Nobe Koji

Researcher

基本情報

Profile and Settings

• 氏名

  Nobe Koji

Affiliation

• Pharmacology, Professor

Location

• Hatanodai Campus

Degree

• Doctor of Pharmaceutical Science, Showa University, Mar. 1995

Achievements

Published Papers

• SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis, Michishige Terasaki; Keita Shibata; Yusaku Mori; Tomomi Saito; Takanori Matsui; Makoto Ohara; Tomoyasu Fukui; Keiji Hasumi; Yuichiro Higashimoto; Koji Nobe; Sho-ichi Yamagishi, International Journal of Molecular Sciences, 24(7):6505 - 6505, Mar. 2023, Peer-reviewed
• The effect of hand therapy on alleviating chemotherapy-induced peripheral neuropathy in a model mouse, Ryosuke Shinouchi; Akiko Sasaki; Takashi Takaki; Mayumi Tsuji; Yuji Kiuchi; Koji Nobe, Neuroscience Letters, 800:137138 - 137138, Mar. 2023, Peer-reviewed, DOI:10.1016/j.neulet.2023.137138
• Effects of dietary palmitoleic acid on vascular function in aorta of diabetic mice, Yasuhiro Takenouchi; Yoshie Seki; Sachiko Shiba; Kazuo Ohtake; Koji Nobe; Keizo Kasono, BMC Endocrine Disorders, 22(1), Dec. 2022
• SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment, Ryosuke Shinouchi; Keita Shibata; Shiori Jono; Keiji Hasumi; Koji Nobe, International Journal of Molecular Sciences, 23(9):5187 - 5187, May 2022, Peer-reviewed, DOI:10.3390/ijms23095187
• Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice., Michiru Nagao; Masataka Tajima; Erika Sugiyama; Ryosuke Shinouchi; Keita Shibata; Masayuki Yoshikawa; Takushi Yamamoto; Vilasinee Hirunpanich Sato; Koji Nobe; Hitoshi Sato, Pharmacology research & perspectives, 10(2):e00919, Apr. 2022
• Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice., Nagao Michiru,Tajima Masataka,Sugiyama Erika,Shinouchi Ryosuke,Shibata Keita,Yoshikawa Masayuki,Yamamoto Takushi,Sato Vilasinee Hirunpanich,Nobe Koji,Sato Hitoshi, Pharmacology research & perspectives, 10(2), Apr. 2022, Peer-reviewed
• Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury., SHIBATA Keita;HASHIMOTO Terumasa;HASUMI Keiji;NOBE Koji, Eur J Pharmacol, 910:174496, Nov. 2021, Peer-reviewed
• Acetic acid treatment causes renal inflammation and chronic kidney disease in mice., HASHIMOTO Terumasa;SHIBATA Keita;HONDA Kazuo;NOBE Koji, J Pharmacol Sci, 146(3):160 - 168, Jul. 2021, Peer-reviewed
• SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities, SHINOUCHI Ryosuke;SHIBATA Keita;HASHIMOTO Terumasa;JONO Shiori;HASUMI Keiji;NOBE Koji, Pharmacol Res Perspect, 8(6):e00648, Dec. 2020, Peer-reviewed
• Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future, SHIBATA Keita;HASHIMOTO Terumasa;MIYAZAKI Takuro;MIYAZAKI Akira;NOBE Koji, Curr Pharm Des, 25(3):242 - 250, Jun. 2019, Peer-reviewed
• Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future., Shibata K; Hashimoto T; Miyazaki T; Miyazaki A; Nobe K, Current pharmaceutical design, 25(3):242 - 250, 2019
• Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice, TAKENOUCHI Yasuhiro;OHTAKE Kazuo;NOBE Koji;KASONO Keizo, Lipids Health Dis, 17(1):118, May 2018, Peer-reviewed
• Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model, SHIBATA Keita;HASHIMOTO Terumasa;HASUMI Keiji;HONDA Kazuo;NOBE Koji, Eur J Pharmacol, 818:221 - 227, Jan. 2018, Peer-reviewed
• 非筋細胞収縮およびその細胞内情報伝達系評価のためのコラーゲンファイバー法の有用性, 野部　浩司;野部　裕美;加園　恵三, 昭和学士会雑誌, 77(4):385 - 396, Aug. 2017, Peer-reviewed, DOI:10.14930/jshowaunivsoc.77.385
• プリン作動性P2X4受容体サブタイプはウシ大動脈内皮細胞の一酸化窒素産生に関与する, 黄　洋一;野部　浩司, 昭和学士会雑誌, 77(3):342 - 348, Jun. 2017, Peer-reviewed, DOI:10.14930/jshowaunivsoc.77.342
