Ohara Makoto

Researcher

基本情報

Profile and Settings

• 氏名

  Ohara Makoto

Affiliation

• Diabetes, Metabolism and Endocrinology, Associate Professor

Location

• University Hospital

Degree

• Doctor of Medical Science, Nippon Medical School, Mar. 2013

Achievements

Published Papers

• SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis, Michishige Terasaki; Keita Shibata; Yusaku Mori; Tomomi Saito; Takanori Matsui; Makoto Ohara; Tomoyasu Fukui; Keiji Hasumi; Yuichiro Higashimoto; Koji Nobe; Sho-ichi Yamagishi, International Journal of Molecular Sciences, 24(7):6505 - 6505, Mar. 2023, Peer-reviewed
• Sequential screening of biomarkers in a case of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms occurring with virus reactivation and autoimmune disease., EunSeon Lee; Suni Lee; Yasuya Tashiro; Mari Ogihara; Hideaki Watanabe; Satoshi Ishibashi; Shigeki Nagata; Kana Miyo; Makoto Ohara; Takemi Otsuki; Hirohiko Sueki, The Journal of dermatology, 49(7):e221-e223, Jul. 2022
• Sequential screening of biomarkers in a case of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms occurring with virus reactivation and autoimmune disease., EunSeon Lee; Suni Lee; Yasuya Tashiro; Mari Ogihara; Hideaki Watanabe; Satoshi Ishibashi; Shigeki Nagata; Kana Miyo; Makoto Ohara; Takemi Otsuki; Hirohiko Sueki, The Journal of dermatology, 49(7):e221-e223, Jul. 2022
• Efficacy of a new enzyme-linked immunosorbent assay system for three islet cell autoantibodies in Japanese patients with acute-onset type 1 diabetes., Tomoyasu Fukui; Nobuaki Takehana; Yusaku Mori; Munenori Hiromura; Michishige Terasaki; Hideki Kushima; Michiya Takada; Masako Tomoyasu; Nobuko Sato; Toshiyuki Hayashi; Makoto Ohara; Tsuyoshi Kikuchi; Yoshihisa Ito; Tetsuro Kobayashi; Sho-Ichi Yamagishi, Endocrine journal, 69(11):1343 - 1349, Jun. 2022
• Efficacy of a new enzyme-linked immunosorbent assay system for three islet cell autoantibodies in Japanese patients with acute-onset type 1 diabetes., Tomoyasu Fukui; Nobuaki Takehana; Yusaku Mori; Munenori Hiromura; Michishige Terasaki; Hideki Kushima; Michiya Takada; Masako Tomoyasu; Nobuko Sato; Toshiyuki Hayashi; Makoto Ohara; Tsuyoshi Kikuchi; Yoshihisa Ito; Tetsuro Kobayashi; Sho-Ichi Yamagishi, Endocrine journal, 69(11):1343 - 1349, Jun. 2022
• Efficacy of a new enzyme-linked immunosorbent assay system for three islet cell autoantibodies in Japanese patients with acute-onset type 1 diabetes., Tomoyasu Fukui; Nobuaki Takehana; Yusaku Mori; Munenori Hiromura; Michishige Terasaki; Hideki Kushima; Michiya Takada; Masako Tomoyasu; Nobuko Sato; Toshiyuki Hayashi; Makoto Ohara; Tsuyoshi Kikuchi; Yoshihisa Ito; Tetsuro Kobayashi; Sho-Ichi Yamagishi, Endocrine journal, 69(11):1343 - 1349, Jun. 2022
• Luseogliflozin inhibits high glucose-induced TGF-β2 expression in mouse cardiomyocytes by suppressing NHE-1 activity., Naoya Osaka; Yusaku Mori; Michishige Terasaki; Munenori Hiromura; Tomomi Saito; Hironori Yashima; Yoshie Shiraga; Raichi Kawakami; Makoto Ohara; Tomoyasu Fukui; Sho-Ichi Yamagishi, The Journal of international medical research, 50(5):3000605221097490 - 3000605221097490, May 2022
• Luseogliflozin inhibits high glucose-induced TGF-β2 expression in mouse cardiomyocytes by suppressing NHE-1 activity., Naoya Osaka; Yusaku Mori; Michishige Terasaki; Munenori Hiromura; Tomomi Saito; Hironori Yashima; Yoshie Shiraga; Raichi Kawakami; Makoto Ohara; Tomoyasu Fukui; Sho-Ichi Yamagishi, The Journal of international medical research, 50(5):3000605221097490 - 3000605221097490, May 2022
• Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population., Tomoyasu Fukui; Ayako Fukase; Hiroto Sasamori; Makoto Ohara; Yusaku Mori; Michishige Terasaki; Munenori Hiromura; Hideki Kushima; Tetsuro Kobayashi; Sho-Ichi Yamagishi, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 59:101396 - 101396, Aug. 2021
• Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population., Tomoyasu Fukui; Ayako Fukase; Hiroto Sasamori; Makoto Ohara; Yusaku Mori; Michishige Terasaki; Munenori Hiromura; Hideki Kushima; Tetsuro Kobayashi; Sho-Ichi Yamagishi, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 59:101396 - 101396, Aug. 2021
