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Hayakawa Daichi

■FacultyBiophysical Chemistry
■PositionSenior Lecturer
Last Updated :2025/04/01

Researcher

基本情報

Profile and Settings

  • 氏名

    Hayakawa Daichi

Affiliation

  • Biophysical Chemistry, Senior Lecturer

Location

  • Hatanodai Campus

Degree

  • Doctor of Engineering, Yokohama National University, Mar. 2015

Achievements

Published Papers

  • Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds, Daichi Hayakawa; Nanako Terauchi; Aika Iwasaki; Yurie Watanabe; Hiroaki Gouda, Chemical Physics Letters, :139754 - 139754, Jun. 2022, Peer-reviewed
  • Unpolarizable molecular model describing electron distribution for treating halogen bonds, HAYAKAWA Daichi;WATANABE-ODA Yurie ;GOUDA Hiroaki, Chemical Physics Letters, 779:138824, Sep. 2021, Peer-reviewed, DOI:10.1016/j.cplett.2021.138824
  • Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives, IWAMATSU Chiharu;HAYAKAWA Daichi;KONO Tomomi;HONJO Ayaka;ISHIZAKI Saki;HIRAYAMA Shigeto;GOUDA Hiroaki;FUJII Hideaki, Molecules, 25(17):3792, Aug. 2020, Peer-reviewed
  • A molecular interaction field describing nonconventional intermolecular interactions and its application to protein-ligand interaction prediction, HAYAKAWA Daichi;SAWADA Nahoko;WATANABE Yurie ;GOUDA Hiroaki, J Mol Graph Model, 96:107515, May 2020, Peer-reviewed
  • Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain, TAKASAKI Ichiro;OGASHI Haruna;OKADA Takuya;SHIMODAIRA Ayaka;HAYAKAWA Daichi;WATANABE Ai;MIYATA Atsuro;KURIHARA Takashi;GOUDA Hiroaki;TOYOOKA Naoki, Eur J Med Chem, 186:111902, Jan. 2020, Peer-reviewed
  • Formal Syntheses of (−)-Lepadiformines A, C, and (−)-Fasicularin, TAKASHIMA Katsuki;HAYAKAWA Daichi;GOUDA Hiroaki;TOYOOKA Naoki, J Org Chem, 84(9):5222 - 5229, May 2019, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring, Yamamoto, Naoshi; Ohrui, Sayaka; Okada, Takahiro; Saitoh, Tsuyoshi; Kutsumura, Noriki; Nagumo, Yasuyuki; Irukayama-Tomobe, Yoko; Ogawa, Yasuhiro; Ishikawa, Yukiko; Watanabe, Yurie; Hayakawa, Daichi; Gouda, Hiroaki; Yanagisawa, Masashi; Nagase, Hiroshi, Bioorganic & medicinal chemistry, 27(8):1747 - 1758, Apr. 2019, Peer-reviewed
  • DFT study of the influence of acetyl groups of cellulose acetate on its intrinsic birefringence and wavelength dependence, Daichi Hayakawa; Hiroaki Gouda; Shuichi Hirono; Kazuyoshi Ueda, Carbohydrate Polymers, 207:122 - 130, Mar. 2019, Peer-reviewed
  • In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor, Takasaki, Ichiro; Watanabe, Ai; Yokai, Masafumi; Watanabe, Yurie; Hayakawa, Daichi; Nagashima, Ryota; Fukuchi, Mamoru; Okada, Takuya; Toyooka, Naoki; Miyata, Atsuro; Gouda, Hiroaki; Kurihara, Takashi, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 365(1):1 - 8, Apr. 2018, Peer-reviewed
  • Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase, TAKAHARA Satoyuki;NAKAGAWA Kiyomi;UCHIYAMA Tsugumi;YOSHIDA Tomoyuki;MATSUMOTO Kazunori;KAWASUMI Yasuo;MIZUGUCHI MIneyuki;OBITA Takayuki;WATANABE Yurie ;HAYAKAWA Daichi;GOUDA Hiroaki;MORI Hisashi;TOYOOKA Naoki, Bioorg Med Chem Lett, 28(3):441 - 445, Feb. 2018, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity, Sayaka Ohrui; Naoshi Yamamoto; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, Bioorganic and Medicinal Chemistry Letters, 28(4):774 - 777, Feb. 2018, Peer-reviewed
  • Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor, Naoshi Yamamoto; Sayaka Ohrui; Takahiro Okada; Masahiro Yata; Tsuyoshi Saitoh; Noriki Kutsumura; Yasuyuki Nagumo; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Yurie Watanabe; Daichi Hayakawa; Hiroaki Gouda; Masashi Yanagisawa; Hiroshi Nagase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(17):4176 - 4179, Sep. 2017, Peer-reviewed
  • Evaluation of hydrogen bond networks in cellulose Iβ and II crystals using density functional theory and Car-Parrinello molecular dynamics, HAYAKAWA Daichi;NISHIYAMA Yoshiharu;MAZEAU Karim;UEDA Kazuyoshi, Carbohydr Res, 449:103 - 113, Sep. 2017, Peer-reviewed
  • In silico analyses of the effects of a point mutation and a pharmacological chaperone on the thermal fluctuation of phenylalanine hydroxylase, HAYAKAWA Daichi;YAMAOTSU Noriyuki;NAKAGOME Izumi;OZAWA Shin-ichiro;YOSHIDA Tomoki ;HIRONO Shuichi, Biophys Chem, 228:47 - 54, Sep. 2017, Peer-reviewed
  • Multi-step virtual screening to develop selective DYRK1A inhibitors, Tomoko Koyama; Noriyuki Yamaotsu; Izumi Nakagome; Shin-ichiro Ozawa; Tomoki Yoshida; Daichi Hayakawa; Shuichi Hirono, JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 72:229 - 239, Mar. 2017, Peer-reviewed
  • Ab initio studies on the structure of and atomic interactions in cellulose IIII crystals, Tetsuya Ishikawa; Daichi Hayakawa; Hitomi Miyamoto; Motoyasu Ozawa; Tomonaga Ozawa; Kazuyoshi Ueda, CARBOHYDRATE RESEARCH, 417:72 - 77, Nov. 2015, Peer-reviewed
  • Computational study to evaluate the birefringence of uniaxially oriented film of cellulose triacetate, Daichi Hayakawa; Kazuyoshi Ueda, CARBOHYDRATE RESEARCH, 402:146 - 151, Jan. 2015, Peer-reviewed
  • Structure and the interactions in the crystal structure of cellulose IIII calculated by using ab initio molecular dynamics simulation, Ueda K; Ishikawa T; Miyamoto H; Hayakawa D, NSTI: Advanced Materials - TechConnect Briefs 2015, 1:95 - 98, 2015
  • Molecular dynamics simulation of dissociation behavior of various crystalline celluloses treated with hot-compressed water, Hitomi Miyamoto; Rosnah Abdullah; Hayato Tokimura; Daichi Hayakawa; Kazuyoshi Ueda; Shiro Saka, CELLULOSE, 21(5):3203 - 3215, Oct. 2014, Peer-reviewed
  • Investigation of the structure and interaction of cellulose triacetate I crystal using ab initio calculations, Takanori Kobayashi; Daichi Hayakawa; Tegshjargal Khishigjargal; Kazuyoshi Ueda, CARBOHYDRATE RESEARCH, 388(1):61 - 66, Mar. 2014, Peer-reviewed
  • Ab initio studies of the structure and the interaction of cellulose III<inf>I</inf> crystal, Kazuyoshi Ueda; Tetsuya Ishikawa; Hitomi Miyamoto; Daichi Hayakawa, Materials Research Society Symposium Proceedings, 1554, 2013, Peer-reviewed
  • Computational study of optical properties of cellulose triacetate film, Daichi Hayakawa; Kazuyoshi Ueda, Materials Research Society Symposium Proceedings, 1524:10 - 16, 2013, Peer-reviewed
  • Folded-chain structure of cellulose II suggested by molecular dynamics simulation, Chihiro Yamane; Hitomi Miyamoto; Daichi Hayakawa; Kazuyoshi Ueda, Carbohydrate Research, 379:30 - 37, 2013, Peer-reviewed
  • Ab initio studies of the crystal structure of cellulose triacetate I, Takanori Kobayashi; Daichi Hayakawa; Tegshjargal Khishigjargal; Kazuyoshi Ueda, Materials Research Society Symposium Proceedings, 1470:21 - 26, 2012, Peer-reviewed
  • Molecular dynamics simulation of the dissolution process of a cellulose triacetate-II nano-sized crystal in DMSO, Daichi Hayakawa; Kazuyoshi Ueda; Chihiro Yamane; Hitomi Miyamoto; Fumitaka Horii, CARBOHYDRATE RESEARCH, 346(18):2940 - 2947, Dec. 2011, Peer-reviewed

