Yoda Emiko

Researcher

基本情報

Profile and Settings

• 氏名

  Yoda Emiko

Affiliation

• Health Chemistry, Senior Lecturer

Location

• Hatanodai Campus

Degree

• Doctor of Pharmaceutical Science, Showa University, Mar. 2008

Awards

• Jun. 2025
• Drug Metabolism and Disposition (DMD), 2020 ASPET Award for Best Manuscript in Drug Metabolism and Disposition, Differential Role of Liver X Receptor (LXR) a and LXRb in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice, Hansmann E., Mennillo E., Yoda E., Verreault M., Barbier O., Chen S., Tukey RH, Apr. 2021

Academic Contributions

• Others
• Others
• Planning etc

Achievements

Published Papers

• Knockdown of iPLA2γ enhances cisplatin-induced apoptosis by increasing ROS-dependent peroxidation of mitochondrial phospholipids in bladder cancer cells., Satoko Nakayama; Emiko Yoda; Saki Yamashita; Yuka Takamatsu; Yasutomo Suzuki; Yukihiro Kondo; Shuntaro Hara, Free radical biology & medicine, 220, May 2024, Peer-reviewed, DOI:10.1016/j.freeradbiomed.2024.05.016
• Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock., Hiroshi Kuwata; Eriko Nakatani; Yuki Tomitsuka; Tsubasa Ochiai; Yuka Sasaki; Emiko Yoda; Shuntaro Hara, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(12):e23330, Dec. 2023, Peer-reviewed, DOI:10.1096/fj.202301314R
• Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups., Tetsuya Hirabayashi; Mai Kawaguchi; Sayaka Harada; Misa Mouri; Rina Takamiya; Yoshimi Miki; Hiroyasu Sato; Yoshitaka Taketomi; Kohei Yokoyama; Tetsuyuki Kobayashi; Suzumi M Tokuoka; Yoshihiro Kita; Emiko Yoda; Shuntaro Hara; Kyohei Mikami; Yasumasa Nishito; Norihito Kikuchi; Rieko Nakata; Mari Kaneko; Hiroshi Kiyonari; Kohji Kasahara; Toshiki Aiba; Kazutaka Ikeda; Tomoyoshi Soga; Makoto Kurano; Yutaka Yatomi; Makoto Murakami, Cell reports, 42(2):111940 - 111940, Feb. 2023, Peer-reviewed, DOI:10.1016/j.celrep.2022.111940
• Role of ACSL4 in the chemical-induced cell death in human proximal tubule epithelial HK-2 cells., Hiroshi Kuwata; Yuki Tomitsuka; Emiko Yoda; Shuntaro Hara, Bioscience reports, 42(2):BSR20212433, Feb. 2022, Peer-reviewed, DOI:10.1042/BSR20212433
• Involvement of prostacyclin synthase in high-fat-diet-induced obesity., SASAKI Yuka; KUWATA Hiroshi; AKATSU Moe; YAMAKAWA Yuri; OCHIAI Tsubasa; YODA Emiko; NAKATANI Yoshihito; YOKOYAMA Chieko; HARA Shuntaro, Prostaglandins & other lipid mediators, 153:106523, Dec. 2020, Peer-reviewed
• Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice., Eva Hansmann; Elvira Mennillo; Emiko Yoda; Mélanie Verreault; Olivier Barbier; Shujuan Chen; Robert H Tukey, Drug metabolism and disposition: the biological fate of chemicals, 48(4):255 - 263, Apr. 2020, Peer-reviewed
• Gene Deletion of Calcium-Independent Phospholipase A2γ (iPLA2γ) Suppresses Adipogenic Differentiation of Mouse Embryonic Fibroblasts., Emiko Yoda; Keiko Hachisu; Hiroshi Kuwata; Yoshihito Nakatani; Shuntaro Hara, Biological & pharmaceutical bulletin, 43(9):1375 - 1381, 2020, Peer-reviewed, DOI:10.1248/bpb.b20-00321
• Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages., KUWATA Hiroshi; NAKATANI Eriko; SHIMBARA-MATSUBAYASHI Satoko; ISHIKAWA Fumihiro; SHIBANUMA Motoko; SASAKI Yuka; YODA Emiko; NAKATANI Yoshihito; HARA Shuntaro, Biochim Biophys Acta Mol Cell Biol Lipids, 1864(11):1606 - 1618, Nov. 2019, Peer-reviewed
• Calcium-independent phospholipase A2γ (iPLA2γ) and its roles in cellular functions and diseases., HARA Shuntaro;YODA Emiko;SASAKI Yuka;NAKATANI Yoshihito;KUWATA Hiroshi, Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(6):861 - 868, Nov. 2018, Peer-reviewed
• The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts., KUWATA Hiroshi; YUZURIHARA Chihiro; KINOSHITA Natsumi; TAKI Yuki; IKEGAMI Yuki; WASHIO Sana; HIRAKAWA Yushi; YODA Emiko; AIUCHI Toshihiro; ITABE Hiroyuki; NAKATANI Yoshihito; HARA Shuntaro, The FEBS journal, 285(11):2056 - 2070, Apr. 2018, Peer-reviewed
• Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans, FUJIWARA Ryoichi; YODA Emiko; TUKEY Robert H., Drug Metabolism and Pharmacokinetics, 33(1):9 - 16, Feb. 2018, Peer-reviewed
• Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress., YODA Emiko; PASZEK Miles; KONOPNICKI Camille; FUJIWARA Ryoichi; CHEN Shujuan; TUKEY Robert H., Scientific Reports, 7:46489, Apr. 2017, Peer-reviewed
• Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice., YODA Emiko;RAI Kohmi;OGAWA Mai;TAKAKURA Yuki;KUWATA Hiroshi; SUZUKI Hidenori; NAKATANI Yoshihito; MURAKAMI Makoto;HARA Shuntaro, PLOS ONE, e0109409, Oct. 2014, Peer-reviewed, DOI:10.1371/journal.pone.0109409
• Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts, KUWATA Hiroshi; YOSHIMURA Makiko; SASAKI Yuka; YODA Emiko; NAKATANI Yoshihito; KUDO Ichiro; HARA Shuntaro, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841(1):44 - 53, Jan. 2014, Peer-reviewed
• Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A(2)gamma-deficient mice, YODA Emiko; HACHISU Keiko; TAKETOMI Yoshitaka; YOSHIDA Kotomi; NAKAMURA Masanori; IKEDA Kazutaka; TAGUCHI Ryo; NAKATANI Yoshihito; KUWATA Hiroshi; MURAKAMI Makoto; KUDO Ichiro; HARA Shuntaro, Journal of Lipid Research, 51(10):3003 - 3015, Oct. 2010, Peer-reviewed
• A novel role of group VIB calcium-independent phospholipase A(2) (iPLA(2)gamma) in the inducible expression of group IIA secretory PLA(2) in rat fibroblastic cells, KUWATA Hiroshi; FUJIMOTO Chikako; YODA Emiko; SHINBARA Satoko; NAKATANI Yoshihito; HARA Shuntaro; MURAKAMI Makoto; KUDO Ichiro, Journal of Biological Chemistry, 282(28):20124 - 20132, Jul. 2007, Peer-reviewed, DOI:10.1074/jbc.M611883200
• Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2., MURAKAMI Makoto; MASUDA Seiko; UEDA-SEMMYO Kaori; YODA Emiko; KUWATA Hiroshi; TAKANEZAWA Yasukazu; AOKI Junken; ARAI Hiroyuki; SUMIMOTO Hideki; ISHIKAWA Yukio; ISHII Toshiharu; NAKATANI Yoshihito; KUDO Ichiro, Journal of Biological Chemistry, 280(14):14028 - 41, Apr. 2005, Peer-reviewed, DOI:10.1074/jbc.M413766200

