Intranasal Immunization with Nasal Immuno-Inducible Sequence-Fused Antigens Elicits Antigen-Specific Antibody Production., Sasaki Hiraku;Suzuki Yoshio;Morimoto Kodai;Takeda Kazuyoshi;Uchida Koichiro;Iyoda Masayuki;Ishikawa Hiroki, International journal of molecular sciences, 25(23), Nov. 2024, Peer-reviewed
Group2 innate lymphoid cells ameliorate renal fibrosis and dysfunction associated with adenine-induced CKD., Nagashima Ryuichi;Ishikawa Hiroki;Kuno Yoshihiro;Kohda Chikara;Eshima Koji;Iyoda Masayuki, Cellular immunology, 401-402, May 2024, Peer-reviewed
In vitro investigation of the effects of Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 exopolysaccharides on tight junction damage caused by influenza virus infection., Ishikawa Hiroki;Kuno Yoshihiro;Yokoo Takehiro;Nagashima Ryuichi;Takaki Takashi;Sasaki Hiraku;Kohda Chikara;Iyoda Masayuki, Letters in applied microbiology, 77(4), 2024, Peer-reviewed
Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice, Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Hiraku Sasaki, Chikara Kohda, Masayuki Iyoda, Diabetes, Metabolic Syndrome and Obesity,
19(16):2855 - 2864, Sep. 2023,
Peer-reviewed,
DOI:10.2147/DMSO.S428190 The essential role of intestinal microbiota in cytomegalovirus reactivation., Kohda Chikara;Ino Satoshi;Ishikawa Hiroki;Kuno Yoshihiro;Nagashima Ryuichi;Iyoda Masayuki, Microbiology spectrum,
11(5):e0234123, Sep. 2023,
Peer-reviewed,
DOI:10.1128/spectrum.02341-23 HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages., Ryuichi Nagashima; Hiroki Ishikawa; Yoshihiro Kuno; Chikara Kohda; Masayuki Iyoda, Scientific reports,
13(1):1867 - 1867, Feb. 2023,
Peer-reviewed,
DOI:10.1038/s41598-023-29161-3 IL-33 attenuates renal fibrosis via group2 innate lymphoid cells., Nagashima Ryuichi;Ishikawa Hiroki;Kuno Yoshihiro;Kohda Chikara;Iyoda Masayuki, Cytokine,
157:155963 - 155963, Sep. 2022,
Peer-reviewed,
DOI:10.1016/j.cyto.2022.155963 Genomic and pathogenic characterization of RTX toxin producing Rodentibacter sp. that is closely related to Rodentibacter haemolyticus., Sasaki H, Ueshiba H, Yanagisawa N, Itoh Y, Ishikawa H, Shigenaga A, Benga L, Ike F., Infect Genet Evol.,
102:105314, Aug. 2022,
Peer-reviewed,
DOI:10.1016/j.meegid.2022.105314 Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk., Ishikawa H, Kuno Y, Kohda C, Sasaki H, Nagashima R, Iyoda M., Lett Appl Microbiol.,
74(5):632 - 639, May 2022,
Peer-reviewed,
DOI:10.1111/lam.13649 Penicillin-Binding Proteins and Associated Protein Mutations Confer Oxacillin/Cefoxitin Tolerance in Borderline Oxacillin-Resistant Staphylococcus aureus, SASAKI H;ISHIKAWA Hiroki;ITOH T;ARANO M;HIRATA K;Ueshiba H, Microb Drug Resist, 27(5):590 - 595, May 2021, Peer-reviewed
Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota., ISHIKAWA Hiroki;INO Satoshi;NAKASHIMA T;MATSUO H;TAKAHASHI Y;KOHDA Chikara;ŌMURA S;IYODA Masayuki;TANAKA Kazuo, Obes Res Clin Pract, 14(4):360 - 367, Jul. 2020, Peer-reviewed
NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway., ISHIKAWA Hiroki;INO Satoshi;YAMOCHI Toshiko;SASAKI Hiraku;KOBAYASHI Takahiro;KOHDA Chikara;TAKIMOTO Masafumi;TANAKA Kazuo, Biochem Biophys Rep, 21:100722, Jan. 2020, Peer-reviewed
