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Takayama Yasunori

■FacultyPhysiology
■PositionSenior Lecturer
Last Updated :2025/04/01

Researcher

基本情報

Profile and Settings

  • 氏名

    Takayama Yasunori

Affiliation

  • Physiology, Senior Lecturer

Location

  • Hatanodai Campus

Degree

  • Doctor of Science, The Graduate University for Advanced Studies, Mar. 2013

Research Keywords

  • Anoctamin, Pain, TRP channel, Cancer

Achievements

Published Papers

  • Propofol reduces human TRPA1 activity in a warm environment, Chihiro Suda , Yasunori Takayama , Makoto Tominaga , Tomoko Akase, Biochemistry and Biophysics Reports, Mar. 2025, Peer-reviewed, DOI:https://doi.org/10.1016/j.bbrep.2025.101918
  • Senso-immunology: the hidden relationship between sensory system and immune system., Miyamoto Satoshi;Takayama Yasunori;Kondo Takeshi;Maruyama Kenta, Journal of bone and mineral metabolism, Jul. 2024, Peer-reviewed
  • Interaction between TRP channels and anoctamins., Takayama Yasunori;Tominaga Makoto, Cell calcium, 121, May 2024, Peer-reviewed
  • Phosphorylated TRPV1 and ANO1/TMEM16A interaction induced by low concentration of capsaicin or innocuous heat stimulation, Yasunori Takayama, Makoto Tominaga, Pain Research, 39(1):1 - 8, Jan. 2024, Peer-reviewed, DOI:https://doi.org/10.11154/pain.39.1
  • TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes., Yamanoi Yu;Lei Jing;Takayama Yasunori;Hosogi Shigekuni;Marunaka Yoshinori;Tominaga Makoto, Communications biology, 6(1):88, Jan. 2023, Peer-reviewed, DOI:10.1038/s42003-023-04482-1
  • Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia., Sugisawa Erika;Kondo Takeshi;Kumagai Yutaro;Kato Hiroki;Takayama Yasunori;Isohashi Kayako;Shimosegawa Eku;Takemura Naoki;Hayashi Yoshinori;Sasaki Takuya;Martino Mikaël M;Tominaga Makoto;Maruyama Kenta, Cell reports, 38(10):110462, Mar. 2022, Peer-reviewed, DOI:10.1016/j.celrep.2022.110462
  • Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment., Okumo Takayuki;Takayama Yasunori;Maruyama Kenta;Kato Mami;Sunagawa Masataka, Frontiers in immunology, 12, Jan. 2022, Peer-reviewed
  • Kampo Formulae for the Treatment of Neuropathic Pain ∼ Especially the Mechanism of Action of Yokukansan ∼., Sunagawa Masataka;Takayama Yasunori;Kato Mami;Tanaka Midori;Fukuoka Seiya;Okumo Takayuki;Tsukada Mana;Yamaguchi Kojiro, Frontiers in molecular neuroscience, 14, Dec. 2021, Peer-reviewed
  • TMC4 is a novel chloride channel involved in high-concentration salt taste sensation, KASAHARA Yoichi;NARUKAWA Masataka;ISHIMARU Yoshiro;KANDA Shinji;UMATANI Chie;TAKAYAMA Yasunori;TOMINAGA Makoto;OKA Yoshitaka;KONDO Kaori;KONDO Takashi;TAKEUCHI Ayako;MISAKA Takumi;ABE Keiko;ASAKURA Tomiko, J Physiol Sci, 71(1):23, Aug. 2021, Peer-reviewed, DOI:10.1186/s12576-021-00807-z
  • The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin., KATO Mami;TAKAYAMA Yasunori;SUNAGAWA Masataka, Front Pharmacol, 12:628968, Apr. 2021, Peer-reviewed
  • Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine "Yokukansan" in Rats with Acute Inflammatory Pain., AKANUMA Yuko;KATO Mami;TAKAYAMA Yasunori;IKEMOTO Hideshi;ADACHI Naoki;OHASHI Yusuke;YOGI Wakako;OKUMO Takayuki;TSUKADA Mana;SUNAGAWA Masataka, Medicines (Basel), 7(12):75, Dec. 2020, Peer-reviewed
  • Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury., FENG X;TAKAYAMA Yasunori;OHNO N;KANDA H;DAI Y;SOKABE T;TOMINAGA M, Commun Biol, 3(1):716, Nov. 2020, Peer-reviewed
  • Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury., Xiaona Feng; Yasunori Takayama; Nobuhiko Ohno; Hirosato Kanda; Yi Dai; Takaaki Sokabe; Makoto Tominaga, Communications biology, 3(1):716 - 716, Nov. 2020, Peer-reviewed
  • RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis., Erika Sugisawa; Yasunori Takayama; Naoki Takemura; Takeshi Kondo; Shigetsugu Hatakeyama; Yutaro Kumagai; Masataka Sunagawa; Makoto Tominaga; Kenta Maruyama, Cell, 182(3):609 - 624, Aug. 2020, Peer-reviewed
  • Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages, MARUYAMA K;KIDOYA H;TAKEMURA N;SUGISAWA E;TAKEUCHI O;KONDO T;EID MMA;TANAKA H;MARTINO MM;TAKAKURA N;TAKAYAMA Yasunori;AKIRA S;VANDENBON A;KUMAGAI Y, Cell Rep, 32(2):107906, Jul. 2020, Peer-reviewed
  • Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages., Kenta Maruyama; Hiroyasu Kidoya; Naoki Takemura; Erika Sugisawa; Osamu Takeuchi; Takeshi Kondo; Mohammed Mansour Abbas Eid; Hiroki Tanaka; Mikaël M Martino; Nobuyuki Takakura; Yasunori Takayama; Shizuo Akira; Alexis Vandenbon; Yutaro Kumagai, Cell reports, 32(2):107906 - 107906, Jul. 2020, Peer-reviewed
  • カルシウム活性化クロライドチャネルとカルシウム透過性チャネルの相互作用　アノクタミン1とTRPチャネル, 髙山　靖規, 医学のあゆみ, 270(10):1017 - 1022, Sep. 2019
  • Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1, TAKAYAMA Yasunori;DEROUICHE Sandra;MARUYAMA Kenta;TOMINAGA Makoto, Int J Mol Sci, 20(14):E3411, Jul. 2019, Peer-reviewed
  • TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets., Kunihiko Araki; Amane Araki; Daiyu Honda; Takako Izumoto; Atsushi Hashizume; Yasuhiro Hijikata; Shinichiro Yamada; Yohei Iguchi; Akitoshi Hara; Kazuhiro Ikumi; Kaori Kawai; Shinsuke Ishigaki; Yoko Nakamichi; Shin Tsunekawa; Yusuke Seino; Akiko Yamamoto; Yasunori Takayama; Shihomi Hidaka; Makoto Tominaga; Mica Ohara-Imaizumi; Atsushi Suzuki; Hiroshi Ishiguro; Atsushi Enomoto; Mari Yoshida; Hiroshi Arima; Shin-Ichi Muramatsu; Gen Sobue; Masahisa Katsuno, The Journal of clinical investigation, 130(9):3578 - 3593, Jul. 2019, Peer-reviewed
  • Physiological responses of ionotropic histamine receptors, PxHCLA and PxHCLB, to neurotransmitter candidates in a butterfly, Papilio xuthus., Akashi HD; Chen PJ; Akiyama T; Terai Y; Wakakuwa M; Takayama Y; Tominaga M; Arikawa K, The Journal of experimental biology, 221(Pt 21), Oct. 2018, Peer-reviewed
  • The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception., Kenta Maruyama; Yasunori Takayama; Erika Sugisawa; Yu Yamanoi; Takashi Yokawa; Takeshi Kondo; Ken-Ichi Ishibashi; Bikash Ranjan Sahoo; Naoki Takemura; Yuki Mori; Hisashi Kanemaru; Yutaro Kumagai; Mikaël M Martino; Yoshichika Yoshioka; Hisao Nishijo; Hiroki Tanaka; Atsushi Sasaki; Naohito Ohno; Yoichiro Iwakura; Yoshinori Moriyama; Masatoshi Nomura; Shizuo Akira; Makoto Tominaga, iScience, 6:306 - 318, Aug. 2018, Peer-reviewed
  • Hypotonicity-induced cell swelling activates TRPA1, Fumitaka Fujita; Kunitoshi Uchida; Yasunori Takayama; Yoshiro Suzuki; Masayuki Takaishi; Makoto Tominaga, Journal of Physiological Sciences, 68(4):431 - 440, Jul. 2018, Peer-reviewed
  • Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation., Masaki Tsuchiya; Yuji Hara; Masaki Okuda; Karin Itoh; Ryotaro Nishioka; Akifumi Shiomi; Kohjiro Nagao; Masayuki Mori; Yasuo Mori; Junichi Ikenouchi; Ryo Suzuki; Motomu Tanaka; Tomohiko Ohwada; Junken Aoki; Motoi Kanagawa; Tatsushi Toda; Yosuke Nagata; Ryoichi Matsuda; Yasunori Takayama; Makoto Tominaga; Masato Umeda, Nature communications, 9(1):2049 - 2049, May 2018, Peer-reviewed
