Sasa Kiyohito

Researcher

基本情報

Profile and Settings

• 氏名

  Sasa Kiyohito

Affiliation

• Oral Physiology, Assistant Professor

Location

• Hatanodai Campus

Degree

• Doctor of Dental Science, Showa University, Mar. 2018

Achievements

Published Papers

• Contribution of the glossopharyngeal nerve in imidapril-mediated enhancement of the swallowing reflex in rats, Takashi Moriya, Kiyomi Nakayama, Ayako Mochizuki, Masanori Dantsuji, Kiyohito Sasa, Seigo Ohba, Tatsuo Shirota, Tomio Inoue, Shiro Nakamura, Journal of Oral Biosciences, 68(3):100774, Mar. 2026, Peer-reviewed, DOI:10.1016/j.job.2026.100774
• Lactate-induced histone lactylation by p300 promotes osteoblast differentiation., Minami Erika;Sasa Kiyohito;Yamada Atsushi;Kawai Ryota;Yoshida Hiroshi;Nakano Haruhisa;Maki Koutaro;Kamijo Ryutaro, PloS one, 18(12), Dec. 2023, Peer-reviewed
• Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates., Sasama Yuji;Yoshimura Kentaro;Hoshino Marie;Sasa Kiyohito;Akaike Takaaki;Morita Masanobu;Baba Kazuyoshi;Shirota Tatsuo;Miyamoto Yoichi, Journal of oral biosciences, Nov. 2023, Peer-reviewed
• BMP-2-mediated signaling suppresses salivary gland development., Ono Shinnosuke;Yamada Atsushi;Tanaka Junichi;Yukimori Akane;Sasa Kiyohito;Mishima Kenji;Funatsu Takahiro;Kamijo Ryutaro, Biochemical and biophysical research communications, 681:1 - 6, Sep. 2023, Peer-reviewed
• Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2., Nagasaki Kei;Yamada Atsushi;Sasa Kiyohito;Kamijo Ryutaro, FEBS open bio, 13(7):1357 - 1364, Jun. 2023, Peer-reviewed
• Cathepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro., Kawai Ryota;Sugisaki Risa;Miyamoto Yoichi;Yano Fumiko;Sasa Kiyohito;Minami Erika;Maki Koutaro;Kamijo Ryutaro, In vitro cellular & developmental biology. Animal, 59(1):10 - 18, Jan. 2023, Peer-reviewed
• Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx., Nishida Rie;Suzuki Dai;Akimoto Yoshihiro;Matsubara Sachie;Hayakawa Junri;Ushiyama Akira;Sasa Kiyohito;Miyamoto Yoichi;Iijima Takehiko;Kamijo Ryutaro, Journal of oral biosciences, 65(1):111 - 118, Jan. 2023, Peer-reviewed
• Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß., Tanaka Motohiro;Miyamoto Yoichi;Sasa Kiyohito;Yoshimura Kentaro;Yamada Atsushi;Shirota Tatsuo;Kamijo Ryutaro, In vitro cellular & developmental biology. Animal, 58(7):521 - 528, Aug. 2022, Peer-reviewed