• 大学男子駅伝選手の常圧下低酸素環境を利用したトレーニングにおける魚油製剤摂取の効果, 櫛部　静二;小林　悟;竹之内　康広;金　賢珠;新井　尚之;野部　浩司;大竹　一男;白幡　晶;加園　恵三, 脂質栄養学, 25(1):61 - 74, Mar. 2016, Peer-reviewed
• Two Types of Overcontraction Are Involved in Intrarenal Artery Dysfunction in Type II Diabetic Mouse, Koji Nobe; Yasuhiro Takenouchi; Keizo Kasono; Terumasa Hashimoto; Kazuo Honda, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 351(1):77 - 86, Oct. 2014
• Adiponectin Enhances Calcium Dependency of Mouse Bladder Contraction Mediated by Protein Kinase C alpha Expression, Koji Nobe; Akiko Fujii; Kiyomi Saito; Takaharu Negoro; Yoshio Ogawa; Yasuko Nakano; Terumasa Hashimoto; Kazuo Honda, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 345(1):62 - 68, Apr. 2013
• 糖尿病合併症において血管平滑筋細胞機能に影響する因子, 野部　浩司, 昭和大学薬学雑誌, 3(2):115 - 128, Dec. 2012, Peer-reviewed
• Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A-Rho kinase signaling pathway, Koji Nobe; Terumasa Hashimoto; Kazuo Honda, EUROPEAN JOURNAL OF PHARMACOLOGY, 683(1-3):217 - 225, May 2012
• Spatiotemporal dynamics of intracellular calcium in the middle cerebral artery isolated from stroke-prone spontaneously hypertensive rats, Terumasa Hashimoto; Mariko Kiya; Hisayuki Ohata; Takuro Miyazaki; Keita Shibata; Koji Nobe; Kazuo Honda, EXPERIMENTAL PHYSIOLOGY, 97(2):265 - 276, Feb. 2012
• Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice, Keita Shibata; Terumasa Hashimoto; Koji Nobe; Keiji Hasumi; Kazuo Honda, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384(1):103 - 108, Jul. 2011
• 客観的臨床能力試験(OSCE)の自主学習を支援する練習システムの構築, 小濵　孝士;渥美　聡孝;野部　浩司;佐野　佳弘;倉田　なおみ;昭和大学薬学部OSCE対策委員会, 昭和大学薬学雑誌, 1(2):183 - 195, Dec. 2010, Peer-reviewed
• A novel embolic model of cerebral infarction and evaluation of Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a novel fungal triprenyl phenol metabolite., HASHIMOTO Terumasa;SHIBATA Keita;NOBE Koji;HASUMI Keiji;HONDA Kazuo, J Pharmacol Sci, 114:41 - 49, Sep. 2010
• A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice., SHIBATA Keita;HASHIMOTO Terumasa;NOBE Koji;HASUMI Keiji;HONDA Kazuo, Naunyn Schmiedebergs Arch Pharmacol, 382:245 - 253, Aug. 2010
• Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells, Koji Nobe; Hiromi Nobe; Hiroko Yoshida; Michael S. Kolodney; Richard J. Paul; Kazuo Honda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 399(2):292 - 299, Aug. 2010
• Comparative Study of Calcium Ion Dynamics and Contractile Response in Rat Middle Cerebral and Basilar Arteries, Terumasa Hashimoto; Hisayuki Ohata; Koji Nobe; Kazuo Honda, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109(4):546 - 555, Apr. 2009
• Glucose-Dependent Enhancement of Diabetic Bladder Contraction Is Associated with a Rho Kinase-Regulated Protein Kinase C Pathway, Koji Nobe; Taigi Yamazaki; Naoki Tsumita; Terumasa Hashimoto; Kazuo Honda, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 328(3):940 - 950, Mar. 2009
• Intra- and extrarenal arteries exhibit different profiles of contractile responses in high glucose conditions, K. Nobe; Y. Nezu; N. Tsumita; T. Hashimoto; K. Honda, BRITISH JOURNAL OF PHARMACOLOGY, 155(8):1204 - 1213, Dec. 2008
• Alterations of glucose-dependent and -independent bladder smooth muscle contraction in spontaneously hypertensive and hyperlipidemic rat, Koji Nobe; Taigi Yamazaki; Toshio Kumai; Masako Okazaki; Shinichi Iwai; Terumasa Hashimoto; Shinichi Kobayashi; Katsuji Oguchi; Kazuo Honda, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 324(2):631 - 642, Feb. 2008
• A novel approach for the determination of contractile and calcium responses of the basilar artery employing real-time confocal laser microscopy, Terumasa Hashimoto; Hisayuki Ohata; Koji Nobe; Yasushi Sakai; Kazuo Honda, Journal of Pharmacological and Toxicological Methods, 56(1):79 - 86, Jul. 2007
