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Aizawa Ryo

■FacultyPeriodontology
■PositionSenior Lecturer
Last Updated :2025/12/13

Researcher

基本情報

Profile and Settings

  • 氏名

    Aizawa Ryo

Affiliation

  • Periodontology, Senior Lecturer

Location

  • Dental Hospital

Degree

  • Showa University, Mar. 2013

Awards

  • Jan. 2023

Achievements

Published Papers

  • Effects of Porphyromonas gingivalis-derived lipopolysaccharide on the barrier function of cultured junctional epithelial cells, Ryo Aizawa; Masaru Sunaga; Keisuke Tanaka; Marika Sugano; Daisuke Saito; Koki Okada; Junichi Tanaka; Kenji Mishima; Matsuo Yamamoto, Journal of Oral Biosciences, 68(1):100721, Feb. 2026, Peer-reviewed, DOI:10.1016/j.job.2025.100721
  • Reply to Dr. Nicholas G. Fischer: Letter to "Mirror-polished ceria-stabilized zirconia/alumina nanocomposite enhances gingival junctional epithelial cell adhesion"., Yamamori Shoma;Urano-Morisawa Eri;Mochizuki Ayako;Aizawa Ryo;Iwasa Fuminori;Yamamoto Matsuo;Baba Kazuyoshi, Journal of oral biosciences, 67(2), Apr. 2025
  • Mirror-polished ceria-stabilized zirconia/alumina nanocomposite enhances gingival junctional epithelial cell adhesion, Shoma Yamamori, Eri Urano-Morisawa, Ayako Mochizuki, Ryo Aizawa, Fuminori Iwasa, Matsuo Yamamoto, Baba Kazuyoshi, Journal of Oral Biosciences, Dec. 2024, Peer-reviewed, DOI:10.1016/j.job.2024.100593
  • Local Concentrations of TGF-β1 and IGF-1 Appear Determinant in Regulating Bone Regeneration in Human Postextraction Tooth Sockets., Asparuhova Maria B;Riedwyl Dominic;Aizawa Ryo;Raabe Clemens;Couso-Queiruga Emilio;Chappuis Vivianne, International journal of molecular sciences, 24(9), May 2023, Peer-reviewed, DOI:10.3390/ijms24098239
  • 知の集積から見えてきた接合上皮の恒常性維持機構, 相澤 怜;田中 準一;美島 健二;山本 松男, 日本歯周病学会会誌, 64(4):121 - 128, Dec. 2022, Peer-reviewed, DOI:https://doi.org/10.2329/perio.64.121
  • The Role of Lactic Acid on Wound Healing, Cell Growth, Cell Cycle Kinetics, and Gene Expression of Cultured Junctional Epithelium Cells in the Pathophysiology of Periodontal Disease., ISHIKAWA T;SASAKI D;AIZAWA Ryo;YAMAMOTO Matsuo;YAEGASHI T;IRIE T;SASAKI M, Pathogens, 10(11):1507, Nov. 2021, Peer-reviewed, DOI:https://doi.org/10.3390/pathogens10111507
  • Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells, 田中　慧介;TANAKA Junichi;AIZAWA Ryo;KATO-TANAKA Mayu;UENO Hiroo ;MISHIMA Kenji;YAMAMOTO Matsuo, Sci Rep, 11(1):18860, Sep. 2021, Peer-reviewed
  • Maintaining a protective state for human periodontal tissue., YAMAMOTO Matsuo;AIZAWA Ryo, Periodontol 2000, 86(1):142 - 156, Jun. 2021, Peer-reviewed
  • Effect of Butyric Acid in the Proliferation and Migration of Junctional Epithelium in the Progression of Periodontitis: An In Vitro Study., Taichi Ishikawa; Daisuke Sasaki; Ryo Aizawa; Yu Shimoyama; Matsuo Yamamoto; Tarou Irié; Minoru Sasaki, Dentistry journal, 9(4):44, Apr. 2021, Peer-reviewed
  • Visualization of junctional epithelial cell replacement by oral gingival epithelial cells over a life time and after gingivectomy, KATO Mayu;TANAKA Junichi;AIZAWA Ryo;YAJIMA-HIMURO Sara;SEKI Tatsuaki;TANAKA Keisuke;YAMADA Atsushi;OGAWA Miho;KAMIJO Ryutaro;TSUJI Takashi;MISHIMA Kenji;YAMAMOTO Matsuo, Sci Rep, 9(1):7640, May 2019, Peer-reviewed
  • Cdc42 regulates cranial suture morphogenesis and ossification., AIZAWA Ryo;YAMADA Atsushi;SEKI Tatsuaki;TANAKA Junichi;NAGAHAMA Ryo;IKEHATA Mikiko;KATO Tadashi;SAKASHITA Akiko;OGATA Hiroaki;CHIKAZU Daichi;MAKI Koutaro;MISHIMA Kenji;YAMAMOTO Matsuo;KAMIJO Ryutaro, Biochem Biophys Res Commun, 512(2):145 - 149, Apr. 2019, Peer-reviewed
