Oguchi Tatsunori

Researcher

基本情報

Profile and Settings

• 氏名

  Oguchi Tatsunori

Affiliation

• Medical Pharmacology, Professor

Location

• Hatanodai Campus

Degree

• Doctor of Medical Science, Showa University, Mar. 2018

Achievements

Published Papers

• Comparison of Protective Effects of Antidepressants Mediated by Serotonin Receptor in Aβ-Oligomer-Induced Neurotoxicity., Yamamoto Ken;Tsuji Mayumi;Oguchi Tatsunori;Momma Yutaro;Ohashi Hideaki;Ito Naohito;Nohara Tetsuhito;Nakanishi Tatsuya;Ishida Atsushi;Hosonuma Masahiro;Nishikawa Toru;Murakami Hidetomo;Kiuchi Yuji, Biomedicines, 12(6), May 2024, Peer-reviewed
• Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine., Aya Osman; Rebecca S Hofford; Katherine R Meckel; Yesha A Dave; Sharon M Zeldin; Ava L Shipman; Kelsey E Lucerne; Kyle J Trageser; Tatsunori Oguchi; Drew D Kiraly, Scientific reports, 13(1):12223 - 12223, Jul. 2023, Peer-reviewed, DOI:1038/s41598-023-39334-9
• Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis., Kyle J Trageser; Eun-Jeong Yang; Chad Smith; Ruth Iban-Arias; Tatsunori Oguchi; Maria Sebastian-Valverde; Umar Haris Iqbal; Henry Wu; Molly Estill; Md Al Rahim; Urdhva Raval; Francis J Herman; Yong Jie Zhang; Leonard Petrucelli; Giulio Maria Pasinetti, Molecular neurobiology, 60(7):4004 - 4016, Jul. 2023, Peer-reviewed
• Neuroprotective Potential of Raloxifene via G-Protein-Coupled Estrogen Receptors in Aβ-Oligomer-Induced Neuronal Injury., Tetsuhito Nohara; Mayumi Tsuji; Tatsunori Oguchi; Yutaro Momma; Hideaki Ohashi; Miki Nagata; Naohito Ito; Ken Yamamoto; Hidetomo Murakami; Yuji Kiuchi, Biomedicines, 11(8):2135, Jul. 2023, Peer-reviewed, DOI:10.3390/biomedicines11082135
• Structural Dynamics of Amyloid-β Protofibrils and Actions of Anti-Amyloid-β Antibodies as Observed by High-Speed Atomic Force Microscopy., Watanabe-Nakayama Takahiro;Tsuji Mayumi;Umeda Kenichi;Oguchi Tatsunori;Konno Hiroki;Noguchi-Shinohara Moeko;Kiuchi Yuji;Kodera Noriyuki;Teplow David B;Ono Kenjiro, Nano letters, 23(13):6259 - 6268, May 2023, Peer-reviewed, DOI:10.1021/acs.nanolett.3c00187
• The Curcumin Derivative GT863 Protects Cell Membranes in Cytotoxicity by Aβ Oligomers., Momma Yutaro;Tsuji Mayumi;Oguchi Tatsunori;Ohashi Hideaki;Nohara Tetsuhito;Ito Naohito;Yamamoto Ken;Nagata Miki;Kimura Atsushi Michael;Nakamura Shiro;Kiuchi Yuji;Ono Kenjiro, International journal of molecular sciences, 24(4):3089 - 3089, Feb. 2023, Peer-reviewed, DOI:10.3390/ijms24043089
• Exposure to World Trade Center Dust Exacerbates Cognitive Impairment and Evokes a Central and Peripheral Pro-Inflammatory Transcriptional Profile in an Animal Model of Alzheimer's Disease., Ruth Iban-Arias; Kyle J Trageser; Eun-Jeong Yang; Elizabeth Griggs; Aurelian Radu; Sean Naughton; Md Al Rahim; Oguchi Tatsunori; Urdhva Raval; Joshua Palmieri; Zerlina Huang; Lung-Chi Chen; Giulio Maria Pasinetti, Journal of Alzheimer's disease : JAD, 91(2):779 - 794, 2023, Peer-reviewed, DOI:10.3233/JAD-221046