  • TRPV4 heats up ANO1-dependent exocrine gland fluid secretion., Derouiche S; Takayama Y; Murakami M; Tominaga M, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(4):1841 - 1854, Apr. 2018, Peer-reviewed
  • Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis, Kenta Maruyama; Yasunori Takayama; Takeshi Kondo; Ken-ichi Ishibashi; Bikash Ranjan Sahoo; Hisashi Kanemaru; Yutaro Kumagai; Mikael M. Martino; Hiroki Tanaka; Naohito Ohno; Yoichiro Iwakura; Naoki Takemura; Makoto Tominaga; Shizuo Akira, CELL REPORTS, 19(13):2730 - 2742, Jun. 2017, Peer-reviewed
  • 4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities, Yasunori Takayama; Hidemasa Furue; Makoto Tominaga, SCIENTIFIC REPORTS, 7:43132 - 43132, Feb. 2017, Peer-reviewed
  • Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families, Hiroko Okuda; Atsuko Noguchi; Hatasu Kobayashi; Daiki Kondo; Kouji H. Harada; Shohab Youssefian; Hirotomo Shioi; Risako Kabata; Yuki Domon; Kazufumi Kubota; Yutaka Kitano; Yasunori Takayama; Toshiaki Hitomi; Kousaku Ohno; Yoshiaki Saito; Takeshi Asano; Makoto Tominaga; Tsutomu Takahashi; Akio Koizumi, PLOS ONE, 11(5):e0154827, May 2016, Peer-reviewed
  • TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation, Ayaka Yoshida; Eriko Furube; Tetsuya Mannari; Yasunori Takayama; Hiroki Kittaka; Makoto Tominaga; Seiji Miyata, SCIENTIFIC REPORTS, 6:26088 - 26088, May 2016, Peer-reviewed
  • Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue, Wuping Sun; Kunitoshi Uchida; Yoshiro Suzuki; Yiming Zhou; Minji Kim; Yasunori Takayama; Nobuyuki Takahashi; Tsuyoshi Goto; Shigeo Wakabayashi; Teruo Kawada; Yuko Iwata; Makoto Tominaga, EMBO REPORTS, 17(3):383 - 399, Mar. 2016, Peer-reviewed
  • Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: Dual analysis of behavior and reflex during the micturition cycle, Mitsuharu Yoshiyama; Tsutomu Mochizuki; Hiroshi Nakagomi; Tatsuya Miyamoto; Satoru Kira; Ryoji Mizumachi; Takaaki Sokabe; Yasunori Takayama; Makoto Tominaga; Masayuki Takeda, American Journal of Physiology - Renal Physiology, 308(10):F1128 - F1134, May 2015, Peer-reviewed
  • Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons, Yasunori Takayama; Daisuke Uta; Hidemasa Furue; Makoto Tominaga, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(16):5213 - 5218, Apr. 2015, Peer-reviewed
  • Adipose Hypothermia in Obesity and Its Association with Period Homolog 1, Insulin Sensitivity, and Inflammation in Fat, Masaya Yamaoka; Norikazu Maeda; Yasunori Takayama; Ryohei Sekimoto; Yu Tsushima; Keisuke Matsuda; Takuya Mori; Kana Inoue; Hitoshi Nishizawa; Makoto Tominaga; Tohru Funahashi; Iichiro Shimomura, PLOS ONE, 9(11):e112813, Nov. 2014, Peer-reviewed
  • Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures, Tatsuya Miyamoto; Tsutomu Mochizuki; Hiroshi Nakagomi; Satoru Kira; Masaki Watanabe; Yasunori Takayama; Yoshiro Suzuki; Schuichi Koizumi; Masayuki Takeda; Makoto Tominaga, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(23):16565 - 16575, Jun. 2014, Peer-reviewed
  • Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1, Yasunori Takayama; Koji Shibasaki; Yoshiro Suzuki; Akihiro Yamanaka; Makoto Tominaga, FASEB JOURNAL, 28(5):2238 - 2248, May 2014, Peer-reviewed
  • Quantitative analysis of toxin extracts from various tissues of wild and cultured puffer fish by an electrophysiological method, Keita Sasaki; Yasunori Takayama; Tatsuo Tahara; Kensaku Anraku; Yushi Ito; Norio Akaike, TOXICON, 51(4):606 - 614, Mar. 2008, Peer-reviewed

