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Ishikawa Fumihiro

■FacultyCenter for Biotechnology
■PositionAssociate Professor
Last Updated :2025/04/01

Researcher

基本情報

Profile and Settings

  • 氏名

    Ishikawa Fumihiro

Affiliation

  • Center for Biotechnology, Associate Professor

Location

  • Collaborative Facilities

Degree

  • Doctor of Pharmaceutical Science, Showa University, Mar. 2008

Achievements

Published Papers

  • Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation., Tomitsuka Yuki;Imaeda Hiroki;Ito Haruka;Asou Isaki;Ohbayashi Masayuki;Ishikawa Fumihiro;Kuwata Hiroshi;Hara Shuntaro, Redox biology, 66:102850 - 102850, Oct. 2023, DOI:10.1016/j.redox.2023.102850
  • Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation., Yuki Tomitsuka; Hiroki Imaeda; Haruka Ito; Isaki Asou; Masayuki Ohbayashi; Fumihiro Ishikawa; Hiroshi Kuwata; Shuntaro Hara, Redox biology, 66:102850 - 102850, Aug. 2023, Peer-reviewed, DOI:10.1016/j.redox.2023.102850
  • An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells., Nakagawa Hidetsugu;Higurashi Masato;Ishikawa Fumihiro;Mori Kazunori;Shibanuma Motoko, Biochemical and biophysical research communications, 649:1 - 9, Mar. 2023
  • Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer., Nishihara Shigetoshi;Yamaoka Toshimitsu;Ishikawa Fumihiro;Higuchi Kensuke;Hasebe Yuki;Manabe Ryo;Kishino Yasunari;Kusumoto Sojiro;Ando Koichi;Kuroda Yusuke;Ohmori Tohru;Sagara Hironori;Yoshida Hitoshi;Tsurutani Junji, Genes, 13(12):2183, Nov. 2022, DOI:10.3390/genes13122183
  • HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA-less cancer cells., Maruyama Tsuyoshi;Saito Koji;Higurashi Masato;Ishikawa Fumihiro;Kohno Yohko;Mori Kazunori;Shibanuma Motoko, Cancer science, 114(1):152 - 163, Sep. 2022, DOI:10.1111/cas.15582
  • Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation., Nishihara Shigetoshi;Yamaoka Toshimitsu;Ishikawa Fumihiro;Ohmori Tohru;Ando Koichi;Kusumoto Sojiro;Kishino Yasunari;Manabe Ryo;Hasebe Yuki;Sagara Hironori;Yoshida Hitoshi;Tsurutani Junji, Cells, 11(14):2201, Jul. 2022, DOI:10.3390/cells11142201
  • Serum cystatin C and CRP are early predictive biomarkers for emergence of hypoxia in COVID-19., Miyata Yoshito;Inoue Hideki;Hirai Kuniaki;Ishikawa Fumihiro;Ohta Shin;Sato Haruna;Mochizuki Kaoru;Ebato Takaya;Mikuni Hatsuko;Kimura Tomoyuki;Fukuda Yosuke;Kishino Yasunari;Homma Tetsuya;Oyamada Hideto;Kusumoto Sojiro;Yamamoto Mayumi;Suzuki Shintaro;Udaka Yuko;Tanaka Akihiko;Ishino Keiko;Kiuchi Yuji;Sagara Hironori, The American journal of the medical sciences, 364(6):706 - 713, Jul. 2022, DOI:10.1016/j.amjms.2022.06.027
  • 新型コロナウイルスに対するPCR検査と大学PCRセンターの役割, 石川 文博;石野 敬子;木内 祐二, ファルマシア, 58(5):425 - 429, May 2022
  • 2. 新型コロナウイルス禍における臨床教育担保のための昭和大学の取組み：大学教員によるPCR 検査とワクチン接種, 石川文博, ファルマシア, 58(5):401 - 403, May 2022