• High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development, Koji Nobe; Mari Miyatake; Tomoko Sone; Kazuo Honda, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 318(2):530 - 539, Aug. 2006
• Distinct agonist responsibilities of the first and second branches of mouse mesenteric artery, K Nobe; C Hagiwara; Y Nezu; K Honda, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 47(3):422 - 427, Mar. 2006
• Thrombin-induced force development in vascular endothelial cells: Contribution to alteration of permeability mediated by calcium-dependent and-independent pathways, K Nobe; T Sone; RJ Paul; K Honda, JOURNAL OF PHARMACOLOGICAL SCIENCES, 99(3):252 - 263, Nov. 2005
• Functional differences of Na+/Ca2+ exchanger expression in Ca2+ transport system of smooth muscle of guinea pig stomach, Y Sakai; H Kinoshita; K Saitou; Homma, I; K Nobe; T Iwamoto, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 83(8-9):791 - 797, Aug. 2005
• A traditional herbal medicine, rikkunshi-to (TJ-43), prevents intracellular signaling disorders in gastric smooth muscle of diabetic rats, Y Sakai; K Nobe; Y Maruyama; K Momose; Homma, I, AMERICAN JOURNAL OF CHINESE MEDICINE, 32(2):245 - 256, 2004
• Fibroblast fiber contraction: role of C and Rho kinase in activation by thromboxane A(2), H Nobe; K Nobe; RJ Paul, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 285(6):C1411 - C1419, Dec. 2003
• Dysfunction of aorta involves different patterns of intracellular signaling pathways in diabetic rats, K Nobe; Y Sakai; H Nobe; K Momose, EUROPEAN JOURNAL OF PHARMACOLOGY, 471(3):195 - 204, Jun. 2003
• The RHOad less traveled: the myosin phosphorylation-independent path from Rho kinase to cell contraction. Focus on "Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation", TM Seasholtz, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284(3):C596 - C598, Mar. 2003
• Effects of Kampo medicine, Keishi-ka Shakuyaku-to (TJ-60) on alteration of diacylglycerol metabolism in gastrointestinal smooth muscle of diabetic rats, K Nobe; K Momose; Y Sakai, ACTA PHARMACOLOGICA SINICA, 23(12):1173 - 1180, Dec. 2002
• Hyper-reactivity of diacylglycerol kinase is involved in the dysfunction of aortic smooth muscle contractility in streptozotocin-induced diabetic rats, K Nobe; Y Sakai; Y Maruyama; K Momose, BRITISH JOURNAL OF PHARMACOLOGY, 136(3):441 - 451, Jun. 2002
• Effects of microtubules and microfilaments on [Ca2+](i) and contractility in a reconstituted fibroblast fiber, K Obara; K Nobe; H Nobe; MS Kolodney; P De Lanerolle; RJ Paul, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 279(3):C785 - C796, Sep. 2000
• Mechanisms of diacylglycerol kinase activation mediated by receptor stimulation, Koji Nobe; Hiromi Aizawa; Hisayuki Ohata; Kazutaka Momose, Folia Pharmacologica Japonica, 106:122 - 126, 1995
• EFFECT OF DIACYLGLYCEROL KINASE INHIBITOR, R59022 ON CYTOSOLIC-FREE CALCIUM LEVEL AND FORCE DEVELOPMENT IN GUINEA-PIG TAENIA-COLI, K NOBE; H OHATA; K MOMOSE, RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 81(3):331 - 343, Sep. 1993
• ROLE OF PHOSPHATIDIC-ACID IN CONTRACTILE MECHANISMS OF SMOOTH-MUSCLE, H OHATA; K NOBE; T YAMAMOTO; K MOMOSE, JOURNAL OF PHARMACOBIO-DYNAMICS, 15(4):S58 - S58, Apr. 1992
• ROLE OF PHOSPHATIDIC-ACID IN CARBACHOL-INDUCED CONTRACTION IN GUINEA-PIG TAENIA-COLI, H OHATA; K NOBE; K MOMOSE, RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 71(1):59 - 72, Jan. 1991

