Takayama Kento

Researcher

基本情報

Profile and Settings

• 氏名

  Takayama Kento

Identifiers

• 研究者番号

  60568559

• ORCID ID

  0009-0009-1578-8324

Affiliation

• Natural Medicine and Therapeutics, Associate Professor

Location

• Hatanodai Campus
• Hatanodai Campus

Degree

• Ph.D., Fukuyama University, Mar. 2017

Research Keywords

• Traditional herbal medicines
• gut microbe
• gut microbial metabolism
• gut immunity
• Rhubarb

Research Areas

• Life Science, Environmental and natural pharmaceutical resources

Committee Memberships

• Aug. 2025

Awards

• Mar. 2022
• Mar. 2025

Achievements

Published Papers

• Occupants and surface types drive microbial dynamics in controlled indoor environments, Jianjian Hou, Makiko Nakajima, Yukiko Nishiuchi, Daisuke Ogura, Atsushi Teramoto, China Kuratomi, Yoko Iwamoto, Yoshiko Okamura, Kazuki Moriguchi, Mateja Dovjak, Kento Takayama, Yusaku Tsugami, So Fujiyoshi , Fumito Maruyama, Environmental Microbiome, Sep. 2025, Peer-reviewed, DOI:https://doi.org/10.1186/s40793-025-00775-6
• Achievements and Future Challenges of Crude Drug "PAEONIAE RADIX" Cultivation in Ibara City, Okayama Prefecture, Masahiro SAKATA; Shigeki HAYASHI; Kento TAKAYAMA; Kiyoshi MORIMOTO; Akira KIKUCHI; Nayu KASHIYAMA; Kouichi NAKAYAMA, Kampo Medicine, 76(2):128 - 139, 2025, Peer-reviewed
• Anti-SARS-CoV-2 Agents in Artemisia Endophytic Fungi and Their Abundance in Artemisia vulgaris Tissue., Shoji Maehara; Shogo Nakajima; Koichi Watashi; Andria Agusta; Misato Kikuchi; Toshiyuki Hata; Kento Takayama, Journal of fungi (Basel, Switzerland), 9(9), Sep. 2023, Peer-reviewed
• Shimanami Leaf Intake Affects Bowel Movement and Intestinal Microbiota in Mice., Sachi Shibata; Kento Takayama; Ken-Ichi Tsurusaki; Shigeyuki Kon, Biological & pharmaceutical bulletin, 46(7):1015 - 1020, 2023, Peer-reviewed
• Anthraquinone-containing compound in rhubarb prevents indole production via functional changes in gut microbiota, Kento Takayama; Shoji Maehara; Norihiko Tabuchi; Nobuyuki Okamura, Journal of Natural Medicines, 75(1):116 - 128, Oct. 2020, Peer-reviewed
• Determination of Short-Chain Fatty Acids in Mouse Feces by High-Performance Liquid Chromatography Using 2-Nitrophenylhydrazine as a Labeling Reagent, Hirofumi Inoue; Kento Takayama; Chiho Takahara; Norihiko Tabuchi; Nobuyuki Okamura; Naoko Narahara; Eijiro Kojima; Yuuko Date; Yasuto Tsuruta, Biological and Pharmaceutical Bulletin, 42(5):845 - 849, May 2019, Peer-reviewed
• Daiokanzoto (Da-Huang-Gan-Cao-Tang) is an effective laxative in gut microbiota associated with constipation, Kento Takayama, Scientific Reports, Feb. 2019, Peer-reviewed
• Demonstration of usefulness of Kampo medicine focuses on the crosstalk between daiokanzoto and intestinal microbiota, 髙山, 健人, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, (36):15 - 36, Dec. 2018
• Rhein 8-O-beta-D-Glucopyranoside Elicited the Purgative Action of Daiokanzoto (Da-Huang-Gan-Cao-Tang), Despite Dysbiosis by Ampicillin, Kento Takayama; Norihiko Tabuchi; Masahito Fukunaga; Nobuyuki Okamura, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39(3):378 - 383, Mar. 2016, Peer-reviewed
• The effect of anthraquinones in daiokanzoto on increasing the synthesis of sennoside A-metabolic enzyme derived from bifidobacteria, Kento Takayama; Tetsuo Morita; Norihiko Tabuchi; Masahito Fukunaga; Nobuyuki Okamura, Journal of Traditional Medicines, 30(5):215 - 220, 2013, Peer-reviewed
• The Influence of Rhein 8-O-beta-D-Glucopyranoside on the Purgative Action of Sennoside A from Rhubarb in Mice, Kento Takayama; Hiroyuki Tsutsumi; Takashi Ishizu; Nobuyuki Okamura, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(12):2204 - 2208, Dec. 2012, Peer-reviewed
• High-Performance Liquid Chromatographic Determination and Metabolic Study of Sennoside A in Daiokanzoto by Mouse Intestinal Bacteria, Kento Takayama; Emi Matsui; Takeshi Kobayashi; Hirofumi Inoue; Yasuto Tsuruta; Nobuyuki Okamura, CHEMICAL & PHARMACEUTICAL BULLETIN, 59(9):1106 - 1109, Sep. 2011, Peer-reviewed
• The Influence of Glycyrrhiza and Antibiotics on the Purgative Action of Sennoside A from Daiokanzoto in Mice, Emi Matsui; Kento Takayama; Eiji Sato; Nobuyuki Okamura, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(9):1438 - 1442, Sep. 2011, Peer-reviewed
• Effect of Goreisan on Diarrhea Model Mouse Induced by Saline Purgative, OKAMURA Nobuyuki;TAKAYAMA Kento;KAITA Tomomi, Kampo Medicine, 60(5):493 - 501, 2009, Peer-reviewed, DOI:10.3937/kampomed.60.493