• Combined Treatment with Curcumin and Ferulic Acid Suppressed the Aβ-Induced Neurotoxicity More than Curcumin and Ferulic Acid Alone, Hideaki Ohashi; Mayumi Tsuji; Tatsunori Oguchi; Yutaro Momma; Tetsuhito Nohara; Naohito Ito; Ken Yamamoto; Miki Nagata; Atsushi Michael Kimura; Yuji Kiuchi; Kenjiro Ono, International Journal of Molecular Sciences, 23(17):9685 - 9685, Aug. 2022, Peer-reviewed, DOI:10.3390/ijms23179685
• Protective Effects of the Alga Fucoidan against Amyloid-β-Induced Neurotoxicity in SH-SY5Y Cells, NAGATA Miki;TSUJI Mayumi;OGUCHI Tatsunori;MOMMA Yutaro;NOHARA Tetsuhito;OHASHI Hideaki;ITO Naohito;YAMAMOTO Ken;UDAKA Yuko;SASAKI Akiko;KIUCHI Yuji;NUMAZAWA Satoshi, BPB Reports, 4(6):206 - 213, Dec. 2021, Peer-reviewed
• Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model., Saito Hiroshi;Nakamura Yuya;Inagaki Masahiro;Yamadera Shiho;Misawa Hideo;Sato Naoki;Oguchi Tatsunori;Inagaki Takae;Tsuji Yuya;Tsuji Mayumi;Ohsawa Isao;Gotoh Hiromichi;Kiuchi Yuji, Journal of inflammation research, 14:5681 - 5686, Nov. 2021, Peer-reviewed
• Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria., Kimura Atsushi Michael;Tsuji Mayumi;Yasumoto Taro;Mori Yukiko;Oguchi Tatsunori;Tsuji Yuya;Umino Masakazu;Umino Asami;Nishikawa Toru;Nakamura Shiro;Inoue Tomio;Kiuchi Yuji;Yamada Masahito;Teplow David B;Ono Kenjiro, Free radical biology & medicine, 171:232 - 244, Aug. 2021, Peer-reviewed
• Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy., Yukiko Mori; Mayumi Tsuji; Tatsunori Oguchi; Kensaku Kasuga; Atsushi Kimura; Akinori Futamura; Azusa Sugimoto; Hideyo Kasai; Takeshi Kuroda; Satoshi Yano; Sotaro Hieda; Yuji Kiuchi; Takeshi Ikeuchi; Kenjiro Ono, Frontiers in neurology, 12:653267 - 653267, Mar. 2021, Peer-reviewed
• Linagliptin Inhibits Lipopolysaccharide-Induced Inflammation Concentration-Dependently And -Independently., Naoki Sato; Yuya Nakamura; Shiho Yamadera; Masahiro Inagaki; Sachiyo Kenmotsu; Hiroshi Saito; Tatsunori Oguchi; Mayumi Tsuji; Hirokazu Chokki; Isao Ohsawa; Hiromichi Gotoh; Shinichi Iwai; Yuji Kiuchi, Journal of inflammation research, 12:285 - 291, Oct. 2019, Peer-reviewed
• Linagliptin inhibits lipopolysaccharide-induced inflammation in human U937 monocytes., Shiho Yamadera; Yuya Nakamura; Masahiro Inagaki; Sachiyo Kenmotsu; Tetsuhito Nohara; Naoki Sato; Tatsunori Oguchi; Mayumi Tsuji; Isao Ohsawa; Hiromichi Gotoh; Yoshikazu Goto; Akihiko Yura; Yuji Kiuchi; Shinichi Iwai, Inflammation and regeneration, 38:13 - 13, Aug. 2018, Peer-reviewed
• Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro., Hidenobu Shozawa; Tatsunori Oguchi; Mayumi Tsuji; Satoshi Yano; Yuji Kiuchi; Kenjiro Ono, Neuroscience letters, 677:19 - 25, Jun. 2018, Peer-reviewed
• Propofol Prevents Amyloid-β-Induced Neurotoxicity through Suppression of Cytosolic Ca^2＋ and MAPK Signaling Pathway in SH-SY5Y Cells, ONO Ran;OGUCHI Tatsunori;TSUJI Mayumi;OHASHI Hideaki;GOHMA Takumi;SOMEI Masayuki;INAGAKI Manami;KIUCHI Yuji, The Showa University Journal of Medical Sciences, 30(2):211 - 226, 2018, Peer-reviewed, DOI:10.15369/sujms.30.211
• Cilostazol Suppresses Aβ-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway., Tatsunori Oguchi; Ran Ono; Mayumi Tsuji; Hidenobu Shozawa; Masayuki Somei; Manami Inagaki; Yukiko Mori; Taro Yasumoto; Kenjiro Ono; Yuji Kiuchi, Frontiers in aging neuroscience, 9:337 - 337, Oct. 2017, Peer-reviewed
• Vitamin E-Coated Dialyzer Inhibits Oxidative Stress., Shiho Yamadera; Yuya Nakamura; Masahiro Inagaki; Isao Ohsawa; Hiromichi Gotoh; Yoshikazu Goto; Naoki Sato; Tatsunori Oguchi; Yurika Gomi; Mayumi Tsuji; Yuji Kiuchi; Shinichi Iwai, Blood purification, 44(4):288 - 293, Oct. 2017, Peer-reviewed
• Soy isoflavones inducing overt hypothyroidism in a patient with chronic lymphocytic thyroiditis: a case report., Nakamura Yuya;Ohsawa Isao;Goto Yoshikazu;Tsuji Mayumi;Oguchi Tatsunori;Sato Naoki;Kiuchi Yuji;Fukumura Motonori;Inagaki Masahiro;Gotoh Hiromichi, Journal of medical case reports, 11(1):253 - 253, Sep. 2017, Peer-reviewed
• Leberʼs Hereditary Optic Neuropathy, Futamura Akinori;Oguchi Tatsunori;Saito Yu;Ono Kenjiro, Neuro-Ophthalmology Japan, 34(2):190 - 195, Jun. 2017, DOI:10.11476/shinkeiganka.34.190
• Significance of Cu/Zn-Superoxide Dismutase Levels in Hemodialysis Patients: A Mini Review, Yuya Nakamura; Masahiro Inagaki; Sachiyo Kenmotsu; Shiho Yamadera; Isao Ohsawa; Hiromichi Gotoh; Yoshikazu Goto; Naoki Sato; Tatsunori Oguchi; Mayumi Tsuji; Yuji Kiuchi, Modern Research in Inflammation, 6(2):9 - 13, May 2017, Peer-reviewed
• Combined Neuroprotective Effects of Propofol and Dexmedetomidine on Endoplasmic Reticulum Stress-mediated Apoptosis in SH-SY5Y Cells, SOMEI Masayuki ;INAGAKI Manami ;OGUCHI Tatsunori;ONO Ran ;TSUJI Mayumi;OGUCHI Katsuji, Showa Univ J Med Sci, 28(3):219 - 231, Sep. 2016, Peer-reviewed, DOI:10.15369/sujms.28.219
• Neuroprotective Effects of Dexmedetomidine against Thapsigargin-induced ER-stress via Activity of α2-adrenoceptors and Imidazoline Receptors, INAGAKI Manami;SOMEI Masayuki;OGUCHI Tatsunori;ONO Ran;FUKUTAKA Sachie;MATSUOKA Ikumi;TSUJI Mayumi;OGUCHI Katsuji, AIMS Neurosci, 3(2):237 - 252, Jul. 2016, Peer-reviewed
• Sitagliptin Inhibits the lipopolysaccharide-induced inflammation, HASEGAWA Hitomi;NAKAMURA Yuya;TSUJI Mayumi;ONO Ran;OGUCHI Tatsunori;OGUCHI Katsuji;KIUCHI Yuji;OHSAWA Isao;GOTOH Hiromichi;GOTO Yoshikazu;INAGAKI Masahiro, J Pharm Drug Deliv Res, 5(2):e, Jun. 2016, Peer-reviewed