Presentations

• Role of mPGES-1 in irinotecan-induced gastrointestinal toxicity, Emiko Yoda, Shuntaro Hara, 10th European Workshop on Lipid Mediators, 02 Jul. 2026
• 昭和医科大学薬学研究実践プログラム「症例研究実践コース」の構築と方略の実施状況, 小池 佑果、嶋村 弘史、唐沢 浩二、戸村 和希、依田 恵美子、栗原 竜也、縄田 修一、坪谷 綾子、滝 伊織、松本 奈都美、田中 克巳、向後 麻里、原 俊太郎, 日本薬学会第146年会, 27 Mar. 2026
• 卵胞成熟における膜結合型Ca2+非依存性ホスホリパーゼA2γ (iPLA2γ)の機能解析, 依田恵美子、東英里佳、福元稔貴、原俊太郎, 日本薬学会第146年会, 27 Mar. 2026
• 膜結合型プロスタグランジン合成酵素(mPGES-1)のイリノテカン誘発性消化管障害における機能解析, 依田恵美子、松村裕菜、室伏海杜、和田都寿、原俊太郎, 第98回日本生化学会, 03 Nov. 2025
• 抗がん剤イリノテカンによる消化管毒性における膜結合型プロスタグランジンE合成酵素 (mPGES)-1の機能の解明, 松村裕菜、依田恵美子、原俊太郎, 第25回PHシンポジウム, 15 Jun. 2025
• 膜結合型Ca2+非依存性ホスホリパーゼA2γ(iPLA2γ)欠損マウスで認められる雌性生殖異常の解析, 東英里佳、依田恵美子、原俊太郎, 第25回PHシンポジウム, 15 Jun. 2025
• 膜結合型プロスタグランジンE合成酵素-1(mPGES-1)の欠損はイリノテカンによる消化器毒性を悪化させる, 依田恵美子;室伏海杜;和田都寿;奥茂真菜;原俊太郎, 第97回日本生化学会, 07 Nov. 2024
• 膜結合型Ca²⁺非依存性ホスホリパーゼA2g(iPLA2g)欠損マウスで認められる雌性生殖異常の解析, 福元稔貴; 依田恵美子; 原俊太郎, 2024年度　日本生化学会関東支部例会, 15 Jun. 2024
• 膜結合型プロスタグランジンE合成酵素-1(mPGES-1)の欠損はイリノテカンによる消化器毒性を悪化させる, 室伏海杜; 依田恵美子; 原俊太郎, 2024年度　日本生化学会関東支部例会, 15 Jun. 2024
• 長鎖アシル CoA 合成酵素 4(ACSL4)の雌性生殖における機能の解析, 柏木遥香;依田恵美子;桑田浩;原俊太郎, 2024年度　日本生化学会関東支部例会, 15 Jun. 2024, 東京
• Knockdown of Ca2+-independent phospholipase A2γ (iPLA2γ) enhances cisplatin-induced apoptosis by increasing ROS-dependent peroxidation of mitochondrial phospholipids in bladder cancer cells., YODA Emiko;NAKAYAMA Satoko;YAMASHITA Saki;TAKAMATSU Yuka;SUZUKI Yasutomo;KONDO Yukihiro;HARA Shuntaro, 3rd Korea-Japan Lipid Joint Symposium, 21 May 2024
• 長鎖アシルCoA合成酵素4の欠損がリポ多糖により惹起される炎症応答に及ぼす影響, 桑田浩;中谷絵理子;冨塚祐希;落合翔;佐々木由香;依田恵美子;原俊太郎, 日本薬学会第144年会, Mar. 2024
• 膜結合型プロスタグランジンE合成酵素-1 (mPGES-1)の欠損はイリノテカンによる消化器毒性を悪化させる, 依田恵美子;和田都寿;奥茂真菜;川又千明;原俊太郎, 日本薬学会第143年会, 29 Mar. 2023
• 膜結合型Ca2+非依存性ホスホリパーゼA2（iPLA2γ）欠損マウスで認められる雌性生殖異常の解析, 依田恵美子;井上彩音;染野梨紗;原俊太郎, 第95回日本生化学会, 09 Nov. 2022
• メチル水銀による脳内脂質代謝機構への影響, 依田恵美子;向田汐里;原俊太郎, フォーラム2018衛生薬学・環境トキシコロジー, 11 Sep. 2018, 佐世保
• メチル水銀毒性によるリン脂質代謝機構の解析と制御酵素の探索, 依田恵美子, 衛生薬学・環境トキシコロジー第5回フォーラム2018　若手研究者の会, 09 Sep. 2018, 佐世保
• がん細胞におけるVIB型カルシウム非依存性ホスホリパーゼA2γの解析, 依田恵美子;保坂和希子;植木拓哉;原俊太郎, 日本薬学会第138年会, 26 Mar. 2018, 金沢
• Induction of UDP-glucuronosyltransferase 1A1 by phenethyl isothiocyanate, YODA Emiko, International workshop on conjugation 2016, 20 Jun. 2016, Vancouver

Research Projects

• 膜リン脂質代謝を介したメチル水銀の毒性発現機構の解明と新たな毒性軽減法の構築, 依田恵美子, Principal investigator, 公益社団法人　薬学研究奨励財団, 第45回（2024年度）研究助成金, From 20250401, To 20260331
• 雌性生殖を制御する膜リン脂質代謝酵素の機能解析, 依田恵美子, Principal investigator, 文部科学省, From 20230401