Improvement Effects of Trehangelin A on High-Fat Diet Causing Metabolic Clinical Conditions., ISHIKAWA Hiroki;INO Satoshi;NAKASHIMA T;MATSUO H;TAKAHASHI Y;KOHDA Chikara;OMURA S;TANAKA Kazuo, Biol Pharm Bull, 42(12):2095 - 2101, Dec. 2019, Peer-reviewed
Mice Treated with an Antibiotic Cocktail Containing Metronidazole Show Attenuated Allergy Responses through the Induction of Regulatory T Cells in the Intestinal Mucosa, KOBAYASHI Takahiro;INO Satoshi;ISHIKAWA Hiroki;KOHDA Chikara;NAGAHAMA Masatsugu;TANAKA Kazuo, Showa Univ J Med Sci, 31(3):283 - 292, Sep. 2019, Peer-reviewed
A Survey of Vaccine-Induced Measles IgG Antibody Titer to Verify Temporal Changes in Response to Measles Vaccination in Young Adults., SASAKI Hiraku;FUKUNAGA Tomoko;ASANO Ai;SUZUKI Yoshio;NAKANISHI Yuko;KONDO Junzi;ISHIKAWA Hiroki;SHIBATA Nobuto, Vaccines (Basel), 7(3):118, Sep. 2019, Peer-reviewed
Anti-inflammatory Effect of the Water-Soluble Portion of Porcine Placental Extract in Lipopolysaccharide-Stimulated RAW264.7 Murine Macrophage Cells., TEBAKARI M;DAIGO Y;ISHIKAWA Hiroki;NAKAMURA M;KAWASHIMA J;TAKANO F, Biol Pharm Bull, 41(8):1251 - 1256, Aug. 2018, Peer-reviewed
Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No. 1088, Yuji Aiba; Hiroki Ishikawa; Masayoshi Tokunaga; Yasuhiko Komatsu, FEMS MICROBIOLOGY LETTERS, 364(11), Jun. 2017
Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung., ISHIKAWA Hiroki;FUKUI Toshie;INO Satoshi;SASAKI Hiraku;AWANO Naoki;KOHDA Chikara;TANAKA Kazuo, Virology, 499:23 - 29, Dec. 2016, Peer-reviewed
Identification of a virulence determinant that is conserved in the Jawetz and Heyl biotypes of [Pasteurella] pneumotropica, Hiraku Sasaki; Hiroki Ishikawa; Hayato Terayama; Ryoki Asano; Eiichi Kawamoto; Hidetoshi Ishibashi; Ron Boot, PATHOGENS AND DISEASE, 74(6), Aug. 2016, Peer-reviewed
Oral tolerance is inducible during active dextran sulfate sodium-induced colitis., Ino S; Kohda C; Takeshima K; Ishikawa H; Norose T; Yamochi T; Takimoto M; Takahashi H; Tanaka K, World journal of gastrointestinal pharmacology and therapeutics, 7(2):242 - 253, May 2016, Peer-reviewed
The Protective Effects of Intranasal Administration of IL-12 Given Before Influenza Virus Infection and the Negative Effects of IL-12 Treatment Given After Viral Infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;FUKUI Toshie;KOHDA Chikara;TANAKA Kazuo, J Med Virol, 88(9):1487 - 1496, Feb. 2016, Peer-reviewed
Draft genome sequence of the rodent opportunistic pathogen Pasteurella pneumotropica ATCC 35149T, Hiraku Sasaki; Hiroki Ishikawa; Ryoki Asano; Hidehiro Ueshiba; Tetsuya Matsumoto; Ron Boot; Eiichi Kawamoto, Genome Announcements, 2(4), 2014, Peer-reviewed
Intranasal immunization with a non-adjuvanted adhesive protein descended from Pasteurella pneumotropica and its preventive efficacy against opportunistic infection in mice, Hiraku Sasaki; Hiroki Ishikawa; Ken Kojima; Masahiro Itoh; Tetsuya Matsumoto; Takumi Itoh; Osamu Hosomi; Eiichi Kawamoto, VACCINE, 31(48):5729 - 5735, Nov. 2013, Peer-reviewed
The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication, Hiroki Ishikawa; Naoki Awano; Toshie Fukui; Hiraku Sasaki; Shigeru Kyuwa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(4):791 - 796, May 2013, Peer-reviewed
