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Adachi Naoki

■FacultyPhysiology
■PositionAssociate Professor
Last Updated :2025/04/09

Researcher

基本情報

Profile and Settings

  • 氏名

    Adachi Naoki

Affiliation

  • Physiology, Associate Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Science, Osaka University, Sep. 2005

Achievements

Published Papers

  • Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation, Fukuoka S, Adachi N, Ouchi E, Ikemoto H, Okumo T, Ishikawa F, Onda H, Sunagawa M., The Ocular Surface, Apr. 2025, Peer-reviewed, DOI:10.1016/j.jtos.2025.01.001
  • Early Intervention With Boiogito to Suppress Knee Osteoarthritis Progression: An Experimental Approach Using a Medial Meniscus Instability Rat Model., Izukashi Kanako;Okumo Takayuki;Tatsuo Tokito;Kachi Itaru;Iida Yuta;Nishio Takumi;Ikemoto Hideshi;Adachi Naoki;Kanzaki Koji;Sunagawa Masataka, Cureus, 17(1), Jan. 2025, Peer-reviewed, DOI:10.7759/cureus.77311
  • Suppressive Activity of Boiogito, a Japanese Traditional Kampo Medicine, on Periostin Secretion in Human Fibroblast-Like Synoviocytes In Vitro., Mochizuki Midori;Okumo Takayuki;Takemura Haruka;Izukashi Kanako;Tatsuo Tokito;Ikemoto Hideshi;Adachi Naoki;Kawate Nobuyuki;Sunagawa Masataka, Cureus, 16(4), Apr. 2024, Peer-reviewed
  • Suppressive Activity of Boiogito, a Japanese Traditional Kampo Medicine, on Periostin Secretion in Human Fibroblast-Like Synoviocytes In Vitro., Mochizuki Midori;Okumo Takayuki;Takemura Haruka;Izukashi Kanako;Tatsuo Tokito;Ikemoto Hideshi;Adachi Naoki;Kawate Nobuyuki;Sunagawa Masataka, Cureus, 16(4), Apr. 2024, Peer-reviewed, DOI:https://doi.org/10.7759/cureus.57690
  • Duration of the preemptive analgesic effects of low- and high-frequency transcutaneous electrical nerve stimulation in rats with acute inflammatory pain., Ikemoto Hideshi;Adachi Naoki;Okumo Takayuki;Chuluunbat Oyunchimeg;Hisamitsu Tadashi;Sunagawa Masataka, The Kaohsiung journal of medical sciences, 40(5), Mar. 2024, Peer-reviewed
  • The Preventive Effects of Platelet-Rich Plasma Against Knee Osteoarthritis Progression in Rats., Takemura Haruka;Okumo Takayuki;Tatsuo Tokito;Izukashi Kanako;Ikemoto Hideshi;Adachi Naoki;Mochizuki Midori;Kanzaki Koji;Sunagawa Masataka, Cureus, 15(11), Nov. 2023, Peer-reviewed, DOI:https://doi.org/10.7759/cureus.48825
  • The Preventive Effects of Platelet-Rich Plasma Against Knee Osteoarthritis Progression in Rats., Takemura Haruka;Okumo Takayuki;Tatsuo Tokito;Izukashi Kanako;Ikemoto Hideshi;Adachi Naoki;Mochizuki Midori;Kanzaki Koji;Sunagawa Masataka, Cureus, 15(11), Nov. 2023, Peer-reviewed
  • Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane., Ito Naohito;Tsuji Mayumi;Adachi Naoki;Nakamura Shiro;Sarkar Avijite Kumer;Ikenaka Kensuke;Aguirre César;Kimura Atsushi Michael;Kiuchi Yuji;Mochizuki Hideki;Teplow David B;Ono Kenjiro, NPJ Parkinson's disease, 9(1), Sep. 2023, Peer-reviewed
  • Boiogito, a Japanese Traditional Herbal Medicine, Inhibits the Osteoclast Differentiation and Proliferation in the Subchondral Bone of an In Vivo Knee Osteoarthritis Rat Model, Taro Kimura; TAKAYUKI OKUMO; Hideshi Ikemoto; Naoki Adachi; Haruka Takemura; Midori Mochizuki; Kanako Izukashi; Koji Kanzaki; MASATAKA SUNAGAWA, Applied Sciences, 12(22), Nov. 2022, Peer-reviewed
