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Doi Hiroyoshi

■FacultyGastroenterology
■Position
Last Updated :2025/04/01

Researcher

基本情報

Profile and Settings

  • 氏名

    Doi Hiroyoshi

Affiliation

  • Gastroenterology

Location

  • University Hospital

Degree

  • Doctor of Medical Science, Showa University, Dec. 2008

Achievements

Published Papers

  • Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated using a second-generation microbubble contrast medium in ultrasonography: case reports, ARAI Jun;SHIMOZUMA Yuu;OTOYAMA Yumi;SUGIURA Ikuya;NAKAJIMA Yoko;HAYASHI Eiichi;KAJIWARA Atsushi;OMORI Risa;UOZUMI Shojiro;MIYASHITA Miyuki;UCHIKOSHI Manabu;DOI Hiroyoshi;SAKAKI Masashi;WANG Tianpeng;EGUCHI Junichi;ITO Takayoshi;KURIHARA Toshikazu;MUNECHIKA Jiro;GOKAN Takehiko;SAITO K;MIURA Sakiko ;TATE Genshu;TAKIMOTO Masafumi;YOSHIDA Hitoshi, BMC Gastroenterol, 19(1):187, Nov. 2019, Peer-reviewed
  • Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia, DOI Hiroyoshi;HAYASHI Eiichi;ARAI Jun;TOJO Masayuki;MORIKAWA Kenichi;EGUCHI Junichi;ITO Takayoshi;KANTO Tatsuya;KAPLAN David E;YOSHIDA Hitoshi, J Gastroenterol Hepatol, 33(9):1667 - 1676, Sep. 2018, Peer-reviewed
  • Increased expression of immuno-inhibitory molecules on peripheral blood lymphocytes may suppress disease progression in autoimmune hepatitis., HIRAIDE-SASAGAWA Ayako;HIROISHI Kazumasa;SHIMAZAKI Tomoe;EGUCHI Junichi;ISHII Shigeaki;MORIKAWA Kenichi;SAKAKI Masashi;DOI Hiroyoshi;OMORI Risa;KAJIWARA Atsushi;HAYASHI Eiichi;SHIINA Masaaki;HIRAYAMA Yuichi;IMAWARI Michio, Hepatol Res, 45(11):1152 - 1154, Nov. 2015, Peer-reviewed
  • Anti-TIM-3 Antibody Prevents Lymphocyte Apoptosis and Enhances Dendritic Cell Cancer Therapy, HAYASHI Eiichi;EGUCHI Junichi;SAKAKI Masashi;DOI Hiroyoshi;OMORI Risa;KAJIWARA Atsushi;YOSHIDA Hitoshi, Showa Univ J Med Sci, 27(1):1 - 9, Mar. 2015, Peer-reviewed, DOI:10.15369/sujms.27.1
  • Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis, DOI Hiroyoshi;TANOUE Shiroh;kAPLAN David E, Clin Immunol, 150(2):184 - 191, Feb. 2014, Peer-reviewed
  • Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection, ADEYEMO Oluwasayo;DOI Hiroyoshi;RAJENDER REDDY K.;KAPLAN David E., J Viral Hepat, 20(7):453 - 462, Jun. 2013, Peer-reviewed
  • Effects of interferon-α-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors., OMORI Risa;EGUCHI Junichi;HIROISHI Kazumasa;ISHII Shigeaki;HIRAIDE Ayako;SAKAKI Masashi;DOI Hiroyoshi;KAJIWARA Atsushi;ITO Takayoshi;KOGO Mari;IMAWARI Michio, Cancer Gene Ther, 19(9):637 - 643, Sep. 2012, Peer-reviewed
  • Interleukin-4 and CpG oligonucleotide therapy suppresses the outgrowth of tumors by activating tumor-specific Th1-type immune responses., KAJIWARA Atsushi;DOI Hiroyoshi;EGUCHI Junichi;ISHII Shigeaki;HIRAIDE-SASAGAWA Ayako;SAKAI Masashi;OMORI Risa;HIROISHI Kazumasa;IMAWARI Michio, Oncol Rep, 27(6):1765 - 1771, Jun. 2012, Peer-reviewed
  • Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors, OMORI Risa;EGUCHI Junichi;HIROISHI Kazumasa;ISHII Shigeaki;SASAGAWA Ayako;SAKAKI Masashi;DOI Hiroyoshi;KAJIWARA Atsushi;IMAWARI Michio, Showa Univ J Med Sci, 24(2):127 - 137, Jun. 2012, Peer-reviewed, DOI:doi.org/10.15369/sujms.24.127
  • Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27+ B-cell population., DOI Hiroyoshi;IYER Tara K.;CARPENTER Erica;LI Hong;CHANG Kyong-Mi;VONDERHEIDE Robert H.;KAPLAN David E., Hepatology, 55(3):709 - 719, Mar. 2012, Peer-reviewed
  • Strong CD8(+) T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma., HIROISHI Kazumasa;EGUCHI Junichi;BABA Toshiyuki;SHIMAZAKI Tomoe;ISHII Shigeaki;HIRAIDE Ayako;SAKAKI Masashi;DOI Hiroyoshi;UOZUMI Shojiro;OMORI Risa;MATSUMURA Takuya;YANAGAWA Tatsuro;ITO Takayoshi;IMAWARI Michio, J Gastroenterol, 45(4):451 - 458, Apr. 2010, Peer-reviewed