  • Establishment of mouse gingival junctional epithelial cell line using a bioengineered tooth system, SEKI Tatsuaki;AIZAWA Ryo;TANAKA Junichi;YAJIMA-HIMURO Sara;KATO Mayu;TANAKA Keisuke;MISHIMA Kenji;YAMAMOTO Matsuo, Biochem Biophys Res Commun, 497(1):167 - 172, Feb. 2018, Peer-reviewed
  • Cdc42 is crucial for facial and palatal formation during craniofacial development., OSHIMA-NAKAYAMA Mutsuko;YAMADA Atsushi;KUROSAWA Tamaki;AIZAWA Ryo;SUZUKI Dai;SAITO Yoshiro;KASSAI Hidetoshi;SATO Yuki;YAMAMOTO Matsuo;SHIROTA Tatsuo;AIBA Atsu;MAKI Koutaro;KAMIJO Ryutaro, Bone Rep, 5:1 - 6, Dec. 2016, Peer-reviewed
  • Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3., HIRANUMA Katsuhiro;YAMADA Atsushi;KUROSAWA Tamaki;AIZAWA Ryo;SUZUKI Dai;SAITO Yoshiro;NAGAHAMA Ryo;IKEHATA Mikiko;TSUKASAKI Masayuki;MORIMURA Naoko;CHIKAZU Daichi;MAKI Koutaro;SHIROTA Tatsuo;TAKAMI Masamichi;YAMAMOTO Matsuo;IIJIMA Takehiko;KAMIJO Ryutaro, FEBS Open Bio, 6(9):914 - 918, Jul. 2016, Peer-reviewed
  • Rho GTPase protein Cdc42 is critical for postnatal cartilage development., NAGAHAMA Ryo;YAMADA Atsushi;TANAKA Junichi;AIZAWA Ryo;SUZUKI Dai;KASSAI Hidetoshi;YAMAMOTO Matsuo;MISHIMA Kenji;AIBA Atsu;MAKI Koutaro;KAMIJO Ryutaro, Biochem Biophys Res Commun, 470(4):813 - 817, Feb. 2016, Peer-reviewed
  • 接合上皮の解析, 山本　松男;氷室　沙羅;西井　浩介;塚本　康己;林　以庸;相澤　怜;関　辰明;田中　準一;美島　健二, 日本歯周病学会会誌, 57(1):11 - 17, May 2015, Peer-reviewed
  • Cdc42 is critical for cartilage development during endochondral ossification., SUZUKI Wataru;YAMADA Atsushi;AIZAWA Ryo;SUZUKI Dai;KASSAI Hidetoshi;HARADA Takeshi;Nakayama Mutsuko;NAGAHAMA Ryo;MAKI Koutaro;TAKEDA Shu;YAMAMOTO Matsuo;AIBA Atsu;BABA Kazuyoshi;KAMIJO Ryutaro, Endocrinology, 156(1):314 - 322, Jan. 2015, Peer-reviewed, DOI:10.1210/en.2014-1032
  • Cdc42 plays important roles in bone formation during limb development., Aizawa, R; Yamada, A; Suzuki, D; Tsukasaki, M; Yamamoto, M; Kamijo, R, Jpn. J. Tissue Cult. Dent. Res., 22:35 - 41, 2015, Peer-reviewed
  • BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation, Takashi Matsumoto; Atsushi Yamada; Ryo Aizawa; Dai Suzuki; Masayuki Tsukasaki; Wataru Suzuki; Mutsuko Nakayama; Koutaro Maki; Matsuo Yamamoto; Kazuyoshi Baba; Ryutaro Kamijo, PLOS ONE, 8(6):e68774, Jun. 2013, Peer-reviewed
  • BMP2 Differentially Regulates the Expression of Gremlin1 and Gremlin2, the Negative Regulators of BMP Function, During Osteoblast Differentiation, Dai Suzuki; Atsushi Yamada; Ryo Aizawa; Sakie Funato; Takashi Matsumoto; Wataru Suzuki; Masamichi Takami; Yoichi Miyamoto; Tetsuo Suzawa; Matsuo Yamamoto; Kazuyoshi Baba; Ryutaro Kamijo, CALCIFIED TISSUE INTERNATIONAL, 91(1):88 - 96, Jul. 2012, Peer-reviewed
  • Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development, Ryo Aizawa; Atsushi Yamada; Dai Suzuki; Tadahiro Iimura; Hidetoshi Kassai; Takeshi Harada; Masayuki Tsukasaki; Gou Yamamoto; Tetsuhiko Tachikawa; Kazuki Nakao; Matsuo Yamamoto; Akira Yamaguchi; Atsu Aiba; Ryutaro Kamijo, MECHANISMS OF DEVELOPMENT, 129(1-4):38 - 50, Mar. 2012, Peer-reviewed
  • Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-alpha, Masayuki Tsukasaki; Atsushi Yamada; Dai Suzuki; Ryo Aizawa; Agasa Miyazono; Yoichi Miyamoto; Tetsuo Suzawa; Masamichi Takami; Kentaro Yoshimura; Naoko Morimura; Matsuo Yamamoto; Ryutaro Kamijo, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 410(4):766 - 770, Jul. 2011, Peer-reviewed