  • Boiogito, a Japanese Traditional Herbal Medicine, Inhibits the Osteoclast Differentiation and Proliferation in the Subchondral Bone of an In Vivo Knee Osteoarthritis Rat Model, Taro Kimura; TAKAYUKI OKUMO; Hideshi Ikemoto; Naoki Adachi; Haruka Takemura; Midori Mochizuki; Kanako Izukashi; Koji Kanzaki; MASATAKA SUNAGAWA, Applied Sciences, 12(22):11518, Nov. 2022, Peer-reviewed, DOI:doi.org/10.3390/app122211518
  • Shoseiryuto Ameliorated TDI-Induced Allergic Rhinitis by Suppressing IL-33 Release from Nasal Epithelial Cells., Kitano Manabu;Fukuoka Seiya;Adachi Naoki;Hisamitsu Tadashi;Sunagawa Masataka, Pharmaceutics, 14(10), Sep. 2022, Peer-reviewed
  • Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons, Yusuke Ohashi; Fatma Zahra Sakhri; Hideshi Ikemoto; Takayuki Okumo; Naoki Adachi; Masataka Sunagawa, FRONTIERS IN PHARMACOLOGY, 13, May 2022, Peer-reviewed
  • Analgesic Effect of Boiogito, a Japanese Traditional Kampo Medicine, on Post-Traumatic Knee Osteoarthritis through Inhibition of ERK1/2 Phosphorylation in the Dorsal Horn of the Spinal Cord, Yusuke Kunieda; Takayuki Okumo; Hideshi Ikemoto; Naoki Adachi; Midori Tanaka; Taro Kimura; Kanako Yusa; Koji Kanzaki; Masataka Sunagawa, Applied Sciences, 11(18):8421 - 8421, Sep. 2021, Peer-reviewed
  • Analgesic Effect of Boiogito, a Japanese Traditional Kampo Medicine, on Post-Traumatic Knee Osteoarthritis through Inhibition of ERK1/2 Phosphorylation in the Dorsal Horn of the Spinal Cord, Yusuke Kunieda; Takayuki Okumo; Hideshi Ikemoto; Naoki Adachi; Midori Tanaka; Taro Kimura; Kanako Yusa; Koji Kanzaki; Masataka Sunagawa, Applied Sciences, 11(18):8421 - 8421, Sep. 2021, Peer-reviewed
  • Brain‐derived neurotrophic factor predominantly regulates the expression of synapse‐related genes in the striatum: Insights from in vitro transcriptomics, Hisatsugu Koshimizu; Hidetada Matsuoka; Yoshihiro Nakajima; Anna Kawai; Junichiro Ono; Ken‐ichi Ohta; Takanori Miki; Masataka Sunagawa; Naoki Adachi; Shingo Suzuki, Neuropsychopharmacology Reports, Sep. 2021, Peer-reviewed
  • Kamikihito rescued depressive-like behaviors and hippocampus neurogenesis in chronic restraint stress rats, Naoki Adachi; Fatma Zahra Sakhri; Hideshi Ikemoto; Yusuke Ohashi; Mami Kato; Tatsuki Inoue; Tadashi Hisamitsu; MasatakaSunagawa, J Tradit Complement Med., Sep. 2021, Peer-reviewed
  • Brain-derived neurotrophic factor predominantly regulates the expression of synapse-related genes in the striatum: Insights from in vitro transcriptomics., Koshimizu Hisatsugu;Matsuoka Hidetada;Nakajima Yoshihiro;Kawai Anna;Ono Junichiro;Ohta Ken-Ichi;Miki Takanori;Sunagawa Masataka;Adachi Naoki;Suzuki Shingo, Neuropsychopharmacology reports, 41(4), Sep. 2021, Peer-reviewed
  • ミクログリア活性化抑制を介した持続性炎症性疼痛に対する自発運動による鎮痛効果(Voluntary running-induced an analgesic effect on persistent inflammatory pain via the inhibition of microglial activation), Ikemoto Hideshi; Yamauchi Risa; Adachi Naoki; Okumo Takayuki; Horikawa Hiroyuki; Nakamura Akiou; Sakaue Satoshi; Hisamitsu Tadashi; Sunagawa Masataka, The Journal of Physiological Sciences, 71(Suppl.1):186 - 186, Aug. 2021, Peer-reviewed