Presentations

  • Enhanced expression of activation-induced cytidine deaminase in memory B cells provokes skewed immu-noglobulin profile in advanced cirrhosis., DOI Hiroyoshi;DAVID E KAPLAN;MORIKAWA Kenichi;EGUCHI Junichi;ITO Takayoshi;KANTO Tatsuya;YOSHIDA Hitoshi, The Liver Meeting 2016, 67th Annual Meeting of the American Association for the Study of Liver Disease, 14 Nov. 2016, Boston
  • インターフェロンフリー療法中、末梢血B細胞内におけるインターフェロン誘導遺伝子の発現動態解析, 荒井　潤;伊藤　敬義;宮下　みゆき;下間　祐;打越　学;林　栄一;梶原　敦;大森　里紗;魚住　祥二郎;土肥　弘義;坂木　理;江口　潤一;野村　憲弘;井上　晴洋;吉田　仁, 第20回日本肝臓学会大会(第24回日本消化器関連学会週間JDDW2016), 03 Nov. 2016, 神戸
  • 慢性肝疾患の高ガンマグロブリン血症における成因と肝障害の影響, 土肥　弘義;林　栄一;荒井　潤;打越　学;森川　賢一;江口　潤一;伊藤　敬義;吉田　仁, 第52回日本肝臓学会総会, 20 May 2016, 千葉
  • HCV感染者に対するIFNフリー療法による免疫異常改善効果の検討, 伊藤　敬義;江口　潤一;野村　憲弘;佐久間　大;佐藤　雅;出口　義雄;打越　学;荒井　潤;下間　祐;土肥　弘義;坂木　理;吉田　仁;井上　晴洋, 第52回日本肝臓学会総会, 20 May 2016, 千葉
  • DCs-based immunotherapy in combination with TIM 3 blockade activate Th-1 type immune responses by enhancing DC., HAYASHI Eiichi;DOI Hiroyoshi;OMORI Risa;KAJIWARA Atsushi;YOSHIDA Hitoshi;ITO Takayoshi;NOMURA Norihiro;INOUE Haruhiro;EGUCHI Junichi, 25th Conference of the Asian Pacific Association for the Study of the Liver, 23 Feb. 2016, Tokyo
  • Predictive factor for therapeutic effects of tolvaptan in patients with refractory ascites., SHIMOZUMA Yuu;ITO Takayoshi;SAKAKI Masashi;UCHIKOSHI Manabu;DOI Hiroyoshi;MIYASHITA Miyuki;UOZUMI Shojiro;ARAI Jun;KAJIWARA Atsushi;HAYASHI Eiichi;YOSHIDA Hitoshi, 25th Conference of the Asian Pacific Association for the Study of the Liver, 23 Feb. 2016, Tokyo
  • Efficacy and mechanism of dendritic cell-based immunotherapy in combination with T cell immunoglobulin and mucin protein 3 blockade in a murine hepatocellular carcinoma model, EGUCHI Junichi;HAYASHI Eiichi;DOI Hiroyoshi;OMORI Risa;KAJIWARA Atsushi;YOSHIDA Hitoshi;ITO Takayoshi;DEGUCHI Yoshio;NOMURA Norihiro;INOUE Haruhiro, The Liver Meeting 2015, 66th Annual Meeting of the American Association for the Study of Liver Diseases, 17 Nov. 2015, San Francisco
  • Toll-like receptor 9 and B-cell activating factor signals induce impaired immunological memory in cirrhosis, DOI Hiroyoshi;KAPLAN David E.;HAYASHI Eiichi;ARAI Jun;OMORI Risa;UCHIKOSHI Manabu;MORIKAWA Kenichi;EGUCHI Junichi;ITO Takayoshi;YOSHIDA Hitoshi, The Liver Meeting 2015, 66th Annual Meeting of the American Association for the Study of Liver Diseases, 16 Nov. 2015, San Francisco