Presentations

• 化学療法誘発性末梢神経障害 (CIPN) モデルマウスを用いたハンドセラピー施術による神経障害改善効果の解明, 篠内　良介;佐々木　晶子;柴田　佳太;古林　創史;芦野　隆;坂井　信裕;細沼　雅弘;髙木　孝士;辻　まゆみ;野部　浩司;木内　祐二, 第53回日本臨床分子形態学会総会・学術集会, 22 Oct. 2021, Web公開
• SMTP-44Dの抗酸化作用および抗炎症作用を介した糖尿病神経障害に対する作用メカニズムの検討, 篠内　良介;柴田　佳太;城野　詩織;蓮見　惠司;野部　浩司, 第36回日本糖尿病合併症学会・第27回日本糖尿病眼学会総会, 08 Oct. 2021, 大津・LIVE 配信・オンデマンド配信
• 糖尿病神経障害モデルマウスに対する SMTP-44D の作用メカニズムの検討, 篠内　良介;柴田　佳太;城野　詩織;橋本　光正;蓮見　惠司;野部　浩司, 日本薬学会第141年会, 29 Mar. 2021, オンライン開催
• ブラックジンジャー由来ポリメトキシフラボンのCYP3A活性に対する阻害効果, 柏渕　弓佳;西村　有希;岩瀬　万里子;倉田　知光;木内　祐二;野部　浩司, 日本薬学会第141年会, 27 Mar. 2021, オンライン開催
• 糖尿病神経障害モデルマウスに対するSMTP-44Dの抗酸化作用および抗炎症作用を介した作用メカニズムの解明, 篠内　良介;柴田　佳太;城野　詩織;橋本　光正;蓮見　惠司;野部　浩司, 第143回日本薬理学会関東部会, 24 Oct. 2020, オンライン開催
• SMTP-44Dは糖尿病神経障害モデルマウスに対する神経障害を改善する, 篠内　良介;柴田　佳太;城野　詩織;橋本　光正;蓮見　惠司;野部　浩司, 第63回日本糖尿病学会年次学術集会, 05 Oct. 2020, Web開催
• 糖尿病腎症モデルマウスにおけるSMTP-27の腎機能改善効果, 柴田　佳太;安田　英里香;西永　朋加;唐澤　更良;山口　智亮;橋本　光正;蓮見　惠司;野部　浩司, 第63回日本糖尿病学会年次学術集会, 05 Oct. 2020, Web開催
• Evaluation of the antioxidant and anti-inflammatory effects of SMTP-44D against streptozotocin-induced diabetic neuropathy in mice, SHINOUCHI Ryosuke;SHIBATA Keita;JONO Shiori;HASHIMOTO Terumasa;HASUMI Keiji;NOBE Koji, EXPERIMENTAL BIOLOGY 2020, 06 Apr. 2020, San Diego
• Effect of the novel compound SMTP-27 in a mouse model of diabetic kidney disease, SHIBATA Keita;YASUDA Erika;NISHINAGA Tomoka;KARASAWA Sarara;YAMAGUCHI Tomoaki;HASHIMOTO Terumasa;HASUMI Keiji;NOBE Koji, EXPERIMENTAL BIOLOGY 2020, 05 Apr. 2020, San Diego
• SMTP-44Dの糖尿病神経障害モデルマウスに対する有効性の検討, 城野　詩織;篠内　良介;柴田　佳太;橋本　光正;蓮見　惠司;野部　浩司, 日本薬学会第140年会, 27 Mar. 2020, Web公開
• 非アルコール性脂肪肝炎 (NASH) モデルマウスにおける新規 sEH 阻害剤 #27 の効果に関する研究, 山口　智亮;山口　愛理;米沢　朋世;柴田　佳太;橋本　光正;蓮見　惠司;野部　浩司, 日本薬学会第140年会, 26 Mar. 2020, Web公開
• 筋芽細胞C2C12におけるcalcineurin B homologous protein 3の役割, 古林　創史;野部　浩司, 第93回日本薬理学会年会, 16 Mar. 2020, 誌上開催
• SMTP-44D improves diabetic neuropathy in mice, 篠内　良介;柴田　佳太;城野　詩織;橋本　光正;蓮見　惠司;野部　浩司, 第93回日本薬理学会年会, 16 Mar. 2020, 誌上開催
• 糖尿病神経障害モデルマウスにおける SMTP-44D の神経機能改善効果に関する研究, 篠内　良介;柴田　佳太;城野　詩織;橋本　光正;蓮見　惠司;野部　浩司, 次世代を担う創薬・医療薬理シンポジウム2019, 31 Aug. 2019, 東京
• 片腎摘出2型糖尿病モデルマウスにおける腎機能変化に関する研究, 香取　瞳;南川　沙貴;柴田　佳太;野部　浩司, 日本薬学会第139年会, 23 Mar. 2019, 千葉
• 筋芽細胞におけるCHP3の役割, 古林　創史;野部　浩司, 第92回日本薬理学会年会, 16 Mar. 2019, 大阪