  • Kamikihito rescued depressive-like behaviors and hippocampus neurogenesis in chronic restraint stress rats., Adachi Naoki;Sakhri Fatma Zahra;Ikemoto Hideshi;Ohashi Yusuke;Kato Mami;Inoue Tatsuki;Hisamitsu Tadashi;Sunagawa Masataka, Journal of traditional and complementary medicine, 12(2), Aug. 2021, Peer-reviewed
  • Analgesic Effect of Combined Therapy with the Japanese Herbal Medicine "Yokukansan" and Electroacupuncture in Rats with Acute Inflammatory Pain., Nachi Ebihara; Hideshi Ikemoto; Naoki Adachi; Takayuki Okumo; Taro Kimura; Kanako Yusa; Satoshi Hattori; Atsufumi Manabe; Tadashi Hisamitsu; Masataka Sunagawa, Medicines (Basel, Switzerland), 8(6):31, Jun. 2021, Peer-reviewed
  • Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord, TAKAHARA-YAMAUCHI Risa;IKEMOTO Hideshi;OKUMO Takayuki;SAKHRI Zahra Fatma;HORIKAWA Hiroyuki;NAKAMURA Akiou;SAKAUE Satoshi;KATO Mami;ADACHI Naoki;SUNAGAWA Masataka, Biomed Res, 42(2):67 - 76, Apr. 2021, Peer-reviewed, DOI:doi.org/10.2220/biomedres.42.67
  • Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats., Fatma Z Sakhri; Naoki Adachi; Sakina Zerizer; Yusuke Ohashi; Hideshi Ikemoto; Mana Tsukada; Zahia Kabouche; Tadashi Hisamitsu; Masataka Sunagawa, Phytotherapy research : PTR, 35(4):2074 - 2084, Apr. 2021, Peer-reviewed
  • Small noncoding vault RNA modulates synapse formation by amplifying MAPK signaling., WAKATSUKI S;TAKAHASHI Y;SHIBATA M;ADACHI Naoki;NUMANAKA T;KUNUGI H;ARAKI T, J Cell Biol, 220(2):e201911078, Feb. 2021, Peer-reviewed
  • Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord., Takahara-Yamauchi Risa;Ikemoto Hideshi;Okumo Takayuki;Sakhri Fatma Zahra;Horikawa Hiroyuki;Nakamura Akiou;Sakaue Satoshi;Kato Mami;Adachi Naoki;Sunagawa Masataka, Biomedical research (Tokyo, Japan), 42(2):67 - 76, 2021, Peer-reviewed, DOI:10.2220/biomedres.42.67
  • Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine "Yokukansan" in Rats with Acute Inflammatory Pain., Yuko Akanuma; Mami Kato; Yasunori Takayama; Hideshi Ikemoto; Naoki Adachi; Yusuke Ohashi; Wakako Yogi; Takayuki Okumo; Mana Tsukada; Masataka Sunagawa, Medicines (Basel, Switzerland), 7(12):75, Dec. 2020, Peer-reviewed
  • 【脳の発生とその異常】外的要因による異常　ストレスとグルココルチコイド　母体にかかるストレスが胎児に与える影響とそのメカニズム, 安達 直樹, Clinical Neuroscience, 38(12):1578 - 1581, Dec. 2020
  • Vexin is upregulated in cerebral cortical neurons by brain‐derived neurotrophic factor, Hisatsugu Koshimizu; Shingo Suzuki; Anna Kawai; Ryuichiro Miura; Ken‐ichi Ohta; Takanori Miki; Naoki Adachi; Hidetada Matsuoka, Neuropsychopharmacology Reports, 40(3):275 - 280, Sep. 2020, Peer-reviewed
  • Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases., NUMAKAWA T;ODAKA H;ADACHI Naoki, Int J Mol Sci, 19(11):3650, Nov. 2018, Peer-reviewed
  • Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway., NUMAKAWA T;ODAKA H;ADACHI Naoki;CHIBA S;OOSHIMA Y;MATSUNO H;NAKAJIMA S;YOSHIMURA A;FUMIMOTO K;HIRAI Y;KUNUGI H, Neurochem Int, 118:217 - 224, Sep. 2018, Peer-reviewed