Prevalence of methicillin-resistant Staphylococcus aureus based on culture and PCR in inpatients at a tertiary care center in Tokyo, Japan, Hirokazu Taguchi; Tetsuya Matsumoto; Hiroki Ishikawa; Shoichi Ohta; Tetsuo Yukioka, JOURNAL OF INFECTION AND CHEMOTHERAPY, 18(5):630 - 636, Oct. 2012
Activation of COL1A2 promoter in human fibroblasts by Escherichia coli, Haruko Miyazaki; Ryo Kobayashi; Hiroki Ishikawa; Naoki Awano; Satoshi Yamagoe; Yoshitsugu Miyazaki; Tetsuya Matsumoto, FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 65(3):481 - 487, Aug. 2012, Peer-reviewed
Mice with Asthma Are More Resistant to Influenza Virus Infection and NK Cells Activated by the Induction of Asthma Have Potentially Protective Effects, Hiroki Ishikawa; Hiraku Sasaki; Toshie Fukui; Koji Fujita; Etsuko Kutsukake; Tetsuya Matsumoto, JOURNAL OF CLINICAL IMMUNOLOGY, 32(2):256 - 267, Apr. 2012, Peer-reviewed
The performance of the BD geneOhm MRSA (TM) assay for MRSA isolated from clinical patients in Japan, including the effects of specimen contamination and ways to improve it, Hiroki Ishikawa; Etsuko Kutsukake; Katsumi Chiba; Toshie Fukui; Tetsuya Matsumoto, JOURNAL OF INFECTION AND CHEMOTHERAPY, 17(2):214 - 218, Apr. 2011, Peer-reviewed
Molecular and virulence characteristics of an outer membrane-associated RTX exoprotein in Pasteurella pneumotropica, Hiraku Sasaki; Hiroki Ishikawa; Toru Sato; Satoshi Sekiguchi; Hiromi Amao; Eiichi Kawamoto; Tetsuya Matsumoto; Kazuhiko Shirama, BMC MICROBIOLOGY, 11:55, Mar. 2011, Peer-reviewed
Prevalence and analysis of Pseudomonas aeruginosa in chinchillas, Yasuko Hirakawa; Hiraku Sasaki; Eiichi Kawamoto; Hiroki Ishikawa; Tetsuya Matsumoto; Naoki Aoyama; Koh Kawasumi; Hiromi Amao, BMC VETERINARY RESEARCH, 6:52, Nov. 2010, Peer-reviewed
IFN-gamma production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8(+) T cells, Hiroki Ishikawa; Kazuo Tanaka; Etsuko Kutsukake; Toshie Fukui; Hiraku Sasaki; Akihiro Hata; Satoshi Noda; Tetsuya Matsumoto, VIROLOGY, 407(2):325 - 332, Nov. 2010, Peer-reviewed
Oral Administration of Heat-Killed Lactobacillus plantarum Strain b240 Protected Mice against Salmonella enterica Serovar Typhimurium, Hiroki Ishikawa; Etsuko Kutsukake; Toshie Fukui; Ikutaro Sato; Toshiaki Shirai; Tatsuya Kurihara; Nobuhiko Okada; Hirofumi Danbara; Masamichi Toba; Noriyuki Kohda; Yasuyuki Maeda; Tetsuya Matsumoto, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(7):1338 - 1342, Jul. 2010, Peer-reviewed
Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia, Tetsuya Horino; Tetsuya Matsumoto; Hiroki Ishikawa; Soichiro Kimura; Masashi Uramatsu; Masaaki Tanabe; Kazuhiro Tateda; Shuichi Miyazaki; Yukihiko Aramaki; Yoichiro Iwakura; Masaki Yoshida; Shoichi Onodera; Keizo Yamaguchi, MICROBIOLOGY AND IMMUNOLOGY, 53(9):502 - 511, Sep. 2009, Peer-reviewed
Cd1d-dependent regulation of bacterial colonization in the intestine of mice, Edward E. S. Nieuwenhuis; Tetsuya Matsumoto; Dicky Lindenbergh; Rob Willemsen; Arthur Kaser; Ytje Simons-Oosterhuis; Sylvia Brugman; Keizo Yamaguchi; Hiroki Ishikawa; Yuji Aiba; Yasuhiro Koga; Janneke N. Samsom; Kenshiro Oshima; Mami Kikuchi; Johanna C. Escher; Masahira Hattori; Andrew B. Onderdonk; Richard S. Blumberg, JOURNAL OF CLINICAL INVESTIGATION, 119(5):1241 - 1250, May 2009, Peer-reviewed