• Effects of omarigliptin on glucose variability and oxidative stress in type 2 diabetes patients: A prospective study., Makoto Ohara; Hiroe Nagaike; Tomoki Fujikawa; Yo Kohata; Maiho Ogawa; Takemasa Omachi; Risa Sasajima; Hirotoshi Chiba; Toshimasa Ara; Ayuka Sugawara; Munenori Hiromura; Michishige Terasaki; Yusaku Mori; Tomoyasu Fukui; Tsutomu Hirano; Hiroki Yokoyama; Sho-Ichi Yamagishi, Diabetes research and clinical practice, 179:108999 - 108999, Aug. 2021
• Effects of omarigliptin on glucose variability and oxidative stress in type 2 diabetes patients: A prospective study., Makoto Ohara; Hiroe Nagaike; Tomoki Fujikawa; Yo Kohata; Maiho Ogawa; Takemasa Omachi; Risa Sasajima; Hirotoshi Chiba; Toshimasa Ara; Ayuka Sugawara; Munenori Hiromura; Michishige Terasaki; Yusaku Mori; Tomoyasu Fukui; Tsutomu Hirano; Hiroki Yokoyama; Sho-Ichi Yamagishi, Diabetes research and clinical practice, 179:108999 - 108999, Aug. 2021
• Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway., TERASAKI Michishige;YASHIMA Hironori;MORI Yusaku;SAITO Tomomi;SHIRAGA Yoshie;KAWAKAMI Raichi;OHARA Makoto;FUKUI Tomoyasu;HIRANO Tsutomu;YAMADA Yuichiro;SEINO Yutaka;YAMAGISHI Sho-ichi, Biomedicines, 9(7):832, Jul. 2021, Peer-reviewed, DOI:10.3390/biomedicines9070832
• 重度の高カリウム血症と心室頻拍を併発した胸腺腫摘出後の劇症1型糖尿病の1例, 尾町 健将; 広村 宗範; 八島 広典; 小林 亮平; 福井 智康; 寺崎 道重; 小原 信; 森 雄作; 山岸 昌一, 糖尿病, 64(7):436 - 436, Jul. 2021
• 重度の高カリウム血症と心室頻拍を併発した胸腺腫摘出後の劇症1型糖尿病の1例, 尾町 健将; 広村 宗範; 八島 広典; 小林 亮平; 福井 智康; 寺崎 道重; 小原 信; 森 雄作; 山岸 昌一, 糖尿病, 64(7):436 - 436, Jul. 2021
• SGLT-2阻害薬による正常血糖ケトアシドーシスを契機に抗IA-2抗体陽性が判明した1例, 竹鼻 伸晃; 福井 智康; 長池 弘江; 小川 舞帆; 尾町 健将; 小原 信; 森 雄作; 山岸 昌一, 糖尿病, 64(7):406 - 406, Jul. 2021
• SGLT-2阻害薬による正常血糖ケトアシドーシスを契機に抗IA-2抗体陽性が判明した1例, 竹鼻 伸晃; 福井 智康; 長池 弘江; 小川 舞帆; 尾町 健将; 小原 信; 森 雄作; 山岸 昌一, 糖尿病, 64(7):406 - 406, Jul. 2021
• 2型糖尿病患者におけるオマリグリプチンによる酸化ストレスおよび血糖変動に対する影響に関する探索的研究, 小原 信; 藤川 大輝; 長池 弘江; 高畑 洋; 笹島 りさ; 千葉 浩利; 荒 敏真; 菅原 愛夕果; 森 雄作; 福井 智康; 横山 宏樹; 山岸 昌一, 日本抗加齢医学会総会プログラム・抄録集, 21回:199 - 199, Jun. 2021
• 2型糖尿病患者におけるオマリグリプチンによる酸化ストレスおよび血糖変動に対する影響に関する探索的研究, 小原 信; 藤川 大輝; 長池 弘江; 高畑 洋; 笹島 りさ; 千葉 浩利; 荒 敏真; 菅原 愛夕果; 森 雄作; 福井 智康; 横山 宏樹; 山岸 昌一, 日本抗加齢医学会総会プログラム・抄録集, 21回:199 - 199, Jun. 2021
• Very rare case of Graves' disease with resistance to methimazole: a case report and literature review., MORI Yusaku;HIROMURA Munenori;TERASAKI Michishige;KUSHIMA Hideki;OHARA Makoto;FUKUI Tomoyasu;TAKAHASHI Yasuyoshi;Yamagishi Sho-Ichi, J Int Med Res, 49(3):3.00061E+14, Mar. 2021, Peer-reviewed
• Glucose-dependent insulinotropic polypeptide inhibits cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β2., HIROMURA Munenori;MORI Yusaku;TERASAKI Michishige;KUSHIMA Hideki;SAITO Tomomi;OSAKA Naoya;YASHIMA Hironori;OHARA Makoto;FUKUI Tomoyasu;MATSUI T;YAMAGISHI Sho-ichi, Diab Vasc Dis Res, 18(2):1.47916E+15, Mar. 2021, Peer-reviewed
• AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation, YASHIMA Hironori;TERASAKI Michishige;SOTOKAWAUCHI Ami;MATSUI Takanori;MORI Yusaku;SAITO Tomomi;OSAKA Naoya;KUSHIMA Hideki;HIROMURA Munenori;OHARA Makoto;FUKUI Tomoyasu;YAMAGISHI Sho-ichi, Int J Mol Sci, 21(23):9263, Dec. 2020, Peer-reviewed
• A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression., TERASAKI Michishige;YASHIMA Hironori;MORI Yusaku;SAITO Tomomi;MATSUI Takanori;HIROMURA Munenori;KUSHIMA Hideki;OSAKA Naoya;OHARA Makoto;FUKUI Tomoyasu;HIRANO Tsutomu;YAMAGISHI Sho-Ichi, Int J Mol Sci, 21(13):4811, Jul. 2020, Peer-reviewed
• Anti-inflammatory and atheroprotective properties of glucagon., OSAKA Naoya;KUSHIMA Hideki;MORI Yusaku;SAITO Tomomi;HIROMURA Munenori;TERASAKI Michishige;YASHIMA Hironori;OHARA Makoto;FUKUI Tomoyasu;MATSUI Takanori;HIRANO Tsutomu;YAMAGISHI Sho-Ichi, Diab Vasc Dis Res, 17(5):1.47916E+15, May 2020, Peer-reviewed
• Association of Hemoglobin A1c, 1,5-Anhydro-D-Glucitol and Glycated Albumin with Oxidative Stress in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study., KOHATA Yo;OHARA Makoto;NAGAIKE Hiroe;FUJIKAWA Tomoki;OSAKA Naoya;GOTO Satoshi;FUKASE Ayako;KUSHIMA Hideki;HIROMURA Munenori;TERASAKI Michishige;MORI Yusaku;FUKUI Tomoyasu;OUCHI Motoshi;SUZUKI Tatsuya;HIRANO Tsutomu;YAMAGISHI Sho-Ichi, Diabetes Ther, 11(3):655 - 665, Mar. 2020, Peer-reviewed
• Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling., MORI Yusaku;TERASAKI Michishige;HIROMURA Munenori;SAITO Tomomi;KUSHIMA Hideki;KOSHIBU Masakazu;OSAKA Naoya;OHARA Makoto;FUKUI Tomoyasu;OHTAKI Hirokazu;HIRANO Tsutomu;YAMAGISHI Sho-Ichi, Cardiovasc Diabetol, 18(1):143, Oct. 2019, Peer-reviewed
• 前立腺膿瘍を契機に黄色ブドウ球菌による敗血症性肺塞栓症,感染性心内膜炎,細菌性眼内炎を併発した2型糖尿病の1例, 八島　広典;小原　信;広村　宗範;田邉　優希;平野　勉, 内科, 124(2):1685 - 1689, Aug. 2019, Peer-reviewed
• Associations of Glucose and Blood Pressure Variability with Cardiac Diastolic Function in Patients with Type 2 Diabetes Mellitus and Hypertension: A Retrospective Observational Study, GOTO Satoshi;OHARA MAKOTO;OSAKA Naoya;FUJIKAWA Tomoki;KOHATA Yo;NAGAIKE Hiroe;FUKASE Ayako;KUSHIMA Hideki;HIROMURA Munenori;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, Showa Univ J Med Sci, 31(2):139 - 149, Jun. 2019, Peer-reviewed
• Effect of Dulaglutide Versus Liraglutide on Glucose Variability, Oxidative Stress, and Endothelial Function in Type 2 Diabetes: A Prospective Study., NAGAIKE Hiroe;OHARA MAKOTO;KOHATA Yo;HIROMURA Munenori;TOMOYASU Masako;TAKADA Michiya;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, Diabetes Ther, 10(1):215 - 228, Feb. 2019, Peer-reviewed
• Comparison of liraglutide plus basal insulin and basal-bolus insulin therapy (BBIT) for glycemic control, body weight stability, and treatment satisfaction in patients treated using BBIT for type 2 diabetes without severe insulin deficiency: A randomized prospective pilot study., YAMAMOTO Saki;HAYASHI Toshiyuki;OHARA Makoto;GOTO Satoshi;SATO Jun;NAGAIKE Hiroe;FUKASE Ayako;SATO Nobuko;HIROMURA Munenori;TOMOYASU Masako;NAKANISHI Noriko;LEE Soushou;OSAMURA Anna;YAMAMOTO Takeshi;FUKUI Tomoyasu;HIRANO Tsutomu, Diabetes Res Clin Pract, 140:339 - 346, Jun. 2018, Peer-reviewed
• Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes., OHARA Makoto;NAGAIKE Hiroe;GOTO Satoshi;FUKASE Ayako;TANABE Yuki;TOMOYASU Masako;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, Diabetes Res Clin Pract, 139:253 - 261, May 2018, Peer-reviewed
• Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin., Toshiyuki Hayashi; Tomoyasu Fukui; Noriko Nakanishi; Saki Yamamoto; Masako Tomoyasu; Anna Osamura; Makoto Ohara; Takeshi Yamamoto; Yasuki Ito; Tsutomu Hirano, Cardiovascular diabetology, 16(1):8 - 8, Jan. 2017
• Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin., Toshiyuki Hayashi; Tomoyasu Fukui; Noriko Nakanishi; Saki Yamamoto; Masako Tomoyasu; Anna Osamura; Makoto Ohara; Takeshi Yamamoto; Yasuki Ito; Tsutomu Hirano, Cardiovascular diabetology, 16(1):8 - 8, Jan. 2017
• Relationship between daily and day-to-day glycemic variability and increased oxidative stress in type 2 diabetes., OHARA Makoto;FUKUI Tomoyasu;OUCHI Motoshi;WATANABE Kentaro;SUZUKI Tatsuya;YAMAMOTO Saki;YAMAMOTO Takeshi;HAYASHI Toshiyuki;OBA Kenzo;HIRANO Tsutomu, Diabetes Res Clin Pract, 122:62 - 70, Dec. 2016, Peer-reviewed
• A higher body mass index attenuates the long-term HbA1c-lowering effects of liraglutide in type 2 diabetes patients treated using sulfonylurea-based therapy, YAMAMOTO Takeshi;FUKUI Tomoyasu;HIGUCHI Akiko;OHARA Makoto;HAYASHI Toshiyuki;HIRANO Tsutomu, Diabetol Int, 7(4):425 - 431, Dec. 2016, Peer-reviewed
• 有痛性糖尿病性神経障害における疼痛の強さは自律神経障害の程度を反映する, 樋口　明子;林　俊行;長池　弘江;山本　咲;友安　雅子;原　賀子;小原　信;山本　剛史;福井　智康;平野　勉, 昭和学士会雑誌, 76(3):361 - 368, Jun. 2016, Peer-reviewed, DOI:10.14930/jshowaunivsoc.76.361
• Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor, Improves Early-Phase Insulin Secretion in Drug-Naive Patients with Type 2 Diabetes, ITO Rika;FUKUI Tomoyasu;HAYASHI Toshiyuki;OSAMURA Anna;OHARA Makoto;HARA Noriko;HIGUCHI Akiko;YAMAMOTO Takeshi;HIRANO Tsutomu, Drugs R D, 15(3):245 - 251, Sep. 2015, Peer-reviewed
• Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor, Improves Early-Phase Insulin Secretion in Drug-Naïve Patients with Type 2 Diabetes., Rika Ito; Tomoyasu Fukui; Toshiyuki Hayashi; Anna Osamura; Makoto Ohara; Noriko Hara; Akiko Higuchi; Takeshi Yamamoto; Tsutomu Hirano, Drugs in R&D, 15(3):245 - 51, Sep. 2015
• Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor, Improves Early-Phase Insulin Secretion in Drug-Naïve Patients with Type 2 Diabetes., Rika Ito; Tomoyasu Fukui; Toshiyuki Hayashi; Anna Osamura; Makoto Ohara; Noriko Hara; Akiko Higuchi; Takeshi Yamamoto; Tsutomu Hirano, Drugs in R&D, 15(3):245 - 51, Sep. 2015
• Change of carotid intima-media thickness is associated with age in elderly Japanese patients without a history of cardiovascular disease., WATANABE Kentaro;OUCHI Motoshi;OHARA Makoto;KAMEDA Wataru;SUSA Shinji;OIZUMI Toshihide;WADA Manabu;SUZUKI Tatsuya;KAWANAMI Toru;OBA Kenzo;KATO Takeo, Geriatr Gerontol Int, 15(8):1023 - 1030, Aug. 2015, Peer-reviewed
• Association between pulse wave velocity and a marker of renal tubular damage (N-acetyl-β-D-glucosaminidase) in patients without diabetes., OUCHI Motoshi;OBA Kenzo;SAIGUSA Taro;WATANABE Kentaro;OHARA Makoto;MATSUMURA Noriaki;SUZUKI Tatsuya;ANZAI Naohiko;TSURUOKA Shuichi;TASUTAKE Masahiro, J Clin Hypertens (Greenwich), 17(4):290 - 297, Apr. 2015, Peer-reviewed
• Association between pulse wave velocity and a marker of renal tubular damage (N-acetyl-β-D-glucosaminidase) in patients without diabetes., Motoshi Ouchi; Kenzo Oba; Taro Saigusa; Kentaro Watanabe; Makoto Ohara; Noriaki Matsumura; Tatsuya Suzuki; Naohiko Anzai; Shuichi Tsuruoka; Masahiro Yasutake, Journal of clinical hypertension (Greenwich, Conn.), 17(4):290 - 7, Apr. 2015
• Association between pulse wave velocity and a marker of renal tubular damage (N-acetyl-β-D-glucosaminidase) in patients without diabetes., Motoshi Ouchi; Kenzo Oba; Taro Saigusa; Kentaro Watanabe; Makoto Ohara; Noriaki Matsumura; Tatsuya Suzuki; Naohiko Anzai; Shuichi Tsuruoka; Masahiro Yasutake, Journal of clinical hypertension (Greenwich, Conn.), 17(4):290 - 7, Apr. 2015
• Correlation between postprandial bile acids and body fat mass in healthy normal-weight subjects., SUZUKI Tatsuya;AOYAMA Junya;HASHIMOTO Masao;OHARA Makoto;FUTAMI-SUDA Shoko;SUZUKI Kazunari;OUCHI Motoshi;IGARI Yoshimasa;WATANABE Kentaro;NAKANO Hiroshi, Clin Biochem, 47(12):1128 - 1131, Aug. 2014, Peer-reviewed
• Biomarkers in the atherosclerosis, 小原　信;平野　勉, Angiol Front, 13(2):121 - 126, Aug. 2014
• Change in urinary N-acetyl-β-d-glucosaminidase levels relevant to postprandial glycemic control conditions in subjects without diabetes mellitus., OUCHI Motoshi;OBA Kenzo;OHARA Makoto;IGARI Yoshimasa;FUTAMI-SUDA Shoko;ISHII Kazuhito;AOYAMA Junya;ONISHI Tetsuro;TSUNODA-KUBOTA Misako;YAMASHITA Hidetoshi;SUZUKI Tatsuya;NAKANO Hiroshi, Clin Chim Acta, 433:88 - 92, Jun. 2014, Peer-reviewed
• Change in urinary N-acetyl-β-d-glucosaminidase levels relevant to postprandial glycemic control conditions in subjects without diabetes mellitus., Motoshi Ouchi; Kenzo Oba; Makoto Ohara; Yoshimasa Igari; Shoko Futami-Suda; Kazuhito Ishii; Junya Aoyama; Tetsuro Onishi; Misako Tsunoda-Kubota; Hidetoshi Yamashita; Tatsuya Suzuki; Hiroshi Nakano, Clinica chimica acta; international journal of clinical chemistry, 433:88 - 92, Jun. 2014
• Change in urinary N-acetyl-β-d-glucosaminidase levels relevant to postprandial glycemic control conditions in subjects without diabetes mellitus., Motoshi Ouchi; Kenzo Oba; Makoto Ohara; Yoshimasa Igari; Shoko Futami-Suda; Kazuhito Ishii; Junya Aoyama; Tetsuro Onishi; Misako Tsunoda-Kubota; Hidetoshi Yamashita; Tatsuya Suzuki; Hiroshi Nakano, Clinica chimica acta; international journal of clinical chemistry, 433:88 - 92, Jun. 2014
• Aortic arch calcification detectable on chest X-ray films is associated with plasma diacron-reactive oxygen metabolites in patients with type 2 diabetes but without cardiovascular disease., WATANABE Kentaro;OHARA Makoto;SUZUKI Tatsuya;OUCHI Motoshi;SUZUKI Kazunari;HASHIMOTO Masao;SAIGUSA Taro;AOYAMA Junya;NAKANO Hiroshi;OBA Kenzo, J Nippon Med Sch, 80(6):410 - 419, Nov. 2013, Peer-reviewed
• Relationship between postprandial glucose level and carotid artery stiffness in patients without diabetes or cardiovascular disease., Kentaro Watanabe; Tatsuya Suzuki; Motoshi Ouchi; Kazunari Suzuki; Makoto Ohara; Masao Hashimoto; Hidetoshi Yamashita; Masaru Okazaki; Kazuhito Ishii; Kenzo Oba, BMC cardiovascular disorders, 13:11 - 11, Feb. 2013