Presentations

  • Mechanoreceptor Piezo1 Activation Induces Inflammatory Cytokine Expression in Conjunctival Epithelial Cells: The Effects of Eye Rubbing, Adachi N, Fukuoka S, Ouchi E, Ikemoto H, Okumo T, Sunagawa M., 第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会合同大会, 18 Mar. 2025
  • Early Intervention with Boiogito to Suppress Knee Osteoarthritis Progression: An Experimental Approach Using a Medial Meniscus Instability Rat Model, Takayuki Okumo, Kanako Izukashi, Tokito Tatsuo, Hideshi Ikemoto, Naoki Adachi, Masataka Sunagawa, APPW2025, 17 Mar. 2025, 千葉・幕張メッセ
  • Effects of electroacupuncture on joint pain and cartilage degeneration in knee osteoarthritis rats, Hideshi Ikemoto, Chuluunbat Oyunchimeg, Takayuki Okumo, Naoki Adachi, Tadashi Hisamitsu, Masataka Sunagawa, IASP 2024 World Congress on Pain, 06 Aug. 2024, Amsterdam (Netherlands)
  • ヒト滑膜細胞に対する防已黄耆湯のペリオスチン産生抑制効果, 奥茂 敬恭;望月 碧;嚴樫 香名子;辰尾 秋斗;竹村 遥;池本 英志;安達 直樹;川手 信行;砂川 正隆, 第52回日本関節病学会, 19 Jul. 2024, 日本関節病学会, 東京
  • グルココルチコイドによる胎仔神経幹細胞分化過程の攪乱, 安達直樹, 神経栄養因子研究会, 04 Nov. 2023, 金沢工業大学
  • 周産期ストレスによる神経幹細胞分化と脳の発達への影響, 安達直樹, 第50回昭和大学神経研究会, 29 Sep. 2023, 昭和大学・旗の台
  • Shoseiryuto improved TDI-induced allergic rhinitis symptoms via inhibiting IL-33 release from nasal epithelial cells., Manabu Kitano;Seiya Fukuoka;Tadashi Hisamitsu;Masataka Sunagawa, 第100回　日本生理学会大会, 15 Mar. 2023, 国立京都国際会館
  • 漢方薬によるモルヒネ耐性発現の抑制作用～基礎研究からの検討～, 安達　直樹;大橋　祐介;Zahra Sakhri Fatma;池本　英志;奥茂　敬恭;砂川　正隆, 第34回　日本疼痛漢方研究会学術集会, 23 Jul. 2022, 東京コンファレンスセンター・品川
  • Yokukansan Suppresses the Development of Morphine Tolerance by Regulating Presynaptic Functions in the Spinal Cord, Naoki Adachi;Yusuke Ohashi;Fatma Zahra Sakhri;Hideshi Ikemoto;Wakako Yogi;Takayuki Okumo;Masataka Sunagawa, 第99回　日本生理学会, 17 Mar. 2022, 東北大学川内北キャンパス
  • 変形性膝関節症に対する防己黄耆湯の作用機序 ～モデルラットを用いた基礎研究～, 奥茂　敬恭;池本　英志;大池　潤;國枝　裕介;中井　真悟;大橋　祐介;髙山　靖規;安達　直樹;塚田　愛;砂川　正隆, 第33回日本疼痛漢方研究会学術集会, 03 Jul. 2021, 東京+Web開催
  • 漢方処方による鎮痛作用の検討～ラット急性炎症性疼痛モデルを用いた基礎研究～, 砂川　正隆;加藤　真未;髙山　靖規;池本　英志;安達　直樹;大橋　祐介;奥茂　敬恭;山口　孝二郎;塚田　愛;石野　尚吾, 第33回日本疼痛漢方研究会学術集会, 03 Jul. 2021, 東京+Web開催
  • An Investigation of the Efficacy of the Japanese Herbal Medicine “Boiogito” on Knee Osteoarthritis, OKUMO Takayuki;IKEMOTO Hideshi;OIKE Jun;KUNIEDA Yusuke;EBIHARA Nachi;ADACHI Naoki;KANZAKI Koji;HISAMITSU Tadashi;SUNAGAWA Masataka, IASP 2020 World Congress on Pain, 27 Jun. 2021, VIRTUAL Congress