Presentations

• 西洋薬とひと味違う漢方薬の魅力とそのメカニズム, 髙山 健人, 上田薬剤師会 第554回調剤事例研究会, 17 Sep. 2025, 上田薬剤師会
• どこで見極める？漢方薬の適正使用のポイント －婦人科系症状・更年期症状を中心に－, 髙山 健人, 福山市薬剤師会府中地区ブロック研修会, 2024, 福山市薬剤師会
• これで怖くない！漢方薬の疑義照会とその時の提案処方, 髙山 健人, 三原市薬剤師会学術講演会, 2024, 三原市薬剤師会
• 明日の服薬指導に活かす漢方薬の使い分け－消化器疾患と婦人科系疾患を中心に－, 髙山 健人, 福山市薬剤師会府中地区ブロック研修会, 2024, 福山市薬剤師会
• 漢方薬研究から学んだ共生と共創 －これまでの知見と新たな取組み－, 髙山 健人, 福山漢方談話会, 2023, 株式会社ツムラ
• 妊婦・授乳婦における漢方薬の有用性と注意点, 髙山 健人, 福山市薬剤師会府中地区ブロック研修会, 2022, 福山市薬剤師会
• 漢方薬と腸内細菌叢 －最近の知見－, 髙山 健人, 福山漢方談話会, 2022, 株式会社ツムラ
• 腸内細菌叢は漢方薬の有用性を紐解く端緒となる, 髙山 健人, 腸内微生物叢研究の最前線シリーズ（第9弾）, 2022, ミヤリサン製薬
• 大黄甘草湯が及ぼす腸管免疫応答および腸管バリア機能への影響, 髙山 健人, 福山漢方談話会, 2021, 株式会社ツムラ
• 「大学における漢方研究」－生体のバランスに寄与する腸内細菌叢と漢方薬のクロストークの解明, 髙山 健人, 漢方療法推進会中国四国支部大会, 2019, クラシエ株式会社

Books etc

• 基礎薬学Ⅵ. 生薬学・天然物化学・漢方療法（新スタンダード薬学シリーズ 第３巻）, 著者, Contributor, 東京化学同人, Sep. 2025

Research Projects

• 薬用作物栽培などにおける土壌微生物叢の影響に関する研究, 髙山健人、川添和義, JA晴れの国岡山 井原市薬用作物部会, 昭和医科大学, From 20250613
• 薬用作物栽培などにおける土壌微生物叢の影響に関する研究, 髙山健人, JA晴れの国岡山 井原市薬用作物部会, 協働事業契約, 福山大学, From 20240129, To 20250331
• 腸管免疫応答から紐解く漢方薬と腸内細菌叢のクロストーク, 髙山 健人, Principal investigator, 科学研究費助成事業, 若手研究, From 202104, To 202403
• 腸内細菌叢の変化を介した緩下薬の下剤活性制御に関する研究, 髙山 健人, Principal investigator, 科学研究費補助金, 若手研究, From 201804, To 202003
• 食餌による腸内細菌叢の変化が大黄甘草湯の下剤活性に及ぼす影響, 髙山 健人, Principal investigator, 日本私立学校振興・共済財団, 若手研究者奨励金, From 201804, To 201903