• Relationship between postprandial glucose level and carotid artery stiffness in patients without diabetes or cardiovascular disease., Kentaro Watanabe; Tatsuya Suzuki; Motoshi Ouchi; Kazunari Suzuki; Makoto Ohara; Masao Hashimoto; Hidetoshi Yamashita; Masaru Okazaki; Kazuhito Ishii; Kenzo Oba, BMC cardiovascular disorders, 13:11 - 11, Feb. 2013
• Improving in the fasting, but not the postprandial, glucose level is associated with reduction of plasma d-ROMs level in patients with type 2 diabetes., Makoto Ohara; Kentaro Watanabe; Tatsuya Suzuki; Ken-ichi Sekimizu; Masayuki Motoyama; Kazuhito Ishii; Keisuke Sawai; Hiroshi Nakano; Kenzo Oba; Kyoichi Mizuno, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 80(3):200 - 10, 2013
• Improving in the fasting, but not the postprandial, glucose level is associated with reduction of plasma d-ROMs level in patients with type 2 diabetes., Makoto Ohara; Kentaro Watanabe; Tatsuya Suzuki; Ken-ichi Sekimizu; Masayuki Motoyama; Kazuhito Ishii; Keisuke Sawai; Hiroshi Nakano; Kenzo Oba; Kyoichi Mizuno, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 80(3):200 - 10, 2013
• Urinary N-acetyl-beta-D-Glucosaminidase Levels are Positively Correlated With 2-Hr Plasma Glucose Levels During Oral Glucose Tolerance Testing in Prediabetes, Motoshi Ouchi; Tatsuya Suzuki; Masao Hashimoto; Masayuki Motoyama; Makoto Ohara; Kazunari Suzuki; Yoshimasa Igari; Kentaro Watanabe; Hiroshi Nakano; Kenzo Oba, JOURNAL OF CLINICAL LABORATORY ANALYSIS, 26(6):473 - 480, Nov. 2012
• Urinary N-acetyl-beta-D-Glucosaminidase Levels are Positively Correlated With 2-Hr Plasma Glucose Levels During Oral Glucose Tolerance Testing in Prediabetes, Motoshi Ouchi; Tatsuya Suzuki; Masao Hashimoto; Masayuki Motoyama; Makoto Ohara; Kazunari Suzuki; Yoshimasa Igari; Kentaro Watanabe; Hiroshi Nakano; Kenzo Oba, JOURNAL OF CLINICAL LABORATORY ANALYSIS, 26(6):473 - 480, Nov. 2012
• Urinary N-acetyl-β-D-glucosaminidase levels are positively correlated with 2-hr plasma glucose levels during oral glucose tolerance testing in prediabetes., Motoshi Ouchi; Tatsuya Suzuki; Masao Hashimoto; Masayuki Motoyama; Makoto Ohara; Kazunari Suzuki; Yoshimasa Igari; Kentaro Watanabe; Hiroshi Nakano; Kenzo Oba, Journal of clinical laboratory analysis, 26(6):473 - 80, Nov. 2012
• Urinary N-acetyl-β-D-glucosaminidase levels are positively correlated with 2-hr plasma glucose levels during oral glucose tolerance testing in prediabetes., Motoshi Ouchi; Tatsuya Suzuki; Masao Hashimoto; Masayuki Motoyama; Makoto Ohara; Kazunari Suzuki; Yoshimasa Igari; Kentaro Watanabe; Hiroshi Nakano; Kenzo Oba, Journal of clinical laboratory analysis, 26(6):473 - 80, Nov. 2012
• Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects, M. Ouchi; K. Oba; H. Yamashita; M. Okazaki; M. Tsunoda; M. Ohara; K. Sekimizu; K. Watanabe; T. Suzuki; H. Nakano, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 120(5):288 - 295, May 2012
• Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects, M. Ouchi; K. Oba; H. Yamashita; M. Okazaki; M. Tsunoda; M. Ohara; K. Sekimizu; K. Watanabe; T. Suzuki; H. Nakano, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 120(5):288 - 295, May 2012
• 低血糖出現と血糖コントロールおよび年齢の関連 血糖日内変動を用いた検討, 渡邉 健太郎; 小原 信; 鈴木 一成; 鈴木 達也; 中野 博司; 大庭 建三; 小林 俊介, 成人病と生活習慣病, 42(5):606 - 606, May 2012
• 低血糖出現と血糖コントロールおよび年齢の関連 血糖日内変動を用いた検討, 渡邉 健太郎; 小原 信; 鈴木 一成; 鈴木 達也; 中野 博司; 大庭 建三; 小林 俊介, 成人病と生活習慣病, 42(5):606 - 606, May 2012
• The importance of assessment of endothelial function according to the time course of flow-mediated dilation of the brachial artery., Kentaro Watanabe; Kenzo Oba; Tatsuya Suzuki; Motoshi Ouchi; Kazunari Suzuki; Shoko Futami-Suda; Kenichi Sekimizu; Jun Norose; Misako Tsunoda; Makoto Ohara; Hiroshi Nakano, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 77(1):59 - 61, Feb. 2010
• The importance of assessment of endothelial function according to the time course of flow-mediated dilation of the brachial artery., Kentaro Watanabe; Kenzo Oba; Tatsuya Suzuki; Motoshi Ouchi; Kazunari Suzuki; Shoko Futami-Suda; Kenichi Sekimizu; Jun Norose; Misako Tsunoda; Makoto Ohara; Hiroshi Nakano, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 77(1):59 - 61, Feb. 2010

