郎;宮本 洋一;上條 竜太郎, 口腔組織培養学会誌, 29(2):49, Oct. 2020, Peer-reviewed
• 神経堤由来細胞　再生医療の自家細胞ソースとしての可能性, 須澤 徹夫;笹 清人;吉村 健太郎;山田 篤;宇山 理紗;宮本 洋一;上條 竜太郎, 細胞, 52(4):203, Apr. 2020, Peer-reviewed
• Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin., Risa Sugisaki; Yoichi Miyamoto; Kentaro Yoshimura; Kiyohito Sasa; Kotaro Kaneko; Motohiro Tanaka; Masakatsu Itose; Sakie Inoue; Kazuyoshi Baba; Tatsuo Shirota; Daichi Chikazu; Ryutaro Kamijo, Bone, 132:115216 - 115216, Mar. 2020, Peer-reviewed
• モノカルボン酸輸送担体は骨形成と骨吸収の両者を調節する, 笹 清人;吉村 健太郎;今井 裕子;山本 松男;上條 竜太郎, 口腔組織培養学会誌, 29(1):29, Mar. 2020, Peer-reviewed
• Functional Analysis of PTH1R Variants Found in Primary Failure of Eruption., E Izumida; T Suzawa; Y Miyamoto; A Yamada; M Otsu; T Saito; T Yamaguchi; K Nishimura; M Ohtaka; M Nakanishi; K Yoshimura; K Sasa; R Takimoto; R Uyama; T Shirota; K Maki; R Kamijo, Journal of dental research, 99(4):22034520901731 - 22034520901731, Jan. 2020, Peer-reviewed
• Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone, IMAI Hiroko;YOSHIMURA Kentaro;MIYAMOTO Yoichi;SASA Kiyohito;SUGANO Marika;CHATANI Masahiro;TANKAMI Masamichi;YAMAMOTO Matsuo;KAMIJO Ryutaro, Sci Rep, 9(1):15608, Oct. 2019, Peer-reviewed
• Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts., Tadashi Kato; Atsushi Yamada; Kiyohito Sasa; Kentaro Yoshimura; Naoko Morimura; Hiroaki Ogata; Akiko Sakashita; Ryutaro Kamijo, Calcified tissue international, 104(2):201 - 206, Feb. 2019, Peer-reviewed
• Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E 2, Kazuhiro Nagayama; Yoichi Miyamoto; Kotaro Kaneko; Kentaro Yoshimura; Kiyohito Sasa; Takaaki Akaike; Shigemoto Fujii; Eri Izumida; Risa Uyama; Daichi Chikazu; Koutaro Maki; Ryutaro Kamijo, In Vitro Cellular and Developmental Biology - Animal, 55(1):45 - 51, Jan. 2019, Peer-reviewed
• Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation., Sasa K; Yoshimura K; Yamada A; Suzuki D; Miyamoto Y; Imai H; Nagayama K; Maki K; Yamamoto M; Kamijo R, Scientific reports, 8(1):10579 - 10579, Jul. 2018, Peer-reviewed
• The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages., Yoko Manome; Dai Suzuki; Ayako Mochizuki; Emi Saito; Kiyohito Sasa; Kentaro Yoshimura; Tomio Inoue; Masamichi Takami; Katsunori Inagaki; Takahiro Funatsu; Ryutaro Kamijo, Oncotarget, 9(52):29934 - 29943, Jul. 2018, Peer-reviewed
• FGF-2 suppresses expression of nephronectin via JNK and PI3K pathways, KATO Tadashi;YAMADA Atsushi;IKEHATA Mikiko;YOSHIDA Yuko;SASA Kiyohito;MORIMURA Naoko;SAKASHITA Akiko;IIJIMA Takehiko;CHIKAZU Daichi;OGATA Hiroaki;KAMIJO Ryutaro, FEBS Open Bio, 8(5):836 - 842, May 2018, Peer-reviewed
• モノカルボン酸トランスポーター1はp53の抑制を介して骨芽細胞分化を正に制御する, 笹 清人;吉村 健太郎;宮本 洋一;馬目 瑤子;上條 竜太郎, 口腔組織培養学会誌, 27(1):7, Mar. 2018, Peer-reviewed
• 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL, K. Kaneko; Y. Miyamoto; R. Tsukuura; K. Sasa; T. Akaike; S. Fujii; K. Yoshimura; K. Nagayama; M. Hoshino; S. Inoue; K. Maki; K. Baba; D. Chikazu; R. Kamijo, Nitric Oxide - Biology and Chemistry, 72:46 - 51, Jan. 2018, Peer-reviewed
• Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules, Reena Rodriguez; Kentaro Yoshimura; Yo Shibata; Yoichi Miyamoto; Reina Tanaka; Risa Uyama; Kiyohito Sasa; Dai Suzuki; Takashi Miyazaki; Ryutaro Kamijo, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 13(8):2545 - 2553, Nov. 2017, Peer-reviewed
• モノカルボン酸トランスポーター1(MCT1)の骨芽細胞分化における役割, 笹 清人;吉村 健太郎;宮本 洋一;上條 竜太郎, 昭和学士会雑誌, 77(4):492, Aug. 2017, Peer-reviewed

Presentations

• Elucidation of a novel histone modification of lactate in osteoblast differentiation, 笹 清⼈、 南 えりか、 ⼭⽥ 篤、中納 治久, 第46回日本分子生物学会年会, 07 Dec. 2023, 神戸
• 骨芽細胞分化における乳酸による新規ヒストン修飾の役割, 南 えりか;笹 清人;河合 良太;吉田 寛;槇 宏太郎;中納 治久;山田 篤, 第82回日本矯正歯科学会学術大会, 02 Nov. 2023
• BMP-2が唾液腺発育に及ぼす影響, 小野慎之, 山田篤, 田中準一, 行森茜, 笹清人, 美島健二, 船津敬弘, 第65回歯科基礎医学会学術大会, 16 Sep. 2023
• Kielin/Chordin-like proteinはBMP-2による骨芽細胞分化を促進する, 長崎 計;山田 篤;笹 清人;上條 竜太郎, 第41回日本骨代謝学会学術集会, 27 Jul. 2023
• Microarray analysis of the periodontal ligament cells derived from human permanent teeth with Down syndrome., 浅川　剛吉;久木野　真純;長谷川　智一;浅川　麻美;吉村　健太郎;笹　清人;松島　瞳;新田　雅一;永田　夏琳;若月　宏之;杉山　智美;島田　幸恵;上條　竜太郎;船津　敬弘, 第57回日本小児歯科学会大会, 09 Jun. 2019, 札幌
• Zoledronate promoted the expression of inflammatory cytokines in CD14+ cells in human peripheral blood mononuclear cells and inhibited their differentiation into osteoclasts, TAKIMOTO Reiko;MIYAMOTO Yoichi;YAMADA Atsushi;SUZAWA Tetsuo;SASA Kiyohito;KAMIJO Ryutaro;SHIROTA Tatsuo, 第66回国際歯科研究学会日本部会総会・学術大会, 17 Nov. 2018, 札幌
• α-cyano-4-hydroxycinnamic acid は破骨細胞の骨吸収を抑制する, 今井　裕子;吉村　健太郎;宮本　洋一;山田　篤;笹　清人;茶谷　昌宏;髙見　正道;山本　松男;上條　竜太郎, 第4回日本骨免疫学会, 25 Jun. 2018, 名護
• Down症候群乳歯歯根膜由来細胞のDYRK1A発現解析, 浅川　剛吉;大川　真純;永田　夏琳;長谷川　智一;宮本　洋一;吉村　健太郎;笹　清人;馬目　瑤子;杉山　智美;上條　竜太郎;島田　幸恵, 第56回日本小児歯科学会大会, 11 May 2018, 大阪
• DYRKIA regulation of expression on periodontal ligament cells derived from Down syndrome deciduous teeth, 浅川　剛吉;大川　真純;永田　夏琳;長谷川　智一;宮本　洋一;吉村　健太郎;笹　清人;馬目　瑶子;杉山　智美;上條　竜太郎;島田　幸恵, 第56回日本小児歯科学会大会, 10 May 2018, 大阪
• Establish of expression on differentiation periodontal ligament cells derived from human teeth-Comparative analysis that SDF-1.ALPHA. regulation of expression on periodontal ligament cells derived from Down syndrome teeth-, ASAKAWA Takeyoshi;MIYAMOTO Yoichi;YOSHIMURA Kentaro;SASA Kiyohito;MANOME Yoko;KAMIJO Ryutaro;HASEGAWA Tomokazu;CHOSA Naoyuki;ISHISAKI Akira;OOKAWA Masumi;SUGIYAMA Tomomi;SHIGA Masayasu;SHIMADA Yukie, 第65回国際歯科研究学会日本部会総会・学術大会, 18 Nov. 2017, 東京
• モノカルボン酸トランスポーター1はp53の抑制を介して骨芽細胞分化を正に制御する, 笹　清人;吉村　健太郎;宮本　洋一;馬目　瑶子;上條　竜太郎, 第54回日本口腔組織培養学会学術大会, 04 Nov. 2017, 盛岡
• モノカルボン酸トランスポーター1は骨芽細分化の新規制御因子である, 笹　清人;吉村　健太郎;宮本　洋一;上條　竜太郎, 第59回歯科基礎医学会学術大会, 17 Sep. 2017, 塩尻
• Small GTPase Rac1 is a negative regulator in calvarial osteoblast differentiation and ossification, 鈴木　大;山田　篤;笹　清人;上條　竜太郎, 第59回歯科基礎医学会学術大会, 17 Sep. 2017, 松本
• モノカルボン酸トランスポーター1は骨芽細胞分化の新しい制御因子である, 笹　清人;吉村　健太郎;宮本　洋一;稲垣　克記;上條　竜太郎, 第17回東京骨関節フォーラム, 15 Jul. 2017, 東京
• NADPHオキシダーゼ依存的軟骨マトリックスの喪失, 笹　清人;吉村　健太郎;宮本　洋一;船登　咲映;安原　理佳;美島　健二;馬場　一美;上條　竜太郎, 第70回日本酸化ストレス学会学術集会, 28 Jun. 2017, つくば