Presentations

  • Involvement of TRPV1/ANO1 interaction in tharmal pain sensation, Yasunori Takayama, APPW2025, 17 Mar. 2025, Makuhari
  • 大腸癌細胞死を齎す漢方薬の検討, 高山靖規, Chu Zewen, 金田祥明, 伊津野拓司, 丸山健太, 砂川正隆, 第８３回　日本癌学会学術総会, 19 Sep. 2024, 福岡
  • Phosphorylated TRPV1 and anoctamin 1 interaction at body temperature, Yasunori Takayama, Makoto Tominaga, The 45th Annual Meeting of Japanese Association for the Study of Pain, 09 Dec. 2023, 福島
  • プロポフォールの温度変化がヒトTRPA1活性化に及ぼす影響, 藤川千啓, 高山靖規, 富永真琴, 赤瀬智子, 日本薬学会　第143年会, 25 Mar. 2023, 札幌
  • 単一ガラスピペットを用いた機械感受性チャネル電流, 高山靖規, 加藤真未, 丸山健太, 砂川正隆, 第99回　日本生理学会大会, 16 Mar. 2022, 仙台
  • TRPA1 and TMEM16A inhibitions by Estrogen, 加藤　真未;髙山　靖規;砂川　正隆, 第44回日本神経科学大会・第1回CJK国際会議, 29 Jul. 2021, 神戸(ハイブリッド開催)
  • 変形性膝関節症に対する防己黄耆湯の作用機序 ～モデルラットを用いた基礎研究～, 奥茂　敬恭;池本　英志;大池　潤;國枝　裕介;中井　真悟;大橋　祐介;髙山　靖規;安達　直樹;塚田　愛;砂川　正隆, 第33回日本疼痛漢方研究会学術集会, 03 Jul. 2021, 東京+Web開催
  • 漢方処方による鎮痛作用の検討～ラット急性炎症性疼痛モデルを用いた基礎研究～, 砂川　正隆;加藤　真未;髙山　靖規;池本　英志;安達　直樹;大橋　祐介;奥茂　敬恭;山口　孝二郎;塚田　愛;石野　尚吾, 第33回日本疼痛漢方研究会学術集会, 03 Jul. 2021, 東京+Web開催
  • Analgesic Efficacy of the Combination of Fentanyl and the Japanese Herbal Medicine “Yokukansan” in Rats with Acute Inflammatory Pain, AKANUMA Yuko;TAKAYAMA Yasunori;KATO Mami;YOGI Wakako;OHASHI Yusuke;TSUKADA Mana;OKADA Mayumi;OTAKE Koji;SUNAGAWA Masataka, IASP 2020 World Congress on Pain, 27 Jun. 2021, VIRTUAL Congress
  • Functional analyses of ion channels affected by environmental factors, 髙山　靖規, 第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会合同大会, 30 Mar. 2021, Web開催