  • 肝硬変における免疫グロブリン異常は、B細胞活性化因子の関与が疑われる, 土肥　弘義;林　栄一;荒井　潤;打越　学;森川　賢一;江口　潤一;伊藤　敬義;吉田　仁, 第19回日本肝臓学会大会(第23回日本消化器関連学会週間JDDW2015), 09 Oct. 2015, 東京
  • C型慢性肝炎におけるシメプレビル、テラプレビル3剤療法、IFNフリー療法中の腎障害および免疫関連マーカー動態の検討, 打越　学;伊藤　敬義;林　栄一;梶原　敦;荒井　潤;大森　里紗;宮下　みゆき;魚住　祥二郎;下間　祐;土肥　弘義;坂木　理;野村　憲弘;江口　潤一;吉田　仁, 第19回日本肝臓学会大会(第23回日本消化器関連学会週間JDDW2015), 08 Oct. 2015, 東京
  • 肝細胞癌に対する抗体療法を併用した樹状細胞療法の検討, 江口　潤一;林　栄一;伊藤　敬義;出口　義雄;三田村　圭太郎;野村　憲弘;佐久間　大;佐藤　雅;保母　貴宏;土肥　弘義;松川　正明;井上　晴洋, 第51回日本肝臓学会総会, 22 May 2015, 熊本
  • C型慢性肝炎におけるバニプレビル、シメプレビル、テラプレビル及びPeg-IFN、リバビリン3剤療法、IFNフリー療法中のHCV動態および有害事象の検討, 打越　学;伊藤　敬義;林　栄一;梶原　敦;荒井　潤;大森　里紗;宮下　みゆき;魚住　祥二郎;下間　祐;土肥　弘義;坂木　理;江口　潤一;吉田　仁, 第51回日本肝臓学会総会, 21 May 2015, 熊本
  • 肝硬変では肝障害の進展に伴いエフェクターメモリーT細胞が障害される, 土肥　弘義;林　栄一;荒井　潤;梶原　敦;大森　里紗;魚住　祥二郎;宮下　みゆき;下間　祐;打越　学;坂木　理;江口　潤一;伊藤　敬義;吉田　仁, 第51回日本肝臓学会総会, 02 May 2015, 熊本
  • 肝硬変における液性免疫異常, 土肥　弘義; 森川　賢一;吉田　仁, 第40回日本肝臓学会東部会　ワークショップ2, 28 Nov. 2014, 東京
  • 肝硬変に合併した門脈血栓症に対してダナパロイドナトリウムによる血栓溶解療法の有効性に関する検討, 魚住　祥二郎;馬場　俊之;坂木　理;梶原　敦;荒井　潤;大森　里紗;下間　祐;土肥　弘義;打越　学;森川　賢一;吉田　仁, 第56回日本消化器病学会大会(第22回日本消化器関連学会週間JDDW2014), 24 Oct. 2014, 神戸
  • TVR3剤併用療法後のC型慢性肝炎SVR患者におけるB細胞HCV、B細胞活性化因子及び免疫グロブリン異常の変化, 打越　学;伊藤　敬義;荒井　潤;下間　祐;宮下　みゆき;坂木　理;土肥　弘義;魚住　祥二郎;大森　理紗;梶原　敦;森川　賢一;江口　潤一;吉田　仁, 第18回日本肝臓学会大会(第22回日本消化器関連学会週間JDDW2014), 23 Oct. 2014, 神戸
  • 当院における肝細胞癌に対するRFA治療後の再発リスク因子についての検討, 梶原　敦;下間　祐;林　栄一;荒井　潤;大森　理沙;宮下　みゆき;魚住　祥二郎;打越　学;土肥　弘義;坂木　理;森川　賢一;江口　潤一;伊藤　敬義;吉田　仁, 第18回日本肝臓学会大会(第22回日本消化器関連学会週間JDDW2014), 23 Oct. 2014, 神戸
  • 肝表病変に対するラジオ波焼灼術の成績と工夫, 下間　祐;伊藤　敬義;江口　潤一;柳川　達郎;森川　賢一;坂木　理;打越　学;土肥　弘義;宮下　みゆき;大森　里紗;荒井　潤;梶原　敦;林　栄一;吉田　仁, 第18回日本肝臓学会大会(第22回日本消化器関連学会週間JDDW2014), 23 Oct. 2014, 神戸
  • バクテリアルトランスロケーションにより増強したToll-like Receptor 4/9シグナルがB細胞を活性化する, 土肥　弘義;吉田　仁, 第50回日本肝臓学会総会, 30 May 2014
  • 肝細胞癌に対する樹状細胞と抗TIM-3抗体を用いた免疫療法の検討, 林　栄一;江口　潤一;坂木　理;土肥　弘義;大森　里紗;梶原　敦;伊藤　敬義;森川　賢一;吉田　仁;石井　成明;広石　和正;井廻　道夫, 第50回日本肝臓学会総会, 30 May 2014, 東京
  • Dendritic cell-based immunotherapy in combination with programmed cell death 1 blockade reduced established tumors by activating Th-1 type immune responses in a murine hepatocellular carcinoma model., HAYASHI Eiichi;EGUCHI Junichi;SAKAKI Masashi;DOI Hiroyoshi;OOMORI Risa;KAJIWARA Atsushi;YOSHIDA Hitoshi;ISHII Shigeaki;HIROISHI Kazumasa;IMAWARI Michio, The 105th Annual Meeting of the American Association for Cancer Research, 07 Apr. 2014, San Diego

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