  • Genetic epidemiology using whole genome sequencing and haplotype networks revealed the linkage of SARS-CoV-2 infection in nosocomial outbreak., Ishikawa Fumihiro;Udaka Yuko;Oyamada Hideto;Ishino Keiko;Tokimatsu Issei;Sagara Hironori;Kiuchi Yuji, Infection prevention in practice, 3(4):100190 - 100190, Nov. 2021, Peer-reviewed, DOI:10.1016/j.infpip.2021.100190
  • Rac1-mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss., Mori Kazunori;Higurashi Masato;Ishikawa Fumihiro;Shibanuma Motoko, Cancer science, 112(8):1 - 13, Jun. 2021, Peer-reviewed
  • 新型コロナウイルスと分析化学　医療系大学の基礎系教員の支援により開設した“新型コロナウイルス対応 PCR センター”の活動, 木内　祐二;小山田　英人;石野　敬子;石川　文博;宇髙　結子, ぶんせき, (552):485 - 489, Dec. 2020, Peer-reviewed
  • High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells., Higurashi Masato;Maruyama Tsuyoshi;Nogami Yusuke;Ishikawa Fumihiro;Yoshida Yukiko;Mori Kazunori;Fujita Ken-Ichi;Shibanuma Motoko, Experimental cell research, 389(1):111889 - 111889, Feb. 2020, Peer-reviewed
  • Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages., Kuwata Hiroshi;Nakatani Eriko;Shimbara-Matsubayashi Satoko;Ishikawa Fumihiro;Shibanuma Motoko;Sasaki Yuka;Yoda Emiko;Nakatani Yoshihito;Hara Shuntaro, Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(11):1606 - 1618, Jul. 2019, Peer-reviewed
  • Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil., Sekido Masae;Fujita Ken-Ichi;Kubota Yutaro;Ishida Hiroo;Takahashi Takehiro;Ohkuma Ryotaro;Tsunoda Takuya;Ishikawa Fumihiro;Shibanuma Motoko;Sasaki Yasutsuna, Cancer chemotherapy and pharmacology, 83(6):1127 - 1135, Apr. 2019, Peer-reviewed
  • A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells, MORI Kazunori;UCHIDA Tetsu;YOSHIE Toshihiko;MIZOTE Yuko;ISHIKAWA Fumihiro;KATSUYAMA Masato;SHIBANUMA Motoko, FEBS J, 286(3):459 - 478, Feb. 2019, Peer-reviewed
  • Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer., ITO Hiroaki;YAMAGUCHI Noriko;ONIMARU Manabu;KIMURA Satoshi;OHMORI Tohru;ISHIKAWA Fumihiro;SATO Jun;ITO Shun;INOUE Haruhiro, Oncol Lett, 12(6):4720 - 4726, Dec. 2016, Peer-reviewed
  • Long-term prognostic impact of circulating tumour cells in gastric cancer patients., ITO Hiroaki;SATO Jun;TSUJINO Yukio;YAMAGICHI Noriko;KIMURA Satoshi;GOHDA Keigo;MURAKAMI Katsuhiro;ONIMARU Manabu;OHMORI Tohru;ISHIKAWA Fumihiro;INOUE Haruhiro, World J Gastroenterol, 22(46):10232 - 10241, Dec. 2016, Peer-reviewed
  • Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells., MORI Kazunori;UCHIDA Tetsu;FUKUMURA Motonori;TAMIYA Shigetoshi;HIGURASHI Masato;SAKAI Hirosato;ISHIKAWA Fumihiro;SHIBANUMA Motoko, Cancer Sci, 107(7):963 - 971, Jul. 2016, Peer-reviewed
  • Intracelluar redox and mitochondria regulation by transforming growth factor-beta-its implication in induction of epithelial-mesenchmal transition, SHIBANUMA Motoko;MORI Kazunori;ISHIKAWA Fumihiro, J Cell Signal, 1(1):1000106, Mar. 2016, Peer-reviewed
  • Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling, F. Ishikawa; K. Ushida; K. Mori; M. Shibanuma, CELL DEATH & DISEASE, 6:e1619, Jan. 2015, Peer-reviewed, DOI:10.1038/cddis.2014.583
  • Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: A prospective study, Hiroaki Ito; Haruhiro Inoue; Satoshi Kimura; Tohru Ohmori; Fumihiro Ishikawa; Keigo Gohda; Jun Sato, INTERNATIONAL JOURNAL OF ONCOLOGY, 45(1):227 - 234, Jul. 2014, Peer-reviewed
  • A mitochondrial thioredoxin-sensitive mechanism regulates TGF-beta-mediated gene expression associated with epithelial-mesenchymal transition, Fumihiro Ishikawa; Emi Kaneko; Tadashi Sugimoto; Takahiro Ishijima; Masami Wakamatsu; Aya Yuasa; Ruriko Sampei; Kazunori Mori; Kiyoshi Nose; Motoko Shibanuma, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443(3):821 - 827, Jan. 2014
  • A HIC-5-and KLF4-dependent Mechanism Transactivates p21(Cip1) in Response to Anchorage Loss, Kazunori Mori; Hiroyuki Hamanaka; Yukiko Oshima; Yuri Araki; Fumihiro Ishikawa; Kiyoshi Nose; Motoko Shibanuma, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(46):38854 - 38865, Nov. 2012
  • Critical roles of the cAMP-responsive element-binding protein-mediated pathway in disorganized epithelial phenotypes caused by mitochondrial dysfunction, Motoko Shibanuma; Fumihiro Ishikawa; Masayuki Kobayashi; Kazufumi Katayama; Hiroyuki Miyoshi; Masami Wakamatsu; Kazunori Mori; Kiyoshi Nose, CANCER SCIENCE, 103(10):1803 - 1810, Oct. 2012
  • Importance of mitochondrial dysfunction in oxidative stress response: A comparative study of gene expression profiles, Motoko Shibanuma; Anna Inoue; Kyota Ushida; Tetsu Uchida; Fumihiro Ishikawa; Kazunori Mori; Kiyoshi Nose, FREE RADICAL RESEARCH, 45(6):672 - 680, Jun. 2011
  • Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs, F. Ishikawa; H. Miyoshi; K. Nose; M. Shibanuma, ONCOGENE, 29(6):909 - 919, Feb. 2010
  • Gene Expression Profiling Identifies a Role for CHOP During Inhibition of the Mitochondrial Respiratory Chain, Fumihiro Ishikawa; Takashi Akimoto; Haruka Yamamoto; Yuri Araki; Toshihiko Yoshie; Kazunori Mori; Hidetoshi Hayashi; Kiyoshi Nose; Motoko Shibanuma, JOURNAL OF BIOCHEMISTRY, 146(1):123 - 132, Jul. 2009
  • Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage Dependence of Cell Growth and Survival, Kazunori Mori; Etsuko Hirao; Yosuke Toya; Yukiko Oshima; Fumihiro Ishikawa; Kiyoshi Nose; Motoko Shibanuma, MOLECULAR BIOLOGY OF THE CELL, 20(1):218 - 232, Jan. 2009
  • TGF-beta and Tumor Progression Mediated by Reactive Oxygen Species, Kiyoshi Nose; Tadashi Sugimoto; Masami Wakamatsu; Fumihiro Ishikawa; Motoko Shibanuma, NEW TRENDS IN THE MOLECULAR AND BIOLOGICAL BASIS FOR CLINICAL ONCOLOGY, :81 - 85, 2009
  • Downregulation of hepatocyte nuclear factor-4 alpha and its role in regulation of gene expression by TGF-beta in mammary epithelial cells, Fumihiro Ishikawa; Kiyoshi Nose; Motoko Shibanuma, EXPERIMENTAL CELL RESEARCH, 314(10):2131 - 2140, Jun. 2008
  • Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta 1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death, T. Kanome; N. Itoh; F. Ishikawa; K. Mori; J-R Kim-Kaneyama; K. Nose; M. Shibanuma, ONCOGENE, 26(41):5991 - 6001, Sep. 2007