  • TMEM16A inhibition by a licorice-derived flavonoid and estrogen, 加藤　真未;髙山　靖規;砂川　正隆, 第216回日本解剖学会総会・全国学術集会・第98回日本生理学会大会, 28 Mar. 2021, Web開催
  • フェンタニルと抑肝散との併用療法による鎮痛作用の検討～ラット急性炎症性疼痛モデルを用いて～, 赤沼　裕子;髙山　靖規;加藤　真未;大橋　祐介;大嶽　浩司;砂川　正隆, 日本麻酔科学会第67回学術集会, 04 Jun. 2020, Web開催
  • Possible Mechanisms of Astrocyte Senescence in a Hepatic Encephalopathy Model, 安達　直樹;安藤　美佐子;SAKHRI Fatma Zahra;池本　英志;大橋　祐介;塚田　愛;髙山　靖規;平井　洋平;砂川　正隆, 第97回日本生理学会大会, 19 Mar. 2020, 別府
  • 連銭草抽出物によるアノクタミン1阻害, 髙山　靖規;加藤　真未;塚田　愛;安達　直樹;池本　英志;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • TRPV1-ANO1相互作用におけるショウガを含む漢方薬の効果, 加藤　真未;髙山　靖規;塚田　愛;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • 急性炎症性疼痛モデルラットに対する補完的アプローチの先取り鎮痛効果, 海老原　那智;池本　英志;安達　直樹;海老原　爲博;海老原　加代子;大池　潤;國枝　裕介;髙山　靖規;久光　正;砂川　正隆, 第97回日本生理学会大会, 18 Mar. 2020, 別府
  • オレキシンの分泌に対する鍼治療の影響 —急性ストレス時の検討—, 藤原　亜季;塚田　愛;伊津野　拓司;池本　英志;髙山　靖規;郭　試瑜;劉　延慶;久光　正;砂川　正隆, 第97回日本生理学会大会, 17 Mar. 2020, 別府
  • 加味帰脾湯のオキシトシンを介した抗ストレス作用～その2～, 塚田　愛;池本　英志;安達　直樹;髙山　靖規;奥茂　敬恭;與儀　和香子;加藤　真未;久光　正;砂川　正隆, 第97回日本生理学会大会, 17 Mar. 2020, 別府
  • 加味帰脾湯の抗ストレス作用～オキシトシン関与の検討～, 塚田　愛;池本　英志;李　暁鵬 （中内暁博）;安達　直樹;髙山　靖規;松山　高明;久光　正;砂川　正隆, 日本情動学会第9回大会, 14 Dec. 2019, 東京
  • TRPV1–ANO1 相互作用の炎症性疼痛への関与, 髙山　靖規;富永　真琴, 第41回日本疼痛学会, 12 Jul. 2019, 名古屋
  • 漢方と鍼治療の併用による先取り鎮痛効果の検証 ～抑肝散を用いた基礎研究～, 池本　英志;海老原　那智;山内　里紗;奥茂　敬恭;髙山　靖規;安達　直樹;塚田　愛;石野　尚吾;久光　正;砂川　正隆, 第32回日本疼痛漢方研究会学術集会, 06 Jul. 2019, 東京

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