• Extracellular acidification augments sclerostin and osteoprotegerin production by Ocy454 mouse osteocytes., Ikezaki-Amada Kaori;Miyamoto Yoichi;Sasa Kiyohito;Yamada Atsushi;Kinoshita Mitsuhiro;Yoshimura Kentaro;Kawai Ryota;Yano Fumiko;Shirota Tatsuo;Kamijo Ryutaro, Biochemical and biophysical research communications, 597, Jan. 2022, Peer-reviewed
• Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors., Kinoshita Mitsuhiro;Yamada Atsushi;Sasa Kiyohito;Ikezaki Kaori;Shirota Tatsuo;Kamijo Ryutaro, Scientific reports, 11(1), Oct. 2021, Peer-reviewed
• 炎症性骨破壊の新展開　プロテアーゼによる破骨細胞形成の促進, 杉崎 リサ;笹 清人;宮本 洋一;宇山 理紗;近津 大地;上條 竜太郎, 口腔組織培養学会誌, 30(1):35, Oct. 2021, Peer-reviewed
• Establishment of Down's syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT., Takeyoshi Asakawa; Atsushi Yamada; Masumi Kugino; Tomokazu Hasegawa; Kentaro Yoshimura; Kiyohito Sasa; Mitsuhiro Kinoshita; Masakazu Nitta; Karin Nagata; Tomomi Sugiyama; Ryutaro Kamijo; Takahiro Funatsu, Human cell, 35(1):379 - 383, Sep. 2021, Peer-reviewed
• Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in presence of γδ T cells., Reiko Takimoto; Tetsuo Suzawa; Atsushi Yamada; Kiyohito Sasa; Yoichi Miyamoto; Kentaro Yoshimura; Yuji Sasama; Motohiro Tanaka; Mitsuhiro Kinoshita; Kaori Ikezaki; Makoto Ichikawa; Matsuo Yamamoto; Tatsuo Shirota; Ryutaro Kamijo, Immunology, 162(3):306 - 313, Nov. 2020, Peer-reviewed
• Osteoblastic differentiation of bone marrow mesenchymal stem cells in uremic rats., KATO Tadashi;MIZOBUCHI Masahide;SASA Kiyohito;YAMADA Atsushi;OGATA Hiroaki;HONDA Hirokazu;SAKASHITA Akiko;KAMIJO Ryutaro, Biochem Biophys Res Commun, 532(1):11 - 18, Oct. 2020, Peer-reviewed, DOI:10.1016/j.bbrc.2020.05.096
• モノカルボン酸トランスポーターによる骨・軟骨代謝の調節, 笹 清人;吉村 健太郎;宮本 洋一;上條 竜太郎, 口腔組織培養学会誌, 29(2):49, Oct. 2020, Peer-reviewed
• 神経堤由来細胞　再生医療の自家細胞ソースとしての可能性, 須澤 徹夫;笹 清人;吉村 健太郎;山田 篤;宇山 理紗;宮本 洋一;上條 竜太郎, 細胞, 52(4):203, Apr. 2020, Peer-reviewed
• Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin., Risa Sugisaki; Yoichi Miyamoto; Kentaro Yoshimura; Kiyohito Sasa; Kotaro Kaneko; Motohiro Tanaka; Masakatsu Itose; Sakie Inoue; Kazuyoshi Baba; Tatsuo Shirota; Daichi Chikazu; Ryutaro Kamijo, Bone, 132:115216 - 115216, Mar. 2020, Peer-reviewed
• モノカルボン酸輸送担体は骨形成と骨吸収の両者を調節する, 笹 清人;吉村 健太郎;今井 裕子;山本 松男;上條 竜太郎, 口腔組織培養学会誌, 29(1):29, Mar. 2020, Peer-reviewed
• Functional Analysis of PTH1R Variants Found in Primary Failure of Eruption., E Izumida; T Suzawa; Y Miyamoto; A Yamada; M Otsu; T Saito; T Yamaguchi; K Nishimura; M Ohtaka; M Nakanishi; K Yoshimura; K Sasa; R Takimoto; R Uyama; T Shirota; K Maki; R Kamijo, Journal of dental research, 99(4):22034520901731 - 22034520901731, Jan. 2020, Peer-reviewed
• Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone, IMAI Hiroko;YOSHIMURA Kentaro;MIYAMOTO Yoichi;SASA Kiyohito;SUGANO Marika;CHATANI Masahiro;TANKAMI Masamichi;YAMAMOTO Matsuo;KAMIJO Ryutaro, Sci Rep, 9(1):15608, Oct. 2019, Peer-reviewed
• Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts., Tadashi Kato; Atsushi Yamada; Kiyohito Sasa; Kentaro Yoshimura; Naoko Morimura; Hiroaki Ogata; Akiko Sakashita; Ryutaro Kamijo, Calcified tissue international, 104(2):201 - 206, Feb. 2019, Peer-reviewed
• Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E 2, Kazuhiro Nagayama; Yoichi Miyamoto; Kotaro Kaneko; Kentaro Yoshimura; Kiyohito Sasa; Takaaki Akaike; Shigemoto Fujii; Eri Izumida; Risa Uyama; Daichi Chikazu; Koutaro Maki; Ryutaro Kamijo, In Vitro Cellular and Developmental Biology - Animal, 55(1):45 - 51, Jan. 2019, Peer-reviewed
• Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation., Sasa K; Yoshimura K; Yamada A; Suzuki D; Miyamoto Y; Imai H; Nagayama K; Maki K; Yamamoto M; Kamijo R, Scientific reports, 8(1):10579 - 10579, Jul. 2018, Peer-reviewed
• The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages., Yoko Manome; Dai Suzuki; Ayako Mochizuki; Emi Saito; Kiyohito Sasa; Kentaro Yoshimura; Tomio Inoue; Masamichi Takami; Katsunori Inagaki; Takahiro Funatsu; Ryutaro Kamijo, Oncotarget, 9(52):29934 - 29943, Jul. 2018, Peer-reviewed
• FGF-2 suppresses expression of nephronectin via JNK and PI3K pathways, KATO Tadashi;YAMADA Atsushi;IKEHATA Mikiko;YOSHIDA Yuko;SASA Kiyohito;MORIMURA Naoko;SAKASHITA Akiko;IIJIMA Takehiko;CHIKAZU Daichi;OGATA Hiroaki;KAMIJO Ryutaro, FEBS Open Bio, 8(5):836 - 842, May 2018, Peer-reviewed
• モノカルボン酸トランスポーター1はp53の抑制を介して骨芽細胞分化を正に制御する, 笹 清人;吉村 健太郎;宮本 洋一;馬目 瑤子;上條 竜太郎, 口腔組織培養学会誌, 27(1):7, Mar. 2018, Peer-reviewed
• 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL, K. Kaneko; Y. Miyamoto; R. Tsukuura; K. Sasa; T. Akaike; S. Fujii; K. Yoshimura; K. Nagayama; M. Hoshino; S. Inoue; K. Maki; K. Baba; D. Chikazu; R. Kamijo, Nitric Oxide - Biology and Chemistry, 72:46 - 51, Jan. 2018, Peer-reviewed
• Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules, Reena Rodriguez; Kentaro Yoshimura; Yo Shibata; Yoichi Miyamoto; Reina Tanaka; Risa Uyama; Kiyohito Sasa; Dai Suzuki; Takashi Miyazaki; Ryutaro Kamijo, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 13(8):2545 - 2553, Nov. 2017, Peer-reviewed
• モノカルボン酸トランスポーター1(MCT1)の骨芽細胞分化における役割, 笹 清人;吉村 健太郎;宮本 洋一;上條 竜太郎, 昭和学士会雑誌, 77(4):492, Aug. 2017, Peer-reviewed

