Iwase Mariko

Researcher

基本情報

Profile and Settings

• 氏名

  Iwase Mariko

Affiliation

• Research Administration Center, Senior Lecturer

Location

• SHOWA Medical University

Degree

• Doctor of Medical Science, Showa University, Feb. 2007

Research Areas

• Life Science, Pharmacology

Achievements

Published Papers

• Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence, Shinya Koichiro;Nishimura Yuki;Ryu Kakei;Sambe Takehiko;Fujishiro Masaya;Nakauchi Akihiro;Kashiwabuchi Yumika;Iwase Mariko;Chokki Hirokazu;Kurata Norimitsu;Matsuyama Takaaki;Kiuchi Yuji, International journal of dermatology, 62(5):694 - 699, May 2023, Peer-reviewed, DOI:10.1111/ijd.16303
• Lack of inhibitory effect of wood creosote on cytochrome P450‐mediated drug metabolism, Hirokazu Chokki; Yuki Nishimura; Mariko Iwase; Norimitsu Kurata; Koichiro Shinya; Mayumi Tsuji; Masafumi Ito; Mutsumi Asai; Hirofumi Morino; Takanori Miura; Takashi Shibata; Yuji Kiuchi, Traditional & Kampo Medicine, 9(1):3 - 9, Apr. 2022, Peer-reviewed
• Inhibition of CYP3A-mediated Midazolam Metabolism by Kaempferia Parviflora., Yumika Kashiwabuchi; Yuki Nishimura; Norimitsu Kurata; Mariko Iwase; Yuji Kiuchi; Koji Nobe, Food Safety, 10(1):32 - 41, 2022, Peer-reviewed
• Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38, IWASE Mariko;FUJITA Ken-ichi;NISHIMURA Yuki;SEBA Natsumi;MASUO Yusuke;ISHIDA Hiroo;KATO Yukio;KIUCHI Yuji, Cancer chemotherapy and pharmacology, 83(5):993 - 998, May 2019, Peer-reviewed, DOI:10.1007/s00280-019-03784-8
• Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism, GOMI Yurika;NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;SHINYA Koichiro;KIUCHI Yuji, The Showa University Journal of Medical Sciences, 31(1):29 - 39, Mar. 2019, Peer-reviewed, DOI:10.15369/sujms.31.29
• Effect of benifuuki tea on cytochrome P450-mediated metabolic activity in rats, Takahito Hirai; Yuki Nishimura; Norimitsu Kurata; Hokuto Namba; Mariko Iwase; Yurika Gomi; Hiromichi Tsuchiya; Tomoyuki Yamakawa; Yuji Kiuchi, In Vivo, 32(1):33 - 40, Jan. 2018, Peer-reviewed
• Inhibitory Effects of Gastrointestinal Drugs on CYP Activities in Human Liver Microsomes, Iwase Mariko;Nishimura Yuki;Kurata Norimitsu;Namba Hokuto;Hirai Takahito;Kiuchi Yuji, Biological and Pharmaceutical Bulletin, 40(10):1654 - 1660, Oct. 2017, Peer-reviewed, DOI:10.1248/bpb.b17-00118
• Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats, Namba Hokuto;Nishimura Yuki;Kurata Norimitsu;Iwase Mariko;Hirai Takahito;Kiuchi Yuji, Biological and Pharmaceutical Bulletin, 40(9):1361 - 1365, Sep. 2017, Peer-reviewed, DOI:10.1248/bpb.b16-01016
• OBJECTIVE AND SUBJECTIVE EVALUATIONS TO DETERMINE THE MIDAZOLAM OPTIMAL DOSE IN THE DENTAL TREATMENT, KONDO Keisuke; IKEDA Miyuki; SAMBE Takehiko; UCHIDA Naoki; IWASE Mariko; NISHIMURA Yuki; MANABE Atsuhumi; RYU Kakei; KOBAYASHI Shinichi; INADA Yoko, Journal of The Showa University Society, 75(6):665 - 674, Dec. 2015, Peer-reviewed, DOI:10.14930/jshowaunivsoc.75.665
• 医薬品添付文書における使用上の注意の記載要領に関する研究　「臨床検査結果に及ぼす影響」，「過量投与」，「臨床成績」，「その他の注意」, 川上　明三;岩瀬　万里子;安原　一;村山　純一郎, 臨床薬理, 44(6):451 - 458, Jul. 2013, Peer-reviewed
• INHIBITION OF CYP3A4-MEDIATED MIDAZOLAM METABOLISM BY REPEAT ORAL ADMINISTRATION OF ANCHUSAN IN HUMANS, TOSHIMA Hirokazu; HIROSAWA Makiko; KOBAYASHI Shinichi; SANBE Takehiko; KIZAKI Junichiro; OGUCHI Katsuji; UCHIDA Naoki; NISHIMURA Yuki; IWASE Mariko; HARIMOTO Yoshie; KAWAKAMI Momoko, Journal of The Showa University Society, 73(2):120 - 128, Apr. 2013, Peer-reviewed, DOI:10.14930/jshowaunivsoc.73.120