New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity, Hirofumi Ochi; Michal Abraham; Hiroki Ishikawa; Dan Frenkel; Kaiyong Yang; Alexandre Basso; Henry Wu; Mei-Ling Chen; Roopali Gandhi; Ariel Miller; Ruth Maron; Howard L. Weiner, JOURNAL OF THE NEUROLOGICAL SCIENCES, 274(1-2):9 - 12, Nov. 2008, Peer-reviewed
Effect of intestinal microbiota on the induction of regulatory CD25(+) CD4(+) T cells, H. Ishikawa; K. Tanaka; Y. Maeda; Y. Aiba; A. Hata; N. M. Tsuji; Y. Koga; T. Matsumoto, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 153(1):127 - 135, Jul. 2008, Peer-reviewed
Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice, T. Matsumoto; H. Ishikawa; K. Tateda; T. Yaeshima; N. Ishibashi; K. Yamaguchi, JOURNAL OF APPLIED MICROBIOLOGY, 104(3):672 - 680, Mar. 2008
Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody, Hiroki Ishikawa; Hirofumi Ochi; Mei-Ling Chen; Dan Frenkel; Ruth Maron; Howard L. Weiner, DIABETES, 56(8):2103 - 2109, Aug. 2007
Oral administration of anti-CD3 antibody suppresses experimental allergic encephalomyelitis by inducing CD4(+)CD25(-)LAP(+) regulatory T cells, Hirofumi Ochi; Michal Abraham; Hiroki Ishikawa; Dan Frenkel; Kaiyong Yang; Alexandre Basso; Henry Wu; Mei-Ling Chen; Roopali Gandhi; Ariel Miller; Ruth Maron; Howard L. Weiner, JOURNAL OF NEUROIMMUNOLOGY, 178:120 - 121, Sep. 2006
Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4(+) CD25(-)LAP(+) T cells, H Ochi; M Abraham; H Ishikawa; D Frenkel; KY Yang; AS Basso; H Wu; ML Chen; R Gandhi; A Miller; R Maron; HL Weiner, NATURE MEDICINE, 12(6):627 - 635, Jun. 2006
Movement and fixation of intestinal microbiota after administration of human feces to germfree mice, R Kibe; M Sakamoto; H Yokota; H Ishikawa; Y Aiba; Y Koga; Y Benno, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(6):3171 - 3178, Jun. 2005
Allergic symptoms and microflora in schoolchildren, S Fukuda; H Ishikawa; Y Koga; Y Aiba; K Nakashima; L Cheng; T Shirakawa, JOURNAL OF ADOLESCENT HEALTH, 35(2):156 - 158, Aug. 2004
Role of intestinal bacterial flora in oral tolerance induction, K Tanaka; H Ishikawa, HISTOLOGY AND HISTOPATHOLOGY, 19(3):907 - 914, Jul. 2004
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease, T Shiba; Y Aiba; H Ishikawa; A Ushiyama; A Takagi; T Mine; Y Koga, MICROBIOLOGY AND IMMUNOLOGY, 47(6):371 - 378, 2003
Role of internalization in the pathogenicity of Shiga toxin-producing Escherichia coli infection in a gnotobiotic murine model, Y Aiba; H Ishikawa; K Shimizu; S Noda; Y Kitada; M Sasaki; Y Koga, MICROBIOLOGY AND IMMUNOLOGY, 46(11):723 - 731, 2002
The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer's patches under germfree conditions, Y Maeda; S Noda; K Tanaka; S Sawamura; Y Aiba; H Ishikawa; H Hasegawa; N Kawabe; M Miyasaka; Y Koga, IMMUNOBIOLOGY, 204(4):442 - 457, Dec. 2001
Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin, H Ishikawa; M Sasaki; S Noda; Y Koga, JOURNAL OF VIROLOGY, 72(8):6574 - 6580, Aug. 1998
Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4(+) cells expressing gp160 of HIV, M Sasaki; J Uchiyama; H Ishikawa; S Matsushita; G Kimura; K Nomoto; Y Koga, VIROLOGY, 224(1):18 - 24, Oct. 1996