• Linagliptin inhibits lipopolysaccharide-stimulated interleukin-6 production, intranuclear p65 expression, and p38 mitogen-activated protein kinase phosphorylation in human umbilical vein endothelial cells, NAKAMURA Yuya;HASEGAWA Hitomi;TSUJI Mayumi;OGUCHI Tatsunori;MIHARA Masatomo;SUZUKI Hiroki;NISHIDA Kazumasa;INOUE Michiyasu;SHIMIZU Tatsuo;OHSAWA Isao;GOTOH Hiromichi;GOTO Yoshikazu;INAGAKI Masahiro;OGUCHI Katsuji, Ren Replace Ther, 2:17, May 2016, Peer-reviewed
• Pleiotropic Effects of Linagliptin Monotherapy on Levels of Nitric Oxide, Nitric Oxide Synthase, and Superoxide Dismutase in Hemodialysis Patients with Diabetes , KIMURA Kengo ;NAKAMURA Yuya ;HASEGAWA Hitomi;TSUJI Mayumi;OGUCHI Tatsunori;TSUCHIYA Hiromichi;GOTOH Hiromichi ;GOTO Yoshikazu ;INAGAKI Masahiro;OGUCHI Katsuji, Showa Univ J Med Sci, 28(1):9 - 17, Mar. 2016, Peer-reviewed, DOI:10.15369/sujms.28.9
• Modified Six Elements test: earlier diagnosis of the correlation between motor and executive dysfunction in Parkinson’s disease without dementia., MURAKAMI Hidetomo;OWAN Yoshiyuki;OGUCHI Tatsunori;NOMOTO Shohei;SHOZAWA Hidenobu;KUBOTA Satomi;MORI Yukiko;MIZUMA Keita;FUTAMURA Akinori;KOBAYAKAWA Mutsutaka;KEZUKA Machiko;MIDORIKAWA Akira;MILLER Michael W.;KAWAMURA Mitsuru, Neurol Clin Neurosci, 3(6):209 - 214, Nov. 2015, Peer-reviewed
• A new method for measuring osteoclast formation by electrical impedance., Haruka Emori; Shinichi Iwai; Kakei Ryu; Hitoshi Amano; Takehiko Sambe; Takahiro Kobayashi; Tatsunori Oguchi; Kiyoshi Ohura; Katsuji Oguchi, Journal of pharmacological sciences, 128(2):87 - 91, Jun. 2015, Peer-reviewed
• 非痙攣性てんかん重積に伴うてんかん性高次脳機能障害を認めた血液透析患者の1例, 小口　達敬;黒田　岳志;大湾　喜行;石垣　征一郎;河村　満, 日本神経救急学会雑誌, 27(3):58 - 62, Jun. 2015, Peer-reviewed
• てんかん　2次性全般化発作とは何ですか?, 小口　達敬;黒田　岳志, Mod Phys, 35(4):417 - 419, Apr. 2015
• 高齢者てんかんに関する検討－認知症や抗てんかん薬との関連を中心に－ , 石垣　征一郎;四郎丸　あずさ;野元　祥平;小口　達敬;森　友紀子;水間　啓太;二村　明徳;黒田　岳志;村上　秀友;河村　満, 昭和学士会雑誌, 75(2):222 - 226, Apr. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.222
• NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice., Kigawa Yasuyoshi;Miyazaki Takuro;Lei Xiao-Feng;Nakamachi Tomoya;Oguchi Tatsunori;Kim-Kaneyama Joo-ri;Taniyama Matsuo;Tsunawaki Shohko;Shioda Seiji;Miyazaki Akira, Arteriosclerosis, thrombosis, and vascular biology, 34(11):2413 - 2420, Nov. 2014, Peer-reviewed
• カルパインと動脈硬化症, 宮崎 拓郎; 黄川 恵慈; 小口 達敬; 宮崎 章, 昭和大学薬学雑誌, 4(1):27 - 35, Jun. 2013, Peer-reviewed
• Calpain and atherosclerosis., Takuro Miyazaki; Takayuki Koya; Yasuyoshi Kigawa; Tatsunori Oguchi; Xiao-Feng Lei; Joo-ri Kim-Kaneyama; Akira Miyazaki, Journal of atherosclerosis and thrombosis, 20(3):228 - 237, Mar. 2013, Peer-reviewed, DOI:http://doi.org/10.5551/jat.14787