Presentations

• Glucose-dependent insulinotropic polypeptideの心筋細胞への作用－糖尿病性心筋症の新たな治療標的－, 森　雄作;寺崎　道重;広村　宗範;小原　信;福井　智康;山岸　昌一, 脳心血管抗加齢研究会第17回学術大会, 17 Dec. 2021, 大阪・Web開催
• Glucose-dependent insulinotropic polypeptideの心リモデリング抑制作用：2型糖尿病モデルマウスにおける検討, 森　雄作;小原　信;山岸　昌一, 第21回日本抗加齢医学会総会, 25 Jun. 2021, 京都・WEB開催
• 終末糖化産物受容体(RAGE)阻害アプタマーはApoE欠損マウスの動脈硬化進展を抑制する, 寺﨑　道重;森　雄作;八島　広典;外川内　亜美;松井　孝憲;斎藤　智美;九島　秀樹;広村　宗範;大坂　直也;小原　信;福井　智康;山岸　昌一, 第64回日本糖尿病学会年次学術集会, 20 May 2021, Web開催
• GIPの心保護作用：肥満2型糖尿病モデルマウスでの検討, 森　雄作;広村　宗範;寺崎　道重;九島　秀樹;斎藤　智美;大阪　直也;八島　広典;小原　信;福井　智康;山岸　昌一, 第94回日本内分泌学会学術総会, 22 Apr. 2021, バーチャル開催
• グルカゴンの抗動脈硬化作用：動脈硬化モデルマウスにおける検討, 森　雄作;九島　秀樹;寺﨑　道重;広村　宗範;斎藤　智美;小渋　正和;大坂　直也;八島　広典;小原　信;福井　智康;平野　勉;山岸　昌一, 第63回日本糖尿病学会年次学術集会, 09 Oct. 2020, Web開催
• GIP（Glucose-dependent insulinotropic polypeptide）はマウスとヒトのマクロファージ泡沫化を抑制する, 八島　広典;寺﨑　道重;齋藤　智美;森　雄作;広村　宗範;九島　秀樹;小澁　正和;大坂　直也;小原　信;福井　智康;山田　祐一郎;清野　裕;平野　勉;山岸　昌一, 第63回日本糖尿病学会年次学術集会, 05 Oct. 2020, Web開催
• Teneligliptinは1型糖尿病マウスと1型糖尿病患者のマクロファージ泡沫化をAGEs系の抑制により改善する, 寺﨑　道重;八島　広典;森　雄作;斎藤　智美;広村　宗範;九島　秀樹;小澁　正和;大坂　直也;小原　信;福井　智康;平野　勉;山岸　昌一, 第63回日本糖尿病学会年次学術集会, 05 Oct. 2020, Web開催
• Glucose-dependent insulinotropic polypeptide (GIP) inhibits macrophages foam cell formation via suppression of CD36 expression, YASHIMA Hironori;TERASAKI Michishige;SAITO Tomomi;MORI Yusaku;HIROMURA Munenori;KUSHIMA Hideki;KOSHIBU Masakazu;OSAKA Naoya;OHARA Makoto;FUKUI Tomoyasu;SEINO Yutaka;YAMADA Yuichiro;HIRANO Tsutomu;YAMAGISHI Sho-ichi, 56th EASD Annual Meeting, 24 Sep. 2020, VIRTUAL Congress
• 2型糖尿病におけるHbA1c、GA及び1,5-AGと酸化ストレスの関連の検討, 九島　秀樹;小原　信;藤川　大輝;後藤　聡;深瀬　絢子;長池　弘江;佐藤　展子;広村　宗範;髙畑　洋;寺﨑　道重;福井　智康;森　雄作;山岸　昌一, 第34回日本糖尿病合併症学会, 28 Sep. 2019, 大阪
• Glucose-dependent insulinotropic peptide remarkably suppresses macrophage foam cell formation in the mice and the humans., YASHIMA Hironori;TERASAKI Michishige;SAITO Tomomi ;MORI Yusaku;HIROMURA Munenori;KUSHIMA Hideki;KOSHIBU Masakazu;OHARA Makoto;FUKUI Tomoyasu;SEINO Yutaka;YAMADA Yuichiro;HIRANO Tsutomu, 55th Annual Meeting of the European Association for the Study of Diabetes, 19 Sep. 2019, Barcelona
• 2型糖尿病においてLDLTGの増加は冠動脈石灰化に関与する, 長池　弘江;林　俊行;高畑　洋;後藤　聡;深瀬　絢子;中西　賀子;小原　信;長村　杏奈;山本　剛史;福井　智康;太田　素子;伊藤　康樹;平野　勉, 第62回日本糖尿病学会年次学術集会, 24 May 2019, 仙台
• Increased Angiopoietin Like Proteins 4(ANGPTL4) Is Associated with Higer Concentration of LDL-Triglycerides in Type 2 Diabetes, NAGAIKE Hiroe;HAYASHI Toshiyuki;NAKANISHI Noriko;OHARA Makoto;YAMAMOTO Takeshi;FUKUI Tomoyasu;HIRANO Tsutomu, 78th Scientific Sessions American Diabetes Association, 23 Jun. 2018, Orlando
• 日本人1型糖尿病の膵体積と各種背景因子との関係, 深瀬　絢子;福井　智康;笹森　寛人;山村　聡;林　俊行;長村　杏奈;森　雄作;山本　剛史;高田　道哉;小原　信;坂下　暁子;新村　京子;小橋　京子;広村　宗範;九島　秀樹;山本　咲;長池　弘江;後藤　聡;高畑　洋;平野　勉, 第61回日本糖尿病学会年次学術集会, 26 May 2018, 東京