Presentations

  • 物理化学的特性を表す特性球に基づいたHLA-抗原ペプチド相互作用のデータベース構築と解析, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会141年会, 28 Mar. 2021, オンライン開催
  • 高精度タンパク質-リガンド相互作用解析を目指したprobe-based QM modeling法の考案と検証, 早川　大地;渡邉　友里江;合田　浩明, 第47回構造活性相関シンポジウム, 13 Dec. 2019, 熊本
  • タンパク質-リガンド相互作用解析のためのprobe-based QM modeling 法, 早川　大地;合田　浩明, 第63回日本薬学会関東支部大会, 14 Sep. 2019, 東京
  • Non-conventional相互作用を記述可能な分子相互作用場計算法の構築とタンパク質-リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第139年会, 22 Mar. 2019, 千葉
  • 量子化学計算とプローブ分子に基づいた分子相互作用場の算出とタンパク質−リガンド相互作用解析への応用, 早川　大地;渡邉　友里江;合田　浩明, 第46回構造活性相関シンポジウム, 04 Dec. 2018, 大阪
  • セルロースアセテートのアセチル基が 固有複屈折へ及ぼす影響の計算化学による検討, 早川　大地;合田　浩明;上田　一義, セルロース学会第25回年次大会, 05 Jul. 2018, 宇治
  • ハロゲン結合や弱い水素結合を記述可能な分子相互作用場計算法の構築, 早川　大地;渡邉　友里江;合田　浩明, 日本薬学会第138年会, 27 Mar. 2018, 金沢
  • 分子動力学計算を用いたアルドケト還元酵素AKR1C3のC154Y及びL159V変異体の溶液構造解析, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 日本薬学会第138年会, 27 Mar. 2018, 金沢
  • Structural analysis of aldo-keto reductase 1C3 and its C154Y mutant using molecular dynamics simulation, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第45回構造活性相関シンポジウム, 29 Nov. 2017, 土浦
  • Molecular dynamics study for C154Y mutant of aldo-keto reductase 1C3, 渡邉　友里江;早川　大地;遠藤　智史;合田　浩明, 第40回ケモインフォマティクス討論会, 26 Oct. 2017, 宇部

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