Presentations

• Phox2b-expressing neurons in the nucleus of the solitary tract generate rhythmic jaw movements via the parvocellular reticular formation, Kiyomi Nakayama, Hikari Oikawa, Keiko Ikeda, Hiroshi Onimaru, Ayako Mochizuki, Masanori Dantsuji, Kiyohito Sasa, Tomio Inoue and Shiro Nakamura, FENS2026, 09 Jul. 2026, Barcelona
• ドーパミンによる咬筋運動ニューロン興奮性調節と咀嚼時の三叉神経運動核内ドーパミン動態の解析, 藤井 志帆 、壇辻 昌典 、中山 希世美 、望月 文子 、笹 清人 、嘉手納 未季、船津 敬弘、中村 史朗, 第 419 回昭和医科大学学士会例会, 27 Jun. 2026
• Elucidation of a novel histone modification of lactate in osteoblast differentiation, 笹 清⼈、 南 えりか、 ⼭⽥ 篤、中納 治久, 第46回日本分子生物学会年会, 07 Dec. 2023, 神戸
• 骨芽細胞分化における乳酸による新規ヒストン修飾の役割, 南 えりか;笹 清人;河合 良太;吉田 寛;槇 宏太郎;中納 治久;山田 篤, 第82回日本矯正歯科学会学術大会, 02 Nov. 2023
• BMP-2が唾液腺発育に及ぼす影響, 小野慎之, 山田篤, 田中準一, 行森茜, 笹清人, 美島健二, 船津敬弘, 第65回歯科基礎医学会学術大会, 16 Sep. 2023
• Kielin/Chordin-like proteinはBMP-2による骨芽細胞分化を促進する, 長崎 計;山田 篤;笹 清人;上條 竜太郎, 第41回日本骨代謝学会学術集会, 27 Jul. 2023
• Microarray analysis of the periodontal ligament cells derived from human permanent teeth with Down syndrome., 浅川　剛吉;久木野　真純;長谷川　智一;浅川　麻美;吉村　健太郎;笹　清人;松島　瞳;新田　雅一;永田　夏琳;若月　宏之;杉山　智美;島田　幸恵;上條　竜太郎;船津　敬弘, 第57回日本小児歯科学会大会, 09 Jun. 2019, 札幌
• Zoledronate promoted the expression of inflammatory cytokines in CD14+ cells in human peripheral blood mononuclear cells and inhibited their differentiation into osteoclasts, TAKIMOTO Reiko;MIYAMOTO Yoichi;YAMADA Atsushi;SUZAWA Tetsuo;SASA Kiyohito;KAMIJO Ryutaro;SHIROTA Tatsuo, 第66回国際歯科研究学会日本部会総会・学術大会, 17 Nov. 2018, 札幌
• α-cyano-4-hydroxycinnamic acid は破骨細胞の骨吸収を抑制する, 今井　裕子;吉村　健太郎;宮本　洋一;山田　篤;笹　清人;茶谷　昌宏;髙見　正道;山本　松男;上條　竜太郎, 第4回日本骨免疫学会, 25 Jun. 2018, 名護
• Down症候群乳歯歯根膜由来細胞のDYRK1A発現解析, 浅川　剛吉;大川　真純;永田　夏琳;長谷川　智一;宮本　洋一;吉村　健太郎;笹　清人;馬目　瑤子;杉山　智美;上條　竜太郎;島田　幸恵, 第56回日本小児歯科学会大会, 11 May 2018, 大阪
• DYRKIA regulation of expression on periodontal ligament cells derived from Down syndrome deciduous teeth, 浅川　剛吉;大川　真純;永田　夏琳;長谷川　智一;宮本　洋一;吉村　健太郎;笹　清人;馬目　瑶子;杉山　智美;上條　竜太郎;島田　幸恵, 第56回日本小児歯科学会大会, 10 May 2018, 大阪
• Establish of expression on differentiation periodontal ligament cells derived from human teeth-Comparative analysis that SDF-1.ALPHA. regulation of expression on periodontal ligament cells derived from Down syndrome teeth-, ASAKAWA Takeyoshi;MIYAMOTO Yoichi;YOSHIMURA Kentaro;SASA Kiyohito;MANOME Yoko;KAMIJO Ryutaro;HASEGAWA Tomokazu;CHOSA Naoyuki;ISHISAKI Akira;OOKAWA Masumi;SUGIYAMA Tomomi;SHIGA Masayasu;SHIMADA Yukie, 第65回国際歯科研究学会日本部会総会・学術大会, 18 Nov. 2017, 東京
• モノカルボン酸トランスポーター1はp53の抑制を介して骨芽細胞分化を正に制御する, 笹　清人;吉村　健太郎;宮本　洋一;馬目　瑶子;上條　竜太郎, 第54回日本口腔組織培養学会学術大会, 04 Nov. 2017, 盛岡
• モノカルボン酸トランスポーター1は骨芽細分化の新規制御因子である, 笹　清人;吉村　健太郎;宮本　洋一;上條　竜太郎, 第59回歯科基礎医学会学術大会, 17 Sep. 2017, 塩尻
• Small GTPase Rac1 is a negative regulator in calvarial osteoblast differentiation and ossification, 鈴木　大;山田　篤;笹　清人;上條　竜太郎, 第59回歯科基礎医学会学術大会, 17 Sep. 2017, 松本
• モノカルボン酸トランスポーター1は骨芽細胞分化の新しい制御因子である, 笹　清人;吉村　健太郎;宮本　洋一;稲垣　克記;上條　竜太郎, 第17回東京骨関節フォーラム, 15 Jul. 2017, 東京
• NADPHオキシダーゼ依存的軟骨マトリックスの喪失, 笹　清人;吉村　健太郎;宮本　洋一;船登　咲映;安原　理佳;美島　健二;馬場　一美;上條　竜太郎, 第70回日本酸化ストレス学会学術集会, 28 Jun. 2017, つくば