• EFFECT OF THE SHORT-TERM ANCHUSAN TREATMENT ON CYP3A4-MEDIATED MIDAZOLAM METABOLISM IN HEALTHY SUBJECTS, SAMBE Takehiko; HARIMOTO Yoshie; KAWAKAMI Momoko; KOBAYASHI Shinichi; TOSHIMA Hirokazu; RYU Kakei; KOBAYASHI Yoshito; KONDO Yasuyuki; OGUCHI Katsuji; NISHIMURA Yuki; UCHIDA Naoki; IWASE Mariko, Journal of The Showa University Society, 73(2):67 - 75, Apr. 2013, Peer-reviewed, DOI:10.14930/jshowaunivsoc.73.67
• In vivo inhibition of CYP3A-mediated midazolam metabolism by anchusan in rats．, Saito Y, Nishimura Y, Kurata N, Iwase M, Aoki K, Yasuhara H, J Pharmacol Sci., 115(3):399 - 407, 2011, Peer-reviewed
• Opsoclonus caused by diphenhydramine self-poisoning., Irioka T, A Yamanami, N Uchida, M Iwase, H Yasuhara, H Mizusawa, J Neuro-Ophthalmol., 29(1):72 - 73, 2009, Peer-reviewed
• Effects of continuous injection of herbal teas on intestinal CYP3A in the rat., Matsuda K, Y Nishimura, N Kurata, M Iwase, H Yasuhara., J Pharmacol Sci., 103(214):221 - 2007, 2007, Peer-reviewed
• CYP2C19活性および遺伝子変異と肝臓癌病態の関連　, 政本多美子，西村有希，岩瀬万里子，安原　一，倉田知光, 昭和医会誌, 67(6):460 - 468, 2007, Peer-reviewed
• Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro, M. Iwase; N. Kurata; R. Ehana; Y. Nishimura; T. Masamoto; H. Yasuhara, HUMAN & EXPERIMENTAL TOXICOLOGY, 25(12):715 - 721, Dec. 2006, Peer-reviewed
• A clinical pharmacological study to evaluate the sedative effects of the antihistaminic drug, diphenhydramine hydrochloride (Drewell) : objective evaluation of the sedative effects by analysis of saccadic eye movement., Nagai T, N Uchida, M Iwase, K Yasuda, Li H, K Kurosawa, H Hirashima, S Ishigaki, K Matsuda, H Yasuhara., Jpn J Clin Pharmacol Ther., 37(1):55 - 64, 2006, Peer-reviewed
• Inhibitory effect of amoxapine on cytochrome P450 enzyme activity in human liver microsome., Sakurai E, M Iwase, N Kurata, T Nagai , H Hirashima, H Yasuhara., Showa Univ J Med Sci., 6(4):329 - 338, 2004, Peer-reviewed
• The inhibitory effects of anticancer drug cyclophosphamide, etoposide and vincristine on CYP2C19-mediated S-mephenytoin 4’-hydroxylation in human liver microsomes., Li H, N Kurata, Y Nishimura, M Iwase, E Uchida, H Yasuhara., Showa Univ J Med.Sci., 14(3):207 - 214, 2002, Peer-reviewed
• The effects of organic solvents on trimethadione N-demethylation in rats., Nishimura Y, K Kurata, M Iwase, H Li, H Yasuhara., Res Commun Mol Path Pharmacol, 104(2):229 - 329, 2000, Peer-reviewed
• Mechanism of alteration of the hepatic and small intestinal drug metabolizing enzymes in adenine-induced renal failure in rats., Watanabe M, N Kurata, Y Nishimura, H Li, N Uchida, M Iwase, E Uchida, H Yasuhara., Res Commun Pharmacol Toxicol., 4(1&2):1 - 16, 1999, Peer-reviewed
• Trimethadione metabolism by human liver cytochrome P450 : evidence for the involvement of CYP2E1., Kurata N, Y Nishimura, M Iwase, NE Fischer, BK Tang, T Inaba, H Yasuhara., Xenobiotica, 11:1041 - 1047, 1998, Peer-reviewed
• Effect of adenine-induced renal failure on hepatic microsomal drug-metabolizing enzymes in rats., Hashimoto M, N Kurata, Y Nishimura, M Iwase, N Uchida, M Watanabe, E Uchida, H Yasuhara., Showa Univ J Med Sci., 9(1):67 - 75, 1997, Peer-reviewed
• Ex vivo and in vivo effects of fluconazole and miconazole on trimethadione metabolism in rats., Shimada K, N Kurata, N Uchida, Y Nishimura, M Iwase, Y Takano, E Uchida, H Yasuhara., Asia Pacific Journal of Pharmacology, 11:63 - 73, 1996, Peer-reviewed
• Pharmacokinetic study of trimethadione and its metabolite in blood, liver and brain by microdialysis in conscious, unrestrained rats, N. Kurata; M. Inagaki; M. Iwase; Y. Nishimura; Y. Kiuchi; Y. Yamazaki; S. Kobayashi; K. Oguchi; E. Uchida; H. Yasuhara, Research Communications in Molecular Pathology and Pharmacology, 89(1):45 - 56, 1995, Peer-reviewed

