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Kohda Chikara

■FacultyMicrobiology and Immunology
■PositionAssociate Professor
Last Updated :2025/06/27

Researcher

基本情報

Profile and Settings

  • 氏名

    Kohda Chikara

Affiliation

  • Microbiology and Immunology, Associate Professor

Location

  • Hatanodai Campus

Degree

  • Doctor of Agricultural Science, Tohoku University, Mar. 1998

Achievements

Published Papers

  • Group2 innate lymphoid cells ameliorate renal fibrosis and dysfunction associated with adenine-induced CKD., Nagashima Ryuichi;Ishikawa Hiroki;Kuno Yoshihiro;Kohda Chikara;Eshima Koji;Iyoda Masayuki, Cellular immunology, 401-402, May 2024, Peer-reviewed
  • In vitro investigation of the effects of Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 exopolysaccharides on tight junction damage caused by influenza virus infection., Ishikawa Hiroki;Kuno Yoshihiro;Yokoo Takehiro;Nagashima Ryuichi;Takaki Takashi;Sasaki Hiraku;Kohda Chikara;Iyoda Masayuki, Letters in applied microbiology, 77(4), 2024, Peer-reviewed
  • Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice, Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Hiraku Sasaki, Chikara Kohda, Masayuki Iyoda, Diabetes, Metabolic Syndrome and Obesity, 19(16):2855 - 2864, Sep. 2023, Peer-reviewed, DOI:10.2147/DMSO.S428190
  • The essential role of intestinal microbiota in cytomegalovirus reactivation., Kohda Chikara;Ino Satoshi;Ishikawa Hiroki;Kuno Yoshihiro;Nagashima Ryuichi;Iyoda Masayuki, Microbiology spectrum, :e0234123, Sep. 2023, Peer-reviewed, DOI:10.1128/spectrum.02341-23
  • HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages., Ryuichi Nagashima; Hiroki Ishikawa; Yoshihiro Kuno; Chikara Kohda; Masayuki Iyoda, Scientific reports, 13(1):1867 - 1867, Feb. 2023, Peer-reviewed, DOI:10.1038/s41598-023-29161-3
  • IL-33 attenuates renal fibrosis via group2 innate lymphoid cells., Nagashima Ryuichi;Ishikawa Hiroki;Kuno Yoshihiro;Kohda Chikara;Iyoda Masayuki, Cytokine, 157:155963 - 155963, Sep. 2022, Peer-reviewed, DOI:10.1016/j.cyto.2022.155963
  • Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk., Ishikawa H, Kuno Y, Kohda C, Sasaki H, Nagashima R, Iyoda M., Lett Appl Microbiol., 74(5):632 - 639, May 2022, Peer-reviewed, DOI:10.1111/lam.13649
  • Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota., Hiroki Ishikawa; Satoshi Ino; Takuji Nakashima; Hirotaka Matsuo; Yōko Takahashi; Chikara Kohda; Satoshi Ōmura; Masayuki Iyoda; Kazuo Tanaka, Obesity research & clinical practice, 14(4):360 - 367, Jul. 2020, Peer-reviewed
  • NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway., ISHIKAWA Hiroki;INO Satoshi;YAMOCHI Toshiko;SASAKI Hiraku;KOBAYASHI Takahiro;KOHDA Chikara;TAKIMOTO Masafumi;TANAKA Kazuo, Biochem Biophys Rep, 21:100722, Jan. 2020, Peer-reviewed
  • Improvement Effects of Trehangelin A on High-Fat Diet Causing Metabolic Clinical Conditions., ISHIKAWA Hiroki;INO Satoshi;NAKASHIMA T;MATSUO H;TAKAHASHI Y;KOHDA Chikara;OMURA S;TANAKA Kazuo, Biol Pharm Bull, 42(12):2095 - 2101, Dec. 2019, Peer-reviewed