• The effect of a bioactive natural product in a mouse model of diabetic neuropathy, 篠内　良介;柴田　佳太;蓮見　惠司;野部　浩司, 第92回日本薬理学会年会, 14 Mar. 2019, 大阪
• 2型糖尿病腎症モデルマウスにおけるDimethyl Resveratrolの腎症改善効果に関する研究, 山口　智亮;柴田　佳太;安田　英里香;木下　翔平;福原　潔;野部　浩司, 次世代を担う創薬・医療薬理シンポジウム2018, 25 Aug. 2018, 福岡
• Calcineurin B homologous protein 3 (CHP3) negatively regulates cardiomyocyte hypertrophy in rat neonatal ventricular cardiomyocytes., KOBAYASHI Soushi;NOBE Koji;WAKABAYASHI Shigeo, 18th World Congress of Basic and Clinical Pharmacology(WCP2018 KYOTO), 03 Jul. 2018, Kyoto
• Evaluation of the effect of a bioactive natural product in a mouse model of acute renal failure, SHIBATA Keita;KINOSHITA Shohei;HASHIMOTO Terumasa;HASUMI Keiji;HONDA Kazuo;NOBE Koji, 18th World Congress of Basic and Clinical Pharmacology(WCP2018), 02 Jul. 2018, Kyoto
• 急性腎不全モデルマウスにおける生理活性天然物の効果の検討, 柴田　佳太;木下　翔平;橋本　光正;蓮見　惠司;本田　一男;野部　浩司, 日本薬学会第138年会, 28 Mar. 2018, 金沢
• II型糖尿病モデルマウスにおけるDimethyl Resveratrolの腎症改善効果の検討, 山口　智亮;安田　英里香;木下　翔平;柴田　佳太;福原　潔;野部　浩司, 日本薬学会第138年会, 28 Mar. 2018, 金沢
• 酢酸誘発慢性腎不全モデルにおよぼすエダラボンの影響, 小関　優太朗;橋本　光正;本田　一男;野部　浩司, 日本薬学会第138年会, 28 Mar. 2018, 金沢
• 酢酸誘発慢性腎不全マウスモデルの確立, 與儀　早和子;橋本　光正;本田　一男;野部　浩司, 第137回日本薬理学会関東部会, 28 Oct. 2017, 東京
• ATPによるウシ大動脈内皮細胞の一酸化窒素産生にはプリン作動性P2X4受容体サブタイプが主に関与する, 清水　祐希;川地　里加;黄　洋一;野部　浩司, 第136回日本薬理学会関東部会, 08 Jul. 2017, 東京
• Vascular functional changes in streptozotocin-induced diabetic and ovariectomized mice, 竹之内　康広;田中　美智子;大竹　一男;野部　浩司;加園　恵三, 第89回日本薬理学会年会, 11 Mar. 2016
• Effect of extracellular glucose enhancement on fibroblast contraction in a wound healing model, 野部　浩司;野部　裕美;竹之内　康広;黄　洋一;橋本　光正;加園　恵三, 第89回日本薬理学会年会, 09 Mar. 2016, 横浜
• Altered gene expression in embolic stroke model with SMTP-7 and t-PA treatment., HASHIMOTO Terumasa;SHIBATA Keita;NOBE Koji;HASUMI Keiji;HONDA Kazuo, Experimental Biology 2012, 21 Apr. 2012, San Diego
• 新規脳梗塞モデルの確立および醗酵代謝物の薬効評価, 橋本　光正;柴田　佳太;野部　浩司;蓮見　惠司;本田　一男, 日本薬学会第132年会, 28 Mar. 2012, 札幌
• Effect of a novel fungal triprenyl phenol metabolite (Cpd-7) on Acetic Acid-induced Embolic Cerebral Infarction Model in Mice., SHIBATA Keita;HASHIMOTO Terumasa;NOBE Koji;HASUMI Keiji;本田　一男, WorldPharma2010 (16th IUPHAR WorldCongress of Basis and Clinical Pharmacology), 17 Jul. 2010, Copenhagen