  • Voluntary running-induced analgesic effect on persistent inflammatory pain via the inhibition of microglial activation, 池本　英志;山内　里紗;安達　直樹;奥茂　敬恭;堀川　浩之;中村　明央;坂上　聡;久光　正;砂川　正隆, 第216回日本解剖学会総会・全国学術集会・第98回日本生理学会大会, 28 Mar. 2021, Web開催
  • Antidepressant-like effect of Kamikihito against chronic restraint stress-induced depressive-like behaviors and impaired hippocampus neurogenesis in rats, 安達　直樹;SAKHRI Zahra Fatma;大橋　祐介;塚田　愛;加藤　真未;池本　英志;砂川　正隆, 第126回日本解剖学会総会･全国学術集会・第98回日本生理学会大会, 28 Mar. 2021, Web開催
  • Antidepressant-like activity of Cydonia oblonga fruit against chronic restrain stress, SAKHRI Fatma;ADACHI Naoki;OHASHI Yusuke;IKEMOTO Hideshi;KABOUCHE Zahia;ZERIZER Sakina;SUNAGAWA Masataka, FENS (the Federation of European Neuroscience Societies) Forum 2020, 11 Jul. 2020, Virtual Forum
  • Possible Mechanisms of Astrocyte Senescence in a Hepatic Encephalopathy Model, 安達　直樹;安藤　美佐子;SAKHRI Fatma Zahra;池本　英志;大橋　祐介;塚田　愛;髙山　靖規;平井　洋平;砂川　正隆, 第97回日本生理学会大会, 19 Mar. 2020, 別府
  • Evaluation of antioxidant property, cytotoxicity and toxicity of Cydonia Oblonga fruit extract, SAKHRI Fatma Zahra;安達　直樹;KABOUCHE Zahia;ZERIZER Sakina;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • 急性炎症性疼痛モデルラットに対する補完的アプローチの先取り鎮痛効果, 海老原　那智;池本　英志;安達　直樹;海老原　爲博;海老原　加代子;大池　潤;國枝　裕介;髙山　靖規;久光　正;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • 炎症性疼痛誘発前後の自発運動の鎮痛効果, 山内　里紗;池本　英志;安達　直樹;奥茂　敬恭;大池　潤;国枝　裕介;堀川　浩之;塚田　愛;久光　正;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • 連銭草抽出物によるアノクタミン1阻害, 髙山　靖規;加藤　真未;塚田　愛;安達　直樹;池本　英志;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • 加味帰脾湯のオキシトシンを介した抗ストレス作用～その2～, 塚田　愛;池本　英志;安達　直樹;髙山　靖規;奥茂　敬恭;與儀　和香子;加藤　真未;久光　正;砂川　正隆, 第97回日本生理学会大会, 17 Mar. 2020, 別府
  • 加味帰脾湯の抗ストレス作用～オキシトシン関与の検討～, 塚田　愛;池本　英志;李　暁鵬 （中内暁博）;安達　直樹;髙山　靖規;松山　高明;久光　正;砂川　正隆, 日本情動学会第9回大会, 14 Dec. 2019, 東京
  • 妊娠期ストレスが子どもの大脳皮質発達に及ぼす影響の解析, 安達　直樹;池本　英志;砂川　正隆, 日本情動学会第9回大会, 14 Dec. 2019, 東京
  • 漢方と鍼治療の併用による先取り鎮痛効果の検証 ～抑肝散を用いた基礎研究～, 池本　英志;海老原　那智;山内　里紗;奥茂　敬恭;髙山　靖規;安達　直樹;塚田　愛;石野　尚吾;久光　正;砂川　正隆, 第32回日本疼痛漢方研究会学術集会, 06 Jul. 2019, 東京
  • Suppressive Activity of Chondroitin Sulfate on Nitric Oxide Production by Knee Synoviocytes in Vitro, OKUMO Takayuki;ASANO Kazuhito;IKEMOTO Hideshi;TSUKADA Mana;GUO Shi-yu;KANZAKI Shunji;HISAMITSU Tadashi;SUNAGAWA Masataka, the 9th Federation of the Asian and Oceanian Physiological Societies Congress, 28 Mar. 2019, Kobe

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