Presentations

• Aβ高分子oligomer誘発性細胞傷害に対する新規治療薬GT863の保護作用, 門馬　佑太郎;辻　まゆみ;小口　達敬;野原　哲人;大橋　英朗;井藤　尚人;山本　謙;永田　未希;中村　史朗;小野　賢二郎;木内　祐二, 第40回日本認知症学会学術集会, 26 Nov. 2021, 東京・LIVE配信・オンデマンド配信
• 血清BDNFのアルツハイマー病のバイオマーカーの可能性, 森　友紀子;辻　まゆみ;小口　達敬;春日　健作;木村　篤史;二村　明徳;杉本　あずさ;笠井　英世;黒田　岳志;矢野　怜;稗田　宗太郎;木内　祐二;池内　健;小野　賢二郎, 第40回日本認知症学会学術集会, 26 Nov. 2021, 東京・LIVE配信・オンデマンド配信
• 藻類であるFucoidanによるアミロイドβ誘発性神経毒性に対する保護作用について, 永田　未希;辻　まゆみ;小口　達敬;門馬　佑太郎;野原　哲人;大橋　英朗;井藤　尚仁;山本　謙;宇髙　結子;佐々木　晶子;木内　祐二;沼澤　聡, 第40回日本認知症学会学術集会, 26 Nov. 2021, 東京・LIVE配信・オンデマンド配信
• クルクミンとフェルラ酸のアミロイドβ凝集および神経細胞傷害への相加的効果, 大橋　英朗;辻　まゆみ;小口　達敬;門馬　佑太郎;野原　哲人;井藤　尚仁;山本　謙;永田　未希;小野　賢二郎;木内　祐二, 第40日本認知症学会学術集会, 26 Nov. 2021, 東京・LIVE配信・オンデマンド配信
• Video imaging of structural dynamics of amyloid β protofibrils, NAKAYAMA Takahiro;TSUJI Mayumi;OGUCHI Tatsunori;ONO Kenjiro, 2021 Alzheimer's Association InternationalConference, 27 Jul. 2021, VIRTUAL
• 抗TLR-4抗体処置下でのLinagliptinの抗炎症作用, 山寺　志保;中村　裕也;稲垣　昌博;稲垣　貴恵;齋藤　拓史;佐藤　直樹;小口　達敬;三澤　英央;辻　勇弥;辻　まゆみ;大澤　勲;後藤　博道;木内　祐二, 第66回日本透析医学会学術集会・総会, 05 Jun. 2021, 横浜・LIVE配信
• 日本人健康成人男性におけるテモカプリルの薬物血中濃度の比較～簡易懸濁法および粉砕による影響の検討～, 町野　英弥;三邉　武彦;倉田　なおみ;原田　努;肥田　典子;龍　家圭;水上　拓也;山崎　太義;諸星　北人;柴田　佳太;村山　信浩;熊木　良太;竹ノ下　祥子;井上　永介;小口　達敬;五位渕　佐紀;池田　藍;中村　明弘;内田　直樹;小林　真一, 日本薬学会第141年会, 27 Mar. 2021, オンライン開催
• 血清BDNF,血清TTRと脳脊髄液irisinとalzheimer疾患重症度との関連性, 森　友紀子;小口　達敬;辻　まゆみ;小野　賢二郎;木内　祐二, 第41回日本臨床薬理学会学術総会, 03 Dec. 2020, 福岡およびWEB開催
• Vitamin B12 may prevent Aβ oligomer-induced neurotoxicity in Alzheimer's Disease, KIMURA Michael Atsushi;TSUJI Mayumi;YASUMOTO Taro;OGUCHI Tatsunori;MORI Yukiko;YANO Satoshi;KINNO Ryuta;NAKAMURA Shiro;INOUE Tomio;TEPLOW David B;KIUCHI Yuji;ONO Kenjiro, Alzheimer's Association International Conference 2020, 26 Jul. 2020, Virtual Event
• Myricetin prevents Aβ oligomers-induced neurotoxicity via cell membrane damage, KIMURA Michael Atsushi;YASUMOTO Taro;MORI Yukiko;OGUCHI Tatsunori;UMINO Asami;NAKAMURA Shiro;INOUE Tomio;YAMADA M;TEPLOW DB;KIUCHI Yuji;TSUJI Mayumi;ONO Kenjiro, The 14th International Conference on Alzheimer's & Parkinson's diseases, 03 Apr. 2020, VIRTUAL MEETING
• Construction and integration of the All-in-One type single double-conditional shRNA expression vectors for spatio-temporal gene and/or cell targeting., 小山田　英人;青　暢子;工藤　芳子;松岡　朋之;岡本　怜子;村山　尚;山澤　徳志子;柿澤　昌;小口　達敬;木村　篤史;安本　太郎;森　友紀子;辻　まゆみ;小口　勝司;木内　祐二, NEURO2019 (第42回日本神経科学大会・第62回日本神経化学会大会), 27 Jul. 2019, 新潟
• Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro, SHOZAWA Hidenobu;OGUCHI Tatsunori;TSUJI Mayumi;YANO Satoshi;KIUCHI Yuji;ONO Kenjiro, The 14th International Conference on Alzheimer's and Parkinson's Diseases, 30 Mar. 2019, Lisbon
• 脳梗塞により下肢近位筋の単麻痺を呈した1例, 大橋　英朗;二村　明徳;三木　綾子;小口　達敬;村上　秀友;小野　賢二郎, 第41回日本神経心理学会学術集会, 12 Oct. 2017, 東京
• 胸部の異常感覚で発症し亜急性に進行する脊髄円錐・馬尾症候群を呈した66歳男性例, 三木　綾子;大橋　英朗;小口　達敬;二村　明徳;岩波　弘明;黒田　岳志;小野　賢二郎, 第221回日本神経学会関東・甲信越地方会, 03 Jun. 2017, 東京
• パーキンソン病発症後初回のドパミン作動薬の投与が認知機能に与える効果, 村上　秀友;大湾　喜行;小口　達敬;野元　祥平;所澤　任修;森　友紀子;齋藤　悠;二村　明徳;黒田　岳志;石垣　征一郎;加藤　大貴;毛束　真知子;河村　満, 第8回パーキンソン病運動障害疾患コングレス, 03 Oct. 2014, 京都