• リラグルチドでの早期治療は経年的なインスリン分泌低下を抑止し得る, 山本　剛史;深瀬　絢子;長池　弘江;後藤　聡;佐藤　展子;山本　咲;小原　信;林　俊行;福井　智康;平野　勉, 第61回日本糖尿病学会年次学術集会, 26 May 2018, 東京
• 2型糖尿病における高LDL-TG血症にアンジオポエチン様蛋白4型が関与する, 長池　弘江;林　俊行;後藤　聡;中西　賀子;小原　信;長村　杏奈;山本　剛史;福井　智康;太田　素子;伊藤　康樹;平野　勉, 第61回日本糖尿病学会年次学術集会, 25 May 2018, 東京
• 高血圧症合併2型糖尿病におけるCGMとABPMを用いた血糖変動指標および血圧変動指標と酸化ストレスの関連についての検討, 小原　信;長池　弘江;後藤　聡;深瀬　絢子;山村　聡;佐藤　展子;山本　咲;九島　秀樹;広村　宗範;小橋　京子;新村　京子;山本　剛史;林　俊行;福井　智康;平野　勉, 第61回日本糖尿病学会年次学術集会, 25 May 2018, 東京
• 世界糖尿病デーイベントでの筋力指標測定と骨折リスクに関するアンケート調査　糖代謝異常による骨折リスクと身体活動量の評価, 吉川　雅之;葛城　怜子;飯野　里佳;諸戸　安惠;中田　美江;八島　広典;小渋　正和;後藤　聡;長池　弘江;深瀬　絢子;山村　聡;佐藤　展子;山本　咲;九島　秀樹;広村　宗範;小橋　京子;新村　京子;小原　信;山本　剛史;森　雄作;長村　杏奈;林　俊行;高橋　育克;福井　智康;佐々木　忠徳;平野　勉, 第61回日本糖尿病学会年次学術集会, 24 May 2018, 東京
• 産後16日目に心不全入院を契機に発見された甲状腺中毒症の一例, 長池　弘江;高橋　育克;広村　宗範;小原　信;林　俊行;福井　智康;平野　勉, 第91回日本内分泌学会学術総会, 26 Apr. 2018, 宮崎
• Clinical factors associated with daily and day-to-day glucose variability determined by continuous glucose monitoring and the glucagon stimulation test in type 2 diabetic patients, OHARA Makoto;TOMOYASU Masako;NAGAIKE Hiroe;GOTO Satoshi;TANABE Yuki;KUSHIMA Hideki;HIROMURA Munenori;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, The 11th International Conference on Advanced Technologies & Treatments for Diabetes, 14 Feb. 2018, Vienna
• Prostatic abscess found with Septic pulmonary embolism and Infective endocarditis in Type 2 diabetes, 八島　広典;田邉　優希;小原　信;藤川　大輝;平野　勉, 第55回日本糖尿病学会関東甲信越地方会, 20 Jan. 2018, 新潟
• 2型糖尿病患者における1,5-AGと酸化ストレスの関連の検討, 九島　秀樹;小原　信;藤川　大輝;八島　広典;大坂　直也;義間　大也;小澁　正和;後藤　聡;佐藤　展子;田邉　優希;広村　宗範;新村　京子;小橋　京子;森　雄作;髙橋　育克;山本　剛史;林　俊行;福井　智康;平野　勉, 第32回日本糖尿病合併症学会, 27 Oct. 2017, 東京
• Relationship between glucose metabolism improvement and oxidative stress improvement in type 2 diabetes, OHARA Makoto;NAGAIKE Hiroe;MAEKI Nobuko;YAMAMOTO Saki;TOMOYASU Masako;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, 77th Scientific Sessions American Diabetes Association, 10 Jun. 2017, San Diego
• 2型糖尿病における持続血糖モニタリング（CGM）を用いた各種血糖変動指標の改善度と酸化ストレスの改善度の関連についての検討, 小原　信;長池　弘江;後藤　聡;前木　展子;田邉　優希;山本　咲;友安　雅子;長村　杏奈;山本　剛史;林　俊行;福井　智康;平野　勉, 第60回日本糖尿病学会年次学術集会, 20 May 2017, 名古屋
• ビルダグリプチンとメトホルミンの併用から同薬の配合錠への切り替えによるHbA1c改善効果　年齢別での検討, 吉川　雅之;林　俊行;葛城　怜子;山田　寛子;名倉　美之;嶋村　弘史;小原　信;山本　剛史;福井　智康;佐々木　忠徳;平野　勉, 第60回日本糖尿病学会年次学術集会, 19 May 2017, 名古屋
• SGLT2阻害薬はALT高値の2型糖尿病患者において優先的に血中アミノ酸を低下させる, 長池　弘江;林　俊行;後藤　聡;前木　展子;田邉　優希;山本　咲;友安　雅子;原　賀子;小原　信;長村　杏奈;山本　剛史;福井　智康;平野　勉, 第60回日本糖尿病学会年次学術集会, 19 May 2017, 名古屋
• 2型糖尿病における血中ノルアドレナリン濃度と臨床的特徴の関係, 山本　剛史;福井　智康;小原　信;広村　宗範;髙橋　育克;林　俊行;平野　勉, 第60回日本糖尿病学会年次学術集会, 18 May 2017, 名古屋
• マウス動脈傷害モデルにおけるliraglutideのnitric oxideを介した動脈リモデリング抑制効果, 九島　秀樹;森　雄作;山本　剛史;小原　信;新村　京子;小橋　京子;広村　宗範;田邉　優希;小澁　正和;後藤　聡;平野　勉, 第60回日本糖尿病学会年次学術集会, 18 May 2017, 名古屋
• 2型糖尿病患者におけるダパグリフロジンは末梢血圧以上に中心血圧を低下させ、心負荷を軽減する, 林　俊行;長池　弘江;深瀬　絢子;後藤　聡;田邉　優希;前木　展子;友安　雅子;高田　道哉;原　賀子;小原　信;長村　杏奈;山本　剛史;福井　智康;平野　勉, 第60回日本糖尿病学会年次学術集会, 18 May 2017, 名古屋