Presentations

  • Porphyromonas gingivalis LPS impairs barrier function in cultured junctional epithelial cells., AIZAWA Ryo, SUNAGA Masaru, SUGANO Marika, SAITO Daisuke, OKADA Koki, YAMAMOTO Matsuo, 日本歯科保存学会2025年度秋季学術大会（第163回）, 06 Nov. 2025, 長崎
  • 接合上皮における加齢変化のトランスクリプトーム解析, 須永　克，行森　茜，田中準一，相澤　怜，岡田昂己，斎藤大輔，美島健二，山本松男, 第68回秋季日本歯周病学会学術大会, 17 Oct. 2025, 新潟
  • Aging-related Changes of Junctional Epithelium in the Protective State of Periodontal tissue, SUNAGA Masaru, YUKIMORI Akane, TANAKA Junichi, AIZAWA Ryo, OKADA Koki, SAITO Daisuke, MISHIMA Kenji, YAMAMOTO Matsuo, EuroPerio11, 15 May 2025, Vienna
  • セリア安定化ジルコニア/アルミナナノ複合体(Ce-TZP/Al₂O₃)の表面粗さが歯肉接合上皮細胞の接着に及ぼす影響., 山森庄馬, 浦野絵里, 望月文子, 相澤怜, 岩佐文則, 山本松男 馬場一美, 第71回昭和大学学士会総会, 30 Nov. 2024
  • Analysis of aging-related changes in the junctional epithelium, 須永克、行森茜、田中準一、相澤怜、岡田昴己、美島健二、山本松男, 第66回歯科基礎医学会学術大会, 02 Nov. 2024
  • Porphyromonas gingivalis由来LPSが不死化接合上皮細胞の細胞機能に及ぼす影響, 相澤 怜;田中 慧介;田中 準一;菅野 真莉加;美島 健二;山本 松男, 第65回秋季日本歯周病学会学術大会, 02 Sep. 2022, 宮城
  • Investigation of junctional epithelial stem/progenitor cells using the multicolor lineage tracing method., TANAKA Keisuke;TANAKA Junichi;AIZAWA Ryo;KATO-TANAKA Mayu;UENO Hiroo;MISHIMA Kenji;YAMAMOTO Matsuo, The 106th Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology, the Japanese Academy of Clinical Periodontology, 06 Nov. 2020, VIRTUAL
  • Clonal analysis of junctional epithelium cells using multicolor lineage tracing method., 田中　慧介;田中　準一;相澤　怜;吉田　真子;松浦　徹;藤田　恭平;田中　麻友;上野　博夫;美島　健二;山本　松男, 第63回秋季日本歯周病学会学術大会, 16 Oct. 2020, Web開催
  • ハイドロキシアパタイト上での培養が不死化接合上皮細胞および口腔上皮細胞の遺伝子発現に及ぼす影響, 田中　慧介;相澤　怜;田中　準一;澤田　直子;関　辰明;田中　麻友;相内　敏弘;板部　洋之;美島　健二;山本　松男, 第62回秋季日本歯周病学会学術大会, 25 Oct. 2019, 北九州
  • Replacement of junctional epithelium by oral epithelium, KATO Mayu;AIZAWA Ryo;TANAKA Junichi;YAJIMA-HIMURO Sara;SEKI Tatsuaki;TANAKA Keisuke;MISHIMA Kenji;YAMAMOTO Matsuo, The 104th Annual Meeting of the American Academy of Periodontology in collaboration with the Canadian Academy of Periodontology,the Japanese Academy of Clinical Periodontology,and the Japanese Society of Periodontology., 29 Oct. 2018, Vancouver