  • Mice Treated with an Antibiotic Cocktail Containing Metronidazole Show Attenuated Allergy Responses through the Induction of Regulatory T Cells in the Intestinal Mucosa, KOBAYASHI Takahiro;INO Satoshi;ISHIKAWA Hiroki;KOHDA Chikara;NAGAHAMA Masatsugu;TANAKA Kazuo, Showa Univ J Med Sci, 31(3):283 - 292, Sep. 2019, Peer-reviewed
  • Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung., ISHIKAWA Hiroki;FUKUI Toshie;INO Satoshi;SASAKI Hiraku;AWANO Naoki;KOHDA Chikara;TANAKA Kazuo, Virology, 499:23 - 29, Dec. 2016, Peer-reviewed
  • Oral tolerance is inducible during active dextran sulfate sodium-induced colitis, INO Satoshi;KOHDA Chikara;TAKESHIMA Kosuke;ISHIKAWA Hiroki;NOROSE Tomoko;YAMOCHI Toshiko;TAKIMOTO Masafumi;TAKAHASHI Hiroshi;TANAKA Kazuo, World J Gastrointest Pharmacol Ther, 7(2):242 - 253, May 2016, Peer-reviewed
  • The Protective Effects of Intranasal Administration of IL-12 Given Before Influenza Virus Infection and the Negative Effects of IL-12 Treatment Given After Viral Infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;FUKUI Toshie;KOHDA Chikara;TANAKA Kazuo, J Med Virol, 88(9):1487 - 1496, Feb. 2016, Peer-reviewed
  • A simple smart amplification assay for the rapid detection of human cytomegalovirus in the urine of neonates., KOHDA Chikara;CHIBA Nao;SHIMOKOBA Kengo;MIZUNO Katsumi;NEGORO Takaharu;NAKANO Yasuko;TANAKA Kazuo, J Virol Methods, 208:160 - 165, Nov. 2014, Peer-reviewed
  • Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain., AKIYAMA Tomohito;MIYAMOTO Yoichi;YOSHIMURA Kentaro;YAMADA Atsushi;TAKAMI Masamichi;SUZAWA Tetsuo;HOSHINO Marie;IMAMURA Takahisa;AKIYAMA Chie;YASUHARA Rika;MISHIMA Kenji;MARUYAMA Toshifumi;KOHDA Chikara;TANAKA Kazuo;POTEMPA Jan;YASUDA Hisataka;BABA Kazuyoshi;KAMIJO Ryutaro, J Biol Chem, 289(22):15621 - 15630, May 2014, Peer-reviewed, DOI:10.1074/jbc.M113.520510
  • サイトメガロウイルス(CMV)　ウイルス学的特徴と測定方法, 幸田　力, 昭和学士会雑誌, 73(3):139 - 144, Jun. 2013, DOI:10.14930/jshowaunivsoc.73.139
  • Low HCMV DNA copies can establish infection and result in significant symptoms in extremely preterm infants: a prospective study., WAKABAYASHI Hitomi;MIZUNO Katsumi;KOHDA Chikara;NEGORO Takaharu;MAEKAWA Chiaki;SAWATO Satomi;TANAKA Kazuo;NAKANO Yasuko;MURAYAMA Junichirou;TAKI Motohiro;MIYAZAWA Tokuo;MURASE Masahiko;AIZAWA Madoka;NAKANO Yuya;SAKURAI Motoichiro;TAKAHASHI Kenichiro;ITABASHI Kazuo, Am J Perinatol, 29(5):377 - 382, May 2012, Peer-reviewed
  • Epigallocatechin gallate inhibits intracellular survival of Listeria monocytogenes in macrophages, Chikara Kohda; Yoko Yanagawa; Tadakatsu Shimamura, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365(2):310 - 315, Jan. 2008, Peer-reviewed
  • Epigallocatechin gallate suppresses expression of receptor activator of NF-kappa B ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells, Ikuo Ishida; Chikara Kohda; Yoko Yanagawa; Hideyo Miyaoka; Tadakatsu Shimamura, JOURNAL OF MEDICAL MICROBIOLOGY, 56(8):1042 - 1046, Aug. 2007, Peer-reviewed
  • Irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic conditions: a distinct difference from allied cytolysins produced by other Gram-positive bacteria, Takamasa Nomura; Ikuo Kawamura; Chikara Kohda; Hisashi Baba; Yutaka Ito; Terumi Kimoto; Isao Watanabe; Masao Mitsuyama, MICROBIOLOGY-SGM, 153(Pt 7):2250 - 2258, Jul. 2007, Peer-reviewed
  • Dependence of the lethal effect of pore-forming haemolysins of Gram-positive bacteria on cytolytic activity, Watanabe, I; T Nomura; T Tominaga; K Yamamoto; C Kohda; Kawamura, I; M Mitsuyama, JOURNAL OF MEDICAL MICROBIOLOGY, 55(5):505 - 510, May 2006, Peer-reviewed
  • Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands, Y Ito; Kawamura, I; C Kohda; K Tsuchiya; T Nomura; M Mitsuyama, INTERNATIONAL IMMUNOLOGY, 17(12):1597 - 1606, Dec. 2005, Peer-reviewed
  • Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro, K Tsuchiya; Kawamura, I; A Takahashi; T Nomura; C Kohda; M Mitsuyama, INFECTION AND IMMUNITY, 73(7):3869 - 3877, Jul. 2005, Peer-reviewed
  • Differences in gamma interferon production induced by listeriolysin O and ivanolysin O result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii, T Kimoto; Kawamura, I; C Kohda; T Nomura; K Tsuchiya; Y Ito; Watanabe, I; T Kaku; E Setianingrum; M Mitsuyama, INFECTION AND IMMUNITY, 71(5):2447 - 2454, May 2003, Peer-reviewed
  • Seeligeriolysin O, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice, Y Ito; Kawamura, I; C Kohda; H Baba; T Nomura; T Kimoto; Watanabe, I; M Mitsuyama, INFECTION AND IMMUNITY, 71(1):234 - 241, Jan. 2003, Peer-reviewed
  • Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes, C Kohda; Kawamura, I; H Baba; T Nomura; Y Ito; T Kimoto; Watanabe, I; M Mitsuyama, INFECTION AND IMMUNITY, 70(3):1334 - 1341, Mar. 2002, Peer-reviewed
  • Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells, T Nomura; Kawamura, I; K Tsuchiya; C Kohda; H Baba; Y Ito; T Kimoto; Watanabe, I; M Mitusyama, INFECTION AND IMMUNITY, 70(3):1049 - 1055, Mar. 2002, Peer-reviewed
  • Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity, H Baba; Kawamura, I; C Kohda; T Nomura; Y Ito; T Kimoto; Watanabe, I; S Ichiyama; M Mitsuyama, INFECTION AND IMMUNITY, 70(1):107 - 113, Jan. 2002, Peer-reviewed
  • Identification of Genus Clostridium Isolated from the Rumen of Malaysian Water Buffalo, KOHDA Chikara; ANDO Tasuke; INAMOTO Tamio; NAKAMURA Shinichi; NAKAI Yutaka; OGIMOTO Keiji, Animal science journal, 69(3):271 - 275, Mar. 1998, Peer-reviewed
  • Anaerobic Microorganisms Degrading 3-Methylindole (Skatole) and Indole in Composting Processes, KOHDA Chikara; ANDO Tasuke; NAKAI Yutaka, The Japanese journal of zootechnical science, 68(11):1045 - 1051, Nov. 1997, Peer-reviewed
  • Isolation and characterization of anaerobic indole- and skatole-degrading bacteria from composting animal wastes, C Kohda; T Ando; Y Nakai, JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 43(5):249 - 255, Oct. 1997, Peer-reviewed
  • Changes in Microbial Flora of Animal Feces after Excretion, NAKAI Yutaka; SAITO Masayoshi; NAKATANI Masayoshi; KOHDA Chikara; ANDO Tasuke; INAMOTO Tamio; OGIMOTO Keiji, The Japanese journal of zootechnical science, 68(2):138 - 143, Feb. 1997, Peer-reviewed