• Relationship between the degree of improvement in glucose metabolism and oxidative stress in type 2 diabetes patients, OHARA Makoto;NAGAIKE Hiroe;MAEKI Nobuko;YAMAMOTO Saki;KUSHIMA Hideki;HIROMURA Munenori;YAMAMOTO Takeshi;HAYASHI Toshiyuki;FUKUI Tomoyasu;HIRANO Tsutomu, 10th Advanced Technologies & Treatments for Diabetes, 15 Feb. 2017, Paris
• オランザピン服用中に急性発症1型糖尿病による糖尿病ケトアシドーシスを発症した1例, 九島　秀樹;小原　信;田邉　優希;友安　雅子;小橋　京子;広村　宗範;山本　咲;笹森　寛人;前木　展子;平野　勉, 第54回日本糖尿病学会関東甲信越地方会, 21 Jan. 2017, 横浜
• “Intra-day” and “Day-to-Day” Glucose Variability Both Increase Oxidative Stress Determined by d-ROMs in Type 2 Diabetes: A Cross-Sectional Study, OHARA Makoto;FUKUI Tomoyasu;OUCHI Motoshi;WATANABE Kentaro;SUZUKI Tatsuya;YAMAMOTO Takeshi;HAYASHI Toshiyuki;OBA Kenzo;HIRANO Tsutomu, 76th Scientific Sessions American Diabetes Association, 13 Jun. 2016, New Orleans
• Sensor augmented pump (SAP) システムを導入した１型糖尿病患者における高血糖、低血糖、血糖変動に関する検討, 山本　剛史;小原　信;森　雄作;山本　咲;林　俊行;福井　智康;平野　勉, 第59回日本糖尿病学会年次学術集会, 21 May 2016, 京都
• 2型糖尿病患者における有痛性糖尿病性神経障害の痛みの強さは自律神経障害を反映する, 長池　弘江;樋口　明子;佐藤　潤;深瀬　絢子;小澁　正和;後藤　聡;山本　咲;友安　雅子;原　賀子;小原　信;長村　杏奈;山本　剛史;林　俊行;福井　智康;平野　勉, 第59回日本糖尿病学会年次学術集会, 21 May 2016, 京都
• 2型糖尿病における血糖日内変動および日差変動と関連する臨床的因子について持続血糖モニターとグルカゴン負荷試験を用いた検討, 小原　信;山本　咲;長池　弘江;深瀬　絢子;後藤　聡;友安　雅子;原　賀子;山本　剛史;長村　杏奈;林　俊行;福井　智康;平野　勉, 第59回日本糖尿病学会年次学術集会, 19 May 2016, 京都
• インスリン治療中2型糖尿病患者に対するリラグルチド併用療法についての検討, 山本　咲;友安　雅子;原　賀子;小原　信;山本　剛史;林　俊行;福井　智康;平野　勉, 第30回日本糖尿病合併症学会, 28 Nov. 2015, 名古屋
• 2型糖尿病患者におけるMDA-LDLと持続血糖モニタリング(CGM)で得られる血糖変動指標および各種検査所見との関係, 九島　秀樹;小原　信;林　俊行;樋口　明子;前木　展子;富田　高臣;山本　咲;広村　宗範;小橋　京子;森　雄作;原　賀子;長村　杏奈;髙橋　育克;福井　智康;平野　勉, 第58回日本糖尿病学会年次学術集会, 23 May 2015, 下関
• 2型糖尿病における持続血糖モニタリング(CGM)を用いた各種血糖変動の指標と酸化ストレスの関連についての検討, 小原　信;樋口　明子;前木　展子;九島　秀樹;寺﨑　道重;友安　雅子;小橋　京子;山本　剛史;長村　杏奈;林　俊行;福井　智康;大内　基司;渡邉　健太郎;鈴木　達也;平野　勉, 第58回日本糖尿病学会年次学術集会, 22 May 2015, 下関
• 閉経後2型糖尿病患者の肥満度は骨リモデリング低下と強く関連する, 福井　智康;林　俊行;山本　剛史;李　相翔;土屋　明子;小原　信;山本　咲;原　賀子;髙橋　育克;長村　杏奈;友安　雅子;平野　勉, 第58回日本糖尿病学会年次学術集会, 22 May 2015, 下関
• リラグルチド長期使用後の脂肪分布と脂質代謝への影響, 山本　剛史;樋口　明子;前木 展子;山本　咲;富田　高臣;九島　秀樹;友安　雅子;李　相翔;原　賀子;小原　信;長村　杏奈;林　俊行;髙橋　育克;福井　智康;平野　勉, 第58回日本糖尿病学会年次学術集会, 22 May 2015, 下関
• 2型糖尿病患者における血中脂肪酸とsmall dense LDLとの関係, 林　俊行;前木　展子;富田　高臣;山本　咲;九島　秀樹;広村　宗範;小橋　京子;新村　京子;樋口　明子;友安　雅子;原　賀子;李　相翔;小原　信;長嶋　理晴;森　雄作;長村　杏奈;山本　剛史;髙橋　育克;福井　智康;平野　勉, 第58回日本糖尿病学会年次学術集会, 22 May 2015, 下関
• 早期糖尿病性神経障害評価における新規機器　足底感覚検査装置の有用性と健常者との比較検討, 樋口　明子;林　俊行;山本　咲;前木　展子;富田　高臣;九島　秀樹;友安　雅子;李　相翔;原　賀子;小原　信;長村　杏奈;山本　剛史;髙橋　育克;佐藤　満;福井　智康;平野　勉, 第58回日本糖尿病学会年次学術集会, 21 May 2015, 下関
• 2型糖尿病患者における軽度認知障害の検討, 小橋　京子;森　友紀子;二村　明徳;前木　展子;九島　秀樹;広村　宗範;伊藤　利香;新村　京子;樋口　明子;野木　孝准;友安　雅子;寺﨑　道重;小原　信;原　賀子;森田　亮;李　相翔;河村　満;平野　勉, 第29回日本糖尿病合併症学会, 03 Oct. 2014, 東京
• 腎機能低下の2型糖尿病に対するインスリンとリナグリプチン併用療法の効果, 小原　信;福井　智康;広村　宗範;野木　孝准;平野　勉, 第57回日本糖尿病学会年次学術集会, 23 May 2014, 大阪