  • 若手研究者の集い　～ベルン大学歯学部留学記～, 相澤　怜, 第61回秋季日本歯周病学会学術大会・第5回若手研究者の集い, 26 Oct. 2018, 大阪
  • Establishment of mouse gingival junctional epithelial cell line using a bioengineered tooth system, 関　辰明;相澤　怜;田中　準一;氷室(矢島)　沙羅;加藤　麻友;田中　慧介;美島　健二;山本　松男, 第61回秋季日本歯周病学会学術大会, 26 Oct. 2018, 大阪
  • Cellular replacement in junctional epithelium using a tooth germ transplantation method, 加藤　麻友;相澤　怜;関　辰明;田中　慧介;美島　健二;山本　松男, 第60回歯科基礎医学会学術大会, 05 Sep. 2018, 福岡
  • The changes of cellular composition in junctional epithelium, KATO Mayu;HIMURO Sara;TANAKA Junichi;AIZAWA Ryo;SEKI Tatsuaki;TANAKA Keisuke;MISHIMA Kenji;YAMAMOTO Matsuo, The 65th Annual Meeting of Japanese Association for Dental Research, 18 Nov. 2017, Tokyo
  • Immortalization of gingival junctional epithelial cells derived from bioengineered tooth, SEKI Tatsuaki;AIZAWA Ryo;TANAKA Junichi;YAJIMA-HIMURO Sara;KATO Mayu;TANAKA Keisuke;MISHIMA Kenji;YAMAMOTO Matsuo, 第65回国際歯科研究学会日本部会総会・学術大会, 18 Nov. 2017, 東京
  • A comprehensive gene expression analysis of junctional epithelium using a bioengineered tooth germ method., SEKI Tatsuaki;AIZAWA Ryo;MISHIMA Kenji;YAMAMOTO Matsuo, 第59回歯科基礎医学会学術大会, 17 Sep. 2017, 塩尻
  • Comprehensive analysis of gene expression in the junctional epithelium from bioengineered tooth., SEKI Tatsuaki;AIZAWA Ryo;TANAKA Junichi;HIMURO Sara;KATO Mayu;MISHIMA Kenji;YAMAMOTO Matsuo, The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology, 12 Sep. 2016, San Diego
  • 再構成歯胚を用いた接合上皮の起源の探索, 氷室　沙羅;相澤　怜;関　辰明;山本　松男, 日本歯科保存学会2015年度秋季学術大会(第143回)・第17回日韓歯科保存学会学術大会, 13 Nov. 2015, 東京
  • Reconfirmation of the junctional epithelium by using the bioengineered tooth germ, HIMURO Sara;TANAKA Junichi;AIZAWA Ryo;SEKI Tatsuaki;MISHIMA Kenji;YAMAMOTO Matsuo, Europerio 8, 03 Jun. 2015, London
  • Cdc42 is essential for cartilage development during endochondral ossification., SUZUKI Wataru;YAMADA Atsushi;AIZAWA Ryo;SUZUKI Dai;TAKEDA Shu;YAMAMOTO Matsuo;BABA Kazuyoshi;KAMIJO Ryutaro, ANZBMS 24th Annual Scientific Meeting, 07 Sep. 2014, Queenstown
  • Cdc42は軟骨分化とそれに続く軟骨内骨化に必須である, 鈴木　航;山田　篤;相澤　怜;鈴木　大;竹田　秀;山本　松男;馬場　一美;上條　竜太郎, 第32回日本骨代謝学会学術集会, 24 Jul. 2014, 大阪

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