Group2 innate lymphoid cells ameliorate renal fibrosis and dysfunction associated with adenine-induced CKD, Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda, 第52回日本免疫学会学術集会, 18 Jan. 2024
高脂肪食摂取誘導肥満におけるNKT細胞の影響, 石川裕樹、長島隆一、久野芳裕、佐々木啓、幸田力、伊與田雅之, 第24回氷川フォーラム, 25 Nov. 2023
Effects of exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on tight junction disruption caused by influenza virus infection, Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Takashi Takaki, Chikara Kohda, Hiraku Sasaki, Masayuki Iyoda, The 70th Annual Meeting of the Japanese Society for Virology, 27 Sep. 2023, 仙台
Effects of estrogen and progesterone on the reactivation of latent cytomegalovirus, 幸田力、石川裕樹、久野芳裕、長島隆一、伊與田 雅之, 第70回日本ウイルス学会学術集会, 26 Sep. 2023
Characterization of Rodentibacter sp. that is closely related to Rodentibacter haemolyticus, 佐々木 啓,上芝 秀博,柳澤 直子,石川 裕樹,伊與田 雅之,池 郁 生, The 96th Annual Meeting of Japanese Society for Bacteriology, 17 Mar. 2023, 姫路
Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 inhibit influenza virus infection and attenuate risk of secondary bacterial infection, 石川裕樹、久野芳裕、幸田力、佐々木啓、長島隆一、狩野宏、石井祥子、伊與田雅之, The 69th Annual Meeting of the Japanese Society for Virology, 13 Nov. 2022, 長崎
2型自然リンパ球(ILC2)は腎間質線維化を軽減する, 長島 隆一;石川 裕樹;久野 芳裕;幸田 力;伊與田 雅之, 第65回日本腎臓学会学術総会, 10 Jun. 2022
Pathogenic characterization of hemolytic Rodentibacter sp. isolated from laboratory rodents, 佐々木 啓;上芝 秀博;柳澤 直子;石川 裕樹;池 郁生, 第95回日本細菌学会総会, 29 Mar. 2022, オンライン開催
A survey of anti-mumps virus antibody titer and vaccination coverage in young adults, 佐々木 啓;石川 裕樹;柴田 展人, 第68回日本ウイルス学会学術集会, 16 Nov. 2021, 神戸・オンライン開催
NKT cells contribute to murine norovirus clearance by inducing the virus-specific secretory IgA in intestine, 石川 裕樹;佐々木 啓;幸田 力;久野 芳裕;長島 隆一;田中 和生;伊與田 雅之, 第68回日本ウイルス学会学術集会, 16 Nov. 2021, 神戸・オンライン
腎間質線維化における2型自然リンパ球(ILC2)の役割, 長島 隆一;石川 裕樹;久野 芳裕;幸田 力;伊與田 雅之, 第20回 氷川フォーラム, 13 Nov. 2021, Web開催
腎間質線維化における2型自然リンパ球(ILC2)の役割, 長島 隆一;石川 裕樹;久野 芳裕;幸田 力;伊與田 雅之, 第20回 氷川フォーラム, 13 Nov. 2021, Web開催
肺パスツレラ近縁種 Rodentibacter sp. の病原性について, 佐々木 啓;上芝 秀博;石川 裕樹;池 郁生, 第68回日本実験動物学会総会, 19 May 2021, Web開催
肺パスツレラ近縁種Rodentibacter sp.の病原性評価, 佐々木 啓;上芝 秀博;石川 裕樹;池 郁生, 第67回日本実験動物学会総会, 23 May 2020, 誌上開催
NKT cells play an important role in the clearance of murine norovirus through the virus-specific secretory IgA production, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第48回日本免疫学会学術集会, 13 Dec. 2019, 浜松
潰瘍性大腸炎の産後増悪の背景にある粘膜免疫の性状, 猪 聡志;幸田 力;小林 孝弘;石川 裕樹;黒木 優一郎;田中 和生, 第61回日本消化器病学会大会(第27回日本消化器関連学会週間JDDW2019), 21 Nov. 2019, 神戸
高脂肪食がCMV感染症および酸化ストレスに及ぼす影響, 猪 聡志;幸田 力;小林 孝弘;石川 裕樹;田中 和生, 第33回日本酸化ストレス学会関東支部会, 15 Dec. 2018, 東京
Influenza virus infection causes reduced G-CSF production in lung, followed by neutrophil dysfunction against secondary bacterial infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第47回日本免疫学会学術集会, 11 Dec. 2018, 福岡
Neutrophil dysfunction in lung during influenza virus infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第66回日本ウイルス学会学術集会, 28 Oct. 2018, 京都
Identification of a virulence that is conserved in the biotypes of [Pasteurella] pneumotropica, 佐々木 啓;石川 裕樹;上芝 秀博;川本 英一;池 郁生, 第90回日本細菌学会総会, 19 Mar. 2017, 仙台