Presentations

  • Butyrate enhanced the immediate-early gene expression of cytomegalovirus, 幸田力、石川裕樹、久野芳裕、伊與田雅之, 第71回日本ウイルス学会学術集会, 05 Nov. 2024
  • Effects of exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on tight junction disruption caused by influenza virus infection, Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Takashi Takaki, Chikara Kohda, Hiraku Sasaki, Masayuki Iyoda, The 70th Annual Meeting of the Japanese Society for Virology, 27 Sep. 2023, 仙台
  • Effects of estrogen and progesterone on the reactivation of latent cytomegalovirus, 幸田力、石川裕樹、久野芳裕、長島隆一、伊與田 雅之, 第70回日本ウイルス学会学術集会, 26 Sep. 2023
  • Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 inhibit influenza virus infection and attenuate risk of secondary bacterial infection, 石川裕樹、久野芳裕、幸田力、佐々木啓、長島隆一、狩野宏、石井祥子、伊與田雅之, The 69th Annual Meeting of the Japanese Society for Virology, 13 Nov. 2022, 長崎
  • サイトメガロウイルス再活性化に及ぼす短鎖脂肪酸の影響, 幸田 力、石川 裕樹、久野 芳裕、長島 隆一、伊與田 雅之, 第69回日本ウイルス学会学術集会, Nov. 2022, 長崎
  • 2型自然リンパ球(ILC2)は腎間質線維化を軽減する, 長島 隆一;石川 裕樹;久野 芳裕;幸田 力;伊與田 雅之, 第65回日本腎臓学会学術総会, 10 Jun. 2022
  • NKT cells contribute to murine norovirus clearance by inducing the virus-specific secretory IgA in intestine, 石川　裕樹;佐々木　啓;幸田　力;久野　芳裕;長島　隆一;田中　和生;伊與田　雅之, 第68回日本ウイルス学会学術集会, 16 Nov. 2021, 神戸・オンライン
  • サイトメガロウイルス再活性化に及ぼすエストロゲンの影響, 幸田力、石川裕樹、久野芳裕、長島隆一、田中和生、伊與田雅之, 第68回日本ウイルス学会学術集会, 16 Nov. 2021, 神戸
  • 腎間質線維化における2型自然リンパ球（ILC2）の役割, 長島　隆一;石川　裕樹;久野　芳裕;幸田　力;伊與田　雅之, 第20回 氷川フォーラム, 13 Nov. 2021, Web開催
  • NKT cells play an important role in the clearance of murine norovirus through the virus-specific secretory IgA production, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第48回日本免疫学会学術集会, 13 Dec. 2019, 浜松
  • 潰瘍性大腸炎の産後増悪の背景にある粘膜免疫の性状, 猪　聡志;幸田　力;小林　孝弘;石川　裕樹;黒木　優一郎;田中　和生, 第61回日本消化器病学会大会(第27回日本消化器関連学会週間JDDW2019), 21 Nov. 2019, 神戸
  • 妊娠に伴うサイトメガロウイルスの再活性化における腸内細菌由来代謝産物の役割, 幸田 力、猪聡志、石川裕樹、田中 和生, 第33回ヘルペスウイルス研究会, 20 Jun. 2019, 沖縄
  • 高脂肪食がCMV感染症および酸化ストレスに及ぼす影響, 猪　聡志;幸田　力;小林　孝弘;石川　裕樹;田中　和生, 第33回日本酸化ストレス学会関東支部会, 15 Dec. 2018, 東京
  • Influenza virus infection causes reduced G-CSF production in lung, followed by neutrophil dysfunction against secondary bacterial infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第47回日本免疫学会学術集会, 11 Dec. 2018, 福岡
  • Neutrophil dysfunction in lung during influenza virus infection, ISHIKAWA Hiroki;INO Satoshi;SASAKI Hiraku;KOHDA Chikara;TANAKA Kazuo, 第66回日本ウイルス学会学術集会, 28 Oct. 2018, 京都
  • 新生児の尿中サイトメガロウイルス核酸検出試薬ジェネリス CMVの開発, 下木場　健吾;千葉　奈穂;幸田　力;田中　和生;井上　直樹, 第58回日本臨床化学会年次学術集会, 25 Aug. 2018, 名古屋
  • The influence of Gut Microbiota on reactivation of murine cytomegalovirus, KOHDA Chikara;INO Satoshi;TANAKA Kazuo, 第65回日本ウイルス学会学術集会, 25 Oct. 2017, 大阪
  • デキストラン硫酸ナトリウム誘導性腸炎における制御性T細胞の可塑性と安定性, 猪　聡志;幸田　力;田中　和生, 第336回昭和大学学士会例会, 27 May 2017, 東京
  • Dysbiosisは腸管関連リンパ組織におけるT細胞のIL-7Rα，GITRの発現を亢進させる, 猪　聡志;幸田　力;黒木　優一郎;田中　和生, 第103回日本消化器病学会総会, 21 Apr. 2017, 東京
  • 早産児における母乳を介した症候性サイトメガロウイルス感染症, 幸田　力;千葉　奈穂;田中　和生, 第62回日本ウイルス学会学術集会, 10 Nov. 2014, 横浜

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