Presentations

  • 昭和大学病院PCRセンターで実施したSARS-CoV-2学生スクリーニング検査, 石野　敬子;宇髙　結子;岩瀬　万里子;小山田　英人;石川　文博;田中　大介;木内　祐二, 日本薬学会第142年会, 26 Mar. 2022, オンライン開催
  • 大学病院付属PCRセンターにおける新型コロナウイルス検出例の分子疫学解析, 石川　文博;石野　敬子;小山田　英人;宇髙　結子;時松　一成;木内　祐二, 第70回日本感染症学会東日本地方会学術集会・第68回日本化学療法学会東日本支部総会合同学会, 27 Oct. 2021, 東京・Web開催
  • Polycomb-group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells, ISHIKAWA Fumihiro;MORI Kazunori;SHIBANUMA Motoko, 第80回日本癌学会学術総会, 01 Oct. 2021, 横浜・ライブ配信・オンデマンド配信
  • Rac1-mediated and sustained β4 integrin expression supports persistence of reattachment ability in breast cancer cells, 森　一憲;日暮　大渡;石川　文博;柴沼　質子, 第80回日本癌学会学術総会, 01 Oct. 2021, 横浜・ライブ配信・オンデマンド配信
  • Cornification-like differentiation is regulated by Hippo pathway in mammary epithelial cells, 石川　文博;森　一憲;柴沼　質子, 第43回日本分子生物学会年会, 04 Dec. 2020, オンライン開催
  • The impact of mitochondrial complex I activity on p21Cip1 expression: the importance of NAD+ levels, 森　一憲;日暮　大渡;石川　文博;柴沼　質子, 第79回日本癌学会学術総会, 01 Oct. 2020, オンデマンド配信
  • Polycomb group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells, 石川　文博;森　一憲;柴沼　質子, 第42回日本分子生物学会年会, 04 Dec. 2019, 福岡
  • ミトコンドリア呼吸鎖複合体IはNAD+の供給を介してp21Cip1の発現を制御する, 日暮　大渡;森　一憲;石川　文博;柴沼　質子, 第42回日本分子生物学会年会, 03 Dec. 2019, 福岡
  • Deubiquitination by OTUB1 and ATM/ATR signals underlying high expression of FOXM1 in hepatocellular carcinoma cells, HIGURASHI Masato;MARUYAMA Tsuyoshi;ISHIKAWA Fumihiro;MORI Kazunori;SHIBANUMA Motoko, 第78回日本癌学会学術総会, 28 Sep. 2019, 京都
  • Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels, MORI Kazunori;HIGURASHI Masato;ISHIKAWA Fumihiro;SHIBANUMA Motoko, 第78回日本癌学会学術総会, 26 Sep. 2019, 京都
  • ラベプラゾールの併用はカペシタビンと代謝物の体内動態に影響しない, 関戸　匡恵;藤田　健一;久保田　祐太郎;石川　文博;石田　博雄;柴沼　質子;佐々木　康綱, 第17回日本臨床腫瘍学会学術集会, 19 Jul. 2019, 京都
  • ミトコンドリア呼吸鎖複合体I活性によるp21発現と細胞増殖制御, 日暮　大渡;森　一憲;丸山　剛;石川　文博;柴沼　質子, 第41回日本分子生物学会年会, 28 Nov. 2018, 横浜
  • Cornification-like differentiation induced in mammary epithelial cells is mediated by AP-1,NF-KB,and PKA, ISHIKAWA Fumihiro;MORI Kazunori;SHIBANUMA Motoko, 第77回日本癌学会学術総会, 28 Sep. 2018, 大阪
  • Mitochondrial respiratory chain complex I activity has emerged as a potential target for cancer therapy, MORI Kazunori;HIGURASHI Masato;MARUYAMA Tsuyoshi;ISHIKAWA Fumihiro;SHIBANUMA Motoko, 第77回日本癌学会学術総会, 28 Sep. 2018, 大阪
  • ミトコンドリア由来活性酸素種によるE2F1転写機能と細胞増殖制御, 日暮　大渡;石川　文博;森　一憲;柴沼　質子, 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）, 06 Dec. 2017, 神戸