Presentations

• 昭和大学附属病院におけるSARS-CoV-2 変異株同定による感染対策の評価, 石野敬子、岩瀬万里子 、宇高結子、 時松一成、木内祐二、石川文博、小山田英人, 第98回日本感染症学会学術講演会, 28 Jun. 2024, 神戸
• 昭和大学附属病院におけるSARS-CoV-2変異株の経時的変化, 石野 敬子、岩瀬 万里子、石川 文博、宇高 結子、小山田 英人、木内 祐二, 日本薬学会第144年会, 30 Mar. 2024, 横浜
• 木クレオソート製剤のチトクロームP450阻害を介する薬物相互作用の検討, 西村 有希;岩瀬 万里子;倉田 知光;一寸木 宏和;新屋 光一朗;柏渕 弓佳;辻 まゆみ;伊藤 雅文;浅井 睦;平野 広諭;三浦 孝典;柴田 高;木内 祐二, 第40回和漢医薬学会学術大会, 26 Aug. 2023, 富山
• 日本人健康成人男性におけるブラックジンジャー反復投与時のCYP3A4を介するミダゾラム代謝に及ぼす影響, 三邉　武彦;諸星　北人;西村　有希;龍　家圭;肥田　典子;山崎　太義;岩瀬　万里子;倉田　知光;五味　由梨佳;木内　祐二;小林　真一;内田　直樹, 第40回日本臨床薬理学会学術総会, 04 Dec. 2019, 東京
• Inhibitory effects of black ginger extract on CYP3A-mediated midazolam metabolism., NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;GOMI Yurika;KASHIWABUCHI Yumika;KIUCHI Yuji, 2018 International Meeteing on 22nd MDO and 33rd JSSX, 02 Oct. 2018, Kanazawa
• Inhibitory effect of Polypodium leucotomos extract on CYP3A-mediated midazolam metabolism, GOMI Yurika;NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;KIUCHI Yuji, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 03 Jul. 2018, Kyoto
• Effect of Benifuuki tea on cytochrome P450s in rats., 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第89回日本薬理学会年会, 10 Mar. 2016, 神奈川
• Effect of Benifuuki tea on cytochrome P450s in rats., 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第89回日本薬理学会年会, 10 Mar. 2016, 神奈川
• べにふうき茶反復投与のラットチトクロームP450に対する影響, 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第36回日本臨床薬理学会学術総会, 11 Dec. 2015, 東京
• べにふうき茶反復投与のラットチトクロームP450に対する影響, 平井隆仁，西村有希，倉田知光，難波北人，岩瀬万里子， 小口勝司．, 第36回日本臨床薬理学会学術総会, 11 Dec. 2015, 東京
• Assessment of potential factors related to low CYP2C19 activity in liver cancer patients, NISHIMURA Yuki;KURATA Norimitsu;IWASE Mariko;YASUHARA Rika;YASUHARA Hajime;KOBAYASHI Yasuna;YAMAMOTO Toshinori;AOKI Takeshi;MURAKAMI Masahiko;SAITO Koji;KOBAYASHI Shinichi;OGUCHI Katsuji, 19th North American ISSX Meeting and 29th JSSX Meeting, 20 Oct. 2014, San Francisco
• The inhibitory effects of gastrointestinal and respiratory drugs on human hepatic microsomal cytochrome P450 activities., Iwase M, Nishimura Y, Kurata N, Tsukurimichi A, Oguchi K, 19th North America ISSX and 29th JSSX meeting, 19 Oct. 2014, San Francisco
• Drug-drug interaction with OTC drugs ～The inhibitory effect of NSAIDs and cough suppressants on CYP activities., IWASE Mariko;NISHIMURA Yuki;KURATA Norimitsu;UCHIDA Naoki;KOBAYASHI Shinichi, 6th European Congress of Pharmacology, 17 Jul. 2012, Granada