  • Polycomb-group protein SUZ12 inhibits anoikis and promotes breast cancer metastasis, 石川　文博;森　一憲;柴沼　質子, 2017年度生命科学系学会合同年次大会, 06 Dec. 2017, 神戸
  • 肝細胞癌の増殖能維持に重要なFOXM1転写因子の脱ユビキチン化酵素OTUBによる発現制御, 丸山　剛;日暮　大渡;石川　文博;森　一憲;柴沼　質子, 第76回日本癌学会学術総会, 30 Sep. 2017, 横浜
  • Rac1活性によるIntegrinβ4発現制御と細胞再接着能維持機構〜がん転移における意義, 森　一憲;石川　文博;柴沼　質子, 第76回日本癌学会学術総会, 30 Sep. 2017, 横浜
  • The HIC-5-NOX4-mtROS axis regulates metastasis of RAS-activated cancer cells by affecting MMP9 mRNA stability, MORI Kazunori;SHIBANUMA Motoko;UCHIDA Tetsu;YOSHIE Toshihiko;MIZOTE Yuko;ISHIKAWA Fumihiro;KATSUYAMA Masato, EMBO Conference on Redox Biology, 18 Jul. 2017, Moscow-Saint Petersburg
  • The polycomb group protein SUZ12 promotes anchorage-independent survival in breast cancer cells, 石川　文博;森　一憲;柴沼　質子, 第75回日本癌学会学術総会, 08 Oct. 2016, 横浜
  • HMGA2 is a promising antitumor target for hepatocellular carcinoma with low mitochondrial activity, HIGURASHI Masato;SAITO Kohji;KOHNO Yohko;ISHIKAWA Fumihiro;MORI Kazunori;AOKI Takeshi;MURAKAMI Masahiko;TAKIMOTO Masafumi;SHIBANUMA Motoko, 第75回日本癌学会学術総会, 06 Oct. 2016, 横浜
  • HIC-5 acts as a negative regulator for MMP-9 expression by inhibiting NOX4 expression in oncogenic RAS-driven cancers, 森　一憲;石川　文博;柴沼　質子, 第75回日本癌学会学術総会, 06 Oct. 2016, 横浜
  • TRAIL regulates detachment-induced cell death via p38 MAPK activation, 石川　文博;森　一憲;柴沼　質子, BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会), 01 Dec. 2015, 神戸
  • Mitochondrial activity is essential for cancer cell growth in regulating a core cell cycle regulator E2F1 and cyclins, SHIBANUMA Motoko;ISHIKAWA Fumihiro;MORI Kazunori, 第74回日本癌学会学術総会, 10 Oct. 2015, 名古屋
  • A novel role of Rac1 in regulating integrin expression that is critical for the reattachment of cancer cells to ECM., MORI Kazunori;ISHIKAWA Fumihiro;SHIBANUMA Motoko, 第74回日本癌学会学術総会, 09 Oct. 2015, 名古屋
  • TRAIL regulates detachment-induced cell death via p38 MAPK activation, ISHIKAWA Fumihiro;MORI Kazunori;SHIBANUMA Motoko, 第73回 日本癌学会学術総会, 27 Sep. 2014, 横浜
  • HIC-5 regulates TGF-β-stimulated MMP-9 expression, anchorage-independent growth, and metastasis of breast cancer cells., MORI Kazunori;ISHIKAWA Fumihiro;SHIBANUMA Motoko, 第73回日本癌学会学術総会, 26 Sep. 2014, 横浜
  • FAKによる足場依存性増殖制御機構, 森　一憲;石川　文博;柴沼　質子, 第72回日本癌学会学術総会, 05 Oct. 2013, 横浜

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